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1. 发明授权

US08691264B2 Implantable or insertable medical devices for controlled drug delivery 失效
标题翻译：用于受控药物递送的可植入或可插入的医疗装置
公开(公告)号：US08691264B2
公开(公告)日：2014-04-08
申请号：US13404832
申请日：2012-02-24
申请人： Jianmin Li , Danielle Conley , Weenna Bucay-Couto , Cang Duy Dao , Hamid Davoudi , Raymond J. Lareau , Kathleen M Miller
发明人： Jianmin Li , Danielle Conley , Weenna Bucay-Couto , Cang Duy Dao , Hamid Davoudi , Raymond J. Lareau , Kathleen M Miller
IPC分类号： A61F2/02
CPC分类号： A61K9/0024 , A61F2002/072 , A61F2250/0067 , A61K9/2027 , A61L2/232 , A61L29/16 , A61L31/16 , A61L31/18 , A61L2300/40 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/602 , A61M31/002
摘要： Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.
摘要翻译：提供可植入或可插入的医疗装置，其包括：（a）生物相容性聚合物; 和（b）选自抗炎剂，止痛剂，麻醉剂和解痉药的至少一种治疗剂。医疗装置适于在植入或插入时与疼痛或不适相关的部位植入或插入。在许多实施方案中，治疗剂将选自（i）酮咯酸及其药学上可接受的盐（例如酮咯酸氨丁三醇）和（ii）4-二乙基氨基-2-丁炔基苯基环己基乙醇酸酯及其药学上可接受的盐（例如，奥昔布宁氯化物）。还提供了用于可植入或可插入的医疗装置的用途，其使用包括减少伴随这种装置的植入或插入的疼痛或不适。进一步的用途可以包括减少沿着装置的微生物累积。还提供了用于制造植入式或可插入医疗装置的方法。

2. 发明授权

US08133501B2 Implantable or insertable medical devices for controlled drug delivery 有权
标题翻译：用于受控药物递送的可植入或可插入的医疗装置
公开(公告)号：US08133501B2
公开(公告)日：2012-03-13
申请号：US10377131
申请日：2003-02-28
申请人： Jianmin Li , Danielle Conley , Weenna Bucay Couto , Cang Duy Dao , Hamid Davoudi , Raymond Lareau , Kathleen M. Miller
发明人： Jianmin Li , Danielle Conley , Weenna Bucay Couto , Cang Duy Dao , Hamid Davoudi , Raymond Lareau , Kathleen M. Miller
IPC分类号： A61F2/02
CPC分类号： A61K9/0024 , A61F2002/072 , A61F2250/0067 , A61K9/2027 , A61L2/232 , A61L29/16 , A61L31/16 , A61L31/18 , A61L2300/40 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/602 , A61M31/002
摘要： Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.
摘要翻译：提供可植入或可插入的医疗装置，其包括：（a）生物相容性聚合物; 和（b）选自抗炎剂，止痛剂，麻醉剂和解痉药的至少一种治疗剂。医疗装置适于在植入或插入时与疼痛或不适相关的部位植入或插入。在许多实施方案中，治疗剂将选自（i）酮咯酸及其药学上可接受的盐（例如酮咯酸氨丁三醇）和（ii）4-二乙基氨基-2-丁炔基苯基环己基乙醇酸酯及其药学上可接受的盐（例如，奥昔布宁氯化物）。还提供了用于可植入或可插入的医疗装置的用途，其使用包括减少伴随这种装置的植入或插入的疼痛或不适。进一步的用途可以包括减少沿着装置的微生物累积。还提供了用于制造植入式或可插入医疗装置的方法。

