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1. 发明授权

US06808705B2 Agarose coated agarose beads containing cancer cells which produce cancer-cell proliferation-suppressing material 有权
标题翻译：琼脂糖包被的琼脂糖珠含有产生癌细胞增殖抑制材料的癌细胞
公开(公告)号：US06808705B2
公开(公告)日：2004-10-26
申请号：US10336379
申请日：2003-01-03
申请人： Shirin Asina , Kanti Jain , Albert L. Rubin , Barry Smith , Kurt Stenzel
发明人： Shirin Asina , Kanti Jain , Albert L. Rubin , Barry Smith , Kurt Stenzel
IPC分类号： A61K3512
CPC分类号： A61K35/13 , A61K35/36 , C12N5/0693 , C12N11/04
摘要： Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.
摘要翻译：描述了含有限制性癌细胞的物质组成。当受限制时，细胞产生意想不到的高量的抑制癌细胞增殖的材料。这种现象跨越癌症类型和种类。还描述了制备这些组合物的方法及其用途。

2. 发明授权

US06699483B1 Cancer treatments 有权
标题翻译：癌症治疗
公开(公告)号：US06699483B1
公开(公告)日：2004-03-02
申请号：US09857690
申请日：2001-09-07
申请人： Angus George Dalgleish , Peter Michael Smith , Andrew Derek Sutton , Anthony Ian Walker
发明人： Angus George Dalgleish , Peter Michael Smith , Andrew Derek Sutton , Anthony Ian Walker
IPC分类号： A61K3512
CPC分类号： A61K39/0011 , A61K2039/5152
摘要： The invention relates to a product comprised of specific combinations of cell lines intended for use as an allogeneic immunotherapy agent for the treatment of prostate cancer in humans. The heterogeneity of the immunotherapeutic matches the heterogeneity of the antigenic profile in the target prostate cancer and immunises the recipients with many of the potential TAA and TSA which are expressed at various stages of the disease. The invention discloses a vaccine comprising a combination of three different cell lines prepared from primary or metastatic prostate cancer biopsy material. The cell lines are lethally irradiated utilising gamma irradiation at 50-300 Gy to ensure that they are replication incompetent.
摘要翻译：本发明涉及由旨在用作治疗人类前列腺癌的同种异体免疫治疗剂的细胞系的特定组合组成的产品。免疫治疗的异质性与目标前列腺癌中的抗原性谱的异质性相匹配，并且在患有疾病的各个阶段的许多潜在的TAA和TSA中免疫接受者。本发明公开了一种疫苗，其包含由原代或转移性前列腺癌活检材料制备的三种不同细胞系的组合。细胞系用50-300Gy的γ辐射进行致死辐射照射，以确保它们是无法复制的。

3. 发明授权

US06432653B1 Device and process for cell capture and recovery 失效
标题翻译：用于细胞捕获和恢复的装置和过程
公开(公告)号：US06432653B1
公开(公告)日：2002-08-13
申请号：US08291335
申请日：1994-08-17
申请人： Thomas B. Okarma
发明人： Thomas B. Okarma
IPC分类号： A61K3512
CPC分类号： C12N7/00 , A61K35/17 , A61K2039/5158 , C12N5/0087 , C12N5/0636 , C12N2501/515 , C12N2740/16051 , G01N33/545 , G01N33/56972 , Y10S436/824
摘要： Devices, processes and compositions are provided for effective separation of cells from a mixture of cells, where depletion or positive selection may be employed to provide a cellular population of interest. Of particular utility is the separation of cells from peripheral blood mononuclear cells, where members of the lymphoid or myeloid lineages may be isolated and used for research, diagnosis or therapy. Also of interest are cellular separation from bone marrow, tumor suspensions or lymphoid tissue suspensions, where cells can be isolated and used for a variety of purposes. The separated cells may be homogeneous, free of exogenous biologicals, viable, capable of replication and exhibit their full complement of biological activities. Multiple phenotypes can be captured simultaneously. Captured cells can be specifically activated with cytokines and antigens to provide cells which are MHC restricted and have antigen-specific effector functions.
摘要翻译：提供了装置，方法和组合物用于从细胞混合物中有效分离细胞，其中可以使用消耗或阳性选择来提供感兴趣的细胞群体。特别有用的是将细胞与外周血单核细胞分离，其中淋巴或骨髓谱系的成员可以被分离并用于研究，诊断或治疗。还有兴趣的是与骨髓，肿瘤悬浮液或淋巴组织悬浮液的细胞分离，其中细胞可以分离并用于各种目的。分离的细胞可以是均匀的，没有外源生物学，可行的，能够复制并表现出其完整的生物活性。可以同时捕获多种表型。捕获的细胞可以用细胞因子和抗原特异性活化，以提供MHC限制的细胞并具有抗原特异性效应子功能。

