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    • 3. 发明授权
    • Bioerodable polymeric adhesives for tissue repair
    • 用于组织修复的生物可蚀塑料聚合物粘合剂
    • US06299905B1
    • 2001-10-09
    • US08633102
    • 1996-04-16
    • Dale R. PetersonZ. David DengTodd P. Glancy
    • Dale R. PetersonZ. David DengTodd P. Glancy
    • A61K910
    • A61L27/18A61K9/204A61L24/0073A61L24/0084A61L24/046A61L27/04A61L27/46C08L67/04Y10S528/931
    • Improved matrices for tissue repair comprising a biocompatible, bioerodable polymer which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa; and pressure sensitive adhesives for tissue repair which have adhesive strength of about 600 to about 150,000 Pa. The matrix or adhesive can further comprise a filler or a bioactive agent, or both. The matrices and adhesives are tissue-adherent and dough-like so they can be molded to fit a repair site. When used for bone/implant fixation, or as a filler for bone or cartilage repair, gradual short-term bioerosion of the adhesive matrix allows it to be replaced with developing bone or cartilage tissue. When used for release of a bioactive agent, the agent can be mixed into the adhesive matrix well before the implantation procedure. After implantation, the bioactive agent is gradually released as the adhesive matrix biodegrades.
    • 用于组织修复的改进的基质包括生物相容的可生物侵蚀的聚合物,其在约25℃下的水溶解度为约0.01至约500mg / mL,粘合强度为约600至约150,000Pa; 以及粘合强度为约600至约150,000Pa的用于组织修复的压敏粘合剂。基质或粘合剂还可包含填料或生物活性剂,或两者。 基质和粘合剂是组织粘附和面团状的,因此它们可以被模塑以适合修复部位。 当用于骨/植入物固定时,或作为骨或软骨修复的填料时,粘合剂基质的逐渐短期生物侵蚀允许其用显影的骨或软骨组织代替。 当用于释放生物活性剂时,可以在植入程序之前将试剂混合到粘合剂基质中。 植入后,随着粘合剂基质的生物降解,生物活性剂逐渐释放。