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1. 发明申请

US20070178267A1 Polyester resin bottle and method of producing the same 有权
标题翻译：聚酯树脂瓶及其制造方法
公开(公告)号：US20070178267A1
公开(公告)日：2007-08-02
申请号：US11587374
申请日：2005-05-21
申请人： Takashi Hama , Toyoaki Sasaki , Kunio Tomita , Takayuki Okuno , Yasuo Kurosaki
发明人： Takashi Hama , Toyoaki Sasaki , Kunio Tomita , Takayuki Okuno , Yasuo Kurosaki
IPC分类号： B32B27/08
CPC分类号： B29C49/6454 , B29B2911/1402 , B29B2911/14026 , B29B2911/14033 , B29B2911/1404 , B29B2911/14106 , B29B2911/14133 , B29B2911/14653 , B29B2911/14713 , B29B2911/14906 , B29C49/0005 , B29C2035/0822 , B29K2067/00 , B65D1/0207 , Y10T428/13 , Y10T428/1352 , Y10T428/1397
摘要： It is an object of the present invention to provide a hollow bottle made of polyester, which has excellent heat resistance and is not likely to undergo deformation or change in capacity even if a liquid of high temperature is filled therein. The present invention relates to a hollow bottle formed by blow molding polyester, which has a thickness in the range of 200 to 400 μm, and satisfies that Δd=d1−d2 is not less than −7 kg/m3 and not more than 7 kg/m3, with d1 [kg/m3] being a density of a part ranging from an outer surface up to 50 μm inward, and d2 [kg/m3] being a density of a part ranging from an inner surface up to 50 μm inward. The polyester is preferably polyethylene terephthalate, and it is preferable that d1=1370 to 1375 kg/m3, while d2=1373 to 1378 kg/m3.
摘要翻译：本发明的目的是提供一种耐热性优异的聚酯制中空瓶，即使在其中填充高温液体也不容易发生变形或容量变化。本发明涉及通过吹塑聚酯形成的中空瓶，该中空瓶的厚度在200-400μm的范围内，并且满足Deltad = d 1 -d 2不小于-7kg / m 3 ＆lt;＆gt;和不超过7kg / m 3，其中d 1 [kg / m 3]是从外表面到 50毫米向内，d 2 [kg / m 3]是从内表面到内径达到50um的内部的密度。聚酯优选为聚对苯二甲酸乙二醇酯，优选d 1 = 1370〜1375kg / m 3，而d 2 = 1373〜1378kg / m 3。

2. 发明申请

US20080193509A1 Liposome Preparation Containing Slightly Water-Soluble Camptothecin 审中-公开
标题翻译：含有轻微水溶性喜树碱的脂质体制备
公开(公告)号：US20080193509A1
公开(公告)日：2008-08-14
申请号：US11629869
申请日：2005-06-17
申请人： Keisuke Yoshino , Shigenori Nozawa , Yoshitaka Ogata , Yasuo Kurosaki , Seigo Sawda , Ikuo Kato , Takeshi Matsuzaki
发明人： Keisuke Yoshino , Shigenori Nozawa , Yoshitaka Ogata , Yasuo Kurosaki , Seigo Sawda , Ikuo Kato , Takeshi Matsuzaki
IPC分类号： A61K9/127 , A61K31/4375
CPC分类号： A61K9/1272 , A61K31/4745
摘要： The present invention aims at providing a slightly water-soluble camptothecin liposome preparation with an excellent retention in blood for a drug, which can stably hold a slightly water-soluble camptothecin compound for a long period of time, whereby hydrolysis of an α-hydroxylactone ring in blood is suppressed and the slightly water-soluble camptothecin compound is kept in a structure in which the ring is not opened and which makes the compound effective as an antitumor-active drug, and, moreover, the liability of the drug to leave a liposome is advantageously reduced, so that it is possible to maintain the drug concentration in plasma for a long period of time after administration. This object is achieved by the liposome preparation as described in the specification. The liposome preparation according to the present invention includes a liposome preparation including as lipid components for forming a membrane a phospholipid and a fatty acid, and containing as a drug a lightly water-soluble camptothecin compound.
摘要翻译：本发明的目的在于提供一种在血液中具有优异的药物保留性的轻微水溶性喜树碱脂质体制剂，其能够长时间稳定地保持轻微的水溶性喜树碱化合物，从而水解α-羟基内酯环在血液中被抑制，轻微的水溶性喜树碱化合物保持在不打开环的结构中，并且使得化合物作为抗肿瘤活性药物有效，此外，药物离开脂质体的责任有利地减少，使得可以在施用后长时间维持血浆中的药物浓度。该目的通过如说明书中所述的脂质体制备来实现。根据本发明的脂质体制剂包括脂质体制剂，其包含作为形成磷脂和脂肪酸的膜的脂质成分，并且作为药物含有轻度水溶性的喜树碱化合物。