4. 发明授权

US06217913B1 Cosmetic compositions with gorgonian extract 失效
标题翻译：化妆品组合物与戈壁绒提取物
公开(公告)号：US06217913B1
公开(公告)日：2001-04-17
申请号：US09436116
申请日：1999-11-08
申请人： Fatemeh Mohammadi
发明人： Fatemeh Mohammadi
IPC分类号： A61K3512
CPC分类号： A61K8/895 , A61K8/987 , A61K31/74 , A61K35/614 , A61K2800/75 , A61Q17/00 , A61Q19/00 , Y10S514/887
摘要： Cosmetic compositions are provided which include a gorgonian extract, a crosslinked polysiloxane elastomer, a surfactant which is preferably anionic and a pharmaceutically acceptable carrier. Gorgonian extract in the polysiloxane elastomer base mediates redness induced by surfactants leaving the skin also free of itchiness and leaving the skin with a healthy and radiant look.
摘要翻译：提供了化妆品组合物，其包括高粱提取物，交联聚硅氧烷弹性体，优选阴离子表面活性剂和药学上可接受的载体。聚硅氧烷弹性体基质中的高锰矿提取物介导由表面活性剂引起的发红，皮肤也没有瘙痒，并使皮肤保持健康而光泽的外观。

5. 发明授权

US06569428B1 Pharmaceutical products comprising endothelial cell precursors 有权
标题翻译：含有内皮细胞前体的药物
公开(公告)号：US06569428B1
公开(公告)日：2003-05-27
申请号：US09228020
申请日：1999-01-11
申请人： Jeffrey M. Isner , Takayuki Asahara
发明人： Jeffrey M. Isner , Takayuki Asahara
IPC分类号： A61K3512
CPC分类号： A61K45/06 , A61K48/00 , A61K2035/124 , C12N5/0691 , C12N5/0692 , C12N2510/00
摘要： Pharmaceutical products are provided comprising EC progenitors for use in methods for regulating angiogenesis, i.e., for enhancing or inhibiting blood vessel formation, in a selected patient and in some preferred embodiments for targeting an angiogenesis modulator to specific locations. For example, the EC progenitors can be used to enhance angiogenesis or to deliver an angiogenesis modulator, e.g., anti- or pro-angiogenic agents, respectively to sites of pathologic or utilitarian angiogenesis. Additionally, in another embodiment, EC progenitors can be used to induce reendothelialization of an injured blood vessel, and thus reduce restenosis by indirectly inhibiting smooth muscle cell proliferation.
摘要翻译：提供的药物产品包括用于调节血管生成的方法的EC祖细胞，即用于增强或抑制所选择的患者中的血管形成，以及用于将血管生成调节剂靶向特定位置的一些优选实施方案。例如，EC祖细胞可用于增强血管发生或将血管生成调节剂例如抗血管生成剂或促血管生成剂分别递送至病理或功能性血管发生部位。此外，在另一个实施方案中，EC祖细胞可用于诱导受损血管的内皮形成，并因此通过间接抑制平滑肌细胞增殖来减少再狭窄。

