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1. 发明授权

US08691264B2 Implantable or insertable medical devices for controlled drug delivery 失效
标题翻译：用于受控药物递送的可植入或可插入的医疗装置
公开(公告)号：US08691264B2
公开(公告)日：2014-04-08
申请号：US13404832
申请日：2012-02-24
申请人： Jianmin Li , Danielle Conley , Weenna Bucay-Couto , Cang Duy Dao , Hamid Davoudi , Raymond J. Lareau , Kathleen M Miller
发明人： Jianmin Li , Danielle Conley , Weenna Bucay-Couto , Cang Duy Dao , Hamid Davoudi , Raymond J. Lareau , Kathleen M Miller
IPC分类号： A61F2/02
CPC分类号： A61K9/0024 , A61F2002/072 , A61F2250/0067 , A61K9/2027 , A61L2/232 , A61L29/16 , A61L31/16 , A61L31/18 , A61L2300/40 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/602 , A61M31/002
摘要： Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.
摘要翻译：提供可植入或可插入的医疗装置，其包括：（a）生物相容性聚合物; 和（b）选自抗炎剂，止痛剂，麻醉剂和解痉药的至少一种治疗剂。医疗装置适于在植入或插入时与疼痛或不适相关的部位植入或插入。在许多实施方案中，治疗剂将选自（i）酮咯酸及其药学上可接受的盐（例如酮咯酸氨丁三醇）和（ii）4-二乙基氨基-2-丁炔基苯基环己基乙醇酸酯及其药学上可接受的盐（例如，奥昔布宁氯化物）。还提供了用于可植入或可插入的医疗装置的用途，其使用包括减少伴随这种装置的植入或插入的疼痛或不适。进一步的用途可以包括减少沿着装置的微生物累积。还提供了用于制造植入式或可插入医疗装置的方法。

2. 发明授权

US07749203B2 Long-term indwelling medical devices containing slow-releasing antimicrobial agents and having a surfactant surface 有权
标题翻译：含有缓释抗菌剂并具有表面活性剂表面的长期留置医疗器械
公开(公告)号：US07749203B2
公开(公告)日：2010-07-06
申请号：US11188367
申请日：2005-07-25
申请人： Weenna Bucay-Couto , Jamie (Jianmin) Li
发明人： Weenna Bucay-Couto , Jamie (Jianmin) Li
IPC分类号： A61M5/32
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/602 , A61L2300/802
摘要： A medical device for long-term implantation is provided, as well as a method of making the same and a method of treatment using the same. The medical device comprises (1) a reservoir including (a) a polymer matrix and (b) an antimicrobial agent disposed within the polymer matrix, wherein the reservoir is adapted for long-term release of the antimicrobial agent from the polymer matrix; and (2) a surfactant region disposed over the reservoir at an outer surface of the device.
摘要翻译：提供了长期植入用的医疗装置及其制造方法以及使用其的治疗方法。医疗装置包括（1）储存器，包括（a）聚合物基质和（b）设置在聚合物基质内的抗微生物剂，其中所述储存器适合于从聚合物基质中长期释放抗微生物剂; 和（2）设在设备外表面上的储存器上的表面活性剂区域。

3. 发明申请

US20090171465A1 Polymeric Regions For Implantable Or Insertable Medical Devices 审中-公开
标题翻译：用于可植入或可插入医疗器械的聚合物区域
公开(公告)号：US20090171465A1
公开(公告)日：2009-07-02
申请号：US12276938
申请日：2008-11-24
申请人： Weenna Bucay-Couto , Jianmin Li
发明人： Weenna Bucay-Couto , Jianmin Li
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2250/0019 , A61F2250/0067 , A61L29/041 , A61L31/048 , A61M27/008 , A61M2025/0057 , C08L29/04
摘要： According to one aspect, the present invention is directed to implantable or insertable medical devices which comprise polymeric regions that comprise high vinyl acetate content EVA (or another soft polymer) and a therapeutic agent. In another aspect, the present invention is directed to implantable or insertable medical devices which comprise (a) a first region comprising a first EVA and (b) a second region adjacent to the first region that is of lower durometer than the first region.
摘要翻译：根据一个方面，本发明涉及可植入或可插入的医疗装置，其包括包含高乙酸乙烯酯含量的EVA（或另一种软性聚合物）和治疗剂的聚合物区域。在另一方面，本发明涉及可植入或可插入的医疗装置，其包括（a）包含第一EVA的第一区域和（b）与第一区域相邻的第二区域，该第二区域的硬度低于第一区域。