3. 发明授权

US07993390B2 Implantable or insertable medical device resistant to microbial growth and biofilm formation 有权
标题翻译：可植入或可插入的医疗器械抗微生物生长和生物膜形成
公开(公告)号：US07993390B2
公开(公告)日：2011-08-09
申请号：US10789398
申请日：2004-02-27
申请人： Kathleen M. Miller , Weenna Bucay-Couto , Jianmin Li
发明人： Kathleen M. Miller , Weenna Bucay-Couto , Jianmin Li
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L2/232 , A61L29/16 , A61L29/18 , A61L31/18 , A61L2300/202 , A61L2300/206 , A61L2300/21 , A61L2300/216 , A61L2300/404 , A61L2300/416 , A61L2300/45 , A61L2300/61
摘要： Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.
摘要翻译：公开了可植入或可插入的医疗装置，其在装置的环境和环境中提供对微生物生长的抵抗力，并且抵抗微生物附着和在装置上的生物膜形成。特别地，本发明公开了可植入或可插入的医疗装置，其包括至少一个生物相容性基质聚合物区域，用于提供对微生物生长的抗性的抗微生物剂和/或用于抑制微生物附着的微生物粘附/生物膜合成抑制剂及其合成和生物膜在医疗器械表面积聚。还公开了在基本上防止任何所述生物活性剂优先分配到生物相容性基质聚合物的表面并基本上防止所述生物活性剂的化学修饰的条件下制造这种装置的方法。

4. 发明申请

US20090171465A1 Polymeric Regions For Implantable Or Insertable Medical Devices 审中-公开
标题翻译：用于可植入或可插入医疗器械的聚合物区域
公开(公告)号：US20090171465A1
公开(公告)日：2009-07-02
申请号：US12276938
申请日：2008-11-24
申请人： Weenna Bucay-Couto , Jianmin Li
发明人： Weenna Bucay-Couto , Jianmin Li
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2250/0019 , A61F2250/0067 , A61L29/041 , A61L31/048 , A61M27/008 , A61M2025/0057 , C08L29/04
摘要： According to one aspect, the present invention is directed to implantable or insertable medical devices which comprise polymeric regions that comprise high vinyl acetate content EVA (or another soft polymer) and a therapeutic agent. In another aspect, the present invention is directed to implantable or insertable medical devices which comprise (a) a first region comprising a first EVA and (b) a second region adjacent to the first region that is of lower durometer than the first region.
摘要翻译：根据一个方面，本发明涉及可植入或可插入的医疗装置，其包括包含高乙酸乙烯酯含量的EVA（或另一种软性聚合物）和治疗剂的聚合物区域。在另一方面，本发明涉及可植入或可插入的医疗装置，其包括（a）包含第一EVA的第一区域和（b）与第一区域相邻的第二区域，该第二区域的硬度低于第一区域。

5. 发明授权

US08685427B2 Controlled drug delivery 失效
标题翻译：控制药物递送
公开(公告)号：US08685427B2
公开(公告)日：2014-04-01
申请号：US10209476
申请日：2002-07-31
申请人： Jianmin Li , Weenna Bucay Couto
发明人： Jianmin Li , Weenna Bucay Couto
IPC分类号： A61F2/00 , A61M31/00 , A61F2/06
CPC分类号： A61L31/10 , A61F2/07 , A61F2250/0067 , A61K9/0024 , A61K31/216 , A61K31/407 , A61L27/16 , A61L29/085 , A61L29/148 , A61L29/16 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/204 , A61L2300/21 , A61L2300/602 , A61L2300/606 , A61L2420/06 , A61M31/002
摘要： A medical device for placement in a body of a mammal is provided. The medical device comprises (1) a polymeric matrix forming the device and defining a lumen through the device, the matrix comprising polymer macromolecules and defining spaces between the polymer macromolecules; (2) a drug contained within at least some of the spaces of the matrix; and (3) a material contained within at least some of the spaces of the matrix to affect diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of the mammal.
摘要翻译：提供了用于放置在哺乳动物体内的医疗装置。所述医疗装置包括（1）形成所述装置并且通过所述装置限定内腔的聚合物基质，所述基质包含聚合物高分子并限定所述聚合物大分子之间的空间; （2）包含在基质的至少一些空间内的药物; 和（3）当所述医疗装置放置在哺乳动物的身体中时，包含在所述基质的至少一些所述空间内的材料以影响所述药物从所述聚合物基质中的扩散。

