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1. 发明授权

US11137403B2 Method for estimating Gleason score of prostate cancer, method for estimating pathological stage, and method for acquiring supplementary information, all on the basis of specific PSA content in specimen 有权
公开(公告)号：US11137403B2
公开(公告)日：2021-10-05
申请号：US16464744
申请日：2017-11-29
申请人： KONICA MINOLTA, INC. , HIROSAKI UNIVERSITY
发明人： Tomonori Kaneko , Takatoshi Kaya , Chikara Ohyama , Tohru Yoneyama , Yuki Tobisawa
IPC分类号： G01N33/574 , G01N21/64
摘要： The present invention provides methods that are for acquiring various types of supplementary information used for diagnosis or treatment of prostate cancer, and that can be implemented in a less-invasive manner at a low cost. Provided are, by measuring the content of prostate specific antigen (PSA) having a β-N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a specimen, and comparing the measured value with a threshold value, (1) a method for estimating whether a Gleason score (primary pattern and secondary pattern) is not less than or less than a prescribed value, (2) a method for estimating whether the pathological stage (pT) is not less than or less than a prescribed value, and (3) a method for acquiring information for assessment indicating diagnosis or treatment should be actively conducted because a GS at gross total removal is expected to be higher than a GS at biopsy.

2. 发明申请

US20210356386A1 DETECTION CHIP, DETECTION SYSTEM, AND DETECTION METHOD 有权
公开(公告)号：US20210356386A1
公开(公告)日：2021-11-18
申请号：US16319046
申请日：2017-07-24
申请人： Konica Minolta, Inc.
发明人： Tomonori KANEKO , Kosuke Nagae , Takatoshi Kaya , Yukito Nakamura
IPC分类号： G01N21/03 , G01N21/64
摘要： The detection system according to the present invention has a detection chip, a light source, and a detection unit. The detection chip has a housing that has an opening at an upper portion, and a reaction field for trapping a substance to be detected, the reaction field being arranged on an inner surface of the side walls included in the housing. The light source irradiates the detection chip with light from the outside such that evanescent light or surface plasmon resonance is generated under the reaction field. The detection unit detects light which is emitted from the detection chip when the light source irradiates the detection chip with light, and the amount of which changes depending on the amount of the substance to be detected trapped in the reaction field.

3. 发明授权

US11105807B2 Method for estimating pathological tissue diagnosis result (Gleason score) of prostate cancer 有权
公开(公告)号：US11105807B2
公开(公告)日：2021-08-31
申请号：US15761637
申请日：2016-09-02
申请人： KONICA MINOLTA, INC.
发明人： Tomonori Kaneko , Takatoshi Kaya
IPC分类号： G01N33/574 , G01N33/543 , G01N33/53
摘要： Provided is a method of obtaining an index value used for pathological tissue diagnosis of prostate cancer, which method has low invasiveness and can be performed at a low cost. The method is a method of estimating a Gleason score that represents the malignancy of prostate cancer, which method includes: measuring the content of a prostate-specific antigen having an N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a sample; and estimating that the Gleason score is 7 or higher when the thus measured value is larger than a threshold value, or estimating that the Gleason score is 6 or lower when the measured value is smaller than a threshold value. The prostate-specific antigen is preferably quantified by a method including the step of binding a molecule having an affinity for β-N-acetylgalactosamine residue, such as Wisteria floribunda lectin, soybean agglutinin, Vicia Villosa lectin or an anti-β-N-acetylgalactosamine antibody, to the prostate-specific antigen.

4. 发明授权

US10677731B2 Method of manufacturing sensing chip and sensing chip 有权
公开(公告)号：US10677731B2
公开(公告)日：2020-06-09
申请号：US15558506
申请日：2016-04-05
申请人： KONICA MINOLTA, INC.
发明人： Yukito Nakamura , Takatoshi Kaya , Tomonori Kaneko , Kosuke Nagae , Hiroshi Hirayama
IPC分类号： G01N21/64 , G01N21/03 , G01N33/543 , G01N21/552
摘要： A first frame having a first through-hole is arranged on a support so that one opening of the first through-hole is closed. A liquid containing a capturer is fed into the first through-hole, and a capturer is immobilized on the support exposed in the first through-hole. After removing the liquid from the support, a second frame having the second through-hole is arranged on the support in the first through-hole so that one opening of the second through-hole is closed.

5. 发明授权

US10254228B2 Detection chip and detection method 有权
公开(公告)号：US10254228B2
公开(公告)日：2019-04-09
申请号：US15534797
申请日：2015-11-20
申请人： Konica Minolta, Inc.
发明人： Kosuke Nagae , Takatoshi Kaya , Yukito Nakamura
IPC分类号： G01N21/55 , G01N21/64 , G01N21/552
摘要： The detection chip according to the present invention has an accommodating part, a metal film, a first reaction field, and a second reaction field. The accommodating part accommodates a liquid. The metal film is arranged in a bottom part of the accommodating part so that one face thereof faces into the accommodating part. The first reaction field and the second reaction field are arranged in mutually different regions on one face of the metal film. A capture body is immobilized in the first reaction field and the second reaction field. When the liquid is accommodated in the accommodating part, the depth of the liquid on the first reaction field differs from the depth of the liquid on the second reaction field.