4. 发明申请

US20060253069A1 Method and device for tissue removal and for delivery of a therapeutic agent or bulking agent 有权
标题翻译：用于组织去除和用于递送治疗剂或填充剂的方法和装置
公开(公告)号：US20060253069A1
公开(公告)日：2006-11-09
申请号：US11124827
申请日：2005-05-09
申请人： Jamie Li , Weenna Bucay-Couto
发明人： Jamie Li , Weenna Bucay-Couto
IPC分类号： A61M31/00 , A61B17/32 , A61M37/00 , A61B17/14
CPC分类号： A61M37/00 , A61B10/0241 , A61B17/22 , A61B17/32002 , A61B2017/00274 , A61B2017/00685 , A61B2017/320775 , A61B2018/00547
摘要： According to an aspect of the present invention, a medical device is provided, which comprises the following: (a) a hollow elongate body (e.g., a elongate cylinder, such as a needle) having distal and proximal ends; and (b) a rotatable member comprising a tissue morselizer and an elongate shaft (e.g., an auger-like tissue-drilling bit). In the devices of the present invention, the elongate shaft is disposed within the hollow elongate body and cooperates with the hollow elongate body to (i) advance material (e.g., morselated tissue) toward the proximal end of the hollow elongate body when the shaft is rotated in a first direction, and (ii) advance material (e.g., a therapeutic agent and/or a bulking agent) toward the distal end of the hollow elongate body when the shaft is rotated in a second direction that is opposite the first direction. According to another aspect of the invention a method of treatment is provided that comprises: (a) inserting the a medical device like that above into the tissue of a patient; (b) morselizing and removing tissue from within the patient while rotating the shaft in a first direction, thereby creating a void within the patient; and (c) introducing a therapeutic agent and/or a bulking agent into the void.
摘要翻译：根据本发明的一个方面，提供一种医疗装置，其包括：（a）具有远端和近端的中空细长体（例如细长圆柱体，例如针头）; 和（b）可旋转构件，其包括组织修整器和细长轴（例如，螺旋状组织钻头）。在本发明的装置中，细长轴设置在中空细长主体内并且与中空细长主体配合以（i）当轴是轴向时将材料（例如，微小的组织）推向中空细长体的近端在第一方向上旋转，并且（ii）当轴沿与第一方向相反的第二方向旋转时，将材料（例如，治疗剂和/或填充剂）推向中空细长体的远端。根据本发明的另一方面，提供了一种治疗方法，其包括：（a）将如上所述的医疗装置插入患者的组织中; （b）在沿着第一方向旋转所述轴的同时从所述患者内进行细致和去除组织，从而在所述患者体内产生空洞; 和（c）将治疗剂和/或填充剂引入空隙中。

5. 发明授权

US08685427B2 Controlled drug delivery 失效
标题翻译：控制药物递送
公开(公告)号：US08685427B2
公开(公告)日：2014-04-01
申请号：US10209476
申请日：2002-07-31
申请人： Jianmin Li , Weenna Bucay Couto
发明人： Jianmin Li , Weenna Bucay Couto
IPC分类号： A61F2/00 , A61M31/00 , A61F2/06
CPC分类号： A61L31/10 , A61F2/07 , A61F2250/0067 , A61K9/0024 , A61K31/216 , A61K31/407 , A61L27/16 , A61L29/085 , A61L29/148 , A61L29/16 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/204 , A61L2300/21 , A61L2300/602 , A61L2300/606 , A61L2420/06 , A61M31/002
摘要： A medical device for placement in a body of a mammal is provided. The medical device comprises (1) a polymeric matrix forming the device and defining a lumen through the device, the matrix comprising polymer macromolecules and defining spaces between the polymer macromolecules; (2) a drug contained within at least some of the spaces of the matrix; and (3) a material contained within at least some of the spaces of the matrix to affect diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of the mammal.
摘要翻译：提供了用于放置在哺乳动物体内的医疗装置。所述医疗装置包括（1）形成所述装置并且通过所述装置限定内腔的聚合物基质，所述基质包含聚合物高分子并限定所述聚合物大分子之间的空间; （2）包含在基质的至少一些空间内的药物; 和（3）当所述医疗装置放置在哺乳动物的身体中时，包含在所述基质的至少一些所述空间内的材料以影响所述药物从所述聚合物基质中的扩散。

