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1. 发明授权

US4310635A Fermentative production of D(-)-.beta.-hydroxyisobutyric acid 失效
标题翻译：发酵生产D（ - ） - β-羟基异丁酸
公开(公告)号：US4310635A
公开(公告)日：1982-01-12
申请号：US201337
申请日：1980-10-27
申请人： Junzo Hasegawa , Masahiro Ogura , Shigeki Hamaguchi , Masami Shimazaki , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Junzo Hasegawa , Masahiro Ogura , Shigeki Hamaguchi , Masami Shimazaki , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C12P7/42
CPC分类号： C12P7/42 , Y10S435/911 , Y10S435/913 , Y10S435/917 , Y10S435/921 , Y10S435/938 , Y10S435/94 , Y10S435/942
摘要： A process is disclosed wherein D(-)-.beta.-hydroxyisobutyric acid is produced fermentatively from isobutyric acid or methacrylic acid by the stereoselective action of microorganisms having the ability to convert isobutyric acid or methacrylic acid into D(-)-.beta.-hydroxyisobutyric acid in an aqueous medium, and D(-)-.beta.-hydroxyisobutyric acid is recovered from the aqueous medium.
摘要翻译：公开了一种方法，其中通过具有将异丁酸或甲基丙烯酸转化为D（ - ） - β-羟基异丁酸的能力的微生物的立体选择性作用，从（异）酸或甲基丙烯酸发酵得到D（ - ） - β-羟基异丁酸）从水介质中回收水性介质和D（ - ） - β-羟基异丁酸。

2. 发明授权

US4415657A Process for preparation of an optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid 失效
标题翻译：制备β-（S） - 氨基戊二酸的光学活性单烷基酯的方法
公开(公告)号：US4415657A
公开(公告)日：1983-11-15
申请号：US328696
申请日：1981-12-08
申请人： Hamao Umezawa , Masaji Ohno , Junzo Hasegawa , Shigeki Hamaguchi , Masahiro Ogura , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Hamao Umezawa , Masaji Ohno , Junzo Hasegawa , Shigeki Hamaguchi , Masahiro Ogura , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C12P13/04 , C07B19/02 , C12P7/62
CPC分类号： C12P13/04 , Y10S435/83 , Y10S435/832 , Y10S435/84 , Y10S435/843 , Y10S435/859 , Y10S435/872 , Y10S435/874 , Y10S435/882 , Y10S435/885 , Y10S435/911 , Y10S435/912 , Y10S435/913 , Y10S435/921 , Y10S435/929 , Y10S435/931 , Y10S435/932 , Y10S435/933 , Y10S435/938 , Y10S435/939
摘要： A process is disclosed in which an optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid is prepared by subjecting a dialkyl ester of .beta.-protected aminoglutaric acid to the action of a culture broth, cells, or treated cells of a microorganism capable of stereoselectively hydrolyzing only one of the ester groups in the above-mentioned dialkyl ester to produce an optically active monoalkyl ester of .beta.-protected (S)-aminoglutaric acid, and then removing the amino-protecting group from the product. An optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid is useful as a starting material for synthesizing .beta.-lactam antibiotics of carbapenem type such as thienamycin.
摘要翻译：公开了一种方法，其中β-（S） - 氨基戊二酸的光学活性单烷基酯通过使β-受保护的氨基戊二酸的二烷基酯经受培养液，细胞或能够处理的微生物的处理细胞的作用立体选择性地水解上述二烷基酯中的一个酯基，得到β-保护（S） - 氨基戊二酸的光学活性单烷基酯，然后从产物中除去氨基保护基。 β-（S） - 氨基戊二酸的光学活性单烷基酯可用作合成碳青霉烯类的β-内酰胺抗生素如噻吩霉素的起始原料。

