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1. 发明申请

US20080021365A1 Granulocyte Adsorbent 有权
标题翻译：粒细胞吸附剂
公开(公告)号：US20080021365A1
公开(公告)日：2008-01-24
申请号：US11661320
申请日：2005-08-30
申请人： Akira Kobayashi , Shinya Yoshida , Hideo Niwa
发明人： Akira Kobayashi , Shinya Yoshida , Hideo Niwa
IPC分类号： A61K35/14 , A01N1/00 , A61M1/38 , B01D15/08 , B01D37/04 , C12N5/08
CPC分类号： B01J20/26 , A61M1/3679 , A61M2202/0441 , B01J20/261 , B01J20/262 , B01J20/265
摘要： This invention relates to a granulocyte adsorbent comprising a polymer compound having an unsubstituted hydroxyl group and a hydroxyl group in which H has been substituted with at least one substituent R, a method for producing such adsorbent, a device for adsorbing granulocytes and a system for removing granulocytes using such adsorbent, and body fluid or a cell suspension from which granulocytes have been removed using such adsorbent.
摘要翻译：本发明涉及一种粒细胞吸附剂，其包含具有未取代的羟基和羟基的高分子化合物，其中H已被至少一个取代基R取代，该方法可用于吸附粒细胞和吸附粒细胞的装置使用这种吸附剂的粒细胞，以及使用这种吸附剂从其中除去粒细胞的体液或细胞悬浮液。

2. 发明申请

US20090142835A1 STEM CELL SEPARATING MATERIAL AND METHOD OF SEPARATION 有权
标题翻译：干细胞分离材料和分离方法
公开(公告)号：US20090142835A1
公开(公告)日：2009-06-04
申请号：US12091029
申请日：2006-10-20
申请人： Akira Kobayashi , Kazuaki Yamamoto , Shinya Yoshida , Hideo Niwa , Naohiro Imai , Hirokazu Kurata , Yoshiaki Miyamoto
发明人： Akira Kobayashi , Kazuaki Yamamoto , Shinya Yoshida , Hideo Niwa , Naohiro Imai , Hirokazu Kurata , Yoshiaki Miyamoto
IPC分类号： C12N5/06
CPC分类号： C12N5/0607 , B01D39/1623 , B01D39/1692 , B01D2239/0414 , C12M33/14 , C12M47/02
摘要： The present invention has its object to provide a material for separating stem cell and a filter for separating stem cell, each is capable of selectively separating and recovering, in a simple and easy manner, stem cells from body fluids or biological tissue-derived treated fluids, a method for separating and recovering stem cells, and stem cells obtained by such method. The present invention is a material for separating stem cell which has a density K of 1.0×104≦K≦1.0×106 and a fiber diameter of 3 to 40 μm; a filter for separating stem cell which comprises the material for separating stem cell as packed in a container having a fluid inlet port and a fluid outlet port; a method of separating and recovering stem cells which comprises using the material for separating stem cell or the filter for separating stem cell; and a method of producing a multipotent cell fraction.
摘要翻译：本发明的目的是提供用于分离干细胞的材料和用于分离干细胞的过滤器，每种能够以简单和容易的方式从体液或生物组织衍生的处理液中分离和回收干细胞，分离和回收干细胞的方法和通过这种方法获得的干细胞。本发明是一种用于分离密度K为1.0×104 <= K <= 1.0×10 6，纤维直径为3〜40μm的干细胞的材料。用于分离干细胞的过滤器，其包括用于分离干细胞的材料，所述干细胞包装在具有流体入口和流体出口的容器中; 分离和回收干细胞的方法，其包括使用用于分离干细胞的材料或用于分离干细胞的过滤器; 以及多能细胞部分的制造方法。

