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1. 发明申请

US20120282235A1 IMPLANTABLE PATCH AND SURGICAL KIT FOR PREPARATION THEREOF 审中-公开
标题翻译：可植入的配方及其手术套件的制备
公开(公告)号：US20120282235A1
公开(公告)日：2012-11-08
申请号：US13498284
申请日：2010-06-01
申请人： Kevin L. Ohashi , Dale R. Peterson , Jamal Rushdy
发明人： Kevin L. Ohashi , Dale R. Peterson , Jamal Rushdy
IPC分类号： A61K35/12 , A61K38/48 , A61K38/18 , B01D43/00 , A61K35/14 , A61K35/28 , B65D77/04 , A61J1/00 , A61K38/36 , A61K33/06
CPC分类号： A61L27/18 , A61L27/3616 , A61L27/3804 , A61L27/3834 , A61L27/54 , A61L2300/30 , C08L67/04
摘要： Embodiments of the present invention include a surgical kit for preparation of a patch for implantation into a human body, characterized in that it comprises a package containing, on one hand, a synthetic substrate (1) and, on the other hand, means for treatment of the substrate with a solution (3) including at least one biologically active component (4, 5), adapted to integrate the biologically active component with the substrate. Embodiments of the invention include a patch for implantation into the human body, comprising a synthetic substrate (1), characterized in that at least one biologically active component (4, 5) is integrated with the substrate using the surgical kit.
摘要翻译：本发明的实施例包括用于制备用于植入人体的贴剂的手术套件，其特征在于，其包括一方面包含合成基底（1），另一方面，所述包装包含用于治疗的装置（3）的溶液（3），该溶液（3）包括至少一种生物活性组分（4,5），其适于将生物活性组分与底物结合。本发明的实施方案包括用于植入人体的贴片，其包括合成基底（1），其特征在于，使用所述手术套件将至少一种生物活性成分（4,5）与所述基底一体化。

2. 发明申请

US20120239145A1 STRONG POROUS TRANS-TENDON REPAIR DEVICE WITH SUTURE TAILS 审中-公开
标题翻译：强大的多功能转换器维修设备，带有尾巴
公开(公告)号：US20120239145A1
公开(公告)日：2012-09-20
申请号：US13230623
申请日：2011-09-12
申请人： Dale R. Peterson , Peter Popper , Justin C. Anderson , Kevin Ohashi , Ralph Mattern , Jamal Rushdy
发明人： Dale R. Peterson , Peter Popper , Justin C. Anderson , Kevin Ohashi , Ralph Mattern , Jamal Rushdy
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2/0063
摘要： This reinforcing band (1) for restoring a soft tissue, such as a tendon or a ligament, comprises a textile component with at least one free edge (2, 4). In addition, the or each free edge is folded back into an inner volume of the textile component in such a way as to define an attachment edge (6, 8) suitable for attachment to the soft tissue.
摘要翻译：用于恢复诸如腱或韧带的软组织的该加强带（1）包括具有至少一个自由边缘（2,4）的织物部件。此外，该或每个自由边缘以这样的方式折回到纺织部件的内部容积中，以便限定适合于附接到软组织的附接边缘（6,8）。

3. 发明授权

US09421085B2 Surgical methods for soft tissue repair 有权
标题翻译：软组织修复手术方法
公开(公告)号：US09421085B2
公开(公告)日：2016-08-23
申请号：US13221766
申请日：2011-08-30
申请人： Randip R. Bindra , Dale R. Peterson , Kevin L. Ohashi
发明人： Randip R. Bindra , Dale R. Peterson , Kevin L. Ohashi
IPC分类号： A61F2/08 , A61B17/11
CPC分类号： A61F2/08 , A61B17/1146 , A61F2/0811 , A61F2002/0894 , D04C1/02 , D10B2509/00
摘要： The device (1) comprises a first snare (10) and a second snare (20), each of these snares comprising a contractable hollow elongated body (11, 21) which defines a longitudinal central axis (X10, X20) and which reduces its cross section when two opposed first (12, 22) and second (13, 23) ends thereof are axially moved away from each other. The first end (12) of the first snare (10) and the first end (22) of the second snare (20) are each open and adapted to be fitted and tightened around, respectively, two stumps (T1, T2) of a soft tissue (T) to be repaired. The second end (13) of the first snare (10) and the second end (23) of the second snare (20) are adapted to the axially pulled so that the second end of each of the two snares is passed alongside or through the body (11, 21) of the other snare.
摘要翻译：装置（1）包括第一圈套（10）和第二圈套（20），这些圈套中的每一个包括限定纵向中心轴线（X10，X20）的可收缩的中空细长主体（11,21），并且其减少当两个相对的第一（12,22）和第二（13,23）端部彼此轴向移动时，横截面。第一圈套（10）的第一端（12）和第二圈套（20）的第一端（22）分别打开并适于被安装和紧固，分别围绕着两个树桩（T1，T2）软组织（T）待修复。第二圈套（10）的第二端（13）和第二圈套（20）的第二端（23）适于轴向拉动，使得两个圈套中的每一个的第二端沿着或穿过另一个圈套的身体（11,21）。

