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1. 发明授权

US08241663B2 Liposome preparation 有权
标题翻译：脂质体制备
公开(公告)号：US08241663B2
公开(公告)日：2012-08-14
申请号：US10594427
申请日：2005-03-25
申请人： Masashi Isozaki , Keisuke Yoshino , Kyoko Taguchi , Masayo Kondo
发明人： Masashi Isozaki , Keisuke Yoshino , Kyoko Taguchi , Masayo Kondo
IPC分类号： A61K9/127 , G01N33/53
CPC分类号： A61K9/1271 , A61K9/1272 , A61K31/704
摘要： A liposome preparation is provided. This liposome preparation is capable of stably encapsulating a drug which is unstable under an acidic condition, and such stable encapsulation is realized without detracting the effect realized by the modification of the membrane by a hydrophilic macromolecule such as stability in blood. More specifically, the liposome preparation comprises a unilamellar vesicle formed from a lipid bilayer comprising a phospholipid as its main membrane component, and an interior aqueous phase of the vesicle at a pH of up to 5. The liposome has a drug loaded therein, and the vesicle is modified with a hydrophilic macromolecule only on its exterior surface.
摘要翻译：提供了脂质体制剂。该脂质体制剂能够稳定地包封在酸性条件下不稳定的药物，并且实现这种稳定的包封，而不会降低通过亲水性高分子如血液稳定性改性膜所产生的效果。更具体地说，脂质体制剂包括由包含磷脂作为其主要成分的脂质双层形成的单层囊泡和pH至多为5的囊泡的内部水相。脂质体中装载有药物，并且囊泡仅在其外表面上用亲水性大分子修饰。

2. 发明申请

US20080069868A1 Irinotecan Preparation 有权
标题翻译：伊立替康制剂
公开(公告)号：US20080069868A1
公开(公告)日：2008-03-20
申请号：US11597435
申请日：2005-05-31
申请人： Keisuke Yoshino , Shigenori Nozawa , Masashi Isozaki , Seigo Sawada , Ikuo Kato , Takeshi Matsuzaki
发明人： Keisuke Yoshino , Shigenori Nozawa , Masashi Isozaki , Seigo Sawada , Ikuo Kato , Takeshi Matsuzaki
IPC分类号： A61K31/437 , A61K9/127 , A61P35/00
CPC分类号： A61K9/1271 , A61K31/4745
摘要： Provided is an irinotecan formulation capable of supporting irinotecan and/or a salt thereof in a closed vesicle carrier at a high concentration and existing in blood for a long period of time by dramatically improved retentivity in blood compared to a conventionally known irinotecan liposome formulation. That is, an irinotecan formulation including a closed vesicle formed by a lipid membrane, in which irinotecan and/or a salt thereof is encapsulated at a concentration of at least 0.07 mol/mol (drug mol/membrane total lipid mol). There is an ion gradient between an inner aqueous phase and an outer aqueous phase in the irinotecan formulation. The closed vesicle is preferably liposome, in which only the outer surface of the liposome is preferably modified with a surface-modifying agent containing a hydrophilic polymer.
摘要翻译：本发明提供了一种伊立替康制剂，其能够通过显着提高血液中的保留性，与常规已知的伊立替康脂质体制剂相比，可以高密度地在密闭囊泡载体中以高浓度和血液中长时间地支持伊立替康和/或其盐。也就是说，包括由脂质膜形成的封闭囊泡的伊立替康制剂，其中伊立替康和/或其盐以至少0.07mol / mol（药物mol /膜总脂质摩尔）的浓度包封。伊立替康制剂中的内部水相和外部水相之间存在离子梯度。封闭的囊泡优选为脂质体，其中仅脂质体的外表面优选用含有亲水性聚合物的表面改性剂改性。

