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1. 发明申请

US20040063146A1 Diffraction-based diagnostic devices 有权
$Diffraction-based diagnostic devices$
标题翻译：基于衍射的诊断装置
公开(公告)号：US20040063146A1
公开(公告)日：2004-04-01
申请号：US10256278
申请日：2002-09-26
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Curtis Sayre , Rosann Kaylor , David Cohen
IPC分类号： C12Q001/70 , G01N033/53 , C12M001/34
CPC分类号： G03H1/182 , G01N21/4788 , G01N33/54373 , Y10S436/805 , Y10S436/815 , Y10S436/82 , Y10S436/901
摘要： A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a masking process wherein areas are exposed through a mask with a light source to induce deactivation.
摘要翻译：生物传感器包括具有设置在其上的辐射吸收部件（RAM）标记的生物分子的受体材料层的基板。受体材料对于感兴趣的分析物是特异性的。受体材料的活性和去活化区域的图案通过掩蔽过程限定在接受材料层中，其中通过具有光源的掩模暴露区域以诱导失活。

2. 发明申请

US20040100376A1 Healthcare monitoring system 审中-公开
标题翻译：医疗监护系统
公开(公告)号：US20040100376A1
公开(公告)日：2004-05-27
申请号：US10305263
申请日：2002-11-26
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Jason Lye , Rosann Kaylor , Jeff Lindsay , Dennis Everhart
IPC分类号： G08B001/08
CPC分类号： A61B5/411 , A61B5/002 , G16H40/67 , H04B1/7163 , Y02A90/22
摘要： A wireless healthcare monitoring system and method are provided. At least one UWB biosensor transmitter is assigned to at least one individual to be remotely monitored. The biosensor transmitter includes a biosensor disposed to detect a health condition of a user and generate a corresponding biosensor reading. The reading is converted by the biosensor transmitter to an ultra wideband (UWB) biosensor signal transmitted by the biosensor transmitter. A UWB receiver disposed remote from and within range of the transmitter receives and converts the UWB biosensor signal to a signal containing information from the biosensor reading. A processor in communication with the UWB receiver processes and displays the converted signal as a readable output indicating a health condition of the user detected by the biosensor.
摘要翻译：提供无线医疗保健监控系统和方法。至少一个UWB生物传感器发射器被分配给至少一个要远程监控的个体。生物传感器发射器包括一个生物传感器，用于检测使用者的健康状况并产生相应的生物传感器读数。读数被生物传感器发射器转换成由生物传感器发射器传输的超宽带（UWB）生物传感器信号。远离发射机的范围内的UWB接收器接收并将UWB生物传感器信号转换成包含来自生物传感器读数的信息的信号。与UWB接收机通信的处理器处理并将转换的信号显示为指示由生物传感器检测到的用户健康状况的可读输出。

3. 发明申请

US20040078219A1 Healthcare networks with biosensors 审中-公开
标题翻译：保健网络与生物传感器
公开(公告)号：US20040078219A1
公开(公告)日：2004-04-22
申请号：US10277170
申请日：2002-10-21
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Rosann Kaylor , Dennis Everhart , Jeff Lindsay
IPC分类号： G06F017/60 , A61B005/00
CPC分类号： G06F19/3418 , G06Q50/22 , Y02A90/22 , Y02A90/26
摘要： A healthcare network is provided for sharing information concerning the health of a user with at least one outside source, the network including a biosensor associated with the user that generates a biosensor signal containing the information; and a personal data control means including receiving means for receiving the biosensor signal, input means for receiving a privacy input from the user, and output means for generating a response signal based on the biosensor signal and privacy input. The network also includes a data allocation and processing module including means for receiving the response signal, and means for generating and directing an output signal to the at least one outside source, wherein the module is responsive to the response signal, and wherein the availability of the information to the at least one outside source is responsive to the privacy input.
摘要翻译：提供医疗保健网络，用于与至少一个外部来源共享关于用户的健康的信息，所述网络包括与用户相关联的生物传感器，其生成包含所述信息的生物传感器信号; 以及个人数据控制装置，包括用于接收生物传感器信号的接收装置，用于从用户接收隐私输入的输入装置，以及用于基于生物传感器信号和隐私输入产生响应信号的输出装置。网络还包括数据分配和处理模块，包括用于接收响应信号的装置，以及用于产生和指导输出信号到至少一个外部源的装置，其中模块响应响应信号，并且其中可用性至少一个外部源的信息响应于隐私输入。

