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1. 发明授权

US06458763B1 Bone sialoprotein-based compositions for enhancing connective tissue repair 有权
标题翻译：基于骨涎蛋白的组合物用于增强结缔组织修复
公开(公告)号：US06458763B1
公开(公告)日：2002-10-01
申请号：US09398330
申请日：1999-09-17
申请人： Dale R. Peterson , Nancy Nousek-Goebl , Todd P. Glancy
发明人： Dale R. Peterson , Nancy Nousek-Goebl , Todd P. Glancy
IPC分类号： A61K3800
CPC分类号： A61L27/227 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/604 , Y10S514/964
摘要： The present invention is directed to bioactive compositions that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in vivo. More particularly the present invention is directed to the use of compositions comprising an effective amount of bone sialoprotein to enhance the repair of damaged or diseased bone.
摘要翻译：本发明涉及在损伤或患病组织与体内组合物接触时诱导损伤或患病结缔组织修复的生物活性组合物。更具体地，本发明涉及使用包含有效量的骨唾液酸蛋白的组合物来增强受损或患病骨的修复。

2. 发明授权

US06303138B1 Endothelin-based compositions for enhancing connective tissue repair 失效
标题翻译：用于促进结缔组织修复的基于内皮素的组合物
公开(公告)号：US06303138B1
公开(公告)日：2001-10-16
申请号：US09398494
申请日：1999-09-17
申请人： Dale R. Peterson , Nancy Nousek-Goebl , Todd P. Glancy
发明人： Dale R. Peterson , Nancy Nousek-Goebl , Todd P. Glancy
IPC分类号： A61F200
CPC分类号： A61L27/227 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2300/604
摘要： The present invention is directed to bioactive composition that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in vivo. More particularly the present invention is directed to the use of a composition comprising an effective amount of endothelin to enhance the repair of damaged or diseased bone and cartilage tissues.
摘要翻译：本发明涉及在损伤或患病组织与体内组合物接触时诱导损伤或患病结缔组织修复的生物活性组合物。更具体地，本发明涉及包含有效量的内皮素的组合物的用途，以增强受损或患病的骨和软骨组织的修复。

3. 发明授权

US06364912B1 Pleiotrophin-based compositions for enhancing connective tissue repair 失效
标题翻译：用于促进结缔组织修复的基于营养蛋白的组合物
公开(公告)号：US06364912B1
公开(公告)日：2002-04-02
申请号：US09398333
申请日：1999-09-17
申请人： Dale R. Peterson , Nancy Nousek-Goebl
发明人： Dale R. Peterson , Nancy Nousek-Goebl
IPC分类号： A61F200
CPC分类号： A61K38/18 , A61L27/227 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2300/604 , Y10S623/908
摘要： Bioactive compositions that induce or enhance the repair of damaged or diseased connective tissues upon contact of the tissues with the compositions in vivo include an effective amount of pleiotrophin. A delivery vehicle is also included in the compositions. The compositions may be delivered to the repair sites by injection or by implantation.
摘要翻译：在组织与体内组合物接触时诱导或增强受损或患病结缔组织修复的生物活性组合物包括有效量的多余营养素。递送载体也包括在组合物中。组合物可以通过注射或通过植入递送至修复部位。

4. 发明授权

US06200606B1 Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration 失效
标题翻译：从造血和非造血组织分离前体细胞及其在体内骨和软骨再生中的应用
公开(公告)号：US06200606B1
公开(公告)日：2001-03-13
申请号：US08891952
申请日：1997-07-14
申请人： Dale R. Peterson , Nancy Nousek-Goebl
发明人： Dale R. Peterson , Nancy Nousek-Goebl
IPC分类号： A61K3512
CPC分类号： C12N5/0667 , A61K35/12 , A61K38/00 , A61K2035/124 , A61L27/3817 , A61L27/3821 , A61L27/3839 , A61L27/3847 , A61L27/3852 , C12N5/0663 , C12N2500/38 , C12N2501/39 , C12N2501/91
摘要： The present invention relates to the isolation of cartilage or bone precursor cells from hematopoietic and non-hematopoietic cells and their use in bone and cartilage regeneration procedures. The precursor cells are used for in vivo bone or cartilage repair by transplanting the cells, with or without a carrier material and without the need for in vitro culturing of the cells, to sites in the body requiring bone or cartilage repair.
摘要翻译：本发明涉及从造血细胞和非造血细胞中分离软骨或骨前体细胞及其在骨和软骨再生过程中的用途。前体细胞用于体内骨或软骨修复，通过移植具有或不具有载体材料的细胞，并且不需要体外培养细胞到体内需要骨或软骨修复的部位。

5. 发明授权

US07122205B2 Bioerodable polymeric adhesives for tissue repair 有权
公开(公告)号：US07122205B2
公开(公告)日：2006-10-17
申请号：US10811649
申请日：2004-03-29
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61K47/34
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.