6. 发明申请

US20080233167A1 UROLOGICAL MEDICAL DEVICES FOR RELEASE OF PROSTATICALLY BENEFICIAL THERAPEUTIC AGENTS 审中-公开
标题翻译：用于释放预防性治疗药物的泌尿医学装置
公开(公告)号：US20080233167A1
公开(公告)日：2008-09-25
申请号：US12052085
申请日：2008-03-20
申请人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
发明人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
IPC分类号： A61F2/04 , A61M25/00 , A61M1/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/40
摘要： According to an aspect of the invention, urological medical devices are provided, which comprise a prostatically beneficial agent selected from alpha-adrenergic blockers, antispasmodic agents, anticholinergic/antimuscarinic agents, calcium channel blockers, anti-inflammatory agents, hormone-affecting agents, anti-cancer agents, and combinations thereof, among others. The urological medical devices are adapted for implantation or insertion into a subject's urinary tract, whereupon at least a portion of the prostatically beneficial agent is released into the subject's prostatic urethra. The release profile of the prostatically beneficial agent is effective to treat a prostatic disorder, for example, benign prostate hypertrophy, prostate cancer or prostatitis, among others. Other aspects of the invention are directed to treating prostatic disorders.
摘要翻译：根据本发明的一个方面，提供泌尿科医疗装置，其包括选自α-肾上腺素能阻滞剂，解痉药，抗胆碱能药/抗毒蕈碱药，钙通道阻断剂，抗炎剂，激素影响剂，抗癌症药剂及其组合等。泌尿科医疗装置适于植入或插入受试者的尿道中，因此至少一部分前列腺有益剂被释放到受试者的前列腺尿道内。前列腺增生症的释放特征对于治疗前列腺疾病，例如良性前列腺肥大，前列腺癌或前列腺炎等是有效的。本发明的其它方面涉及治疗前列腺疾病。

7. 发明申请

US20110171272A1 UROLOGICAL MEDICAL DEVICES FOR RELEASE OF PROSTATICALLY BENEFICIAL THERAPEUTIC AGENTS 审中-公开
标题翻译：用于释放预防性治疗药物的泌尿医学装置
公开(公告)号：US20110171272A1
公开(公告)日：2011-07-14
申请号：US13046989
申请日：2011-03-14
申请人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
发明人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
IPC分类号： A61K9/00 , A61K31/517 , A61K31/131 , A61K31/704 , A61K31/136 , A61K31/337 , A61K38/12 , A61K31/48 , A61K31/475 , A61K31/4709 , A61K31/573 , A61K31/485 , A61K31/616 , A61K31/46 , A61P35/00 , A61P29/00 , A61P31/04 , A61P25/04 , A61P23/02 , A61M27/00 , A61F2/04
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/40
摘要： According to an aspect of the invention, urological medical devices are provided, which comprise a prostatically beneficial agent selected from alpha-adrenergic blockers, antispasmodic agents, anticholinergic/antimuscarinic agents, calcium channel blockers, anti-inflammatory agents, hormone affecting agents, anti-cancer agents, and combinations thereof, among others. The urological medical devices are adapted for implantation or insertion into a subject's urinary tract, whereupon at least a portion of the prostatically beneficial agent is released into the subject's prostatic urethra. The release profile of the prostatically beneficial agent is effective to treat a prostatic disorder, for example, benign prostate hypertrophy, prostate cancer or prostatitis, among others. Other aspects of the invention are directed to treating prostatic disorders.
摘要翻译：根据本发明的一个方面，提供泌尿科医疗装置，其包括选自α-肾上腺素能阻滞剂，解痉药，抗胆碱能药/抗毒蕈碱药，钙通道阻滞剂，抗炎药，激素影响剂，癌症药物及其组合等。泌尿科医疗装置适于植入或插入受试者的尿道中，因此至少一部分前列腺有益剂被释放到受试者的前列腺尿道内。前列腺增生症的释放特征对于治疗前列腺疾病，例如良性前列腺肥大，前列腺癌或前列腺炎等是有效的。本发明的其它方面涉及治疗前列腺疾病。

