专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11137403B2 Method for estimating Gleason score of prostate cancer, method for estimating pathological stage, and method for acquiring supplementary information, all on the basis of specific PSA content in specimen 有权
公开(公告)号：US11137403B2
公开(公告)日：2021-10-05
申请号：US16464744
申请日：2017-11-29
申请人： KONICA MINOLTA, INC. , HIROSAKI UNIVERSITY
发明人： Tomonori Kaneko , Takatoshi Kaya , Chikara Ohyama , Tohru Yoneyama , Yuki Tobisawa
IPC分类号： G01N33/574 , G01N21/64
摘要： The present invention provides methods that are for acquiring various types of supplementary information used for diagnosis or treatment of prostate cancer, and that can be implemented in a less-invasive manner at a low cost. Provided are, by measuring the content of prostate specific antigen (PSA) having a β-N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a specimen, and comparing the measured value with a threshold value, (1) a method for estimating whether a Gleason score (primary pattern and secondary pattern) is not less than or less than a prescribed value, (2) a method for estimating whether the pathological stage (pT) is not less than or less than a prescribed value, and (3) a method for acquiring information for assessment indicating diagnosis or treatment should be actively conducted because a GS at gross total removal is expected to be higher than a GS at biopsy.

2. 发明申请

US20150260720A1 METHOD AND KIT FOR DISTINGUISHING BETWEEN PROSTATE CARCINOMA AND BENIGN PROSTATIC HYPERPLASIA 有权
标题翻译：前列腺癌与复发性高血压之间的鉴别方法和试剂盒
公开(公告)号：US20150260720A1
公开(公告)日：2015-09-17
申请号：US14432902
申请日：2013-10-09
申请人： HIROSAKI UNIVERSITY , SHIZUOKA PREFECTURAL UNIVERSITY CORPORATION
发明人： Chikara Ohyama , Tohru Yoneyama , Yuki Tobisawa , Shingo Hatakeyama , Takashi Suzuki , Ilpal Jwa , Maho Yamaguchi
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , G01N2333/96433 , G01N2400/02 , G01N2400/12
摘要： An object of the present invention is to provide a method for distinguishing between prostate carcinoma and benign prostatic hyperplasia with high sensitivity and good reproducibility using a small amount of an analyte sample. The method for distinguishing between prostate carcinoma and benign prostatic hyperplasia according to the present invention as a solution means thereof comprises: bringing an analyte sample containing a prostate-specific antigen (PSA) into contact with a carrier having an anti-free PSA antibody immobilized thereon, thereby binding free PSA to the anti-free PSA antibody immobilized on the carrier; thereafter bringing the carrier in which the free PSA is bound to the immobilized anti-free PSA antibody into contact with a monoclonal antibody capable of specifically recognizing a glycan in which a terminal sialic acid residue is bound to galactose through an α(2,3) bond, thereby binding the monoclonal antibody capable of specifically recognizing a glycan in which a terminal sialic acid residue is bound to galactose through an α(2,3) bond to the free PSA bound to the anti-free PSA antibody immobilized on the carrier; measuring the amount of the free PSA having an N-type glycan in which a terminal sialic acid residue is bound to galactose through an α(2,3) bond; comparing the measured amount thus obtained with a preset cutoff value for prostate carcinoma and benign prostatic hyperplasia, thereby determining that when the measured amount is larger than the cutoff value, prostate carcinoma is developed or the probability of developing prostate carcinoma is high, and when the measured amount is smaller than the cutoff value, benign prostatic hyperplasia is developed or the probability of developing benign prostatic hyperplasia is high.
摘要翻译：本发明的目的是提供使用少量分析物样品来区分前列腺癌和良性前列腺增生的方法，其具有高灵敏度和良好的再现性。根据本发明的用于区分前列腺癌和良性前列腺增生的方法作为其溶液方法包括：将含有前列腺特异性抗原（PSA）的分析物样品与其上固定有抗PSA抗体抗体的载体接触从而将游离PSA结合到固定在载体上的抗自由PSA抗体; 然后将游离PSA与固定化抗体PSA抗体结合的载体与能够特异性识别末端唾液酸残基通过α（2,3）结合到半乳糖的聚糖的单克隆抗体接触，从而将能够通过α（2,3）键特异性识别末端唾液酸残基与半乳糖结合的聚糖的单克隆抗体结合到与固定在载体上的抗自由PSA抗体结合的游离PSA; 测量其中末端唾液酸残基通过α（2,3）键与半乳糖结合的N-型聚糖的游离PSA的量; 将由此获得的测量量与用于前列腺癌和良性前列腺增生的预设截止值进行比较，从而确定当测量的量大于截止值时，前列腺癌发展或发展为前列腺癌的概率高，并且当测量量小于临界值，发展良性前列腺增生或发展良性前列腺增生的可能性高。