3. 发明申请

US20130261407A1 MOISTURE METER 审中-公开
标题翻译：水分仪
公开(公告)号：US20130261407A1
公开(公告)日：2013-10-03
申请号：US13876735
申请日：2011-09-28
申请人： Miyuki Koyama , Keisuke Yoshino
发明人： Miyuki Koyama , Keisuke Yoshino
IPC分类号： A61B5/00 , A61B5/1455 , A61B5/01
CPC分类号： A61B5/4875 , A61B5/0059 , A61B5/01 , A61B5/1455 , A61B5/6824 , A61B2562/029
摘要： A moisture meter that can easily measure a moisture content of a subject and can be effectively used to assist the subject in appropriately regulating the moisture content. A moisture meter for measuring a moisture content of a subject includes; a probe-type moisture measuring unit held in an armpit of the subject so as to measure a moisture content in the armpit in order to measure the moisture content of the subject; and a temperature measuring unit held in the armpit of the subject so as to measure the temperature of the subject. The moisture meter further includes; a main body; a measuring unit holder that is sandwiched in the armpit while holding the probe-type moisture measuring unit and the temperature measuring unit; and a display unit holder that holds a display unit that displays the measured moisture content of the subject and the measured temperature of the subject.
摘要翻译：一种水分计，其可以容易地测量受试者的水分含量，并且可以有效地用于辅助受试者适当调节水分含量。用于测量受试者的水分含量的水分计包括：探针型水分测量单元，其保持在所述对象的腋下，以测量所述腋下的水分含量，以便测量所述对象的水分含量; 以及温度测量单元，其保持在被检体的腋下，以测量被检体的温度。水分计还包括：主体; 测量单元保持器，其在保持探针型水分测量单元和温度测量单元的同时夹在腋下; 以及显示单元保持器，其保持显示被测物的测量的水分含量的显示单元和被测体的测量温度。

4. 发明授权

US08354064B2 Apparatus for producing liposomes and method of producing liposomes 有权
标题翻译：用于生产脂质体的装置和生产脂质体的方法
公开(公告)号：US08354064B2
公开(公告)日：2013-01-15
申请号：US12935430
申请日：2009-03-30
申请人： Koji Nakamura , Keisuke Yoshino , Yasuo Kurosaki
发明人： Koji Nakamura , Keisuke Yoshino , Yasuo Kurosaki
IPC分类号： B01J19/18
CPC分类号： B01J13/22 , A61K9/1271 , A61K9/1277 , A61K31/573 , B01J13/04
摘要： Disclosed herein are an apparatus for producing liposomes and a method of producing liposomes by which it is made possible to produce liposomes under sterile conditions during the manufacturing process while monitoring in line the particle diameter of liposomes. The apparatus for producing liposomes includes a unit for regulating the particle diameter of liposomes, a supply flow channel for supplying the particle diameter regulating unit with a solution under processing containing a liposome-forming lipid, and a discharge flow channel for discharging from the particle diameter regulating unit a solution under processing containing liposomes, the supply flow channel having an input port through which the solution under processing containing the liposome-forming lipid is put into the supply flow channel, wherein the discharge flow channel has a first light transmitting part at least a portion of which is made of material transparent to light, and also has at least a first light transmittance measuring unit which measures the light transmittance of the solution under processing containing liposomes by directing light to the first light-transmitting part from the outside of the first light-transmitting part. A method of producing liposomes by use of the apparatus.
摘要翻译：本文公开了一种用于生产脂质体的装置和一种生产脂质体的方法，通过该方法，可以在制造过程中在无菌条件下制备脂质体，同时监测脂质体的粒径。用于制备脂质体的装置包括用于调节脂质体的粒径的单元，用于向粒径调节单元供给含有形成脂质体的脂质的处理液的供给流路和从粒径排出的排出流路调节单元处理含有脂质体的溶液，所述供给流动通道具有输入口，将含有形成脂质体的脂质的处理中的溶液通过该输入口放入供给流路中，其中，排出流路至少具有第一透光部其一部分由对光透明的材料制成，并且还具有至少第一透光率测量单元，该第一透光率测量单元通过将来自外部的光引导到第一透光部分来测量包含脂质体的处理中的溶液的透光率第一透光部。通过使用该装置生产脂质体的方法。

5. 发明申请

US20120315902A1 WIRELESS COMMUNICATION SYSTEM, WIRELESS COMMUNICATION TERMINAL, AND SUBSCRIBER INFORMATION MANAGEMENT DEVICE 有权
标题翻译：无线通信系统，无线通信终端和订户信息管理设备
公开(公告)号：US20120315902A1
公开(公告)日：2012-12-13
申请号：US13477873
申请日：2012-05-22
申请人： Koichi NAKAHAMA , Tatsuya TANOUE , Shinichi KURANARI , Atsushi TSUKAZOE , Marie KAWANO , Ryuichi EBUCHI , Mari HAMACHI , Takeshi YAGYU , Keisuke YOSHINO , Shuang XU
发明人： Koichi NAKAHAMA , Tatsuya TANOUE , Shinichi KURANARI , Atsushi TSUKAZOE , Marie KAWANO , Ryuichi EBUCHI , Mari HAMACHI , Takeshi YAGYU , Keisuke YOSHINO , Shuang XU
IPC分类号： H04W8/02 , H04W60/00
CPC分类号： H04W8/02 , H04L67/28 , H04W4/021 , H04W4/023
摘要： A wireless communication system includes: a first wireless communication terminal to register an external device, wherein a subscriber information management device transmits a location of the external device to the first wireless communication terminal based on a search result of the external device based on a search request for the external device, the search request being transmitted from the subscriber information management device to a second wireless communication terminal within a search target area, the second wireless communication terminal being identified by the subscriber information management device based on registration information including certain information and location information of the external device.
摘要翻译：一种无线通信系统包括：第一无线通信终端，用于注册外部设备，其中用户信息管理设备基于搜索请求，基于所述外部设备的搜索结果向所述第一无线通信终端发送所述外部设备的位置对于外部设备，搜索请求从用户信息管理设备发送到搜索目标区域内的第二无线通信终端，第二无线通信终端由用户信息管理设备基于包括某些信息和位置的注册信息来识别外部设备的信息。