4. 发明申请

US20040043511A1 Membrane-based assay devices 有权
标题翻译：基于膜的测定装置
公开(公告)号：US20040043511A1
公开(公告)日：2004-03-04
申请号：US10228836
申请日：2002-08-27
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Xuedong Song , Rosann Kaylor
IPC分类号： G01N033/558
CPC分类号： G01N33/54326 , G01N21/274 , G01N21/6408 , G01N33/525 , G01N33/558 , G01N33/582 , G01N2021/6439 , Y10S435/803 , Y10S435/805 , Y10S435/97 , Y10S436/80 , Y10S436/806 , Y10S436/824 , Y10T436/13
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating a calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional (e.g., directly or inversely) to the intensity of the detection signal calibrated by the intensity of the calibration signal. It has been discovered that the fluidics-based device of the present invention provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置使用包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能够产生校准信号的校准探针的自校准磁结合测定格式（例如，夹层，竞争性等）例如荧光磁性颗粒）。测试样品内的分析物的量与由校准信号的强度校准的检测信号的强度成正比（例如，直接或反向）。已经发现，本发明的基于流体的装置提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。

5. 发明申请

US20040043507A1 Fluidics-based assay devices 有权
标题翻译：基于流体的测定装置
公开(公告)号：US20040043507A1
公开(公告)日：2004-03-04
申请号：US10228838
申请日：2002-08-27
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Xuedong Song , Rosann Kaylor , Shawn Feaster , Kaiyuan Yang
IPC分类号： G01N033/553
CPC分类号： G01N33/54366 , B01L3/502761 , B01L2200/0668 , B01L2300/0825 , B01L2400/0406 , B01L2400/043 , B01L2400/0677 , G01N33/54333 , Y10S435/969 , Y10S435/97 , Y10T436/10
摘要： A fluidics-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating a calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional (e.g., directly or inversely) to the intensity of the detection signal calibrated by the intensity of the calibration signal. It has been discovered that the fluidics-based device of the present invention provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于流体学的测定装置。该装置使用包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能够产生校准信号的校准探针的自校准磁结合测定格式（例如，夹层，竞争性等）例如荧光磁性颗粒）。测试样品内的分析物的量与由校准信号的强度校准的检测信号的强度成正比（例如，直接或反向）。已经发现，本发明的基于流体的装置提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。

6. 发明申请

US20030119202A1 Reading device, method, and system for conducting lateral flow assays 有权
标题翻译：用于进行横向流量测定的阅读装置，方法和系统
公开(公告)号：US20030119202A1
公开(公告)日：2003-06-26
申请号：US10035013
申请日：2001-12-24
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Rosann Kaylor , Difei Yang , Michael Knotts
IPC分类号： G01N033/543
CPC分类号： G01N21/8483 , G01N33/558
摘要： An optical reflectance kit including a reading device and membrane test strip is disclosed for conducting a lateral flow assay. The reading device is portable. Assays may be conducted on bodily fluids to detect with high sensitivity the presence of certain hormones, glucose, or other bodily fluids of interest. Membrane test strips may receive a test fluid or test sample containing an analyte to be detected. The membrane test strips may be inserted directly into a receiving port of a reading device. Shielding stray light from the receiving port improves sensitivity and reduces the entry of stray or ambient light into the reading device. The reading device also includes one or more sensors capable of detecting the intensity of reflected electromagnetic radiation.
摘要翻译：公开了一种包括读取装置和膜测试条的光反射试剂盒，用于进行侧流测定。读取装置是便携式的。可以对体液进行测定，以高灵敏度检测某些激素，葡萄糖或感兴趣的其他体液的存在。膜测试条可以接收含有待检测分析物的测试流体或测试样品。膜测试条可以直接插入读取装置的接收端口。从接收端口屏蔽杂散光提高灵敏度，并减少杂散或环境光进入读取装置。读取装置还包括能够检测反射的电磁辐射的强度的一个或多个传感器。