6. 发明申请

US20080233167A1 UROLOGICAL MEDICAL DEVICES FOR RELEASE OF PROSTATICALLY BENEFICIAL THERAPEUTIC AGENTS 审中-公开
标题翻译：用于释放预防性治疗药物的泌尿医学装置
公开(公告)号：US20080233167A1
公开(公告)日：2008-09-25
申请号：US12052085
申请日：2008-03-20
申请人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
发明人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
IPC分类号： A61F2/04 , A61M25/00 , A61M1/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/40
摘要： According to an aspect of the invention, urological medical devices are provided, which comprise a prostatically beneficial agent selected from alpha-adrenergic blockers, antispasmodic agents, anticholinergic/antimuscarinic agents, calcium channel blockers, anti-inflammatory agents, hormone-affecting agents, anti-cancer agents, and combinations thereof, among others. The urological medical devices are adapted for implantation or insertion into a subject's urinary tract, whereupon at least a portion of the prostatically beneficial agent is released into the subject's prostatic urethra. The release profile of the prostatically beneficial agent is effective to treat a prostatic disorder, for example, benign prostate hypertrophy, prostate cancer or prostatitis, among others. Other aspects of the invention are directed to treating prostatic disorders.
摘要翻译：根据本发明的一个方面，提供泌尿科医疗装置，其包括选自α-肾上腺素能阻滞剂，解痉药，抗胆碱能药/抗毒蕈碱药，钙通道阻断剂，抗炎剂，激素影响剂，抗癌症药剂及其组合等。泌尿科医疗装置适于植入或插入受试者的尿道中，因此至少一部分前列腺有益剂被释放到受试者的前列腺尿道内。前列腺增生症的释放特征对于治疗前列腺疾病，例如良性前列腺肥大，前列腺癌或前列腺炎等是有效的。本发明的其它方面涉及治疗前列腺疾病。

7. 发明申请

US20050271698A1 Long-term indwelling medical devices containing slow-releasing antimicrobial agents and having a surfactant surface 有权
公开(公告)号：US20050271698A1
公开(公告)日：2005-12-08
申请号：US11188367
申请日：2005-07-25
申请人： Weenna Bucay-Couto , Jamie Li
发明人： Weenna Bucay-Couto , Jamie Li
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61F2/00
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/602 , A61L2300/802
摘要： A medical device for long-term implantation is provided, as well as a method of making the same and a method of treatment using the same. The medical device comprises (1) a reservoir including (a) a polymer matrix and (b) an antimicrobial agent disposed within the polymer matrix, wherein the reservoir is adapted for long-term release of the antimicrobial agent from the polymer matrix; and (2) a surfactant region disposed over the reservoir at an outer surface of the device.

8. 发明授权

US08133501B2 Implantable or insertable medical devices for controlled drug delivery 有权
标题翻译：用于受控药物递送的可植入或可插入的医疗装置
公开(公告)号：US08133501B2
公开(公告)日：2012-03-13
申请号：US10377131
申请日：2003-02-28
申请人： Jianmin Li , Danielle Conley , Weenna Bucay Couto , Cang Duy Dao , Hamid Davoudi , Raymond Lareau , Kathleen M. Miller
发明人： Jianmin Li , Danielle Conley , Weenna Bucay Couto , Cang Duy Dao , Hamid Davoudi , Raymond Lareau , Kathleen M. Miller
IPC分类号： A61F2/02
CPC分类号： A61K9/0024 , A61F2002/072 , A61F2250/0067 , A61K9/2027 , A61L2/232 , A61L29/16 , A61L31/16 , A61L31/18 , A61L2300/40 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/602 , A61M31/002
摘要： Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.
摘要翻译：提供可植入或可插入的医疗装置，其包括：（a）生物相容性聚合物; 和（b）选自抗炎剂，止痛剂，麻醉剂和解痉药的至少一种治疗剂。医疗装置适于在植入或插入时与疼痛或不适相关的部位植入或插入。在许多实施方案中，治疗剂将选自（i）酮咯酸及其药学上可接受的盐（例如酮咯酸氨丁三醇）和（ii）4-二乙基氨基-2-丁炔基苯基环己基乙醇酸酯及其药学上可接受的盐（例如，奥昔布宁氯化物）。还提供了用于可植入或可插入的医疗装置的用途，其使用包括减少伴随这种装置的植入或插入的疼痛或不适。进一步的用途可以包括减少沿着装置的微生物累积。还提供了用于制造植入式或可插入医疗装置的方法。