3. 发明授权

US06614620B2 Thin film magnetic head 失效
公开(公告)号：US06614620B2
公开(公告)日：2003-09-02
申请号：US09778007
申请日：2001-02-06
申请人： Ikuya Tagawa , Tomoko Kutsuzawa , Hideo Niwa , Yukinori Ikegawa , Yoshinori Ohtsuka , Hiroshi Maeda , Takashi Sekikawa , Hiroki Fujimoto
发明人： Ikuya Tagawa , Tomoko Kutsuzawa , Hideo Niwa , Yukinori Ikegawa , Yoshinori Ohtsuka , Hiroshi Maeda , Takashi Sekikawa , Hiroki Fujimoto
IPC分类号： G11B5147
CPC分类号： G11B5/313 , G11B5/3116 , G11B5/3163 , Y10S977/934 , Y10S977/935
摘要： A thin film magnetic head includes an upper magnetic pole maintaining a constant thickness in a range determined by the so-called gap depth. A thinner film portion is defined in the upper magnetic pole in a range rearward of the range determined by the gap depth. The thinner film portion has a reduced thickness smaller than the constant thickness. The upper magnetic pole starts to enlarge the core width in the lateral direction at the rear end of the region determined by the so-called neck height. The neck height smaller than the gap depth serves to establish a reduction in the thickness of the upper magnetic pole after the upper magnetic pole gets larger in the lateral direction. A magnetic saturation can reliably be prevented at the thinner film portion in the upper magnetic pole. The front end of the upper magnetic pole is allowed to receive a larger quantity of a magnetic flux. It is possible to reliably enhance a magnetic field for recordation in the thin film magnetic head.

4. 发明授权

US5556943A Cell adhesion protein, gene coding for the same, process for preparing the same and carrier onto which the same is immobilized 失效
标题翻译：细胞粘附蛋白，编码相同的基因，其制备方法和其上固定有载体的载体
公开(公告)号：US5556943A
公开(公告)日：1996-09-17
申请号：US328152
申请日：1994-10-24
申请人： Kenji Yamashita , Takaaki Ohara , Hideo Niwa , Fumio Osakada , Takeshi Fukuchi , Tadahiro Edamura , Tetsu Kakutani
发明人： Kenji Yamashita , Takaaki Ohara , Hideo Niwa , Fumio Osakada , Takeshi Fukuchi , Tadahiro Edamura , Tetsu Kakutani
IPC分类号： A61K38/00 , C07K14/705 , C12N1/21 , C12N15/12 , C07K14/47
CPC分类号： C07K14/70528 , A61K38/00
摘要： A sheep LFA-3 protein and derivertires thereof, and derivertives of a human LFA-3 protein, gene coding for the proteins, and processes for preparing the proteins. Said proteins have high affinity for human T-cells.
摘要翻译：绵羊LFA-3蛋白质及其衍生物，人LFA-3蛋白质的衍生物，编码蛋白质的基因，以及制备蛋白质的方法。所述蛋白质对人T细胞具有高亲和力。

5. 发明授权

US5018939A Apparatus for separating iron sheets 失效
标题翻译：铁片分离装置
公开(公告)号：US5018939A
公开(公告)日：1991-05-28
申请号：US313344
申请日：1989-02-21
申请人： Tomomi Kishi , Kanshi Nonami , Masahiko Takeuchi , Naoyuki Yoshitani , Hideo Niwa
发明人： Tomomi Kishi , Kanshi Nonami , Masahiko Takeuchi , Naoyuki Yoshitani , Hideo Niwa
IPC分类号： B21D43/20 , B65G59/04 , H01F7/02
CPC分类号： B21D43/20 , B65G59/04 , H01F7/0247 , Y10S271/901
摘要： An apparatus for separating piled iron sheets one by one has a plurality of magnets arranged vertically with the same magnetic poles thereof facing each other. Magnetic fluxes generated from the magnets react with each other at a position between the magnets and flow horizontally and then vertically, with the result that opposite, vertically separating forces act on two superposed iron sheets.
摘要翻译：一个一个地分离堆积的铁片的设备具有垂直排列的多个磁体，其中相同磁极彼此面对。从磁体产生的磁通在磁体之间的位置处相互反应，并且水平且垂直地流动，结果是相反的垂直分离力作用在两个重叠的铁片上。

6. 发明授权

US4970161A Human interferon-gamma 失效
标题翻译：人类干扰素-γ
公开(公告)号：US4970161A
公开(公告)日：1990-11-13
申请号：US144988
申请日：1988-01-19
申请人： Tetsu Kakutani , Keiji Matsumoto , Hiroyuki Maruyama , Kaku Nakagawa , Shinichi Yokota , Hideo Niwa , Katsuhiro Shinjo , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Tetsu Kakutani , Keiji Matsumoto , Hiroyuki Maruyama , Kaku Nakagawa , Shinichi Yokota , Hideo Niwa , Katsuhiro Shinjo , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C07K14/57 , C12N15/23
CPC分类号： C07K14/57
摘要： A DNA sequence on which a chromosomal DNA sequence coding for human interferon-.gamma. (HuIFN-.gamma.) and having a TATA box is ligated to a sequence of a promoter. Cell cultures transformed with said DNA revealed a higher expression of HuIFN- than cell cultures transformed with a DNA which does not have such TATA box. When transformed with said DNA, cell cultures produced HuIFN-.gamma. in a serum free medium. Transformed cell cultures derived from blood cells of HuIFN-.gamma. resistant human cell-line also could produce HuIFN-.gamma..
摘要翻译：将编码人干扰素-γ（HuIFN-γ）并具有TATA盒的染色体DNA序列连接到启动子序列的DNA序列。用所述DNA转化的细胞培养物显示出用不具有这种TATA盒的DNA转化的细胞培养物更高的HuIFN表达。当用所述DNA转化时，细胞培养物在无血清培养基中产生HuIFN-γ。来自HuIFN-γ抗性人细胞系血细胞的转化细胞培养物也可产生HuIFN-γ。

