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1. 发明申请

US20080069868A1 Irinotecan Preparation 有权
标题翻译：伊立替康制剂
公开(公告)号：US20080069868A1
公开(公告)日：2008-03-20
申请号：US11597435
申请日：2005-05-31
申请人： Keisuke Yoshino , Shigenori Nozawa , Masashi Isozaki , Seigo Sawada , Ikuo Kato , Takeshi Matsuzaki
发明人： Keisuke Yoshino , Shigenori Nozawa , Masashi Isozaki , Seigo Sawada , Ikuo Kato , Takeshi Matsuzaki
IPC分类号： A61K31/437 , A61K9/127 , A61P35/00
CPC分类号： A61K9/1271 , A61K31/4745
摘要： Provided is an irinotecan formulation capable of supporting irinotecan and/or a salt thereof in a closed vesicle carrier at a high concentration and existing in blood for a long period of time by dramatically improved retentivity in blood compared to a conventionally known irinotecan liposome formulation. That is, an irinotecan formulation including a closed vesicle formed by a lipid membrane, in which irinotecan and/or a salt thereof is encapsulated at a concentration of at least 0.07 mol/mol (drug mol/membrane total lipid mol). There is an ion gradient between an inner aqueous phase and an outer aqueous phase in the irinotecan formulation. The closed vesicle is preferably liposome, in which only the outer surface of the liposome is preferably modified with a surface-modifying agent containing a hydrophilic polymer.
摘要翻译：本发明提供了一种伊立替康制剂，其能够通过显着提高血液中的保留性，与常规已知的伊立替康脂质体制剂相比，可以高密度地在密闭囊泡载体中以高浓度和血液中长时间地支持伊立替康和/或其盐。也就是说，包括由脂质膜形成的封闭囊泡的伊立替康制剂，其中伊立替康和/或其盐以至少0.07mol / mol（药物mol /膜总脂质摩尔）的浓度包封。伊立替康制剂中的内部水相和外部水相之间存在离子梯度。封闭的囊泡优选为脂质体，其中仅脂质体的外表面优选用含有亲水性聚合物的表面改性剂改性。

2. 发明授权

US07846473B2 Irinotecan preparation 有权
标题翻译：伊立替康制剂
公开(公告)号：US07846473B2
公开(公告)日：2010-12-07
申请号：US11597435
申请日：2005-05-31
申请人： Keisuke Yoshino , Shigenori Nozawa , Masashi Isozaki , Seigo Sawada , Ikuo Kato , Takeshi Matsuzaki
发明人： Keisuke Yoshino , Shigenori Nozawa , Masashi Isozaki , Seigo Sawada , Ikuo Kato , Takeshi Matsuzaki
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , A61K31/4745
摘要： Provided is an irinotecan formulation capable of supporting irinotecan and/or a salt thereof in a closed vesicle carrier at a high concentration and existing in blood for a long period of time by dramatically improved retentivity in blood compared to a conventionally known irinotecan liposome formulation. That is, an irinotecan formulation including a closed vesicle formed by a lipid membrane, in which irinotecan and/or a salt thereof is encapsulated at a concentration of at least 0.07 mol/mol (drug mol/membrane total lipid mol). There is an ion gradient between an inner aqueous phase and an outer aqueous phase in the irinotecan formulation. The closed vesicle is preferably liposome, in which only the outer surface of the liposome is preferably modified with a surface-modifying agent containing a hydrophilic polymer.
摘要翻译：本发明提供了一种伊立替康制剂，其能够通过显着提高血液中的保留性，与常规已知的伊立替康脂质体制剂相比，可以高密度地在密闭囊泡载体中以高浓度和血液中长时间地支持伊立替康和/或其盐。也就是说，包括由脂质膜形成的封闭囊泡的伊立替康制剂，其中伊立替康和/或其盐以至少0.07mol / mol（药物mol /膜总脂质摩尔）的浓度包封。伊立替康制剂中的内部水相和外部水相之间存在离子梯度。封闭的囊泡优选为脂质体，其中仅脂质体的外表面优选用含有亲水性聚合物的表面改性剂改性。

