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1. 发明申请

US20090012603A1 IMPLANTABLE MEDICAL DEVICES HAVING ADJUSTABLE PORE VOLUME AND METHODS FOR MAKING THE SAME 有权
标题翻译：具有可调节孔体积的可植入医疗装置及其制造方法
公开(公告)号：US20090012603A1
公开(公告)日：2009-01-08
申请号：US12166377
申请日：2008-07-02
申请人： Yixin Xu , Min-Shyan Sheu , Steve Walak
发明人： Yixin Xu , Min-Shyan Sheu , Steve Walak
IPC分类号： A61F2/82 , A61F2/00 , A61M37/00
CPC分类号： A61L31/16 , A61L31/14 , A61L31/146 , A61L2300/60 , A61L2300/608 , A61L2420/08
摘要： The present invention is directed to implantable medical devices which may be used for controllably releasing a therapeutic agent within a patient and methods for making the same. These medical devices may include porous coatings, which may be polymer-free, located on an outer surface or abluminal surface of the medical device. The medical device may be a stent. The pores of the porous coating may be expandable to facilitate loading of the therapeutic agent. The medical device may be triggerable upon implantation of the medical device such that the volume of the voids shrinks to eject the therapeutic agent. The voids may be slots in the stent. Expandable materials or structures may be positioned in the voids to expand upon implantation and eject the therapeutic agent.
摘要翻译：本发明涉及可用于可控地释放患者内的治疗剂的可植入医疗装置及其制造方法。这些医疗装置可以包括位于医疗装置的外表面或外表面上的多孔涂层，其可以是无聚合物的。医疗装置可以是支架。多孔涂层的孔可以是可膨胀的，以便于治疗剂的加载。医疗装置可以在植入医疗装置时触发，使得空隙的体积收缩以喷射治疗剂。空隙可以是支架中的狭槽。可膨胀材料或结构可以位于空隙中，以在植入时膨胀并喷射治疗剂。

2. 发明申请

US20070298069A1 Medical devices for release of low solubility therapeutic agents 审中-公开
标题翻译：用于释放低溶解度治疗剂的医疗装置
公开(公告)号：US20070298069A1
公开(公告)日：2007-12-27
申请号：US11474850
申请日：2006-06-26
申请人： Weenna Bucay-Couto , Jianmin Li , Min-Shyan Sheu
发明人： Weenna Bucay-Couto , Jianmin Li , Min-Shyan Sheu
IPC分类号： A61F2/02 , C08G63/91
CPC分类号： A61L27/54 , A61L27/14 , A61L27/50 , A61L29/14 , A61L31/04 , A61L31/14 , A61L31/16 , A61L2300/802 , A61M27/008
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric carrier regions. These polymeric carrier regions, in turn, contain a polymer, a low solubility therapeutic agent, and a solubilizing agent.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物载体区域。这些聚合物载体区域又包含聚合物，低溶解度治疗剂和增溶剂。

3. 发明申请

US20080233167A1 UROLOGICAL MEDICAL DEVICES FOR RELEASE OF PROSTATICALLY BENEFICIAL THERAPEUTIC AGENTS 审中-公开
标题翻译：用于释放预防性治疗药物的泌尿医学装置
公开(公告)号：US20080233167A1
公开(公告)日：2008-09-25
申请号：US12052085
申请日：2008-03-20
申请人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
发明人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
IPC分类号： A61F2/04 , A61M25/00 , A61M1/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/40
摘要： According to an aspect of the invention, urological medical devices are provided, which comprise a prostatically beneficial agent selected from alpha-adrenergic blockers, antispasmodic agents, anticholinergic/antimuscarinic agents, calcium channel blockers, anti-inflammatory agents, hormone-affecting agents, anti-cancer agents, and combinations thereof, among others. The urological medical devices are adapted for implantation or insertion into a subject's urinary tract, whereupon at least a portion of the prostatically beneficial agent is released into the subject's prostatic urethra. The release profile of the prostatically beneficial agent is effective to treat a prostatic disorder, for example, benign prostate hypertrophy, prostate cancer or prostatitis, among others. Other aspects of the invention are directed to treating prostatic disorders.
摘要翻译：根据本发明的一个方面，提供泌尿科医疗装置，其包括选自α-肾上腺素能阻滞剂，解痉药，抗胆碱能药/抗毒蕈碱药，钙通道阻断剂，抗炎剂，激素影响剂，抗癌症药剂及其组合等。泌尿科医疗装置适于植入或插入受试者的尿道中，因此至少一部分前列腺有益剂被释放到受试者的前列腺尿道内。前列腺增生症的释放特征对于治疗前列腺疾病，例如良性前列腺肥大，前列腺癌或前列腺炎等是有效的。本发明的其它方面涉及治疗前列腺疾病。