3. 发明授权

US4588694A Process for production of optically active oxazolidinone derivative 失效
标题翻译：光学活性恶唑烷酮衍生物的制备方法
公开(公告)号：US4588694A
公开(公告)日：1986-05-13
申请号：US522687
申请日：1983-08-12
申请人： Shigeki Hamaguchi , Hiroshi Yamamura , Junzo Hasegawa , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Shigeki Hamaguchi , Hiroshi Yamamura , Junzo Hasegawa , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C07D263/24 , C12P17/14 , C12P41/00 , C12R1/01 , C12R1/185 , C12R1/22 , C12R1/265 , C12R1/38 , C12R1/44 , C12R1/465 , C12R1/645 , C12R1/72 , C12R1/78 , C12R1/84 , C07B19/02
CPC分类号： C12P41/004 , C07D263/24 , C12P17/14
摘要： A process for preparing the optically active oxazolidinone derivative [(S)-I] by utilizing microorganisms or enzymes having a stereoselective esterase activity capable of asymmetrically hydrolyzing the racemates of the acyloxyoxazolidinone derivative [(R,S)-II], by separating the unreacted compound [(S)-II] from the hydrolyzed compound [(R)-I] and by hydrolyzing the compound [(S)-II]. The compounds are useful as intermediates for preparing optically active .beta.-adrenergic blocking agents.
摘要翻译：通过利用具有能够不对称地水解酰氧基恶唑烷酮衍生物[（R，S）-II]的外消旋体的立体选择性酯酶活性的微生物或酶制备光学活性恶唑烷酮衍生物[（S）-I]的方法，化合物[（S）-II]，水解化合物[（R）-I]和水解化合物[（S）-II]。该化合物可用作制备光学活性β-肾上腺素能阻断剂的中间体。

4. 发明授权

US4540665A Process for producing D-.beta.-hydroxyalkanoic acid 失效
标题翻译：生产D-β-羟基链烷酸的方法
公开(公告)号：US4540665A
公开(公告)日：1985-09-10
申请号：US475603
申请日：1983-03-15
申请人： Junzo Hasegawa , Masahiro Ogura , Hiroshi Kanema , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Junzo Hasegawa , Masahiro Ogura , Hiroshi Kanema , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C12P7/42 , C12N1/14 , C12N1/16 , C12N1/32 , C12N15/00 , C12P1/02 , C12R1/72
CPC分类号： C12P7/42 , Y10S435/921
摘要： A process for producing D-.beta.-hydroxyalkanoic acids by utilizing microorganisms having an ability of stereospecifically converting alkanoic acids, 2-alkenoic acids or alcohols into D-.beta.-hydroxyalkanoic acids.
摘要翻译：通过利用具有立体选择性将链烷酸，2-链烯酸或醇转化为D-β-羟基链烷酸的能力的微生物来生产D-β-羟基链烷酸的方法。

5. 发明授权

US4447362A Process for the production of coenzyme Q 失效
标题翻译：生产辅酶Q的方法
公开(公告)号：US4447362A
公开(公告)日：1984-05-08
申请号：US831426
申请日：1977-09-08
申请人： Kiyoshi Watanabe , Satoshi Ideguchi , Masahiro Ogura , Masahiko Shimada , Hajime Kawaharada
发明人： Kiyoshi Watanabe , Satoshi Ideguchi , Masahiro Ogura , Masahiko Shimada , Hajime Kawaharada
IPC分类号： A61K31/12 , C12P7/66 , C07C46/10 , C07C50/06
CPC分类号： C12P7/66 , A61K31/12
摘要： A process is disclosed wherein coenzyme Q is prepared from tissues of animals and plants or microbial cells by treating a water suspension of said materials with an alkali, or with an acid and then an alkali, and by extracting the treated suspension with at least one water-immiscible organic solvent followed by recovery of coenzyme Q from the extract.
摘要翻译：公开了一种方法，其中辅酶Q由动物和植物或微生物细胞的组织制备，通过用碱或用酸碱化处理所述材料的水悬浮液，并用至少一种水提取处理的悬浮液可混溶的有机溶剂，然后从提取物中回收辅酶Q。

