专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4540665A Process for producing D-.beta.-hydroxyalkanoic acid 失效
标题翻译：生产D-β-羟基链烷酸的方法
公开(公告)号：US4540665A
公开(公告)日：1985-09-10
申请号：US475603
申请日：1983-03-15
申请人： Junzo Hasegawa , Masahiro Ogura , Hiroshi Kanema , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Junzo Hasegawa , Masahiro Ogura , Hiroshi Kanema , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C12P7/42 , C12N1/14 , C12N1/16 , C12N1/32 , C12N15/00 , C12P1/02 , C12R1/72
CPC分类号： C12P7/42 , Y10S435/921
摘要： A process for producing D-.beta.-hydroxyalkanoic acids by utilizing microorganisms having an ability of stereospecifically converting alkanoic acids, 2-alkenoic acids or alcohols into D-.beta.-hydroxyalkanoic acids.
摘要翻译：通过利用具有立体选择性将链烷酸，2-链烯酸或醇转化为D-β-羟基链烷酸的能力的微生物来生产D-β-羟基链烷酸的方法。

2. 发明授权

US4415657A Process for preparation of an optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid 失效
标题翻译：制备β-（S） - 氨基戊二酸的光学活性单烷基酯的方法
公开(公告)号：US4415657A
公开(公告)日：1983-11-15
申请号：US328696
申请日：1981-12-08
申请人： Hamao Umezawa , Masaji Ohno , Junzo Hasegawa , Shigeki Hamaguchi , Masahiro Ogura , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Hamao Umezawa , Masaji Ohno , Junzo Hasegawa , Shigeki Hamaguchi , Masahiro Ogura , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C12P13/04 , C07B19/02 , C12P7/62
CPC分类号： C12P13/04 , Y10S435/83 , Y10S435/832 , Y10S435/84 , Y10S435/843 , Y10S435/859 , Y10S435/872 , Y10S435/874 , Y10S435/882 , Y10S435/885 , Y10S435/911 , Y10S435/912 , Y10S435/913 , Y10S435/921 , Y10S435/929 , Y10S435/931 , Y10S435/932 , Y10S435/933 , Y10S435/938 , Y10S435/939
摘要： A process is disclosed in which an optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid is prepared by subjecting a dialkyl ester of .beta.-protected aminoglutaric acid to the action of a culture broth, cells, or treated cells of a microorganism capable of stereoselectively hydrolyzing only one of the ester groups in the above-mentioned dialkyl ester to produce an optically active monoalkyl ester of .beta.-protected (S)-aminoglutaric acid, and then removing the amino-protecting group from the product. An optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid is useful as a starting material for synthesizing .beta.-lactam antibiotics of carbapenem type such as thienamycin.
摘要翻译：公开了一种方法，其中β-（S） - 氨基戊二酸的光学活性单烷基酯通过使β-受保护的氨基戊二酸的二烷基酯经受培养液，细胞或能够处理的微生物的处理细胞的作用立体选择性地水解上述二烷基酯中的一个酯基，得到β-保护（S） - 氨基戊二酸的光学活性单烷基酯，然后从产物中除去氨基保护基。 β-（S） - 氨基戊二酸的光学活性单烷基酯可用作合成碳青霉烯类的β-内酰胺抗生素如噻吩霉素的起始原料。

3. 发明授权

US4310635A Fermentative production of D(-)-.beta.-hydroxyisobutyric acid 失效
标题翻译：发酵生产D（ - ） - β-羟基异丁酸
公开(公告)号：US4310635A
公开(公告)日：1982-01-12
申请号：US201337
申请日：1980-10-27
申请人： Junzo Hasegawa , Masahiro Ogura , Shigeki Hamaguchi , Masami Shimazaki , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Junzo Hasegawa , Masahiro Ogura , Shigeki Hamaguchi , Masami Shimazaki , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C12P7/42
CPC分类号： C12P7/42 , Y10S435/911 , Y10S435/913 , Y10S435/917 , Y10S435/921 , Y10S435/938 , Y10S435/94 , Y10S435/942
摘要： A process is disclosed wherein D(-)-.beta.-hydroxyisobutyric acid is produced fermentatively from isobutyric acid or methacrylic acid by the stereoselective action of microorganisms having the ability to convert isobutyric acid or methacrylic acid into D(-)-.beta.-hydroxyisobutyric acid in an aqueous medium, and D(-)-.beta.-hydroxyisobutyric acid is recovered from the aqueous medium.
摘要翻译：公开了一种方法，其中通过具有将异丁酸或甲基丙烯酸转化为D（ - ） - β-羟基异丁酸的能力的微生物的立体选择性作用，从（异）酸或甲基丙烯酸发酵得到D（ - ） - β-羟基异丁酸）从水介质中回收水性介质和D（ - ） - β-羟基异丁酸。