3. 发明申请

US20070284788A1 Process for Producing Hollow Molded Product of Thermoplastic Resin 审中-公开
标题翻译：生产热塑性树脂中空成型产品的工艺
公开(公告)号：US20070284788A1
公开(公告)日：2007-12-13
申请号：US11572736
申请日：2005-07-27
申请人： Yasuo Kurosaki , Takashi Hama
发明人： Yasuo Kurosaki , Takashi Hama
IPC分类号： B29C49/64
CPC分类号： B29C49/64 , B29B2911/1402 , B29B2911/14026 , B29B2911/14033 , B29B2911/1404 , B29B2911/14106 , B29B2911/14133 , B29C49/06 , B29C2035/0822 , B29K2067/00
摘要： A process for producing a hollow blow-molded product with high productivity is provided by improving heating efficiency of a parison without significant changes to a molding machine for producing the product. The invention relates to the following production process. A process for producing a resin hollow molded product, which comprises the step of heating a parison formed of a thermoplastic resin material, and the step of blow-molding the heated parison, the heating step involving a near-infrared heater with a maximum energy wavelength in the range of 900 nm to 1500 nm and a wavelength converter disposed outside the parison, which absorbs the radiation from the near-infrared heater and emits the radiation as an infrared radiation longer than the maximum radiation energy. The wavelength converter emits radiation preferably with a maximum energy wavelength in the range of 3000 nm to 5000 nm.
摘要翻译：通过提高型坯的加热效率，而不会对制造产品的成型机造成显着变化，提供了高生产率的中空吹塑成型制品的制造方法。本发明涉及以下生产方法。一种树脂中空成型体的制造方法，其特征在于，包括对由热塑性树脂材料形成的型坯进行加热的步骤和对所述加热的型坯进行吹塑的步骤，所述加热工序涉及具有最大能量波长的近红外加热器在900nm至1500nm的范围内，以及布置在型坯外部的波长转换器，其吸收来自近红外加热器的辐射并且发射作为比最大辐射能量更长的红外辐射的辐射。波长转换器优选以3000nm至5000nm范围内的最大能量波长发射辐射。

4. 发明授权

US08354064B2 Apparatus for producing liposomes and method of producing liposomes 有权
标题翻译：用于生产脂质体的装置和生产脂质体的方法
公开(公告)号：US08354064B2
公开(公告)日：2013-01-15
申请号：US12935430
申请日：2009-03-30
申请人： Koji Nakamura , Keisuke Yoshino , Yasuo Kurosaki
发明人： Koji Nakamura , Keisuke Yoshino , Yasuo Kurosaki
IPC分类号： B01J19/18
CPC分类号： B01J13/22 , A61K9/1271 , A61K9/1277 , A61K31/573 , B01J13/04
摘要： Disclosed herein are an apparatus for producing liposomes and a method of producing liposomes by which it is made possible to produce liposomes under sterile conditions during the manufacturing process while monitoring in line the particle diameter of liposomes. The apparatus for producing liposomes includes a unit for regulating the particle diameter of liposomes, a supply flow channel for supplying the particle diameter regulating unit with a solution under processing containing a liposome-forming lipid, and a discharge flow channel for discharging from the particle diameter regulating unit a solution under processing containing liposomes, the supply flow channel having an input port through which the solution under processing containing the liposome-forming lipid is put into the supply flow channel, wherein the discharge flow channel has a first light transmitting part at least a portion of which is made of material transparent to light, and also has at least a first light transmittance measuring unit which measures the light transmittance of the solution under processing containing liposomes by directing light to the first light-transmitting part from the outside of the first light-transmitting part. A method of producing liposomes by use of the apparatus.
摘要翻译：本文公开了一种用于生产脂质体的装置和一种生产脂质体的方法，通过该方法，可以在制造过程中在无菌条件下制备脂质体，同时监测脂质体的粒径。用于制备脂质体的装置包括用于调节脂质体的粒径的单元，用于向粒径调节单元供给含有形成脂质体的脂质的处理液的供给流路和从粒径排出的排出流路调节单元处理含有脂质体的溶液，所述供给流动通道具有输入口，将含有形成脂质体的脂质的处理中的溶液通过该输入口放入供给流路中，其中，排出流路至少具有第一透光部其一部分由对光透明的材料制成，并且还具有至少第一透光率测量单元，该第一透光率测量单元通过将来自外部的光引导到第一透光部分来测量包含脂质体的处理中的溶液的透光率第一透光部。通过使用该装置生产脂质体的方法。