3. 发明授权

US10302638B2 Analyzing apparatus 有权
公开(公告)号：US10302638B2
公开(公告)日：2019-05-28
申请号：US15115234
申请日：2014-05-19
申请人： SYSTEM INSTRUMENTS CO., LTD. , HIROSAKI UNIVERSITY , NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
发明人： Kazuyuki Hamada , Takeshi Akiba , Chikara Ohyama , Tohru Yoneyama , Yuki Tobisawa , Toshifumi Takeuchi
IPC分类号： G01N35/00 , G01N35/10 , G01N33/543 , G01N21/59 , G01N21/03 , G01N21/64 , G01N33/573 , B01L9/00
摘要： An automatic analyzing apparatus 10 includes a chip rack 11 that stores a pipette chip, a pipette 12 into which a specimen is injected, a conveyance unit that conveys the pipette 12 by parallel translation, a reagent rack 14, a reaction unit 15, a detection unit 16, and a detection block unit 17. The pipette chip stored by the chip rack 11 has a planar structure to directly and optically detect the specimen. The chip rack 11 includes, in a hole that receives the pipette chip, a guide corresponding to the structure of the pipette chip. The pipette 12 sucks or discharges the specimen via the pipette chip mounted onto the tip thereof by a drive of a pump. In the detection unit 16, a measurement is carried out with the pipette chip arranged so that the plane that receives light is vertical to an optical axis.

4. 发明授权

US09933430B2 Method and kit for distinguishing between prostate carcinoma and benign prostatic hyperplasia 有权
公开(公告)号：US09933430B2
公开(公告)日：2018-04-03
申请号：US14432902
申请日：2013-10-09
申请人： HIROSAKI UNIVERSITY , Shizuoka Prefectural University Corporation
发明人： Chikara Ohyama , Tohru Yoneyama , Yuki Tobisawa , Shingo Hatakeyama , Takashi Suzuki , Ilpal Jwa , Maho Yamaguchi
IPC分类号： G01N33/574 , C07K16/18
CPC分类号： G01N33/57434 , G01N2333/96433 , G01N2400/02 , G01N2400/12
摘要： The method for distinguishing between prostate carcinoma and benign prostatic hyperplasia comprising: bringing an analyte sample containing a prostate-specific antigen (PSA) into contact with a carrier having an anti-free PSA antibody immobilized thereon, thereby binding free PSA to the anti-free PSA antibody immobilized on the carrier; thereafter bringing the carrier in which the free PSA is bound to the immobilized anti-free PSA antibody into contact with a monoclonal antibody capable of specifically recognizing a glycan in which a terminal sialic acid residue is bound to galactose through an α(2,3) bond, thereby binding the monoclonal antibody recognizing the glycan to the free PSA bound to the anti-free PSA antibody; measuring the amount of the free PSA having an N-type glycan in which a terminal sialic acid residue is bound to galactose through an α(2,3) bond; comparing the measured amount thus obtained with a preset cutoff value for prostate carcinoma and benign prostatic hyperplasia, thereby determining that when the measured amount is larger than the cutoff value, prostate carcinoma is developed or the probability of developing prostate carcinoma is high, and when the measured amount is smaller than the cutoff value, benign prostatic hyperplasia is developed or the probability of developing benign prostatic hyperplasia is high.

