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1. 发明申请

US20120156780A1 Polymer Substrates Having Improved Biological Response From HKDCS 审中-公开
标题翻译：具有改善HKDCS生物反应的聚合物底物
公开(公告)号：US20120156780A1
公开(公告)日：2012-06-21
申请号：US12974216
申请日：2010-12-21
申请人： Kevin L. Cooper , Alisha Martin , Sriram Natarajan , Robert Vetrecin , Changdeng Liu
发明人： Kevin L. Cooper , Alisha Martin , Sriram Natarajan , Robert Vetrecin , Changdeng Liu
IPC分类号： C12N5/071 , C08J3/28 , B32B3/00
CPC分类号： C08J3/28 , B29C59/14 , C08J7/12 , Y10T428/24355
摘要： A method of surface modification of a biocompatible, biodegradable polymer substrate using RF plasma treatment is disclosed. This method and the resulting surface provide for enhanced adhesion and proliferation of cells, such as hKDCs, and can be used with scaffolds for tissue regeneration and with other delivery vehicles such as medical devices.
摘要翻译：公开了使用RF等离子体处理的生物相容性可生物降解的聚合物基材的表面改性方法。该方法和所得表面提供细胞如hKDC的增强的粘附和增殖，并且可以与用于组织再生的支架和与其它递送载体如医疗装置一起使用。

2. 发明申请

US20160296677A1 ENDOPROSTHESES 审中-公开
公开(公告)号：US20160296677A1
公开(公告)日：2016-10-13
申请号：US15185851
申请日：2016-06-17
申请人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
发明人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
IPC分类号： A61L31/10 , A61L31/02 , A61L31/04 , A61L31/16
CPC分类号： A61L31/10 , A61F2250/0067 , A61L31/022 , A61L31/04 , A61L31/16 , A61L2300/402 , Y10T428/24926 , C08L75/04 , C08L83/04
摘要： Endoprostheses are disclosed.
摘要翻译：公布内裤假体。

3. 发明申请

US20110071562A1 MEDICAL DEVICES 审中-公开
标题翻译：医疗设备
公开(公告)号：US20110071562A1
公开(公告)日：2011-03-24
申请号：US12958069
申请日：2010-12-01
申请人： Kinh-Luan Dao , Changdeng Liu , Patrick T. Mather , Ronald A. Sahatjian , Sheng-Ping Zhong
发明人： Kinh-Luan Dao , Changdeng Liu , Patrick T. Mather , Ronald A. Sahatjian , Sheng-Ping Zhong
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B90/39 , A61B2017/00292 , A61B2017/00867 , A61B2017/1205 , A61B2090/3925 , A61B2090/3954 , A61M25/0041 , A61M25/0043 , A61M25/0074 , A61M25/0158
摘要： A medical device, such as, for example, a catheter, includes a tubular member having a first portion having a shape memory polymer.
摘要翻译：医疗装置，例如导管，包括具有第一部分的管状部件，该第一部分具有形状记忆聚合物。

4. 发明授权

US07795350B2 Blends of amorphous and semicrystalline polymers having shape memory properties 有权
标题翻译：具有形状记忆特性的无定形和半结晶聚合物的共混物
公开(公告)号：US07795350B2
公开(公告)日：2010-09-14
申请号：US12106376
申请日：2008-04-21
申请人： Patrick T. Mather , Changdeng Liu , Cheryl J. Campo
发明人： Patrick T. Mather , Changdeng Liu , Cheryl J. Campo
IPC分类号： C08L23/00 , C08L27/06 , C08L27/12 , C08L33/04 , C08G63/02
CPC分类号： C08G18/3893 , C08G61/08 , C08G2230/00 , C08J3/005 , C08L27/16 , C08L31/04 , C08L33/12 , C08L65/00 , C08L67/04 , C08L2666/04
摘要： A shape memory polymeric material has a glass transition temperature, Tg, exceeding room temperature and exhibits rubber modulus and elasticity derived substantially from physical crosslinks is prepared by blending components including one crystalline polymer and two amorphous polymers. Methods of preparing the polymeric materials and uses of the polymeric materials, for example, as smart medical devices, are also disclosed.
摘要翻译：形状记忆聚合物材料具有超过室温的玻璃化转变温度Tg，并且通过将包括一种结晶聚合物和两种无定形聚合物的组分共混来制备基本上由物理交联得到的橡胶模量和弹性。还公开了制备聚合物材料的方法和聚合材料的用途，例如作为智能医疗装置。