7. 发明申请

US20080057558A1 Method and apparatus for separating cells 审中-公开
标题翻译：用于分离细胞的方法和装置
公开(公告)号：US20080057558A1
公开(公告)日：2008-03-06
申请号：US11893372
申请日：2007-08-15
申请人： Hideo Niwa , Akira Kobayashi , Setsuya Sato , Yoshitaka Matsumoto , Isamu Oh
发明人： Hideo Niwa , Akira Kobayashi , Setsuya Sato , Yoshitaka Matsumoto , Isamu Oh
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： G02B21/365 , C12M47/04 , G02B21/0088 , G02B21/16
摘要： The present invention provides a method and an apparatus for selectively removing non-target cells from a mixed cell population of different types of cells to selectively separate target cells. Individual cells or cell groups of at least two cells from a mixed cell population of different types of cells are placed on a certain two-dimensional, coordinate system. Then a distinction is made among the individual cells or cells in the cell groups, based on the shape or size of the cells or by using a cell marker. Physical energy such as laser light is applied to the positions or regions occupied by non-target cells or cell groups including non-target cells in order to selectively kill the non-target cells or cause dysfunction of the non-target cells.
摘要翻译：本发明提供一种用于从不同类型细胞的混合细胞群体中选择性除去非靶细胞以选择性分离靶细胞的方法和装置。来自不同类型细胞的混合细胞群体的至少两个细胞的单个细胞或细胞群被放置在某个二维坐标系上。然后，基于细胞的形状或大小或通过使用细胞标记，在细胞组中的各个细胞或细胞之间进行区分。将诸如激光的物理能量施加到非靶细胞或包括非靶细胞的细胞群占据的位置或区域，以选择性地杀死非靶细胞或引起非靶细胞的功能障碍。

8. 发明申请

US20070031894A1 Novel nerve stem cell marker 审中-公开
标题翻译：新型神经干细胞标记
公开(公告)号：US20070031894A1
公开(公告)日：2007-02-08
申请号：US10571268
申请日：2004-09-10
申请人： Tomoko Syofuda , Yonehiro Kanemura , Jun Miyake , Hideo Niwa , Kenji Yamashita
发明人： Tomoko Syofuda , Yonehiro Kanemura , Jun Miyake , Hideo Niwa , Kenji Yamashita
IPC分类号： G01N33/567 , C07K14/475 , C07K16/22 , C07H21/04
CPC分类号： G01N33/5058 , C12Q1/6876 , G01N33/5008 , G01N33/5023 , G01N33/5073 , G01N2500/00
摘要： It is an object of the present invention to provide a method for detecting nerve stem cells/progenitor cells among a tissue or a mass of cells as constituted of a plurality of cell species, and a method for screening for a drug functioning as a nerve differentiation factor or the like by using the above-mentioned detection method. It was found in this invention that the expression of the NC1 gene was high in undifferentiated nerve stem cells and said expression decreased with an advance of differentiation. Furthermore in this invention, by using the NC1 gene, the product thereof (NC1 protein) and the base sequences or the amino acid sequences thereof, antibodies or the like, it became possible to detect nerve stem cells/progenitor cells by way of various methods, so that a novel method for screening for a drug functioning as a nerve differentiation factor or the like was provided.
摘要翻译：本发明的目的是提供一种由多种细胞种组成的组织或大量细胞中的神经干细胞/祖细胞的检测方法，以及筛选作为神经分化的药物的方法因子等通过使用上述检测方法。在本发明中发现NC1基因的表达在未分化神经干细胞中高，并且所述表达随着分化的进展而降低。此外，在本发明中，通过使用NC1基因，其产物（NC1蛋白）及其碱基序列或其氨基酸序列，抗体等，可以通过各种方法检测神经干细胞/祖细胞，因此提供了筛选用作神经分化因子等的药物的新方法。