5. 发明申请

US20160341725A1 ANALYZING APPARATUS 审中-公开
标题翻译：分析装置
公开(公告)号：US20160341725A1
公开(公告)日：2016-11-24
申请号：US15115234
申请日：2014-05-19
申请人： SYSTEM INSTRUMENTS CO., LTD. , HIROSAKI UNIVERSITY , NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
发明人： Kazuyuki Hamada , Takeshi Akiba , Chikara Ohyama , Tohru Yoneyama , Yuki Tobisawa , Toshifumi Takeuchi
IPC分类号： G01N33/543 , G01N21/59 , G01N33/573 , G01N35/10 , G01N35/00 , G01N21/03 , G01N21/64
CPC分类号： G01N33/54386 , B01L3/0275 , B01L2300/0609 , C12Y304/21077 , G01N21/0303 , G01N21/59 , G01N21/6428 , G01N33/573 , G01N35/00 , G01N35/00029 , G01N35/1011 , G01N2021/6439 , G01N2035/1062 , G01N2201/068 , G01N2333/96455
摘要： An automatic analyzing apparatus 10 includes a chip rack 11 that stores a pipette chip, a pipette 12 into which a specimen is injected, a conveyance unit that conveys the pipette 12 by parallel translation, a reagent rack 14, a reaction unit 15, a detection unit 16, and a detection block unit 17. The pipette chip stored by the chip rack 11 has a planar structure to directly and optically detect the specimen. The chip rack 11 includes, in a hole that receives the pipette chip, a guide corresponding to the structure of the pipette chip. The pipette 12 sucks or discharges the specimen via the pipette chip mounted onto the tip thereof by a drive of a pump. In the detection unit 16, a measurement is carried out with the pipette chip arranged so that the plane that receives light is vertical to an optical axis.
摘要翻译：自动分析装置10包括存储移液管芯片的芯片架11，注入试样的移液管12，通过并行平移输送移液管12的输送单元，试剂架14，反应单元15，检测单元16和检测块单元17.由芯片架11存储的移液管芯片具有直接和光学地检测样本的平面结构。芯片架11在接收移液管芯片的孔中包括与移液管芯片的结构相对应的引导件。移液管12通过泵的驱动器通过安装在其尖端上的移液管芯片吸取或排出样品。在检测单元16中，使用吸液管芯片进行测量，使得接收光的平面垂直于光轴。

6. 发明授权

US11987643B2 Monoclonal antibody that specifically binds to sugar chain in which terminal sialic acid residue is bonded to galactose by alpha 2,3 bond, and measurement method for sugar chain in which terminal sialic acid residue is bonded to galactose by alpha 2,3 bond 有权
公开(公告)号：US11987643B2
公开(公告)日：2024-05-21
申请号：US17918042
申请日：2021-03-18
申请人： Hirosaki University , System Instruments Co., Ltd.
发明人： Chikara Ohyama , Tohru Yoneyama , Kazuyuki Hamada
IPC分类号： C07K16/44 , G01N33/66
CPC分类号： C07K16/44 , G01N33/66 , C07K2317/565
摘要： A monoclonal antibody or an antibody fragment thereof is provided, in which the monoclonal antibody or the antibody fragment thereof specifically binds to a sugar chain in which a terminal sialic acid residue is bonded to galactose by an α2,3 bond, and is not dissociated from the sugar chain after the binding to the sugar chain in which the terminal sialic acid residue is bonded to the galactose by the α2,3 bond.α2,3

7. 发明公开

US20240034811A1 MONOCLONAL ANTIBODY THAT SPECIFICALLY BINDS TO SUGAR CHAIN IN WHICH TERMINAL SIALIC ACID RESIDUE IS BONDED TO GALACTOSE BY a2,3 BOND, AND MEASUREMENT METHOD FOR SUGAR CHAIN IN WHICH TERMINAL SIALIC ACID RESIDUE IS BONDED TO GALACTOSE BY a2,3 BOND 审中-公开
公开(公告)号：US20240034811A1
公开(公告)日：2024-02-01
申请号：US17918042
申请日：2021-03-18
申请人： Hirosaki University , System Instruments Co., Ltd.
发明人： Chikara Ohyama , Tohru Yoneyama , Kazuyuki Hamada
IPC分类号： C07K16/44 , G01N33/66
CPC分类号： C07K16/44 , G01N33/66 , C07K2317/565
摘要： A monoclonal antibody or an antibody fragment thereof is provided, in which the monoclonal antibody or the antibody fragment thereof specifically binds to a sugar chain in which a terminal sialic acid residue is bonded to galactose by an α2,3 bond, and is not dissociated from the sugar chain after the binding to the sugar chain in which the terminal sialic acid residue is bonded to the galactose by the α2,3 bond.α2,3

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式