5. 发明申请

US20090294047A1 METHOD AND DEVICE FOR WELDING THERMOPLASTIC RESIN ARTICLES 审中-公开
标题翻译：焊接热塑性树脂制品的方法和装置
公开(公告)号：US20090294047A1
公开(公告)日：2009-12-03
申请号：US12361565
申请日：2009-01-29
申请人： Yasuo Kurosaki , Kimitoshi Satoh
发明人： Yasuo Kurosaki , Kimitoshi Satoh
IPC分类号： B32B37/06
CPC分类号： B32B37/06 , B29C65/1412 , B29C65/1435 , B29C65/1454 , B29C65/1612 , B29C65/1616 , B29C65/1619 , B29C65/1629 , B29C65/1635 , B29C65/1654 , B29C66/003 , B29C66/3474 , B29C66/71 , B29C66/73143 , B29C66/7352 , B29C66/73921 , B29C66/80 , B29C66/81267 , B29C66/81457 , B29C66/8181 , B29C66/836 , B29C2035/0822 , B29K2021/003 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2027/12 , B29K2067/00 , B29K2069/00 , B29K2077/00 , B29K2101/12 , B29K2995/0027 , B29K2025/06
摘要： A plurality of thermoplastic articles are superimposed against a support, an infrared transparent solid is superimposed to form a superimposed body and infrared is irradiated to the superimposed body from the side of the infrared transparent solid. For the irradiation source, an Er: YAG laser or fiber laser is used. The interface temperature of the thermoplastic article becomes relatively lower and a high temperature region can be developed within the superimposed body due to the infiltration of laser energy. As a result, degradation of the surface configuration due to thermal damages in the infrared irradiation side surface layer of the thermoplastic articles can be suppressed.
摘要翻译：将多个热塑性制品叠置在支撑体上，叠加红外透明固体以形成叠加体，并且红外透射固体的一侧将红外线照射到叠加体上。对于照射源，使用Er：YAG激光器或光纤激光器。热塑性制品的界面温度变得相对较低，并且由于激光能量的渗透，叠加体内可以形成高温区域。结果，可以抑制由于热塑性制品的红外线照射侧表面层中的热损伤导致的表面形状的劣化。