3. 发明申请

US20080193509A1 Liposome Preparation Containing Slightly Water-Soluble Camptothecin 审中-公开
标题翻译：含有轻微水溶性喜树碱的脂质体制备
公开(公告)号：US20080193509A1
公开(公告)日：2008-08-14
申请号：US11629869
申请日：2005-06-17
申请人： Keisuke Yoshino , Shigenori Nozawa , Yoshitaka Ogata , Yasuo Kurosaki , Seigo Sawda , Ikuo Kato , Takeshi Matsuzaki
发明人： Keisuke Yoshino , Shigenori Nozawa , Yoshitaka Ogata , Yasuo Kurosaki , Seigo Sawda , Ikuo Kato , Takeshi Matsuzaki
IPC分类号： A61K9/127 , A61K31/4375
CPC分类号： A61K9/1272 , A61K31/4745
摘要： The present invention aims at providing a slightly water-soluble camptothecin liposome preparation with an excellent retention in blood for a drug, which can stably hold a slightly water-soluble camptothecin compound for a long period of time, whereby hydrolysis of an α-hydroxylactone ring in blood is suppressed and the slightly water-soluble camptothecin compound is kept in a structure in which the ring is not opened and which makes the compound effective as an antitumor-active drug, and, moreover, the liability of the drug to leave a liposome is advantageously reduced, so that it is possible to maintain the drug concentration in plasma for a long period of time after administration. This object is achieved by the liposome preparation as described in the specification. The liposome preparation according to the present invention includes a liposome preparation including as lipid components for forming a membrane a phospholipid and a fatty acid, and containing as a drug a lightly water-soluble camptothecin compound.
摘要翻译：本发明的目的在于提供一种在血液中具有优异的药物保留性的轻微水溶性喜树碱脂质体制剂，其能够长时间稳定地保持轻微的水溶性喜树碱化合物，从而水解α-羟基内酯环在血液中被抑制，轻微的水溶性喜树碱化合物保持在不打开环的结构中，并且使得化合物作为抗肿瘤活性药物有效，此外，药物离开脂质体的责任有利地减少，使得可以在施用后长时间维持血浆中的药物浓度。该目的通过如说明书中所述的脂质体制备来实现。根据本发明的脂质体制剂包括脂质体制剂，其包含作为形成磷脂和脂肪酸的膜的脂质成分，并且作为药物含有轻度水溶性的喜树碱化合物。

4. 发明授权

US06399318B1 Immunoassay for phthalic acid esters 失效
标题翻译：邻苯二甲酸酯的免疫测定
公开(公告)号：US06399318B1
公开(公告)日：2002-06-04
申请号：US09984451
申请日：2001-10-30
申请人： Noboru Yanaihara , Ikuo Kato , Shingo Nagasawa , Tsukasa Kodaira
发明人： Noboru Yanaihara , Ikuo Kato , Shingo Nagasawa , Tsukasa Kodaira
IPC分类号： G01N33532
CPC分类号： G01N33/5308 , C07K16/44 , Y10S436/815
摘要： The present invention provides an immunoassay for phthalic acid esters, which comprises measuring the phthalic acid esters contained in a sample using an antibody produced with a conjugate of a carrier protein and a phthalic acid ester derivative represented by the formula wherein R1 and R2 may be the same or different and are hydrogen, alkyl, cycloalkyl or phenylalkyl, with the proviso that both of R1 and R2 are not hydrogen; m is an integer from 1 to 5; and Y is amino or carboxyl.
摘要翻译：本发明提供了一种邻苯二甲酸酯的免疫测定法，该方法包括用由载体蛋白质和由式R 1和R 2表示的邻苯二甲酸酯衍生物的缀合物产生的抗体测量样品中所含的邻苯二甲酸酯可以相同或者不同的是氢，烷基，环烷基或苯基烷基，条件是R 1和R 2都不是氢; m为1〜5的整数; Y是氨基或羧基。

5. 发明申请

US20060265876A1 Wheel rim, wheel, and methods of producing them 有权
标题翻译：轮辋，轮子及其制造方法
公开(公告)号：US20060265876A1
公开(公告)日：2006-11-30
申请号：US10560835
申请日：2004-06-17
申请人： Shizuo Kimura , Kenzo Takeda , Ikuo Kato , Yukio Uchiyama , Tadashi Goto , Nobuyuki Kakiya , Kiyoshi Satou , Shinichi Ohnaka , Tatsuo Yamanaka
发明人： Shizuo Kimura , Kenzo Takeda , Ikuo Kato , Yukio Uchiyama , Tadashi Goto , Nobuyuki Kakiya , Kiyoshi Satou , Shinichi Ohnaka , Tatsuo Yamanaka
IPC分类号： B21K1/38
CPC分类号： B21D53/30 , Y10T29/49499 , Y10T29/49524 , Y10T29/49526 , Y10T29/49529 , Y10T29/49995
摘要： A rim (10) is produced by a production process including a step (A) of bending a workpiece (11) to bring end faces of the workpiece into contact with each other, a step (B) of forming a circular cylinder body (12) by joining the end faces brought to be in contact with each other, a step (C) of inspecting a joint portion (13) of the circular cylinder body (12), a step (D) of forming a drop portion (16), subsiding toward the inner peripheral wall (15) side, in an outer peripheral wall (14) of the circular cylinder body (12), a by bending both end portions of the circular cylinder body (12), a step (F) of forming hump portions (20) by pressing the circular cylinder body (12) from the inner peripheral wall (15) side to raise the outer peripheral wall (14), and a step (G) for forming a valve hole (22) and water drain holes (24) in the drop portion (16) and the curl portions (18). The rim (10) and a disk (102) that is separately produced are welded to form a wheel (122).
摘要翻译：通过包括使工件（11）弯曲以使工件的端面相互接触的工序（A）的制造方法制造边缘（10）;形成圆筒体（12）的工序（B））通过连接彼此接触的端面，检查圆筒体（12）的接合部（13）的台阶（C），形成液滴部分（16）的台阶（D）在所述圆筒体（12）的外周壁（14）内朝向所述内周壁（15）侧平坦化，通过使所述圆筒体（12）的两端部弯曲，将所述圆筒体通过从所述内周壁（15）侧按压所述圆筒体（12）来形成隆起部（20），以使外周壁（14）升高;以及步骤（G），用于形成阀孔（22）和水下降部分（16）和卷曲部分（18）中的排放孔（24）。分别制造的轮辋（10）和盘（102）被焊接以形成车轮（122）。