6. 发明授权

US4970161A Human interferon-gamma 失效
标题翻译：人类干扰素-γ
公开(公告)号：US4970161A
公开(公告)日：1990-11-13
申请号：US144988
申请日：1988-01-19
申请人： Tetsu Kakutani , Keiji Matsumoto , Hiroyuki Maruyama , Kaku Nakagawa , Shinichi Yokota , Hideo Niwa , Katsuhiro Shinjo , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Tetsu Kakutani , Keiji Matsumoto , Hiroyuki Maruyama , Kaku Nakagawa , Shinichi Yokota , Hideo Niwa , Katsuhiro Shinjo , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C07K14/57 , C12N15/23
CPC分类号： C07K14/57
摘要： A DNA sequence on which a chromosomal DNA sequence coding for human interferon-.gamma. (HuIFN-.gamma.) and having a TATA box is ligated to a sequence of a promoter. Cell cultures transformed with said DNA revealed a higher expression of HuIFN- than cell cultures transformed with a DNA which does not have such TATA box. When transformed with said DNA, cell cultures produced HuIFN-.gamma. in a serum free medium. Transformed cell cultures derived from blood cells of HuIFN-.gamma. resistant human cell-line also could produce HuIFN-.gamma..
摘要翻译：将编码人干扰素-γ（HuIFN-γ）并具有TATA盒的染色体DNA序列连接到启动子序列的DNA序列。用所述DNA转化的细胞培养物显示出用不具有这种TATA盒的DNA转化的细胞培养物更高的HuIFN表达。当用所述DNA转化时，细胞培养物在无血清培养基中产生HuIFN-γ。来自HuIFN-γ抗性人细胞系血细胞的转化细胞培养物也可产生HuIFN-γ。

7. 发明授权

US4748176A 7-hydroxyguanine compounds 失效
标题翻译： 7-羟基鸟嘌呤化合物
公开(公告)号：US4748176A
公开(公告)日：1988-05-31
申请号：US867032
申请日：1986-05-27
申请人： Kiyoto Ishii , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Kiyoto Ishii , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： A61K31/52 , A61K31/522 , A61P35/00 , C07D473/18 , C12P17/18 , C12R1/465
CPC分类号： C07D473/18
摘要： Novel 7-hydroxyguanine compounds of the formula: ##STR1## wherein R is hydrogen atom, tetrahydropyranyl group or tetrahydrofuryl group, and R.sub.2 is hydrogen atom, tetrahydropyranyl group or tetrahydrofuryl group, provided that when R.sub.1 is hydrogen atom, R.sub.2 is tetrahydropyranyl group or tetrahydrofuryl group, and a salt thereof, which have excellent anti-tumor activity, process for preparing the compounds, and anti-tumor agent containing said compound as an active ingredient.
摘要翻译：下式的新型7-羟基鸟嘌呤化合物：其中R是氢原子，四氢吡喃基或四氢呋喃基，R2是氢原子，四氢吡喃基或四氢呋喃基，条件是当R1是氢原子时，R2是四氢吡喃基基团或四氢呋喃基及其盐，其具有优异的抗肿瘤活性，制备该化合物的方法，以及含有所述化合物作为活性成分的抗肿瘤剂。

8. 发明授权

US4369177A Stable composition of S-adenosyl-L-methionine 失效
标题翻译： S-腺苷-L-甲硫氨酸的稳定组成
公开(公告)号：US4369177A
公开(公告)日：1983-01-18
申请号：US208842
申请日：1980-11-20
申请人： Yuichi Kozaki , Shingo Hata , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Yuichi Kozaki , Shingo Hata , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C07H19/16 , A61K31/70
CPC分类号： C07H19/16 , Y10S514/97 , Y10S514/973
摘要： A stable composition of S-adenosyl-L-methionine is disclosed which includes a salt of S-adenosyl-L-methionine and a pharmaceutically acceptable, water-soluble salt of a bivalent or trivalent metal. The salt of S-adenosyl-L-methionine is, for example, a salt of S-adenosyl-L-methionine with hydrochloric acid, sulfuric acid, p-toluenesulfonic acid, phosphoric acid, formic acid, acetic acid, citric acid, tartaric acid, or maleic acid; or a double salt of S-adenosyl-L-methionine with the foregoing acids. The salt of a bivalent or trivalent metal is, for example, calcium chloride, ferric chloride, magnesium chloride, or magnesium sulfate. A process for preparing the composition is also disclosed. The composition is suitable for preparing pharmaceutical preparations of S-adenosyl-L-methionine.
摘要翻译：公开了S-腺苷-L-甲硫氨酸的稳定组合物，其包括S-腺苷-L-甲硫氨酸的盐和二价或三价金属的药学上可接受的水溶性盐。 S-腺苷-L-甲硫氨酸的盐例如是S-腺苷-L-甲硫氨酸与盐酸，硫酸，对甲苯磺酸，磷酸，甲酸，乙酸，柠檬酸，酒石酸的盐酸或马来酸; 或S-腺苷-L-甲硫氨酸与上述酸的双重盐。二价或三价金属的盐是例如氯化钙，氯化铁，氯化镁或硫酸镁。还公开了制备该组合物的方法。该组合物适用于制备S-腺苷-L-甲硫氨酸的药物制剂。