4. 发明授权

US06992127B2 Polymeric coatings containing a pH buffer agent 有权
标题翻译：含有pH缓冲剂的聚合物涂料
公开(公告)号：US06992127B2
公开(公告)日：2006-01-31
申请号：US10303226
申请日：2002-11-25
申请人： Tung-Liang Lin , Min-Shyan Sheu , Ih-Huong Loh
发明人： Tung-Liang Lin , Min-Shyan Sheu , Ih-Huong Loh
IPC分类号： C08L3/32
CPC分类号： C08K3/32 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
摘要： A device containing a support member, a cross-linked polymer, and a pH buffer agent. A surface of the support member is coated with the cross-linked polymer in which the pH buffer agent is embedded.
摘要翻译：含有支持体，交联聚合物和pH缓冲剂的装置。支撑构件的表面涂覆有其中嵌入有pH缓冲剂的交联聚合物。

5. 发明授权

US5807636A Durable hydrophilic surface coatings 失效
标题翻译：耐用的亲水性表面涂层
公开(公告)号：US5807636A
公开(公告)日：1998-09-15
申请号：US770649
申请日：1996-12-19
申请人： Min-Shyan Sheu , Ih-Houng Loh
发明人： Min-Shyan Sheu , Ih-Houng Loh
IPC分类号： G02C7/04 , A61L27/00 , A61L27/34 , B01D67/00 , B32B5/18 , B32B7/02 , B32B27/32 , C08J7/04 , G02B1/04 , G02B1/10 , B32B7/04
CPC分类号： B01D67/0088 , A61L27/34 , B01D67/0093 , C08J7/04 , C08J7/047 , C08J2479/00 , Y10T428/249992 , Y10T428/249993 , Y10T428/2991 , Y10T428/2998 , Y10T428/31507 , Y10T428/31511 , Y10T428/31536 , Y10T428/3154 , Y10T428/31573 , Y10T428/31663 , Y10T428/31721 , Y10T428/31743 , Y10T428/31797 , Y10T428/31855 , Y10T428/31909 , Y10T428/31913
摘要： A hydrophilic article for use in aqueous environments, including a substrate, an ionic polymeric layer on said substrate, and a disordered polyelectrolyte coating ionically bonded to said polymeric layer.
摘要翻译：用于水性环境的亲水制品，包括底物，所述基底上的离子聚合物层和离子键合到所述聚合物层上的无序聚电解质涂层。