6. 发明申请

US20050244559A1 Method of manufacturing raw material beans drinks and solid fermented food 审中-公开
标题翻译：生产原料豆饮料和固体发酵食品的方法
公开(公告)号：US20050244559A1
公开(公告)日：2005-11-03
申请号：US10519798
申请日：2003-06-02
申请人： Ikuo Kato , Toshihiro Yano , Hiroshi Ogawa , Nobuhiro Yajima
发明人： Ikuo Kato , Toshihiro Yano , Hiroshi Ogawa , Nobuhiro Yajima
IPC分类号： A23C11/10 , A23C20/02 , A23L2/62 , A23L11/00 , A23P1/00
CPC分类号： A23C20/025 , A23C11/103 , A23C11/106 , A23L11/07 , A23L11/09
摘要： A method for manufacturing a drink made from beans as a raw material and a solid fermented food. It is characterized in that it comprises the steps of: preparing a stabilized suspension by homogenization-treating an aqueous slurry of whole grain-mash of beans once or a plurality of times using a homogenizer; denaturing protein by adding a coagulant and/or a pH adjustor to the stabilized suspension; and performing the dispersing treatment for making the relevant protein denaturation raw material dispersed by a physical dispersing means. In a solid fermented food, it comprises a step of fermenting for fermenting/solidifying by adding a lactic bacterium starter following the step of performing a homogenization treatment, and manufactures it via the step of maturating it if it is necessary.
摘要翻译：一种制造由豆类作为原料的饮料的方法和固体发酵食品。其特征在于，其包括以下步骤：通过使用均化器均化 - 处理全谷物糊状物的水浆料一次或多次来制备稳定的悬浮液; 通过向稳定的悬浮液中加入凝结剂和/或pH调节剂来变性蛋白质; 并进行用于通过物理分散装置分散的相关蛋白质变性原料的分散处理。在固体发酵食品中，其包括通过在进行均质化处理的步骤之后通过添加乳酸菌起子发酵/固化的步骤，如果需要，通过使其成熟的步骤制造。

7. 发明授权

US06509462B2 Estradiol derivative and immunoassy using the same 失效
标题翻译：雌二醇衍生物和免疫应用使用它们
公开(公告)号：US06509462B2
公开(公告)日：2003-01-21
申请号：US09905945
申请日：2001-07-17
申请人： Noboru Yanaihara , Ikuo Kato , Kazuyuki Kitamura , Tsukasa Kodaira
发明人： Noboru Yanaihara , Ikuo Kato , Kazuyuki Kitamura , Tsukasa Kodaira
IPC分类号： C07J4300
CPC分类号： C07J43/00 , Y10S436/811 , Y10S436/815 , Y10S436/817
摘要： The present invention provides a highly sensitive immunoassay system for estrogens, which utilizes as a labeled compound a biotinylated estradiol derivative of the formula (1) wherein one of R1 and R2 is hydrogen and the other is a group represented by wherein R3s are the same or different and represent an arginine residue or a lysine residue, x is 0 or 1, y is an integer from 1 to 5, and z is an integer from 1 to 3.
摘要翻译：本发明提供了一种用于雌激素的高度灵敏的免疫测定系统，其利用标记化合物作为式（1）的生物素化雌二醇衍生物，其中R 1和R 2之一是氢，另一个是由其中R3表示的基团相同或不同并且表示精氨酸残基或赖氨酸残基，x为0或1，y为1〜5的整数，z为1〜3的整数。