6. 发明申请

US20060175004A1 Process for welding of thermoplastic resins 审中-公开
标题翻译：热塑性树脂焊接工艺
公开(公告)号：US20060175004A1
公开(公告)日：2006-08-10
申请号：US10494637
申请日：2002-11-07
申请人： Yasuo Kurosaki , Tomoya Matayoshi , Kimitoshi Satoh , Mamoru Kagami , Takayuki Kajihara , Hiroshi Tanaka
发明人： Yasuo Kurosaki , Tomoya Matayoshi , Kimitoshi Satoh , Mamoru Kagami , Takayuki Kajihara , Hiroshi Tanaka
IPC分类号： B32B37/00
CPC分类号： B29C66/81267 , B29C65/1412 , B29C65/1416 , B29C65/1435 , B29C65/1612 , B29C65/1616 , B29C65/1619 , B29C65/1635 , B29C65/1654 , B29C65/1687 , B29C65/1696 , B29C65/7841 , B29C65/8253 , B29C66/1122 , B29C66/244 , B29C66/3474 , B29C66/43 , B29C66/522 , B29C66/65 , B29C66/71 , B29C66/723 , B29C66/73115 , B29C66/73117 , B29C66/7313 , B29C66/73161 , B29C66/7332 , B29C66/73321 , B29C66/73521 , B29C66/73753 , B29C66/73772 , B29C66/73776 , B29C66/73921 , B29C66/8122 , B29C66/81261 , B29C66/81268 , B29C66/834 , B29C66/83411 , B29C66/91411 , B29C66/91631 , B29C66/919 , B29C66/9192 , B29C66/91921 , B29C66/929 , B29C66/93431 , B29C66/939 , B29C66/944 , B29C66/949 , B29C66/9592 , B29C2035/0822 , B29K2995/0027 , B29K2995/0072 , B29K2995/0073 , B29K2909/02 , B29K2081/06 , B29K2077/00 , B29K2075/00 , B29K2071/00 , B29K2069/00 , B29K2067/006 , B29K2067/003 , B29K2067/00 , B29K2055/02 , B29K2033/20 , B29K2033/12 , B29K2033/08 , B29K2027/08 , B29K2027/06 , B29K2025/06 , B29K2023/38 , B29K2023/18 , B29K2023/12 , B29K2023/083 , B29K2023/06 , B29K2021/003 , B29K2009/00
摘要： Weld bead of excellent surface features with high welding strength can be obtained without development of significant shrinkage and thermal damages.
摘要翻译：可以获得具有高焊接强度的优异表面特征的焊道，而不会发生显着的收缩和热损伤。

7. 发明授权

US5843486A Polymer injection molding unit 失效
标题翻译：聚合物注塑单元
公开(公告)号：US5843486A
公开(公告)日：1998-12-01
申请号：US673169
申请日：1996-06-26
申请人： Yasuo Kurosaki , Isao Sato
发明人： Yasuo Kurosaki , Isao Sato
IPC分类号： B29C45/37 , B29C45/73 , B29C35/08
CPC分类号： B29C45/73 , B29C45/37 , B29C2033/0005
摘要： A polymer injection molding unit is disclosed having a mold wall which includes a portion made of an infrared transmissible material which is radiated by an external infrared radiation source. Due to the passage of the infrared radiation through the infrared transmissible material, the infrared radiation is not absorbed by the mold wall and the mold wall is not substantially heated. The infrared radiation passes through the mold wall and is absorbed by the molten polymer material near the mold wall. As a result, the temperature of the molten polymer material rises and its viscosity is lowered to thereby enhance the shape transcription of complicated or fine shapes present on the mold wall, without increasing the temperature of the mold wall.
摘要翻译：公开了一种聚合物注射成型单元，其具有模具壁，该模具壁包括由外部红外辐射源辐射的由红外线传输材料制成的部分。由于红外辐射通过红外透射材料，红外辐射不被模具壁吸收，并且模具壁基本上不被加热。红外辐射通过模具壁，并被模具壁附近的熔融聚合物材料吸收。结果，熔融聚合物材料的温度升高并且其粘度降低，从而增加存在于模具壁上的复杂或精细形状的形状转印，而不增加模具壁的温度。