6. 发明申请

US20090232883A1 METHOD OF SEPARATING VESICLE, PROCESS FOR PRODUCING MEDICINAL PREPARATION, AND METHOD OF EVALUATION 审中-公开
标题翻译：分离药物的方法，生产药物制剂的方法和评价方法
公开(公告)号：US20090232883A1
公开(公告)日：2009-09-17
申请号：US12307232
申请日：2007-07-03
申请人： Keisuke Yoshino
发明人： Keisuke Yoshino
IPC分类号： A61K9/127 , B01D15/04 , B32B9/00
CPC分类号： A61K9/1271 , A61K31/704 , B01D15/166 , B01D15/363 , Y10T428/2984
摘要： A method of separating vesicles whose membrane has been modified with a hydrophilic polymer (polyethylene glycol, etc.). In the method, vesicles (liposome, etc.) differing in the degree of membrane modification are separated by ion-exchange chromatography using a concentration gradient in which the ionic intensity of an eluent is changed with time. Also provided are: a process for producing vesicles purified so as to have a desired degree of modification with a hydrophilic polymer which comprises utilizing the separation method in the step of purifying vesicles; a method of evaluating a medicinal vesicle preparation containing a drug therein, the method comprising using the separation method; and vesicles in which the membrane has been modified with a hydrophilic polymer and which include no vesicle having a degree of membrane modification less than 0.5 mol %.
摘要翻译：分离其膜已经用亲水性聚合物（聚乙二醇等）改性的囊泡的分离方法。在该方法中，使用浓度梯度，通过离子交换层析分离膜修饰程度不同的囊泡（脂质体等），其中洗脱液的离子强度随时间而变化。还提供了：一种纯化的囊泡的制造方法，其具有亲水性聚合物的所需程度的改性，其包括在净化囊泡的步骤中使用分离方法; 评估含有药物的药物囊泡制剂的方法，所述方法包括使用所述分离方法; 以及其中膜已经用亲水性聚合物改性且不包括膜修饰程度小于0.5mol％的囊泡的囊泡。

7. 发明申请

US20090053029A1 ALIGNER 有权
标题翻译：对准
公开(公告)号：US20090053029A1
公开(公告)日：2009-02-26
申请号：US11917076
申请日：2006-05-25
申请人： Keisuke Yoshino , Mitsuaki Hagio , Shin Osaki , Yoshihiro Kusama
发明人： Keisuke Yoshino , Mitsuaki Hagio , Shin Osaki , Yoshihiro Kusama
IPC分类号： H01L21/68
CPC分类号： H01L21/682 , H01L21/67259 , Y10S414/136 , Y10S414/141 , Y10T279/1291 , Y10T279/1953
摘要： It is an object to provide an aligner for centering a wafer and adjusting an angle of a notch or the like of the wafer while gripping edges of the wafer capable of attaining a shortened takt time and miniaturization of the apparatus by employing a mechanism capable of infinite rotation without being restricted by a rotational range, by eliminating cables and/or tubes at the rotating portion. The link mechanism for causing opening and closing movements of the gripping mechanism for gripping a wafer 1 is supported via a bearing 14 with respect to the link mechanism driving portion for driving the link mechanism so that only the gripping portion and the link mechanism can be rotated.
摘要翻译：本发明的目的是提供一种用于使晶片居中并调整晶片的凹口等的角度的对准器，同时通过采用能够无限大的机构来抓住晶片的能够获得缩短的时间和小型化的晶片的边缘通过消除旋转部分处的电缆和/或管而不受旋转范围的限制。用于使用于夹持晶片1的把持机构的打开和关闭运动的连杆机构经由轴承14相对于用于驱动连杆机构的连杆机构驱动部分被支撑，使得只有夹持部分和连杆机构能够旋转。