6. 发明授权

US06565843B1 Protein-induced tissue morphogenesis 失效
标题翻译：蛋白质诱导的组织形态发生
公开(公告)号：US06565843B1
公开(公告)日：2003-05-20
申请号：US08404113
申请日：1995-03-14
申请人： Charles M. Cohen , Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger
发明人： Charles M. Cohen , Thangavel Kuberasampath , Roy H. L. Pang , Hermann Oppermann , David C. Rueger
IPC分类号： A61K3512
CPC分类号： A61K6/0032 , A01N1/0226 , A61F2310/00365 , A61K38/17 , A61K38/1703 , A61K38/1875 , A61L27/227 , A61L27/24 , A61L2430/28 , C07K14/495 , C07K14/51 , C07K16/22 , G01N2500/10 , A61K2300/00
摘要： The invention provides methods, compositions and devices for inducing tissue-specific regeneration in a mammal, or for stimulating proliferation of mammalian progenitor cells. The present methods, compositions and devices make use of osteogenic protein 1 (OP-1), which is appreciated herein as a tissue morphogen, i.e., a substance competent to induce tissue-specific morphogenesis of mammalian body tissues in addition to bone and/or cartilage. Alternatively, the present methods, compositions and devices make use of other naturally-occurring or biosynthetic proteins sharing a defined structural and functional relationship with OP-1 and thus appreciated herein also to function as tissue morphogens. Optionally, OP-1 or a related protein can be used alone or when adsorbed on a support matrix which provides an anchoring substratum for proliferation and/or differentiation of progenitor cells during tissue-specific morphogenesis. In another embodiment, OP-1 or a related protein is used to stimulate mammalian progenitor cells ex vivo, such that the stimulated cells, when disposed in vivo in a mammal, undergo tissue-specific morphogenesis to produce replacement tissue at a nonskeletal tissue locus in need thereof (i.e., at a nonbony or noncartilaginous tissue locus in need thereof).
摘要翻译：本发明提供用于在哺乳动物中诱导组织特异性再生或用于刺激哺乳动物祖细胞增殖的方法，组合物和装置。本发明的方法，组合物和装置利用成骨蛋白1（OP-1），其在本文中被认为是组织形态发生体，即，除骨骼和/或骨骼之外还能够诱导哺乳动物身体组织的组织特异性形态发生的物质软骨。或者，本发明的方法，组合物和装置利用与OP-1共享定义的结构和功能关系的其它天然存在或生物合成蛋白，因此在本文中也可以用作组织形态发生剂。任选地，OP-1或相关蛋白质可以单独使用或当被吸附在支持物基质上时，其在组织特异性形态发生过程中提供用于祖细胞增殖和/或分化的锚定底物。在另一个实施方案中，OP-1或相关蛋白用于离体刺激哺乳动物祖细胞，使得当被哺乳动物体内植入时，被刺激的细胞经历组织特异性形态发生以在非骨骼组织基因座处产生替代组织需要（即在有需要的非糖或非糖化组织位点）。

7. 发明授权

US06544560B1 Culture of sessile marine animals 有权
公开(公告)号：US06544560B1
公开(公告)日：2003-04-08
申请号：US09674796
申请日：2001-05-29
申请人： Kukurtcu Targotay Bullent , Naranjo Lozano Santiago , Barbero Garcia Carlos , Martin Benitez Silvia
发明人： Kukurtcu Targotay Bullent , Naranjo Lozano Santiago , Barbero Garcia Carlos , Martin Benitez Silvia
IPC分类号： A61K3512
CPC分类号： A01K67/033 , A01K61/00 , A01K61/54 , Y02A40/81 , Y02A40/822
摘要： Sessile marine organisms are a source of many marine pharmaceuticals. A method of producing such a marine pharmaceutical is provided which involves positioning a plurality of like substrates in sea water, growing the organism on the plurality of substrates, harvesting the grown organism, and extracting the pharmaceutical from the harvested organism.