6. 发明授权

US5171779A Use of plasma to immobilize protein on polymeric surfaces 失效
标题翻译：使用血浆将蛋白质固定在聚合物表面上
公开(公告)号：US5171779A
公开(公告)日：1992-12-15
申请号：US687224
申请日：1991-04-18
申请人： Tien-Tsai Hsu , Mann-Tchao Wang , Kuang-Pin Hsiung , Ging H. Hsiue , Min-Shyan Sheu
发明人： Tien-Tsai Hsu , Mann-Tchao Wang , Kuang-Pin Hsiung , Ging H. Hsiue , Min-Shyan Sheu
IPC分类号： C12N11/08 , C12Q1/00 , G01N33/545
CPC分类号： G01N33/545 , C12N11/08 , C12Q1/003 , Y10S530/815
摘要： The present invention relates to a method of immobilizing proteins on a polymeric matrix by means of plasma activation and an apparatus and process for the use of such material. The protein mixture is applied to the surface of the polymeric matrix with or without the addition of a crosslinking agent. It is then placed into a plasma generator, wherein the functional groups on both the protein and the matrix molecules are activated to form free radicals. Upon returning from their high energy state, the free radicals form covalent bonds between the proteins and between the protein and the polymeric matrix. Using this method, the proteins are nonspecifically immobilized on the surface of the polymeric matrix. The method can be utilized to immobilize proteins on the surfaces of polymeric membranes, polymeric beads, polymeric tubes and polymeric plates. The immobilized protein has high biological activity and stability.
摘要翻译：本发明涉及通过等离子体激活将蛋白质固定在聚合物基体上的方法以及使用这种材料的装置和方法。使用或不加入交联剂将蛋白质混合物施加到聚合物基质的表面。然后将其放入等离子体发生器中，其中蛋白质和基质分子上的官能团被活化以形成自由基。从高能量状态返回时，自由基在蛋白质之间和蛋白质与聚合物基质之间形成共价键。使用这种方法，蛋白质非特异性地固定在聚合物基质的表面上。该方法可用于将蛋白质固定在聚合物膜，聚合物珠，聚合物管和聚合物板的表面上。固定化蛋白具有很高的生物活性和稳定性。

7. 发明授权

US08721519B2 Implantable mesh combining biodegradable and non-biodegradable fibers 有权
标题翻译：可植入网结合生物降解和不可生物降解的纤维
公开(公告)号：US08721519B2
公开(公告)日：2014-05-13
申请号：US11448252
申请日：2006-06-06
申请人： Min-Shyan Sheu , Jianmin Li
发明人： Min-Shyan Sheu , Jianmin Li
IPC分类号： A61F2/02
CPC分类号： A61F2/0063 , A61F2/0045 , A61F2002/0068 , A61F2250/0031 , A61L31/148 , A61L2430/22 , A61M37/0069
摘要： Disclosed are mesh materials adapted for use in an implantable sling. The mesh materials include biodegradable and non-degradable components that may be adapted to facilitate scar-tissue in-growth as the biodegradable components degrade.
摘要翻译：公开了适用于可植入吊索的网状材料。网状材料包括可生物降解和不可降解的组分，其可以适于随着生物降解性组分降解而促进瘢痕组织生长。

8. 发明申请

US20130085451A1 PLASMA-TREATED DIALYSIS CATHETER CUFF 审中-公开
标题翻译：等离子体处理的透析导管
公开(公告)号：US20130085451A1
公开(公告)日：2013-04-04
申请号：US13248436
申请日：2011-09-29
申请人： Min-Shyan Sheu
发明人： Min-Shyan Sheu
IPC分类号： A61M25/02 , B29C71/04
CPC分类号： A61M1/3661 , A61L29/06 , A61L2400/18 , A61M1/3653 , A61M1/3659 , A61M25/0029 , A61M2025/0006 , C08L67/02
摘要： A catheter is disclosed. The catheter includes an elongated tubular body defining a longitudinal axis and extending to a distal end thereof, the tubular body having at least one lumen and a cuff disposed around the tubular body configured to contact tissue, the cuff formed from a plasma-treated material having enhanced tissue ingrowth properties.
摘要翻译：公开了导管。所述导管包括限定纵向轴线并延伸到其远端的细长管状体，所述管状体具有至少一个内腔和围绕所述管状主体设置以接触组织的袖带，所述袖带由等离子体处理材料形成，所述袖带由具有增强组织向内生长特性。