5. 发明申请

US20090275704A1 CROSSLINKED POLYCYCLOOCTENE 失效
标题翻译：交联聚碳酸酯
公开(公告)号：US20090275704A1
公开(公告)日：2009-11-05
申请号：US12480957
申请日：2009-06-09
申请人： Patrick T. Mather , Changdeng Liu , Seung B. Chun , E. Bryan Coughlin
发明人： Patrick T. Mather , Changdeng Liu , Seung B. Chun , E. Bryan Coughlin
IPC分类号： C08F8/00 , C08F10/14 , C08L25/04 , C08L33/04 , C08L75/04
CPC分类号： C08G18/3893 , C08G61/08 , C08G2230/00 , C08L65/00
摘要： Chemically crosslinked polycyclooctene having excellent shape recovery properties is prepared by ring-opening metathesis polymerization of cis-cyclooctene followed by chemical crosslinking. The crosslinked polycyclooctene can be shaped, the shape memorized, a new shape imparted with the original shape being recoverable by suitable temperature adjustment. The dependence of shape memory characteristics on degree of crosslinking was established. In addition to polycyclooctene, blends thereof with other materials such as SBR, EVA, polyurethane rubbers, and inorganic fillers can be utilized to provide chemically crosslinked products having excellent and tailored shape memory properties.
摘要翻译：具有优异形状恢复性能的化学交联的聚环辛烯通过顺式 - 环辛烯的开环易位聚合进行化学交联来制备。交联的多环辛烯可以成形，记忆形状，赋予原始形状的新形状可通过适当的温度调节而恢复。形状记忆特性对交联度的依赖性已被确立。除了聚环辛烯之外，可以使用其与其它材料如SBR，EVA，聚氨酯橡胶和无机填料的共混物来提供具有优良和定制形状记忆性质的化学交联产物。

6. 发明申请

US20140135889A9 IMPLANTABLE MEDICAL DEVICES 审中-公开
公开(公告)号：US20140135889A9
公开(公告)日：2014-05-15
申请号：US12880483
申请日：2010-09-13
申请人： Ronald A Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Cheryl J. Campo
发明人： Ronald A Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Cheryl J. Campo
IPC分类号： A61F2/84
CPC分类号： C08G61/08 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/8483 , A61F2002/91541 , A61F2002/9528 , A61F2220/0016 , A61F2250/0039 , A61F2250/0068 , A61L29/14 , A61L31/14 , A61M25/1027 , C08G18/3893 , C08G18/4277 , C08G18/4833 , C08G2230/00 , C08L65/00
摘要： A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diameter for delivery into the body and can be expanded to a larger diameter by inflating the balloon.

7. 发明申请

US20070135578A1 BLENDS OF AMORPHOUS AND SEMICRYSTALLINE POLYMERS HAVING SHAPE MEMORY PROPERTIES 失效
标题翻译：具有形状记忆性质的非晶态和半结晶聚合物的共混物
公开(公告)号：US20070135578A1
公开(公告)日：2007-06-14
申请号：US11624952
申请日：2007-01-19
申请人： Patrick Mather , Changdeng Liu , Cheryl Campo
发明人： Patrick Mather , Changdeng Liu , Cheryl Campo
IPC分类号： C08L27/12
CPC分类号： C08G18/3893 , C08G61/08 , C08G2230/00 , C08J3/005 , C08L27/16 , C08L31/04 , C08L33/12 , C08L65/00 , C08L67/04 , C08L2666/04
摘要： Blends of amorphous and semicrystalline polymers having shape memory properties were prepared by blending a crystalline polymer such as poly(vinylidene fluoride), polylactide, poly(hydroxxybutyrate), poly(ethylene glycol) polyethylene, polyethylene-co-vinyl acetate, poly(vinyl chloride), poly(vinylidene chloride) and copolymers of poly(vinylidene chloride) and poly(vinyle chloride) and an amorphous polymer such as poly(vinyl acetate), poly methyl acrylate, poly ethyl acrylate, atactic poly methyl methacrylate, isotactic poly methyl methacrylate, syndiotactic poly methyl methacrylate and other poly alkyl methacrylates. The method for preparing the polymeric materials and applications thereof, for example, as smart medical devices, are also disclosed.
摘要翻译：通过混合结晶聚合物如聚（偏二氟乙烯），聚丙交酯，聚（羟基丁酸酯），聚（乙二醇）聚乙烯，聚乙烯 - 共 - 乙酸乙烯酯，聚（氯乙烯）等制备具有形状记忆性质的无定形和半结晶聚合物的共混物），聚（偏二氯乙烯）和聚（偏二氯乙烯）和聚（氯乙烯）的共聚物和无定形聚合物如聚（乙酸乙烯酯），聚甲基丙烯酸酯，聚丙烯酸乙酯，无规立构聚甲基丙烯酸甲酯，全同立构聚甲基丙烯酸甲酯间同立构聚甲基丙烯酸甲酯和其他聚甲基丙烯酸烷基酯。还公开了制备聚合物材料的方法及其应用，例如智能医疗装置。

