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1. 发明申请

US20210356386A1 DETECTION CHIP, DETECTION SYSTEM, AND DETECTION METHOD 有权
公开(公告)号：US20210356386A1
公开(公告)日：2021-11-18
申请号：US16319046
申请日：2017-07-24
申请人： Konica Minolta, Inc.
发明人： Tomonori KANEKO , Kosuke Nagae , Takatoshi Kaya , Yukito Nakamura
IPC分类号： G01N21/03 , G01N21/64
摘要： The detection system according to the present invention has a detection chip, a light source, and a detection unit. The detection chip has a housing that has an opening at an upper portion, and a reaction field for trapping a substance to be detected, the reaction field being arranged on an inner surface of the side walls included in the housing. The light source irradiates the detection chip with light from the outside such that evanescent light or surface plasmon resonance is generated under the reaction field. The detection unit detects light which is emitted from the detection chip when the light source irradiates the detection chip with light, and the amount of which changes depending on the amount of the substance to be detected trapped in the reaction field.

2. 发明授权

US11137403B2 Method for estimating Gleason score of prostate cancer, method for estimating pathological stage, and method for acquiring supplementary information, all on the basis of specific PSA content in specimen 有权
公开(公告)号：US11137403B2
公开(公告)日：2021-10-05
申请号：US16464744
申请日：2017-11-29
申请人： KONICA MINOLTA, INC. , HIROSAKI UNIVERSITY
发明人： Tomonori Kaneko , Takatoshi Kaya , Chikara Ohyama , Tohru Yoneyama , Yuki Tobisawa
IPC分类号： G01N33/574 , G01N21/64
摘要： The present invention provides methods that are for acquiring various types of supplementary information used for diagnosis or treatment of prostate cancer, and that can be implemented in a less-invasive manner at a low cost. Provided are, by measuring the content of prostate specific antigen (PSA) having a β-N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a specimen, and comparing the measured value with a threshold value, (1) a method for estimating whether a Gleason score (primary pattern and secondary pattern) is not less than or less than a prescribed value, (2) a method for estimating whether the pathological stage (pT) is not less than or less than a prescribed value, and (3) a method for acquiring information for assessment indicating diagnosis or treatment should be actively conducted because a GS at gross total removal is expected to be higher than a GS at biopsy.

3. 发明授权

US11224879B2 Inspection chip and inspection system 有权
公开(公告)号：US11224879B2
公开(公告)日：2022-01-18
申请号：US16482293
申请日：2018-02-06
申请人： Konica Minolta, Inc.
发明人： Takatoshi Kaya , Tomonori Kaneko
IPC分类号： B01L3/00 , G01N21/01 , G01N21/64 , G01N21/65
摘要： An inspection chip according to the present invention is an inspection chip for stirring liquid by a circular movement of a bottom surface end, including a well main body for accommodating the liquid and a side wall member arranged on a side surface of the well main body. The bottom surface end has a bottom surface structure in contact with a rotating member for allowing the bottom surface end to perform the circular movement in a position leaning from a center line of the well main body toward the side wall member.

4. 发明授权

US10976250B2 Position detection method and position detection device for sensor chip in optical sample detection system 有权
公开(公告)号：US10976250B2
公开(公告)日：2021-04-13
申请号：US16478243
申请日：2018-01-16
申请人： KONICA MINOLTA, INC.
发明人： Yukito Nakamura , Takatoshi Kaya , Kosuke Nagae
IPC分类号： G01N21/552 , G01N21/13 , G01N21/64 , G01N21/84
摘要： Provided is a position detection method and a position detection device for detecting a position of a sensor chip and obtaining relative positional information between a well member and a prism as for a well chip type sensor chip in which the well member is provided on a prism. By applying measurement light to the sensor chip while changing a distance between the sensor chip and a measurement light irradiation unit and detecting reflected light traveling in a predetermined direction out of the reflected light generated when the measurement light is reflected by the sensor chip, at least any one of the position of the sensor chip and the relative position between a dielectric member and a sample solution holding member is detected on the basis of a change in intensity of the detected reflected light.

5. 发明授权

US10697959B2 Sandwich assay using labeled lectin and kit therefor 有权
公开(公告)号：US10697959B2
公开(公告)日：2020-06-30
申请号：US15320118
申请日：2015-06-01
申请人： Konica Minolta, Inc.
发明人： Tomonori Kaneko , Takatoshi Kaya
IPC分类号： G01N33/543
摘要： The present invention provides a sandwich assay for quantifying a glycoprotein, which is a substance to be detected, in a sample using a labeled lectin, wherein the effect attributed to a contaminant, namely noise on the quantified value of the substance to be detected, is suppressed by introduction of a simple treatment. The sandwich assay includes a treatment for inhibiting the binding of the labeled lectin to a sugar chain carried by the contaminant non-specifically adsorbed to the measurement region, which contaminant is contained in the sample and which sugar chain is the same as that of the substance to be detected.

6. 发明授权

US10495575B2 Surface plasmon enhanced fluorescence measurement device and surface plasmon enhanced fluorescence measurement method 有权
公开(公告)号：US10495575B2
公开(公告)日：2019-12-03
申请号：US15301538
申请日：2014-04-08
申请人： Konica Minolta, Inc.
发明人： Yukito Nakamura , Takatoshi Kaya , Kosuke Nagae , Akitoshi Nozaki , Fumio Nagai , Ryouta Ishikawa , Akiyuki Namatame
IPC分类号： G01N33/553 , G01N21/64 , G01N33/543
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/6445 , G01N33/54373 , G01N2021/6439 , G01N2021/6463 , G01N2201/0612 , G01N2201/0683
摘要： The present invention pertains to a surface plasmon enhanced fluorescence analysis device and a surface plasmon enhanced fluorescence measurement method which use GC-SPFS and make it possible to detect a substance to be detected with high sensitivity. This surface plasmon enhanced fluorescence measurement device has: a light source for irradiating the diffraction grating of a chip with excited light; a polarizer for removing linearly polarized light from fluorescent light emitted from a fluorescent substance on the diffraction grating; and a photodetector for detecting the linearly polarized light removed by the polarizer.

