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1. 发明授权

US06923985B2 Bioerodable polymeric adhesives for tissue repair 有权
标题翻译：用于组织修复的生物可蚀塑料聚合物粘合剂
公开(公告)号：US06923985B2
公开(公告)日：2005-08-02
申请号：US09923118
申请日：2001-08-06
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61L27/00 , A61K9/20 , A61L24/00 , A61L24/04 , A61L27/04 , A61L27/18 , A61L27/46 , C09J9/00 , A61K9/10 , A61K47/34 , A61K31/765 , C08G63/08
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Improved matrices and adhesives for tissue repair comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
摘要翻译：用于组织修复的改进的基质和粘合剂，其包含生物相容的可生物侵蚀的聚合物，所述聚合物包含衍生自乳酸，乙醇酸和己内酯或戊内酯的单体单元的热塑性丙交酯三元共聚物，其水溶解度为约0.01至约在约25℃下为500mg / mL，粘合强度为约600至约150,000Pa。基质或粘合剂可进一步包含填料或生物活性剂，或两者。

2. 发明授权

US06326025B1 Tissue reactive adhesive compositions 有权
标题翻译：组织反应性粘合剂组合物
公开(公告)号：US06326025B1
公开(公告)日：2001-12-04
申请号：US09530172
申请日：2000-04-24
申请人： Gerry Sigler , Z. David Deng , Dale R. Peterson , Todd P. Glancy , Samuel I. Stupp
发明人： Gerry Sigler , Z. David Deng , Dale R. Peterson , Todd P. Glancy , Samuel I. Stupp
IPC分类号： A61F1302
CPC分类号： A61L24/04 , C08L101/02 , Y10S602/904
摘要： The present invention is directed to a biocompatible tissue reactive composition comprising a functionalized polymer having tissue reactive substituents that are capable of forming covalent bonds with tissue associated functional groups.
摘要翻译：本发明涉及生物相容性组织反应性组合物，其包含具有能与组织相关官能团形成共价键的组织反应性取代基的官能化聚合物。

3. 发明授权

US06299905B1 Bioerodable polymeric adhesives for tissue repair 失效
标题翻译：用于组织修复的生物可蚀塑料聚合物粘合剂
公开(公告)号：US06299905B1
公开(公告)日：2001-10-09
申请号：US08633102
申请日：1996-04-16
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61K910
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Improved matrices for tissue repair comprising a biocompatible, bioerodable polymer which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa; and pressure sensitive adhesives for tissue repair which have adhesive strength of about 600 to about 150,000 Pa. The matrix or adhesive can further comprise a filler or a bioactive agent, or both. The matrices and adhesives are tissue-adherent and dough-like so they can be molded to fit a repair site. When used for bone/implant fixation, or as a filler for bone or cartilage repair, gradual short-term bioerosion of the adhesive matrix allows it to be replaced with developing bone or cartilage tissue. When used for release of a bioactive agent, the agent can be mixed into the adhesive matrix well before the implantation procedure. After implantation, the bioactive agent is gradually released as the adhesive matrix biodegrades.
摘要翻译：用于组织修复的改进的基质包括生物相容的可生物侵蚀的聚合物，其在约25℃下的水溶解度为约0.01至约500mg / mL，粘合强度为约600至约150,000Pa; 以及粘合强度为约600至约150,000Pa的用于组织修复的压敏粘合剂。基质或粘合剂还可包含填料或生物活性剂，或两者。基质和粘合剂是组织粘附和面团状的，因此它们可以被模塑以适合修复部位。当用于骨/植入物固定时，或作为骨或软骨修复的填料时，粘合剂基质的逐渐短期生物侵蚀允许其用显影的骨或软骨组织代替。当用于释放生物活性剂时，可以在植入程序之前将试剂混合到粘合剂基质中。植入后，随着粘合剂基质的生物降解，生物活性剂逐渐释放。

4. 发明授权

US5756652A Poly (ester-anhydrides) and intermediates therefor 失效
标题翻译：聚（酯 - 酸酐）及其中间体
公开(公告)号：US5756652A
公开(公告)日：1998-05-26
申请号：US609099
申请日：1996-02-29
申请人： Robson F. Storey , Z. David Deng , Dale R. Peterson , Todd P. Glancy
发明人： Robson F. Storey , Z. David Deng , Dale R. Peterson , Todd P. Glancy
IPC分类号： C08G63/08 , C08G63/692 , C08G63/91 , C08G67/04 , C08L101/16 , C08G63/06
CPC分类号： C08G63/692 , C08G63/08 , C08G67/04
摘要： Biodegradable poly(ester-anhydrides) designed to display two-stage degradation profiles are described. The presence of the anhydride linkages allows a relatively rapid decrease in molecular weight, the extent of which is governed by the concentration of the anhydride linkages along the chain, followed by possible dissolution and a slower degradation of the remaining oligomers, the rate of which is governed by the composition of the polyester prepolymers. Methods for the preparation of the poly(ester-anhydrides) and their polyester precursors are also described.
摘要翻译：描述了设计用于显示两阶段降解曲线的可生物降解的聚（酯 - 酸酐）。酸酐键的存在允许分子量的相对快速降低，其程度由沿着链的酸酐键的浓度决定，随后可能的溶解和残留的低聚物的较慢降解，其速率是由聚酯预聚物的组成决定。还描述了制备聚（酯 - 酸酐）及其聚酯前体的方法。

5. 发明授权

US5668288A Polyester ionomers for implant fabrication 失效
标题翻译：用于植入物制造的聚酯离聚物
公开(公告)号：US5668288A
公开(公告)日：1997-09-16
申请号：US633120
申请日：1996-04-16
申请人： Robson F. Storey , Z. David Deng , Todd P. Glancy , Dale R. Peterson
发明人： Robson F. Storey , Z. David Deng , Todd P. Glancy , Dale R. Peterson
IPC分类号： A61C8/00 , A61L27/00 , A61L27/18 , A61L31/06 , C08G63/06 , C08G63/16 , C08G63/68 , C07D213/22
CPC分类号： C08G63/16 , A61L27/18 , A61L31/06 , C08G63/06
摘要： Carboxy-terminated polyester ionomers useful for bioresorbable implant construction are described. They comprise biocompatible salts or partial salts of mono- or bis-carboxy-terminated polyesters.
摘要翻译：描述了可用于生物再吸收植入物结构的羧基封端的聚酯离聚物。它们包括单羧基或双羧基封端的聚酯的生物相容性盐或部分盐。

6. 发明授权

US07122205B2 Bioerodable polymeric adhesives for tissue repair 有权
公开(公告)号：US07122205B2
公开(公告)日：2006-10-17
申请号：US10811649
申请日：2004-03-29
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61K47/34
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.

7. 发明授权

US06733787B2 Bioerodable polymeric adhesives for tissue repair 有权
标题翻译：用于组织修复的生物可蚀塑料聚合物粘合剂
公开(公告)号：US06733787B2
公开(公告)日：2004-05-11
申请号：US09956390
申请日：2001-09-19
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61K910
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
摘要翻译：提供了使用包含生物相容的生物侵蚀性聚合物的基质的组织修复方法，所述聚合物包含衍生自乳酸，乙醇酸和己内酯或戊内酯的单体单元的热塑性丙交酯三元共聚物，其水溶性为约0.01 在约25℃下为约500mg / mL，粘合强度为约600至约150,000Pa，并将基质施加于组织缺损。基质或粘合剂可进一步包含填料或生物活性剂，或两者。

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