6. 发明授权

US10222385B2 Methods for discriminating between prostate cancer and a benign prostate-disease 有权
公开(公告)号：US10222385B2
公开(公告)日：2019-03-05
申请号：US15108286
申请日：2013-12-27
申请人： KONICA MINOLTA, INC.
发明人： Katsuko Yamashita , Takatoshi Kaya , Youichi Ide , Tomonori Kaneko
IPC分类号： G01N33/68 , G01N33/574 , G01N33/573
摘要： A method of analyzing diagnostic information, the method including: measuring the concentration of all mucin-1s (total MUC1) in a blood sample originated from a subject to be diagnosed; comparing the measured value with a threshold value; and estimating that a disease affecting the subject to be diagnosed is not prostate cancer but a benign prostate disease when the measured value of the concentration of total MUC1 is greater than the threshold value.

7. 发明申请

US20180266954A1 Detection Chip and Detection Method 审中-公开
公开(公告)号：US20180266954A1
公开(公告)日：2018-09-20
申请号：US15534797
申请日：2015-11-20
申请人： Konica Minolta, Inc.
发明人： Kosuke Nagae , Takatoshi Kaya , Yukito Nakamura
IPC分类号： G01N21/64 , G01N21/552
CPC分类号： G01N21/648 , G01N21/553 , G01N21/64
摘要： The detection chip according to the present invention has an accommodating part, a metal film, a first reaction field, and a second reaction field. The accommodating part accommodates a liquid. The metal film is arranged in a bottom part of the accommodating part so that one face thereof faces into the accommodating part. The first reaction field and the second reaction field are arranged in mutually different regions on one face of the metal film. A capture body is immobilized in the first reaction field and the second reaction field. When the liquid is accommodated in the accommodating part, the depth of the liquid on the first reaction field differs from the depth of the liquid on the second reaction field.

8. 发明申请

US20150260654A1 IMMUNOASSAY METHOD UTILIZING SURFACE PLASMON 审中-公开
标题翻译：使用表面等离子体的免疫测定方法
公开(公告)号：US20150260654A1
公开(公告)日：2015-09-17
申请号：US14433230
申请日：2013-09-10
申请人： KONICA MINOLTA, INC.
发明人： Makiko Ootani , Takatoshi Kaya
IPC分类号： G01N21/64 , G01N21/552 , G01N33/53
CPC分类号： G01N21/6428 , G01N21/553 , G01N21/648 , G01N33/53 , G01N33/54373
摘要： At least an embodiment addresses the problem of providing a SPR (surface plasmon resonance) or SPFS (surface plasmon-field enhanced fluorescence spectroscopy) immunoassay, which enables the measurement of whole blood, undergoes little fluctuations in measurement values, and can measure whole blood, serum and plasma in a single apparatus. At least an embodiment solves the above-mentioned problem by a SPR or SPFS immunoassay, which is an immunoassay utilizing SPR or SPFS, including an absorbance measurement step of measuring an absorbance of a sample, a mode setting step of setting a mode that corresponds to the result of the absorbance measured in the absorbance measurement step, and one or multiple step(s) for which treatment condition(s) has/have been set in accordance with the mode set in the mode setting step.
摘要翻译：至少一个实施例解决了提供能够测量全血的SPR（表面等离子体共振）或SPFS（表面等离子体增强荧光光谱）免疫测定的问题几乎没有测量值的波动，并且可以测量全血，血清和血浆。至少一个实施方案通过SPR或SPFS免疫测定法解决了上述问题，SPR或SPFS免疫测定法是使用SPR或SPFS的免疫测定法，包括测量样品的吸光度的吸光度测量步骤，设定对应于在吸光度测量步骤中测量的吸光度的结果以及根据在模式设置步骤中设置的模式已经设置了一个或多个处理条件的一个或多个步骤。

9. 发明授权

US11224879B2 Inspection chip and inspection system 有权
公开(公告)号：US11224879B2
公开(公告)日：2022-01-18
申请号：US16482293
申请日：2018-02-06
申请人： Konica Minolta, Inc.
发明人： Takatoshi Kaya , Tomonori Kaneko
IPC分类号： B01L3/00 , G01N21/01 , G01N21/64 , G01N21/65
摘要： An inspection chip according to the present invention is an inspection chip for stirring liquid by a circular movement of a bottom surface end, including a well main body for accommodating the liquid and a side wall member arranged on a side surface of the well main body. The bottom surface end has a bottom surface structure in contact with a rotating member for allowing the bottom surface end to perform the circular movement in a position leaning from a center line of the well main body toward the side wall member.

10. 发明授权

US10976250B2 Position detection method and position detection device for sensor chip in optical sample detection system 有权
公开(公告)号：US10976250B2
公开(公告)日：2021-04-13
申请号：US16478243
申请日：2018-01-16
申请人： KONICA MINOLTA, INC.
发明人： Yukito Nakamura , Takatoshi Kaya , Kosuke Nagae
IPC分类号： G01N21/552 , G01N21/13 , G01N21/64 , G01N21/84
摘要： Provided is a position detection method and a position detection device for detecting a position of a sensor chip and obtaining relative positional information between a well member and a prism as for a well chip type sensor chip in which the well member is provided on a prism. By applying measurement light to the sensor chip while changing a distance between the sensor chip and a measurement light irradiation unit and detecting reflected light traveling in a predetermined direction out of the reflected light generated when the measurement light is reflected by the sensor chip, at least any one of the position of the sensor chip and the relative position between a dielectric member and a sample solution holding member is detected on the basis of a change in intensity of the detected reflected light.

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