7. 发明申请

US20040197819A1 Assay devices that utilize hollow particles 审中-公开
标题翻译：使用中空颗粒的测定装置
公开(公告)号：US20040197819A1
公开(公告)日：2004-10-07
申请号：US10406577
申请日：2003-04-03
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
IPC分类号： G01N033/53 , C12M003/00
CPC分类号： G01N33/587 , G01N33/558
摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.
摘要翻译：提供了用于各种类型的测定装置的中空颗粒。由于其中空或空隙结构，颗粒可能表现出各种有益的性质。例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

8. 发明申请

US20040121334A1 Self-calibrated flow-through assay devices 审中-公开
标题翻译：自校准流通测定装置
公开(公告)号：US20040121334A1
公开(公告)日：2004-06-24
申请号：US10325429
申请日：2002-12-19
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Ning Wei , Yanbin Huang , Xuedong Song , Rosann Kaylor
IPC分类号： C12Q001/68 , C12M001/34
CPC分类号： G01N33/558 , G01N33/54393
摘要： An internal, self-calibrated system for flow-through assay devices is provided. In particular, the present invention employs the use of a single calibration/detection zone defined by a porous membrane of the assay. It has been discovered that the internal, self-calibrated system provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.
摘要翻译：提供了一种用于流通测定装置的内部自校准系统。特别地，本发明使用由测定的多孔膜限定的单个校准/检测区域。已经发现，内部的自校准系统提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。

9. 发明申请

US20040043512A1 Self-calibration system for a magnetic binding assay 有权
标题翻译：用于磁性结合测定的自校准系统
公开(公告)号：US20040043512A1
公开(公告)日：2004-03-04
申请号：US10228837
申请日：2002-08-27
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Xuedong Song , Rosann Kaylor
IPC分类号： G01N033/553
CPC分类号： G01N33/582 , G01N33/54326 , Y10S435/967 , Y10S436/80 , Y10S436/905 , Y10T436/10 , Y10T436/101666 , Y10T436/105831
摘要： A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional to the intensity of the detection signal calibrated by the intensity of the calibration signal.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的存在或数量的自校准的磁性结合测定（例如，夹心，竞争性等）。磁结合测定法包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能产生校准信号的校准探针（例如，荧光磁性颗粒）。测试样品中分析物的量与由校准信号的强度校准的检测信号的强度成比例。

10. 发明申请

US20040043502A1 Membrane-based assay devices that utilize time-resolved fluorescence 有权
标题翻译：利用时间分辨荧光的基于膜的测定装置
公开(公告)号：US20040043502A1
公开(公告)日：2004-03-04
申请号：US10286342
申请日：2002-11-01
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Xuedong Song , Rosann Kaylor , Michael Knotts , Ning Wei
IPC分类号： G01N021/64
CPC分类号： G01N33/54326 , G01N21/274 , G01N21/6408 , G01N33/525 , G01N33/558 , G01N33/582 , G01N2021/6439 , Y10S435/803 , Y10S435/805 , Y10S435/97 , Y10S436/80 , Y10S436/806 , Y10S436/824 , Y10T436/13
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes time-resolved fluorescence to detect the signals generated by excited fluorescent labels. Because the labels can have relatively long emission lifetime, short-lived background interference can be practically eliminated through delayed fluorescence detection. In addition, the resulting fluorescent reader can have a simple and inexpensive design. For instance, in one embodiment, the reader can utilize a silicon photodiode and a pulsed light-emitting diode (LED) to accurately excite labels and detect fluorescence on a membrane-based assay device without requiring the use of expensive components, such as monochromators or narrow emission band width optical filters.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置利用时间分辨荧光检测激发的荧光标记产生的信号。因为标签的发光寿命可以较长，所以通过延迟荧光检测实际上可以消除短暂的背景干扰。此外，所得到的荧光读取器可以具有简单且便宜的设计。例如，在一个实施例中，读取器可以利用硅光电二极管和脉冲发光二极管（LED）来精确地激发标签并在基于膜的测定装置上检测荧光，而不需要使用昂贵的组件，例如单色仪或窄发射带宽滤光片。

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