8. 发明授权

US08394476B2 Polyester resin bottle and method of producing the same 有权
标题翻译：聚酯树脂瓶及其制造方法
公开(公告)号：US08394476B2
公开(公告)日：2013-03-12
申请号：US11587374
申请日：2005-05-21
申请人： Takashi Hama , Toyoaki Sasaki , Kunio Tomita , Takayuki Okuno , Yasuo Kurosaki
发明人： Takashi Hama , Toyoaki Sasaki , Kunio Tomita , Takayuki Okuno , Yasuo Kurosaki
IPC分类号： B29D22/00
CPC分类号： B29C49/6454 , B29B2911/1402 , B29B2911/14026 , B29B2911/14033 , B29B2911/1404 , B29B2911/14106 , B29B2911/14133 , B29B2911/14653 , B29B2911/14713 , B29B2911/14906 , B29C49/0005 , B29C2035/0822 , B29K2067/00 , B65D1/0207 , Y10T428/13 , Y10T428/1352 , Y10T428/1397
摘要： It is an object of the present invention to provide a hollow bottle made of polyester, which has excellent heat resistance and is not likely to undergo deformation or change in capacity even if a liquid of high temperature is filled therein. The present invention relates to a hollow bottle formed by blow molding polyester, which has a thickness in the range of 200 to 400 μm, and satisfies that Δd=d1−d2 is not less than −7 kg/m3 and more than 7 kg/m3, with d1 [kg/m3] being a density of a part ranging from an outer surface up to 50 μm inward, and d2 [kg/m3] being a density of a part of the body portion ranging from an inner surface up to 50 μm inward. The polyester is preferably polyethylene terephthalate, and it is preferable that d1=1370 to 1375 kg/m3, while d2=1373 to 1378 kg/m3.
摘要翻译：本发明的目的是提供一种耐热性优异的聚酯制中空瓶，即使在其中填充高温液体也不容易发生变形或容量变化。本发明涉及通过吹塑聚酯形成的中空瓶，其厚度在200-400μm的范围内，并且满足＆Dgr; d = d1-d2不小于-7kg / m 3且大于7 kg / m 3，其中d1 [kg / m3]是从外表面到内部达到50μm的部分的密度，以及从主体部分的内表面的一部分的密度的d2 [kg / m3] 高达50微米向内。聚酯优选为聚对苯二甲酸乙二醇酯，优选d1 = 1370〜1375kg / m3，d2 = 1373〜1378kg / m3。

9. 发明申请

US20110024929A1 APPARATUS FOR PRODUCING LIPOSOMES AND METHOD OF PRODUCING LIPOSOMES 有权
标题翻译：用于生产脂质体的装置和生产脂质体的方法
公开(公告)号：US20110024929A1
公开(公告)日：2011-02-03
申请号：US12935430
申请日：2009-03-30
申请人： Koji Nakamura , Keisuke Yoshino , Yasuo Kurosaki
发明人： Koji Nakamura , Keisuke Yoshino , Yasuo Kurosaki
IPC分类号： A61K9/127 , A61J3/07 , B01J13/02
CPC分类号： B01J13/22 , A61K9/1271 , A61K9/1277 , A61K31/573 , B01J13/04
摘要： Disclosed herein are an apparatus for producing liposomes and a method of producing liposomes by which it is made possible to produce liposomes under sterile conditions during the manufacturing process while monitoring in line the particle diameter of liposomes. The apparatus for producing liposomes includes a unit for regulating the particle diameter of liposomes, a supply flow channel for supplying the particle diameter regulating unit with a solution under processing containing a liposome-forming lipid, and a discharge flow channel for discharging from the particle diameter regulating unit a solution under processing containing liposomes, the supply flow channel having an input port through which the solution under processing containing the liposome-forming lipid is put into the supply flow channel, wherein the discharge flow channel has a first light transmitting part at least a portion of which is made of material transparent to light, and also has at least a first light transmittance measuring unit which measures the light transmittance of the solution under processing containing liposomes by directing light to the first light-transmitting part from the outside of the first light-transmitting part. A method of producing liposomes by use of the apparatus.
摘要翻译：本文公开了一种用于生产脂质体的装置和一种生产脂质体的方法，通过该方法，可以在制造过程中在无菌条件下制备脂质体，同时监测脂质体的粒径。用于制备脂质体的装置包括用于调节脂质体的粒径的单元，用于向粒径调节单元供给含有形成脂质体的脂质的处理液的供给流路和从粒径排出的排出流路调节单元处理含有脂质体的溶液，所述供给流动通道具有输入口，将含有形成脂质体的脂质的处理中的溶液通过该输入口放入供给流路中，其中，排出流路至少具有第一透光部其一部分由对光透明的材料制成，并且还具有至少第一透光率测量单元，该第一透光率测量单元通过将来自外部的光引导到第一透光部分来测量包含脂质体的处理中的溶液的透光率第一透光部。通过使用该装置生产脂质体的方法。

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