9. 发明授权

US4988624A Lymphotoxin DNA, lymphotoxin expression vector 失效
标题翻译：淋巴毒素DNA，淋巴毒素表达载体
公开(公告)号：US4988624A
公开(公告)日：1991-01-29
申请号：US882109
申请日：1986-07-03
申请人： Tetsu Kakutani , Kenji Yamashita , yasuhiro Ikenaka , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Tetsu Kakutani , Kenji Yamashita , yasuhiro Ikenaka , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C07K14/525 , C12N15/19 , C12N15/85
CPC分类号： C07K14/525 , C12N15/85
摘要： A chromosomal DNA sequence which codes for human lymphotoxin, a lymphotoxin expression vector which contains a DNA sequence wherein a chromosomal DNA sequence coding for human lymphotoxin and promoter region which functions in animal cell are linked together, lymphotoxin resistant cell line, transformed animal cell culture which is formed by transforming cultured animal cell with a lymphotoxin expression vector which contains a chromosomal DNA sequence coding for human lymphotoxin and, a process for preparing human lymphotoxin, which comprises transforming cultured animal cell with a lymphotoxin expression vector which contains a chromosomal DNA sequence coding for human lymphotoxin, culturing the transformed cell culture to produce human lymphotoxin, and collecting the human lymphotoxin.According to the present invention, LT which is expected for application as the antitumor agent can be produced effectively in a large amount.
摘要翻译：编码人淋巴毒素的染色体DNA序列，含有DNA序列的淋巴毒素表达载体，其中编码人类淋巴毒素的染色体DNA序列和在动物细胞中起作用的启动子区连接在一起，淋巴毒素抗性细胞系，转化的动物细胞培养物是通过用含有编码人淋巴毒素的染色体DNA序列的淋巴毒素表达载体转化培养的动物细胞，以及制备人淋巴毒素的方法形成的，其包括用含有染色体DNA序列编码的淋巴毒素表达载体转化培养的动物细胞，人淋巴毒素，培养转化的细胞培养物以产生人淋巴毒素，并收集人淋巴毒素。根据本发明，可以有效地大量生产预期用作抗肿瘤剂的LT。

10. 发明授权

US4786723A 7-hydroxyguanine compounds, process for preparing said compounds, and anti-tumor agent containing the same 失效
标题翻译： 7-羟基鸟嘌呤化合物，所述化合物的制备方法和含有该化合物的抗肿瘤剂
公开(公告)号：US4786723A
公开(公告)日：1988-11-22
申请号：US844687
申请日：1986-03-27
申请人： Mikio Kitahara , Kiyoto Ishii , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Mikio Kitahara , Kiyoto Ishii , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61K31/708 , A61P35/00 , C07H19/16 , C07H19/167 , C07H19/173 , C12P19/40 , C12R1/01 , C12R1/025 , C12R1/07 , C12R1/13 , C12R1/18 , C12R1/19 , C12R1/22 , C12R1/37 , C12R1/38 , C07H17/00 , C07H15/12 , C07H19/06
CPC分类号： C07H19/16
摘要： Novel 7-hydroxyguanine compounds of the formula: ##STR1## wherein R is hydrogen atom or hydroxy, and a salt thereof, which have excellent anti-tumor activity, process for preparing the compounds, and anti-tumor agent containing said compound as an active ingredient.
摘要翻译：具有下式的新型7-羟基鸟嘌呤化合物：其中R是氢原子或羟基，其盐具有优异的抗肿瘤活性，制备该化合物的方法和含有所述化合物的抗肿瘤剂作为活性成分。

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