4. 发明申请

US20140074247A1 JOINT RECONSTRUCTION SYSTEM AND METHOD 审中-公开
标题翻译：联合重建系统和方法
公开(公告)号：US20140074247A1
公开(公告)日：2014-03-13
申请号：US13319068
申请日：2010-05-07
申请人： Kevin L. Ohashi , Donald E. Running , Robert J. Ball , Randip R. Bindra , John J. Fernandez , Dale R. Peterson
发明人： Kevin L. Ohashi , Donald E. Running , Robert J. Ball , Randip R. Bindra , John J. Fernandez , Dale R. Peterson
IPC分类号： A61F2/46 , A61F2/42
CPC分类号： A61F2/4601 , A61F2/4241 , A61F2/4261 , A61F2002/30062 , A61F2002/30069 , A61F2002/3008 , A61F2002/30556 , A61F2002/30583 , A61F2002/30588 , A61F2002/3092 , A61F2002/4258 , A61F2002/4276 , A61F2210/0004 , A61F2210/0085 , A61F2250/0009 , A61F2250/0098
摘要： The implant (20) is shaped to generally mimic the form of the trapezium (12), or portions thereof. For example, the implant optionally defines a first metacarpal projection (32) and a second metacarpal projection (34) spaced from the first metacarpal projection to form a C-type, or cuff-type receptacle (36) for receiving the first metacarpal (15) such as the first and second metacarpal projections extend along either side of the first metacarpal. The receptacle optionally acts as a support surface (36A) for the first metacarpal during articulation thereof. In some embodiments, the first metacarpal projection is configured to extend adjacent the end portion of the first metacarpal that is adjacent the CMC joint (10) and the second metacarpal projection is configured to extend into the space (19) between the end portions of the first and second metacarpals (15, 18), thereby helping maintain the intermetacarpal spacing between the first and second metacarpals. The implant may comprise an inflatable cover for minimally invasive implantation.
摘要翻译：植入物（20）的形状通常模拟梯形（12）或其部分的形式。例如，植入物任选地限定与第一掌骨突起间隔开的第一掌骨突起（32）和第二掌骨突起（34），以形成C型或袖带型容器（36），用于接收第一掌骨（15）），例如第一和第二掌骨突起沿着第一掌骨的任一侧延伸。该插座任选地用作第一掌骨在其铰接期间的支撑表面（36A）。在一些实施例中，第一掌骨突起构造成邻近第一掌骨的靠近CMC关节（10）的端部延伸，并且第二掌骨突出部被构造成延伸到第二掌骨端部的端部之间的空间（19）第一和第二掌骨（15,18），从而有助于保持第一和第二掌骨之间的间距。植入物可以包括用于微创植入的可充气盖。

5. 发明申请

US20080188936A1 SYSTEM AND METHOD FOR REPAIRING TENDONS AND LIGAMENTS 审中-公开
标题翻译：修复吊坠和吊坠的系统和方法
公开(公告)号：US20080188936A1
公开(公告)日：2008-08-07
申请号：US12025449
申请日：2008-02-04
申请人： Robert J. Ball , Thomas D. Egan , Paul V. Fenton , Kevin L. Ohashi , Dale R. Peterson , Peter Sorenson , Douglas Snell , John Yannone , Patrick Fenton
发明人： Robert J. Ball , Thomas D. Egan , Paul V. Fenton , Kevin L. Ohashi , Dale R. Peterson , Peter Sorenson , Douglas Snell , John Yannone , Patrick Fenton
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61B17/1146 , A61B2017/0404 , A61B2017/0417 , A61B2017/0496 , A61F2/0063
摘要： An implant and method for the repair of a tendon or a ligament along at least one load direction. The implant includes at least one first anchor portion and at least one tension member oriented along a load direction. The first anchor portion preferably has a larger surface area of engagement with the tendon or ligament to spread loads across more tissue. The tension member is preferably secured to the first anchor portion with an overlapping attachment. Tension on the tension member is preferably adjustable by the surgeon.
摘要翻译：用于沿至少一个负载方向修复腱或韧带的植入物和方法。植入物包括至少一个第一锚定部分和沿着负载方向定向的至少一个张紧构件。第一锚固部分优选地具有与腱或韧带接合的更大的表面积，以将载荷跨越更多的组织。张紧构件优选地以重叠的附接件固定到第一锚固部分。张力构件上的张力优选由外科医生调节。