8. 再颁专利

USRE38027E1 Preparation of agarose coated, solid agarose-collagen beads containing secretory cells 有权
标题翻译：制备含有分泌细胞的琼脂糖包被的固体琼脂糖胶原珠
公开(公告)号：USRE38027E1
公开(公告)日：2003-03-11
申请号：US09345196
申请日：1999-06-30
申请人： Kanti Jain , Albert L. Rubin , Barry Smith
发明人： Kanti Jain , Albert L. Rubin , Barry Smith
IPC分类号： A61K3512
CPC分类号： A61K9/1652 , A61K9/1658 , A61K9/5036 , A61K35/39 , A61K38/00 , A61K2035/126 , C12N5/0012 , C12N5/0677 , C12N11/04 , C12N2533/54 , C12N2533/76
摘要： Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and secretory cells such as pancreatic islets, the collagen is polymerized to form solid, agarose-collagen beads and the solid beads are coated with agarose. Coating is preferably by rolling the solid beads in about 5-10% agarose, contacting the rolled beads with mineral oil and washing oil from the beads. Beads containing secretory cells can be transplanted into a mammal to treat a condition caused by impaired secretory cell function.
摘要翻译：生物制剂如分泌细胞被包封在由琼脂糖或胶原 - 琼脂糖和明胶海绵 - 琼脂糖组合制成的亲水凝胶中。在优选的实施方案中，半固体珠粒由含有胶原蛋白，琼脂糖和分泌细胞例如胰岛的悬浮液形成，胶原聚合形成固体，琼脂糖胶原珠粒，固体珠粒用琼脂糖涂覆。涂覆优选通过在约5-10％的琼脂糖中滚动固体珠粒，使滚珠与矿物油接触并从珠粒洗涤油。含有分泌细胞的珠可以移植到哺乳动物中以治疗由分泌细胞功能受损引起的病症。

9. 发明授权

US06284284B1 Compositions and methods for production and use of an injectable naturally secreted extracellular matrix 有权
标题翻译：用于生产和使用可注射天然分泌的细胞外基质的组合物和方法
公开(公告)号：US06284284B1
公开(公告)日：2001-09-04
申请号：US09182822
申请日：1998-10-29
申请人： Gail K. Naughton
发明人： Gail K. Naughton
IPC分类号： A61K3512
CPC分类号： A61L27/3633 , A61F2/0059 , A61F2/105 , A61K8/99 , A61L27/3683 , A61L27/3804 , A61L27/3839 , A61Q19/08 , Y10S514/801 , Y10T442/2525
摘要： The present invention discloses compositions containing natural human extracellular matrices and methods for the use thereof. More particularly, the present invention provides compositions and methods for the repair of skin defects using natural human extracellular matrix by injection.
摘要翻译：本发明公开了含天然人细胞外基质的组合物及其使用方法。更具体地，本发明提供了通过注射使用天然人细胞外基质修复皮肤缺陷的组合物和方法。

10. 发明授权

US06514499B1 Compositions exhibiting ADP-ribosyltransferase activity and methods for the preparation and use thereof 失效
公开(公告)号：US06514499B1
公开(公告)日：2003-02-04
申请号：US09510664
申请日：2000-02-22
申请人： Harvey R. Kaslow
发明人： Harvey R. Kaslow
IPC分类号： A61K3512
CPC分类号： C12N9/1077 , A61K38/164 , A61K39/39 , A61K2039/55544
摘要： Compositions characterized by ADP-ribosyltransferase activity are useful in promoting prophylactic and/or therapeutic responses as are promoted by, e.g., pertussis toxin but directed against another target antigen (e.g., a cancer-related antigen) in a mammalian patient.

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