7. 发明授权

US09933366B2 Assay method using surface plasmon-field enhanced fluorescence spectroscopy 有权
公开(公告)号：US09933366B2
公开(公告)日：2018-04-03
申请号：US14435867
申请日：2013-10-17
申请人： Konica Minolta, Inc.
发明人： Takatoshi Kaya , Makiko Ootani
IPC分类号： G01N21/64 , G01N33/543 , G01N33/569
CPC分类号： G01N21/648 , G01N33/54306 , G01N33/56966 , G01N2021/6439
摘要： Provided is an assay method utilizing surface plasmon-field enhanced fluorescence spectroscopy, which suppresses fluctuations in an absolute value of a background signal that is referred to as a resonance angle or an optical blank by improving the effect when a whole blood sample is used, specifically, the effect by the blood cell components remaining in a measurement liquid during a SPFS measurement, with regards to a photometric condition setting step, which is a characteristic step in assay methods utilizing SPFS. The above-mentioned problem is solved by an assay method utilizing surface plasmon-field enhanced fluorescence spectroscopy, including a primary reaction step of a sample, a first washing step, a labeling reaction step, and a measurement step, wherein the method includes a step for evaluating a blood cell component quantity between the primary reaction step and the labeling reaction step.

8. 发明申请

US20150268167A1 ASSAY METHOD USING SURFACE PLASMON-FIELD ENHANCED FLUORESCENCE SPECTROSCOPY 有权
标题翻译：使用表面等离子体增强荧光光谱的测定方法
公开(公告)号：US20150268167A1
公开(公告)日：2015-09-24
申请号：US14435867
申请日：2013-10-17
申请人： KONICA MINOLTA, INC.
发明人： Takatoshi Kaya , Makiko Ootani
IPC分类号： G01N21/64 , G01N33/569 , G01N33/543
CPC分类号： G01N21/648 , G01N33/54306 , G01N33/56966 , G01N2021/6439
摘要： Provided is an assay method utilizing surface plasmon-field enhanced fluorescence spectroscopy, which suppresses fluctuations in an absolute value of a background signal that is referred to as a resonance angle or an optical blank by improving the effect when a whole blood sample is used, specifically, the effect by the blood cell components remaining in a measurement liquid during a SPFS measurement, with regards to a photometric condition setting step, which is a characteristic step in assay methods utilizing SPFS. The above-mentioned problem is solved by an assay method utilizing surface plasmon-field enhanced fluorescence spectroscopy, including a primary reaction step of a sample, a first washing step, a labeling reaction step, and a measurement step, wherein the method includes a step for evaluating a blood cell component quantity between the primary reaction step and the labeling reaction step.
摘要翻译：提供了利用表面等离子体场增强荧光光谱法的测定方法，其通过改善使用全血样品时的效果来抑制被称为共振角或光学毛坯的背景信号的绝对值的波动在SPFS测量期间由血细胞成分残留在测量液中的效果，关于作为利用SPFS的测定方法中的特征步骤的光度条件设定步骤。上述问题通过利用表面等离子体场增强荧光光谱法的测定方法来解决，包括样品的一级反应步骤，第一洗涤步骤，标记反应步骤和测量步骤，其中该方法包括步骤用于评估初级反应步骤和标记反应步骤之间的血球成分量。

9. 发明授权

US11105807B2 Method for estimating pathological tissue diagnosis result (Gleason score) of prostate cancer 有权
公开(公告)号：US11105807B2
公开(公告)日：2021-08-31
申请号：US15761637
申请日：2016-09-02
申请人： KONICA MINOLTA, INC.
发明人： Tomonori Kaneko , Takatoshi Kaya
IPC分类号： G01N33/574 , G01N33/543 , G01N33/53
摘要： Provided is a method of obtaining an index value used for pathological tissue diagnosis of prostate cancer, which method has low invasiveness and can be performed at a low cost. The method is a method of estimating a Gleason score that represents the malignancy of prostate cancer, which method includes: measuring the content of a prostate-specific antigen having an N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a sample; and estimating that the Gleason score is 7 or higher when the thus measured value is larger than a threshold value, or estimating that the Gleason score is 6 or lower when the measured value is smaller than a threshold value. The prostate-specific antigen is preferably quantified by a method including the step of binding a molecule having an affinity for β-N-acetylgalactosamine residue, such as Wisteria floribunda lectin, soybean agglutinin, Vicia Villosa lectin or an anti-β-N-acetylgalactosamine antibody, to the prostate-specific antigen.

10. 发明授权

US10677731B2 Method of manufacturing sensing chip and sensing chip 有权
公开(公告)号：US10677731B2
公开(公告)日：2020-06-09
申请号：US15558506
申请日：2016-04-05
申请人： KONICA MINOLTA, INC.
发明人： Yukito Nakamura , Takatoshi Kaya , Tomonori Kaneko , Kosuke Nagae , Hiroshi Hirayama
IPC分类号： G01N21/64 , G01N21/03 , G01N33/543 , G01N21/552
摘要： A first frame having a first through-hole is arranged on a support so that one opening of the first through-hole is closed. A liquid containing a capturer is fed into the first through-hole, and a capturer is immobilized on the support exposed in the first through-hole. After removing the liquid from the support, a second frame having the second through-hole is arranged on the support in the first through-hole so that one opening of the second through-hole is closed.

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