6. 发明授权

US06458763B1 Bone sialoprotein-based compositions for enhancing connective tissue repair 有权
标题翻译：基于骨涎蛋白的组合物用于增强结缔组织修复
公开(公告)号：US06458763B1
公开(公告)日：2002-10-01
申请号：US09398330
申请日：1999-09-17
申请人： Dale R. Peterson , Nancy Nousek-Goebl , Todd P. Glancy
发明人： Dale R. Peterson , Nancy Nousek-Goebl , Todd P. Glancy
IPC分类号： A61K3800
CPC分类号： A61L27/227 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/604 , Y10S514/964
摘要： The present invention is directed to bioactive compositions that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in vivo. More particularly the present invention is directed to the use of compositions comprising an effective amount of bone sialoprotein to enhance the repair of damaged or diseased bone.
摘要翻译：本发明涉及在损伤或患病组织与体内组合物接触时诱导损伤或患病结缔组织修复的生物活性组合物。更具体地，本发明涉及使用包含有效量的骨唾液酸蛋白的组合物来增强受损或患病骨的修复。

7. 发明授权

US07122205B2 Bioerodable polymeric adhesives for tissue repair 有权
公开(公告)号：US07122205B2
公开(公告)日：2006-10-17
申请号：US10811649
申请日：2004-03-29
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61K47/34
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.

8. 发明授权

US06733787B2 Bioerodable polymeric adhesives for tissue repair 有权
标题翻译：用于组织修复的生物可蚀塑料聚合物粘合剂
公开(公告)号：US06733787B2
公开(公告)日：2004-05-11
申请号：US09956390
申请日：2001-09-19
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61K910
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
摘要翻译：提供了使用包含生物相容的生物侵蚀性聚合物的基质的组织修复方法，所述聚合物包含衍生自乳酸，乙醇酸和己内酯或戊内酯的单体单元的热塑性丙交酯三元共聚物，其水溶性为约0.01 在约25℃下为约500mg / mL，粘合强度为约600至约150,000Pa，并将基质施加于组织缺损。基质或粘合剂可进一步包含填料或生物活性剂，或两者。

9. 发明授权

US06303138B1 Endothelin-based compositions for enhancing connective tissue repair 失效
标题翻译：用于促进结缔组织修复的基于内皮素的组合物
公开(公告)号：US06303138B1
公开(公告)日：2001-10-16
申请号：US09398494
申请日：1999-09-17
申请人： Dale R. Peterson , Nancy Nousek-Goebl , Todd P. Glancy
发明人： Dale R. Peterson , Nancy Nousek-Goebl , Todd P. Glancy
IPC分类号： A61F200
CPC分类号： A61L27/227 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2300/604
摘要： The present invention is directed to bioactive composition that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in vivo. More particularly the present invention is directed to the use of a composition comprising an effective amount of endothelin to enhance the repair of damaged or diseased bone and cartilage tissues.
摘要翻译：本发明涉及在损伤或患病组织与体内组合物接触时诱导损伤或患病结缔组织修复的生物活性组合物。更具体地，本发明涉及包含有效量的内皮素的组合物的用途，以增强受损或患病的骨和软骨组织的修复。

10. 发明授权

US06200606B1 Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration 失效
标题翻译：从造血和非造血组织分离前体细胞及其在体内骨和软骨再生中的应用
公开(公告)号：US06200606B1
公开(公告)日：2001-03-13
申请号：US08891952
申请日：1997-07-14
申请人： Dale R. Peterson , Nancy Nousek-Goebl
发明人： Dale R. Peterson , Nancy Nousek-Goebl
IPC分类号： A61K3512
CPC分类号： C12N5/0667 , A61K35/12 , A61K38/00 , A61K2035/124 , A61L27/3817 , A61L27/3821 , A61L27/3839 , A61L27/3847 , A61L27/3852 , C12N5/0663 , C12N2500/38 , C12N2501/39 , C12N2501/91
摘要： The present invention relates to the isolation of cartilage or bone precursor cells from hematopoietic and non-hematopoietic cells and their use in bone and cartilage regeneration procedures. The precursor cells are used for in vivo bone or cartilage repair by transplanting the cells, with or without a carrier material and without the need for in vitro culturing of the cells, to sites in the body requiring bone or cartilage repair.
摘要翻译：本发明涉及从造血细胞和非造血细胞中分离软骨或骨前体细胞及其在骨和软骨再生过程中的用途。前体细胞用于体内骨或软骨修复，通过移植具有或不具有载体材料的细胞，并且不需要体外培养细胞到体内需要骨或软骨修复的部位。

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