9. 发明授权

US09057052B2 Stem cell separating material and method of separation 有权
标题翻译：干细胞分离材料和分离方法
公开(公告)号：US09057052B2
公开(公告)日：2015-06-16
申请号：US12091029
申请日：2006-10-20
申请人： Akira Kobayashi , Kazuaki Yamamoto , Shinya Yoshida , Hideo Niwa , Naohiro Imai , Hirokazu Kurata , Yoshiaki Miyamoto
发明人： Akira Kobayashi , Kazuaki Yamamoto , Shinya Yoshida , Hideo Niwa , Naohiro Imai , Hirokazu Kurata , Yoshiaki Miyamoto
IPC分类号： C12M1/12 , C12M1/00 , C12M1/36 , C12N5/00 , C12N5/074 , B01D39/16 , C12M1/26
CPC分类号： C12N5/0607 , B01D39/1623 , B01D39/1692 , B01D2239/0414 , C12M33/14 , C12M47/02
摘要： The present invention has its object to provide a material for separating stem cell and a filter for separating stem cell, each is capable of selectively separating and recovering, in a simple and easy manner, stem cells from body fluids or biological tissue-derived treated fluids, a method for separating and recovering stem cells, and stem cells obtained by such method. The present invention is a material for separating stem cell which has a density K of 1.0×104≦K≦1.0×106 and a fiber diameter of 3 to 40 μm; a filter for separating stem cell which comprises the material for separating stem cell as packed in a container having a fluid inlet port and a fluid outlet port; a method of separating and recovering stem cells which comprises using the material for separating stem cell or the filter for separating stem cell; and a method of producing a multipotent cell fraction.
摘要翻译：本发明的目的是提供用于分离干细胞的材料和用于分离干细胞的过滤器，每种能够以简单和容易的方式从体液或生物组织衍生的处理液中分离和回收干细胞，分离和回收干细胞的方法和通过这种方法获得的干细胞。本发明是一种分离干细胞的材料，其密度K为1.0×104＆nlE; K＆NlE; 1.0×106，纤维直径为3〜40μm; 用于分离干细胞的过滤器，其包括用于分离干细胞的材料，所述干细胞包装在具有流体入口和流体出口的容器中; 分离和回收干细胞的方法，其包括使用用于分离干细胞的材料或用于分离干细胞的过滤器; 以及多能细胞部分的制造方法。

10. 发明申请

US20090204051A1 Method of removing lymphocyte growth inhibitor 审中-公开
标题翻译：清除淋巴细胞生长抑制剂的方法
公开(公告)号：US20090204051A1
公开(公告)日：2009-08-13
申请号：US11910027
申请日：2006-03-29
申请人： Akira Kobayashi , Shinya Yoshida , Hideo Niwa
发明人： Akira Kobayashi , Shinya Yoshida , Hideo Niwa
IPC分类号： A61M1/34 , A61M1/36 , B01J20/26
CPC分类号： B01J20/262 , A61M1/3679 , B01D15/00 , B01J20/20 , B01J20/22 , B01J20/261 , B01J20/3242
摘要： The present invention relates to a method of body fluid treatment for relieving the condition of inhibited lymphocyte proliferation which comprises bringing a mammalian body fluid into contact with an adsorbent comprising a high-molecular compound having a water contact angle within the range of 40° to 98° in the presence of a divalent cation chelating agent in the manner of extracorporeal circulation, or comprises bringing a mammalian body fluid into contact with an active carbon-containing adsorbent in the manner of extracorporeal circulation; and relates to a system for extracorporeal circulation which comprises a body fluid transfer pump, an anticoagulant infusion pump, and a device comprising a container wherein an adsorbent comprising a high-molecular compound having a water contact angle within the range of 40° to 98° is contained, or comprises a body fluid transfer pump, and a device comprising a container wherein an active carbon-containing adsorbent is contained.
摘要翻译：本发明涉及一种用于缓解淋巴细胞增殖抑制状况的体液治疗方法，其包括使哺乳动物体液与包含水接触角在40°〜98°范围内的高分子化合物的吸附剂接触在二价阳离子螯合剂存在下以体外循环的方式，或包括使哺乳动物体液以体外循环的方式与含活性炭的吸附剂接触; 涉及一种用于体外循环的系统，其包括体液输送泵，抗凝血剂输注泵和包括容器的装置，其中包含水接触角在40°至98°范围内的高分子化合物的吸附剂被包含或包括体液输送泵，以及包含其中含有活性碳的吸附剂的容器的装置。

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