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1. 发明申请

US20040106190A1 Flow-through assay devices 审中-公开
标题翻译：流通测定装置
公开(公告)号：US20040106190A1
公开(公告)日：2004-06-03
申请号：US10308926
申请日：2002-12-03
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Kaiyuan Yang , Xuedong Song , Kevin Peter McGrath , Rameshbabu Boga , Shawn Ray Feaster , David Cohen
IPC分类号： C12M001/34
CPC分类号： G01N33/5438
摘要： A flow-through assay device capable of detecting the presence or quantity of an analyte of interest is provided. The device is in communication with an electrochemical biosensor that utilizes detection and calibration working electrodes that communicate with affinity reagents, such as redox mediators and capture ligands. For instance, capture ligands that are specific binding members for the analyte of interest may be applied to the detection electrode to serve as the primary location for detection of the analyte. The calibration working electrode may be used to calibrate the detection working electrode for any intrinsic background current not generated by the reagents of the biosensor system. Moreover, capture ligands that are non-specific binding members for the analyte of interest may also be applied to the calibration electrode. In such instances, the calibration electrode may be used to calibrate the detection working electrode for any non-specific binding that may contribute to the current generated on the surface thereof.
摘要翻译：提供了能够检测感兴趣的分析物的存在或数量的流通测定装置。该装置与电化学生物传感器连通，其利用与亲和试剂如氧化还原介体和捕获配体进行通信的检测和校准工作电极。例如，可以将作为感兴趣分析物的特异性结合成员的捕获配体施加到检测电极，以用作检测分析物的主要位置。校正工作电极可用于校准检测工作电极，用于由生物传感器系统的试剂不产生的任何本征背景电流。此外，也可以将用于感兴趣分析物的非特异性结合成分的捕获配体施加到校准电极。在这种情况下，校准电极可以用于校准检测工作电极，用于任何可能有助于在其表面上产生的电流的非特异性结合。

2. 发明申请

US20040043507A1 Fluidics-based assay devices 有权
标题翻译：基于流体的测定装置
公开(公告)号：US20040043507A1
公开(公告)日：2004-03-04
申请号：US10228838
申请日：2002-08-27
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Xuedong Song , Rosann Kaylor , Shawn Feaster , Kaiyuan Yang
IPC分类号： G01N033/553
CPC分类号： G01N33/54366 , B01L3/502761 , B01L2200/0668 , B01L2300/0825 , B01L2400/0406 , B01L2400/043 , B01L2400/0677 , G01N33/54333 , Y10S435/969 , Y10S435/97 , Y10T436/10
摘要： A fluidics-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating a calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional (e.g., directly or inversely) to the intensity of the detection signal calibrated by the intensity of the calibration signal. It has been discovered that the fluidics-based device of the present invention provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于流体学的测定装置。该装置使用包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能够产生校准信号的校准探针的自校准磁结合测定格式（例如，夹层，竞争性等）例如荧光磁性颗粒）。测试样品内的分析物的量与由校准信号的强度校准的检测信号的强度成正比（例如，直接或反向）。已经发现，本发明的基于流体的装置提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。

3. 发明申请

US20030206852A1 Nickel-rich quaternary metal oxide materials as cathodes for lithium-ion and lithium-ion polymer batteries 有权
公开(公告)号：US20030206852A1
公开(公告)日：2003-11-06
申请号：US10456106
申请日：2003-06-06
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Kaiyuan Yang , Kevin P. McGrath , Naveen Agarwal , Jaeho Kim
IPC分类号： H01M004/48 , H01M004/58 , H01M004/50 , H01M004/52
CPC分类号： H01M10/0525 , H01M4/0471 , H01M4/131 , H01M4/1391 , H01M4/485 , H01M4/505 , H01M4/525
摘要： Positive electrode-active materials for use in lithium-ion and lithium-ion polymer batteries contain quaternary composite oxides of manganese, nickel, cobalt and aluminum where one of the four is present at levels of over 70 mol percent. The composite oxides can be lithiated to form positive electrode-active materials that are stable over at least ten charge/discharge cycles at voltage levels over 4.8 volts, and have capacities of over 200 mAh/g. Methods for producing the materials and electrochemical cells and batteries that include the materials are also provided.

4. 发明申请

US20040197820A1 Reduction of the hook effect in assay devices 有权
标题翻译：在测定装置中减少钩效应
公开(公告)号：US20040197820A1
公开(公告)日：2004-10-07
申请号：US10406631
申请日：2003-04-03
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Ning Wei , Yanbin Huang , Kaiyuan Yang
IPC分类号： G01N033/53 , G01N033/558
CPC分类号： G01N33/587 , G01N33/54393 , G01N33/558
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes conjugated probes that contain a specific binding member for the analyte of interest. The specific binding member preferentially complexes with the analyte within a test sample when contacted therewith. Excess analyte that remains uncomplexed with the specific binding member undergoes non-specific binding, such as to a hydrophobic domain. As a result, the ability of the uncomplexed analyte to compete with the complexed analyte at the detection zone of the device is restricted. Thus, the incidence of nullfalse negativesnull is limited in a simple, efficient, and relatively inexpensive manner.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置使用包含感兴趣分析物的特异性结合成员的缀合探针。当与其接触时，特异性结合成分优先与测试样品内的分析物复合。与特异性结合成员保持未复合的过量分析物经历非特异性结合，例如疏水结构域。因此，未配合的分析物在装置的检测区域与复合分析物竞争的能力受到限制。因此，“假阴性”的发生率以简单，有效和相对便宜的方式受到限制。

5. 发明申请

US20040197819A1 Assay devices that utilize hollow particles 审中-公开
标题翻译：使用中空颗粒的测定装置
公开(公告)号：US20040197819A1
公开(公告)日：2004-10-07
申请号：US10406577
申请日：2003-04-03
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
IPC分类号： G01N033/53 , C12M003/00
CPC分类号： G01N33/587 , G01N33/558
摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.
摘要翻译：提供了用于各种类型的测定装置的中空颗粒。由于其中空或空隙结构，颗粒可能表现出各种有益的性质。例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

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