9. 发明申请

US20110171272A1 UROLOGICAL MEDICAL DEVICES FOR RELEASE OF PROSTATICALLY BENEFICIAL THERAPEUTIC AGENTS 审中-公开
标题翻译：用于释放预防性治疗药物的泌尿医学装置
公开(公告)号：US20110171272A1
公开(公告)日：2011-07-14
申请号：US13046989
申请日：2011-03-14
申请人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
发明人： Jianmin Li , Min-Shyan Sheu , Weenna Bucay-Couto
IPC分类号： A61K9/00 , A61K31/517 , A61K31/131 , A61K31/704 , A61K31/136 , A61K31/337 , A61K38/12 , A61K31/48 , A61K31/475 , A61K31/4709 , A61K31/573 , A61K31/485 , A61K31/616 , A61K31/46 , A61P35/00 , A61P29/00 , A61P31/04 , A61P25/04 , A61P23/02 , A61M27/00 , A61F2/04
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/40
摘要： According to an aspect of the invention, urological medical devices are provided, which comprise a prostatically beneficial agent selected from alpha-adrenergic blockers, antispasmodic agents, anticholinergic/antimuscarinic agents, calcium channel blockers, anti-inflammatory agents, hormone affecting agents, anti-cancer agents, and combinations thereof, among others. The urological medical devices are adapted for implantation or insertion into a subject's urinary tract, whereupon at least a portion of the prostatically beneficial agent is released into the subject's prostatic urethra. The release profile of the prostatically beneficial agent is effective to treat a prostatic disorder, for example, benign prostate hypertrophy, prostate cancer or prostatitis, among others. Other aspects of the invention are directed to treating prostatic disorders.
摘要翻译：根据本发明的一个方面，提供泌尿科医疗装置，其包括选自α-肾上腺素能阻滞剂，解痉药，抗胆碱能药/抗毒蕈碱药，钙通道阻滞剂，抗炎药，激素影响剂，癌症药物及其组合等。泌尿科医疗装置适于植入或插入受试者的尿道中，因此至少一部分前列腺有益剂被释放到受试者的前列腺尿道内。前列腺增生症的释放特征对于治疗前列腺疾病，例如良性前列腺肥大，前列腺癌或前列腺炎等是有效的。本发明的其它方面涉及治疗前列腺疾病。

10. 发明授权

US07909864B2 Implantable medical devices having adjustable pore volume and methods for making the same 有权
标题翻译：具有可调孔容积的可植入医疗器械及其制造方法
公开(公告)号：US07909864B2
公开(公告)日：2011-03-22
申请号：US12166377
申请日：2008-07-02
申请人： Min-Shyan Sheu , Steve Walak , Yixin Xu
发明人： Min-Shyan Sheu , Steve Walak , Yixin Xu
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/14 , A61L31/146 , A61L2300/60 , A61L2300/608 , A61L2420/08
摘要： The present invention is directed to implantable medical devices which may be used for controllably releasing a therapeutic agent within a patient and methods for making the same. These medical devices may include porous coatings, which may be polymer-free, located on an outer surface or abluminal surface of the medical device. The medical device may be a stent. The pores of the porous coating may be expandable to facilitate loading of the therapeutic agent. The medical device may be triggerable upon implantation of the medical device such that the volume of the voids shrinks to eject the therapeutic agent. The voids may be slots in the stent. Expandable materials or structures may be positioned in the voids to expand upon implantation and eject the therapeutic agent.
摘要翻译：本发明涉及可用于可控地释放患者内的治疗剂的可植入医疗装置及其制造方法。这些医疗装置可以包括位于医疗装置的外表面或外表面上的多孔涂层，其可以是无聚合物的。医疗装置可以是支架。多孔涂层的孔可以是可膨胀的，以便于治疗剂的加载。医疗装置可以在植入医疗装置时触发，使得空隙的体积收缩以喷射治疗剂。空隙可以是支架中的狭槽。可膨胀材料或结构可以位于空隙中，以在植入时膨胀并喷射治疗剂。

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