8. 发明申请

US20080095600A1 ALIGNER, WAFER TRANSFERRING DEVICE, AND SEMICONDUCTOR PRODUCTION DEVICE 有权
标题翻译：对位器，转移传输装置和半导体生产装置
公开(公告)号：US20080095600A1
公开(公告)日：2008-04-24
申请号：US11873770
申请日：2007-10-17
申请人： Mitsuaki HAGIO , Shin OSAKI , Keisuke YOSHINO
发明人： Mitsuaki HAGIO , Shin OSAKI , Keisuke YOSHINO
IPC分类号： H01L21/673 , H01L21/68
CPC分类号： H01L21/682 , H01L21/68 , H01L21/68707 , H01L21/68728 , Y10S414/136
摘要： In a preferred embodiment, an aligner includes a grip mechanism provided with a plurality of damp arms for holding an external periphery of a wafer; a rotary mechanism for rotating the grip mechanism to rotate the wafer in a prescribed rotational direction, and a lifter mechanism provided with a plurality of lift arms for lifting up the wafer above the grip mechanism. The aligner is configured to align the wafer by the grip operation of the grip mechanism and the rotary operation of the rotary mechanism, and one or more of the plurality of the lift arms which interfere with one or more of the plurality of clamp arms at the time of lifting up the plurality of lift arms are engaged with restriction members provided on the grip mechanism to prevent an upward movement thereof.
摘要翻译：在优选实施例中，对准器包括夹持机构，该夹持机构设置有用于保持晶片的外周的多个湿臂; 旋转机构，用于使所述夹持机构旋转以使所述晶片沿规定的旋转方向旋转;以及升降机构，其设置有用于将所述晶片提升到所述夹持机构上方的多个提升臂。对准器被配置为通过抓握机构的夹持操作和旋转机构的旋转操作以及多个提升臂中的一个或多个在多个夹臂中的一个或多个与提升多个提升臂的时间与设置在抓握机构上的限制构件接合以防止其向上移动。

9. 发明授权

US09433370B2 Moisture meter 有权
标题翻译：水分计
公开(公告)号：US09433370B2
公开(公告)日：2016-09-06
申请号：US13877090
申请日：2011-09-28
申请人： Miyuki Koyama , Keisuke Yoshino
发明人： Miyuki Koyama , Keisuke Yoshino
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61B5/0531 , A61B5/0537 , A61B5/4875 , A61B5/6824 , A61B2562/029
摘要： Provided is a moisture meter that can easily measure a moisture content of a subject and can be effectively used as means for assisting the subject in appropriately regulating the moisture content. A moisture meter for measuring a moisture content of a subject includes: a moisture measuring unit that is held in an armpit of a subject so as to measure a moisture content of the subject, the moisture measuring unit including measurement current supply electrode portions and voltage measurement electrode portions that make contact with a skin surface of the armpit; and a temperature measuring unit that is held in the armpit of the subject so as to measure the temperature of the subject.
摘要翻译：本发明提供一种可以容易地测量受试者的水分含量的水分计，并且可以有效地用作辅助受试者适当调节水分含量的手段。用于测量受试者的水分含量的水份计包括：水分测量单元，其被保持在受试者的腋下以便测量被检体的水分含量，所述水分测量单元包括测量电流供应电极部分和电压测量与腋窝皮肤表面接触的电极部分; 以及温度测量单元，其被保持在被检体的腋下，以便测量被检体的温度。

10. 发明申请

US20130274566A1 MOISTURE METER 有权
标题翻译：水分仪
公开(公告)号：US20130274566A1
公开(公告)日：2013-10-17
申请号：US13877090
申请日：2011-09-28
申请人： Miyuki Koyama , Keisuke Yoshino
发明人： Miyuki Koyama , Keisuke Yoshino
IPC分类号： A61B5/00 , A61B5/053
CPC分类号： A61B5/0531 , A61B5/0537 , A61B5/4875 , A61B5/6824 , A61B2562/029
摘要： Provided is a moisture meter that can easily measure a moisture content of a subject and can be effectively used as means for assisting the subject in appropriately regulating the moisture content. A moisture meter for measuring a moisture content of a subject includes: a moisture measuring unit that is held in an armpit of a subject so as to measure a moisture content of the subject, the moisture measuring unit including measurement current supply electrode portions and voltage measurement electrode portions that make contact with a skin surface of the armpit; and a temperature measuring unit that is held in the armpit of the subject so as to measure the temperature of the subject.
摘要翻译：本发明提供一种可以容易地测量受试者的水分含量的水分计，并且可以有效地用作辅助受试者适当调节水分含量的手段。用于测量受试者的水分含量的水份计包括：水分测量单元，其被保持在受试者的腋下以便测量被检体的水分含量，所述水分测量单元包括测量电流供应电极部分和电压测量与腋窝皮肤表面接触的电极部分; 以及温度测量单元，其被保持在被检体的腋下，以便测量被检体的温度。

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