6. 发明授权

US06733787B2 Bioerodable polymeric adhesives for tissue repair 有权
标题翻译：用于组织修复的生物可蚀塑料聚合物粘合剂
公开(公告)号：US06733787B2
公开(公告)日：2004-05-11
申请号：US09956390
申请日：2001-09-19
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61K910
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
摘要翻译：提供了使用包含生物相容的生物侵蚀性聚合物的基质的组织修复方法，所述聚合物包含衍生自乳酸，乙醇酸和己内酯或戊内酯的单体单元的热塑性丙交酯三元共聚物，其水溶性为约0.01 在约25℃下为约500mg / mL，粘合强度为约600至约150,000Pa，并将基质施加于组织缺损。基质或粘合剂可进一步包含填料或生物活性剂，或两者。

7. 发明授权

US5668288A Polyester ionomers for implant fabrication 失效
标题翻译：用于植入物制造的聚酯离聚物
公开(公告)号：US5668288A
公开(公告)日：1997-09-16
申请号：US633120
申请日：1996-04-16
申请人： Robson F. Storey , Z. David Deng , Todd P. Glancy , Dale R. Peterson
发明人： Robson F. Storey , Z. David Deng , Todd P. Glancy , Dale R. Peterson
IPC分类号： A61C8/00 , A61L27/00 , A61L27/18 , A61L31/06 , C08G63/06 , C08G63/16 , C08G63/68 , C07D213/22
CPC分类号： C08G63/16 , A61L27/18 , A61L31/06 , C08G63/06
摘要： Carboxy-terminated polyester ionomers useful for bioresorbable implant construction are described. They comprise biocompatible salts or partial salts of mono- or bis-carboxy-terminated polyesters.
摘要翻译：描述了可用于生物再吸收植入物结构的羧基封端的聚酯离聚物。它们包括单羧基或双羧基封端的聚酯的生物相容性盐或部分盐。

8. 发明授权

US06923985B2 Bioerodable polymeric adhesives for tissue repair 有权
标题翻译：用于组织修复的生物可蚀塑料聚合物粘合剂
公开(公告)号：US06923985B2
公开(公告)日：2005-08-02
申请号：US09923118
申请日：2001-08-06
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61L27/00 , A61K9/20 , A61L24/00 , A61L24/04 , A61L27/04 , A61L27/18 , A61L27/46 , C09J9/00 , A61K9/10 , A61K47/34 , A61K31/765 , C08G63/08
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Improved matrices and adhesives for tissue repair comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
摘要翻译：用于组织修复的改进的基质和粘合剂，其包含生物相容的可生物侵蚀的聚合物，所述聚合物包含衍生自乳酸，乙醇酸和己内酯或戊内酯的单体单元的热塑性丙交酯三元共聚物，其水溶解度为约0.01至约在约25℃下为500mg / mL，粘合强度为约600至约150,000Pa。基质或粘合剂可进一步包含填料或生物活性剂，或两者。

9. 发明授权

US06326025B1 Tissue reactive adhesive compositions 有权
标题翻译：组织反应性粘合剂组合物
公开(公告)号：US06326025B1
公开(公告)日：2001-12-04
申请号：US09530172
申请日：2000-04-24
申请人： Gerry Sigler , Z. David Deng , Dale R. Peterson , Todd P. Glancy , Samuel I. Stupp
发明人： Gerry Sigler , Z. David Deng , Dale R. Peterson , Todd P. Glancy , Samuel I. Stupp
IPC分类号： A61F1302
CPC分类号： A61L24/04 , C08L101/02 , Y10S602/904
摘要： The present invention is directed to a biocompatible tissue reactive composition comprising a functionalized polymer having tissue reactive substituents that are capable of forming covalent bonds with tissue associated functional groups.
摘要翻译：本发明涉及生物相容性组织反应性组合物，其包含具有能与组织相关官能团形成共价键的组织反应性取代基的官能化聚合物。

10. 发明授权

US06299905B1 Bioerodable polymeric adhesives for tissue repair 失效
标题翻译：用于组织修复的生物可蚀塑料聚合物粘合剂
公开(公告)号：US06299905B1
公开(公告)日：2001-10-09
申请号：US08633102
申请日：1996-04-16
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61K910
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Improved matrices for tissue repair comprising a biocompatible, bioerodable polymer which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa; and pressure sensitive adhesives for tissue repair which have adhesive strength of about 600 to about 150,000 Pa. The matrix or adhesive can further comprise a filler or a bioactive agent, or both. The matrices and adhesives are tissue-adherent and dough-like so they can be molded to fit a repair site. When used for bone/implant fixation, or as a filler for bone or cartilage repair, gradual short-term bioerosion of the adhesive matrix allows it to be replaced with developing bone or cartilage tissue. When used for release of a bioactive agent, the agent can be mixed into the adhesive matrix well before the implantation procedure. After implantation, the bioactive agent is gradually released as the adhesive matrix biodegrades.
摘要翻译：用于组织修复的改进的基质包括生物相容的可生物侵蚀的聚合物，其在约25℃下的水溶解度为约0.01至约500mg / mL，粘合强度为约600至约150,000Pa; 以及粘合强度为约600至约150,000Pa的用于组织修复的压敏粘合剂。基质或粘合剂还可包含填料或生物活性剂，或两者。基质和粘合剂是组织粘附和面团状的，因此它们可以被模塑以适合修复部位。当用于骨/植入物固定时，或作为骨或软骨修复的填料时，粘合剂基质的逐渐短期生物侵蚀允许其用显影的骨或软骨组织代替。当用于释放生物活性剂时，可以在植入程序之前将试剂混合到粘合剂基质中。植入后，随着粘合剂基质的生物降解，生物活性剂逐渐释放。

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