8. 发明授权

US06693089B1 Reducing adhesion 有权
标题翻译：降低附着力
公开(公告)号：US06693089B1
公开(公告)日：2004-02-17
申请号：US10339905
申请日：2003-01-10
申请人： Jianmin Li , Weenna Bucay-Couto , Timothy P. Harrah
发明人： Jianmin Li , Weenna Bucay-Couto , Timothy P. Harrah
IPC分类号： A61K31715
CPC分类号： C08L5/04 , A61K47/6957 , A61L27/20 , A61L27/26 , A61L31/041 , A61L31/042
摘要： A method of reducing adhesion at a site of trauma includes forming a film from an alginate solution, contacting the film with a cross-linking solution to form a cross-linked mechanically stable sheet, and placing at least a portion of the sheet at the site of trauma. An anti-adhesion barrier includes a sheet of ionically cross-linked alginate having a thickness in a range of 0.25 mm to 10 mm. The sheet has a tear strength sufficient for suturing and repositioning. A drug delivery device includes a cross-linked alginate container that can be filled with a drug.
摘要翻译：降低创伤部位的粘附性的方法包括从藻酸盐溶液形成膜，使膜与交联溶液接触以形成交联的机械稳定的片材，并将片材的至少一部分放置在位置的创伤。抗粘连屏障包括厚度在0.25mm至10mm范围内的离子交联藻酸盐片。该片具有足以缝合和重新定位的撕裂强度。药物递送装置包括可以填充药物的交联藻酸盐容器。

9. 发明授权

US08517994B2 Method and device for tissue removal and for delivery of a therapeutic agent or bulking agent 有权
标题翻译：用于组织去除和用于递送治疗剂或填充剂的方法和装置
公开(公告)号：US08517994B2
公开(公告)日：2013-08-27
申请号：US12893168
申请日：2010-09-29
申请人： Jianmin Li , Weenna Bucay-Couto
发明人： Jianmin Li , Weenna Bucay-Couto
IPC分类号： A61M5/178 , A61M37/00 , A61M5/32 , A61M31/00 , A61B17/20 , A61B17/32
CPC分类号： A61M37/00 , A61B10/0241 , A61B17/22 , A61B17/32002 , A61B2017/00274 , A61B2017/00685 , A61B2017/320775 , A61B2018/00547
摘要： According to an aspect of the present invention, a medical device is provided, which comprises the following: (a) a hollow elongate body (e.g., an elongate cylinder, such as a needle) having distal and proximal ends; and (b) a rotatable member comprising a tissue morselizer and an elongate shaft (e.g., an auger-like tissue-drilling bit). The device (i) advance material (e.g., morselated tissue) toward the proximal end of the hollow elongate body when the shaft is rotated in a first direction, and (ii) advance material (e.g., a therapeutic agent and/or a bulking agent) toward the distal end of the hollow elongate body when the shaft is rotated in a second direction that is opposite the first direction. The invention also provides a method of treatment for morselizing and removing tissue from within the patient and creating a void within the patient and introducing a therapeutic agent and/or a bulking agent into the void.
摘要翻译：根据本发明的一个方面，提供一种医疗装置，其包括：（a）具有远端和近端的中空细长体（例如细长圆柱体，例如针头）; 和（b）可旋转构件，其包括组织修整器和细长轴（例如，螺旋状组织钻头）。当所述轴沿第一方向旋转时，所述装置（i）朝着所述中空细长主体的近端向前推进材料（例如，组织），和（ii）推进材料（例如，治疗剂和/或填充剂）当所述轴沿与第一方向相反的第二方向旋转时朝向所述中空细长体的远端。本发明还提供了一种治疗方法，用于从患者内部进行细胞破碎和去除组织，并在患者体内产生空洞并将治疗剂和/或填充剂引入空隙中。

10. 发明申请

US20070298069A1 Medical devices for release of low solubility therapeutic agents 审中-公开
标题翻译：用于释放低溶解度治疗剂的医疗装置
公开(公告)号：US20070298069A1
公开(公告)日：2007-12-27
申请号：US11474850
申请日：2006-06-26
申请人： Weenna Bucay-Couto , Jianmin Li , Min-Shyan Sheu
发明人： Weenna Bucay-Couto , Jianmin Li , Min-Shyan Sheu
IPC分类号： A61F2/02 , C08G63/91
CPC分类号： A61L27/54 , A61L27/14 , A61L27/50 , A61L29/14 , A61L31/04 , A61L31/14 , A61L31/16 , A61L2300/802 , A61M27/008
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric carrier regions. These polymeric carrier regions, in turn, contain a polymer, a low solubility therapeutic agent, and a solubilizing agent.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物载体区域。这些聚合物载体区域又包含聚合物，低溶解度治疗剂和增溶剂。

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