8. 发明申请

US20060154195A1 Shape memory polymer orthodontic appliances, and methods of making and using the same 审中-公开
标题翻译：形状记忆聚合物正畸矫治器及其使用方法
公开(公告)号：US20060154195A1
公开(公告)日：2006-07-13
申请号：US11301795
申请日：2005-12-12
申请人： Patrick Mather , Charles Burstone , Changdeng Liu
发明人： Patrick Mather , Charles Burstone , Changdeng Liu
IPC分类号： A61C3/00
CPC分类号： A61C7/00 , A61C2201/007 , B82Y30/00 , F03G7/065
摘要： Described are fixed and removable orthodontic appliances and components thereof fabricated from shape memory polymer compositions. The preparation and use of such appliances are also disclosed.
摘要翻译：描述了由形状记忆聚合物组合物制成的固定和可移除的矫正器具及其部件。还公开了这种电器的制备和使用。

9. 发明授权

US07067606B2 Nonionic telechelic polymers incorporating polyhedral oligosilsesquioxane (POSS) and uses thereof 失效
标题翻译：加入多面体低聚倍半硅氧烷（POSS）的非离子遥爪聚合物及其用途
公开(公告)号：US07067606B2
公开(公告)日：2006-06-27
申请号：US10620644
申请日：2003-07-16
申请人： Patrick T. Mather , Byoung-Suhk Kim , Qing Ge , Changdeng Liu
发明人： Patrick T. Mather , Byoung-Suhk Kim , Qing Ge , Changdeng Liu
IPC分类号： C08G77/04
CPC分类号： C08G18/3893 , C08G18/4833 , C08G18/718 , C08G65/336 , C08L71/02 , C08L2205/05 , C08L83/00
摘要： Amphiphilic telechelics incorporating polyhedraloligosilsesquioxane (POSS) synthesized by direct urethane linkage between the diol end groups of polyethylene glycol (PEG) homopolymers and the monoisocyanate group of POSS macromers. The hydrophobicity of the amphiphilic telechelics can be varied by using PEG homopolymers of increasing MW, providing for control over molecular architecture by hydrophilic/hydrophobic balance. Methods for synthesizing the amphiphilic telechelics and their use as surfactants, thickening agents, additives to plastic such as PMMA′(Plexiglass), epoxyadhesives for improving their properties are also disclosed.
摘要翻译：通过在聚乙二醇（PEG）均聚物的二醇端基与POSS大单体的单异氰酸酯基团之间通过直接氨基甲酸酯键合成的多面体聚二甲基倍半硅氧烷（POSS）的两亲电视电影。通过使用增加MW的PEG均聚物可以改变两亲性电视电泳的疏水性，通过亲水/疏水平衡提供对分子结构的控制。还公开了合成两亲电视电影的方法及其作为表面活性剂，增稠剂，塑料添加剂如PMMA（有机玻璃）的用途，用于改善其性能的环氧树脂粘合剂。

10. 发明申请

US20060041089A1 Castable shape memory polymers 审中-公开
标题翻译：铸造形状记忆聚合物
公开(公告)号：US20060041089A1
公开(公告)日：2006-02-23
申请号：US10965917
申请日：2004-10-15
申请人： Patrick Mather , Changdeng Liu
发明人： Patrick Mather , Changdeng Liu
IPC分类号： C08F4/06
CPC分类号： C08F246/00
摘要： Shape memory polymers prepared by copolymerizing two monomers, which each separately produce polymers characterized by different glass transition temperatures in the presence of a difunctional monomer whereby the copolymer formed is cross-linked during the polymerization to form a theremoset network. The transition temperature of the final polymers is adjusted by the ratio of the monomers selected, to from about 20 to about 110° C., while the degree of cross-linking controls the rubbery modulus plateau. The shape memory polymers can be processed as castable formulations in the form of coatings and films. The copolymers are optically transparent and are useful as medical plastics. The invention also relates to the articles of manufacture thereof and methods of the preparation and use thereof.
摘要翻译：通过共聚两种单体制备的形状记忆聚合物，它们分别在双官能单体的存在下产生以不同玻璃化转变温度为特征的聚合物，由此形成的共聚物在聚合反应过程中交联以形成聚集体网络。最终聚合物的转变温度通过所选单体的比例调节至约20至约110℃，而交联度控制橡胶模量平台。形状记忆聚合物可以以涂料和薄膜的形式加工成可浇铸的制剂。共聚物是光学透明的并且可用作医用塑料。本发明还涉及其制造方法及其制备和使用方法。

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