8. 发明申请

US20110229603A1 NEW LACTIC ACID BACTERIA STRAIN,FERMENTED FOOD OR DRINK, AND METHOD FOR PRODUCING THE FERMENTED FOOD OR DRINK 审中-公开
标题翻译：新的酸性细菌菌株，发酵食品或饮料以及生产食品或饮料的方法
公开(公告)号：US20110229603A1
公开(公告)日：2011-09-22
申请号：US12451676
申请日：2008-05-21
申请人： Shigenori Suzuki , Masahiko Takeda , Takuro Inoue , Rika Kawasaki , Chinatsu Arakawa , Ikuo Kato , Takafumi Yakabe
发明人： Shigenori Suzuki , Masahiko Takeda , Takuro Inoue , Rika Kawasaki , Chinatsu Arakawa , Ikuo Kato , Takafumi Yakabe
IPC分类号： A23L1/48 , A23L2/00 , C12N1/20
CPC分类号： C12R1/225 , A23C11/106 , A23L2/382 , A23L27/86 , A23Y2220/65 , C12N1/20
摘要： The present invention relates to a Lactobacillus pentosus strain FERM BP-10958, a method for producing fermented food or drink with a fermentation process using the lactic acid bacteria, and fermented food or drink produced by fermentations using the lactic acid bacteria.
摘要翻译：本发明涉及戊糖酸乳杆菌菌株FERM BP-10958，使用乳酸菌的发酵方法生产发酵食品或饮料的方法，以及使用乳酸菌发酵产生的发酵食品或饮料。

9. 发明申请

US20110005292A1 METHOD OF FORMING CURLED PORTION 有权
标题翻译：形成弯曲部分的方法
公开(公告)号：US20110005292A1
公开(公告)日：2011-01-13
申请号：US12830119
申请日：2010-07-02
申请人： Tsunenari Futagi , Nobuyuki Kakiya , Tadahisa Akiyama , Ikuo Kato , Akitoshi Uchiumi
发明人： Tsunenari Futagi , Nobuyuki Kakiya , Tadahisa Akiyama , Ikuo Kato , Akitoshi Uchiumi
IPC分类号： B21D19/12
CPC分类号： B21D19/12 , B21D51/2615
摘要： A method of forming a hollow curled portion on a hollow body, the curled portion being oriented from one end to the other end of the hollow body. The method includes a bending step of curving an end of the hollow body toward another end of the hollow body, thereby forming a curled portion, an ironing step of ironing the curled portion with a die, and a recurving step of stopping the die from ironing the curled portion and allowing the curled portion to recurve under its own resiliency in a direction opposite to the direction in which the end of the hollow body has been curved. The ironing step and the recurving step are repeated.
摘要翻译：一种在中空体上形成中空卷曲部分的方法，所述卷曲部分从所述中空体的一端朝向另一端。该方法包括将中空体的端部朝向中空体的另一端弯曲的弯曲步骤，从而形成卷曲部分，用模具熨烫卷曲部分的熨烫步骤以及使模具停止熨烫的循环步骤卷曲部分并且允许卷曲部分在与其中空主体的端部已经弯曲的方向相反的方向上在其自身的弹性下弯曲。重复熨烫步骤和循环步骤。

10. 发明授权

US6012219A Method for making electronic parts 失效
标题翻译：制造电子零件的方法
公开(公告)号：US6012219A
公开(公告)日：2000-01-11
申请号：US877586
申请日：1997-06-17
申请人： Ikuo Kato , Kenichiro Nogi
发明人： Ikuo Kato , Kenichiro Nogi
IPC分类号： B22F3/11 , B22F7/06 , B29C47/02 , H01F17/06 , H01F41/02 , H01F7/06
CPC分类号： B22F7/06 , B22F3/1134 , B29C47/003 , B29C47/025 , H01F17/06 , H01F41/0246 , B22F2998/00 , B29L2031/3462 , H01F2017/065 , Y10T29/4902 , Y10T29/49073 , Y10T29/49076
摘要： Electronic parts, such as an inductor, of improved connectivity between magnetic and conductive materials are made by sintering magnetic material under a condition in which no accumulation is developed, by forming a hollow-core of a shape different from an external shape of said conductive material through said magnetic material to be molded by an extrusion-molding means while inserting said magnetic material into said hollow-core, or by providing an erasable means to be removed by a heat treatment in said conductive material and conducting extrusion molding so as to embed said conductive material into said magnetic material, said erasable means being removed during a sintering treatment to form a space between said conductive material and said magnetic material, and a method for making same.
摘要翻译：通过形成不同于所述导电材料的外部形状的中空芯，通过在没有积累的条件下烧结磁性材料来制造磁性材料和导电材料之间的改善的连接性的电子部件，例如电感器通过将所述磁性材料插入所述中空芯中，通过挤出成形装置将所述磁性材料模制，或者通过提供可通过所述导电材料中的热处理除去的可擦除装置并进行挤压成型，从而将所述导电材料进入所述磁性材料，所述可擦除装置在烧结处理期间被去除以在所述导电材料和所述磁性材料之间形成空间，以及制造其的方法。

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