9. 发明申请

US20110171272A1 UROLOGICAL MEDICAL DEVICES FOR RELEASE OF PROSTATICALLY BENEFICIAL THERAPEUTIC AGENTS 审中-公开
标题翻译：用于释放预防性治疗药物的泌尿医学装置
公开(公告)号：US20110171272A1
公开(公告)日：2011-07-14
申请号：US13046989
申请日：2011-03-14
申请人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
发明人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
IPC分类号： A61K9/00 , A61K31/517 , A61K31/131 , A61K31/704 , A61K31/136 , A61K31/337 , A61K38/12 , A61K31/48 , A61K31/475 , A61K31/4709 , A61K31/573 , A61K31/485 , A61K31/616 , A61K31/46 , A61P35/00 , A61P29/00 , A61P31/04 , A61P25/04 , A61P23/02 , A61M27/00 , A61F2/04
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/40
摘要： According to an aspect of the invention, urological medical devices are provided, which comprise a prostatically beneficial agent selected from alpha-adrenergic blockers, antispasmodic agents, anticholinergic/antimuscarinic agents, calcium channel blockers, anti-inflammatory agents, hormone affecting agents, anti-cancer agents, and combinations thereof, among others. The urological medical devices are adapted for implantation or insertion into a subject's urinary tract, whereupon at least a portion of the prostatically beneficial agent is released into the subject's prostatic urethra. The release profile of the prostatically beneficial agent is effective to treat a prostatic disorder, for example, benign prostate hypertrophy, prostate cancer or prostatitis, among others. Other aspects of the invention are directed to treating prostatic disorders.
摘要翻译：根据本发明的一个方面，提供泌尿科医疗装置，其包括选自α-肾上腺素能阻滞剂，解痉药，抗胆碱能药/抗毒蕈碱药，钙通道阻滞剂，抗炎药，激素影响剂，癌症药物及其组合等。泌尿科医疗装置适于植入或插入受试者的尿道中，因此至少一部分前列腺有益剂被释放到受试者的前列腺尿道内。前列腺增生症的释放特征对于治疗前列腺疾病，例如良性前列腺肥大，前列腺癌或前列腺炎等是有效的。本发明的其它方面涉及治疗前列腺疾病。

10. 发明申请

US20110021976A1 METHOD AND DEVICE FOR TISSUE REMOVAL AND FOR DELIVERY OF A THERAPEUTIC AGENT OR BULKING AGENT 有权
标题翻译：用于组织去除和用于递送治疗剂或者破坏剂的方法和装置
公开(公告)号：US20110021976A1
公开(公告)日：2011-01-27
申请号：US12893168
申请日：2010-09-29
申请人： Jamie (Jianmin) Li , Weenna Bucay-Couto
发明人： Jamie (Jianmin) Li , Weenna Bucay-Couto
IPC分类号： A61M37/00 , A61B17/3205
CPC分类号： A61M37/00 , A61B10/0241 , A61B17/22 , A61B17/32002 , A61B2017/00274 , A61B2017/00685 , A61B2017/320775 , A61B2018/00547
摘要： According to an aspect of the present invention, a medical device is provided, which comprises the following: (a) a hollow elongate body (e.g., a elongate cylinder, such as a needle) having distal and proximal ends; and (b) a rotatable member comprising a tissue morselizer and an elongate shaft (e.g., an auger-like tissue-drilling bit). In the devices of the present invention, the elongate shaft is disposed within the hollow elongate body and cooperates with the hollow elongate body to (i) advance material (e.g., morselated tissue) toward the proximal end of the hollow elongate body when the shaft is rotated in a first direction, and (ii) advance material (e.g., a therapeutic agent and/or a bulking agent) toward the distal end of the hollow elongate body when the shaft is rotated in a second direction that is opposite the first direction. According to another aspect of the invention a method of treatment is provided that comprises: (a) inserting the a medical device like that above into the tissue of a patient; (b) morselizing and removing tissue from within the patient while rotating the shaft in a first direction, thereby creating a void within the patient; and (c) introducing a therapeutic agent and/or a bulking agent into the void.
摘要翻译：根据本发明的一个方面，提供一种医疗装置，其包括：（a）具有远端和近端的中空细长体（例如细长圆柱体，例如针头）; 和（b）可旋转构件，其包括组织修整器和细长轴（例如，螺旋状组织钻头）。在本发明的装置中，细长轴设置在中空细长主体内并且与中空细长主体配合以（i）当轴是轴向时将材料（例如，微小的组织）推向中空细长体的近端在第一方向上旋转，并且（ii）当轴沿与第一方向相反的第二方向旋转时，将材料（例如，治疗剂和/或填充剂）推向中空细长体的远端。根据本发明的另一方面，提供了一种治疗方法，其包括：（a）将如上所述的医疗装置插入患者的组织中; （b）在沿着第一方向旋转所述轴的同时从所述患者内进行细致和去除组织，从而在所述患者体内产生空洞; 和（c）将治疗剂和/或填充剂引入空隙中。

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