4. 发明授权

US4588694A Process for production of optically active oxazolidinone derivative 失效
标题翻译：光学活性恶唑烷酮衍生物的制备方法
公开(公告)号：US4588694A
公开(公告)日：1986-05-13
申请号：US522687
申请日：1983-08-12
申请人： Shigeki Hamaguchi , Hiroshi Yamamura , Junzo Hasegawa , Hajime Kawaharada , Kiyoshi Watanabe
发明人： Shigeki Hamaguchi , Hiroshi Yamamura , Junzo Hasegawa , Hajime Kawaharada , Kiyoshi Watanabe
IPC分类号： C07D263/24 , C12P17/14 , C12P41/00 , C12R1/01 , C12R1/185 , C12R1/22 , C12R1/265 , C12R1/38 , C12R1/44 , C12R1/465 , C12R1/645 , C12R1/72 , C12R1/78 , C12R1/84 , C07B19/02
CPC分类号： C12P41/004 , C07D263/24 , C12P17/14
摘要： A process for preparing the optically active oxazolidinone derivative [(S)-I] by utilizing microorganisms or enzymes having a stereoselective esterase activity capable of asymmetrically hydrolyzing the racemates of the acyloxyoxazolidinone derivative [(R,S)-II], by separating the unreacted compound [(S)-II] from the hydrolyzed compound [(R)-I] and by hydrolyzing the compound [(S)-II]. The compounds are useful as intermediates for preparing optically active .beta.-adrenergic blocking agents.
摘要翻译：通过利用具有能够不对称地水解酰氧基恶唑烷酮衍生物[（R，S）-II]的外消旋体的立体选择性酯酶活性的微生物或酶制备光学活性恶唑烷酮衍生物[（S）-I]的方法，化合物[（S）-II]，水解化合物[（R）-I]和水解化合物[（S）-II]。该化合物可用作制备光学活性β-肾上腺素能阻断剂的中间体。

5. 发明授权

US06221638B1 Process for producing optically active amino compounds 失效
标题翻译：光学活性氨基化合物的制造方法
公开(公告)号：US06221638B1
公开(公告)日：2001-04-24
申请号：US09064750
申请日：1998-04-23
申请人： Yukio Yamada , Akira Iwasaki , Noriyuki Kizaki , Yasuhiro Ikenaka , Masahiro Ogura , Junzo Hasegawa
发明人： Yukio Yamada , Akira Iwasaki , Noriyuki Kizaki , Yasuhiro Ikenaka , Masahiro Ogura , Junzo Hasegawa
IPC分类号： C12P1300
CPC分类号： C12P13/001 , C12N9/1096 , C12P13/005 , C12P13/008 , C12P13/04 , C12P41/006 , Y10S435/83
摘要： The method for preparing an optically active (R)-amino compound characterized by the method comprising stereoselectively carrying out amino group transfer by action of an (R)-form-specific transaminase in the co-presence of a ketone compound (amino acceptor), and an amino compound (amino donor) of a racemic form or an (R)-form, to give an optically active (R)-amino compound. According to the present invention, it is made possible to easily prepare at a high yield the optically active (R)-amino compounds and the like having an aryl group and the like at their 1-position, which have been conventionally difficult to prepare.
摘要翻译：制备光学活性（R） - 氨基化合物的方法，其特征在于在酮化合物（氨基受体）的共存下通过（R） - 形式 - 特异性转氨酶的作用立体选择性地进行氨基转移的方法，和外消旋形式的氨基化合物（氨基供体）或（R） - 形式，得到光学活性（R） - 氨基化合物。根据本发明，可以容易地容易地制备其1-位上具有芳基等的光学活性（R） - 氨基化合物等，其通常难以制备。

6. 发明授权

US4981796A Manufacturing method of optically-active 1,2-diols 失效
标题翻译：光学活性1,2-二醇的制备方法
公开(公告)号：US4981796A
公开(公告)日：1991-01-01
申请号：US275200
申请日：1988-11-23
申请人： Masahiro Ogura , Tadayoshi Shiraishi , Hideyuki Takahashi , Junzo Hasegawa
发明人： Masahiro Ogura , Tadayoshi Shiraishi , Hideyuki Takahashi , Junzo Hasegawa
IPC分类号： C12P7/18 , C12P41/00
CPC分类号： C12P7/18 , C12P41/00 , Y10S435/911 , Y10S435/921 , Y10S435/938
摘要： A process of manufacturing optically active (S)-1,2-diols, wherein (R)-1,2-diols represented by the general formula [I] ##STR1## (where: R represents a substituted or unsubstituted alkyl group, alkenyl group, aryl group or aralkyl group) or a mixture of diols of the general formula [I] and (S)-1,2-diols represented by the general formula [II] ##STR2## (Where: R represents the same as above) having an opposite configuration to the general formula [I] is subjected to the action of a microorganism capable of selectively metabolizing the diols of the general formula [I], or capable of converting the diols of the general formula [I] into the diols of the general formula [II], or having the both capabilities, and the formed and accumulated (S)-1,2-diols of the general formula [II] is collected. According to the present invention, optically active (S)-1,2-diols can be produced commercially and advantageously.

7. 发明授权

US07169592B2 Producing optically active amino compounds 有权
标题翻译：生产光学活性氨基化合物
公开(公告)号：US07169592B2
公开(公告)日：2007-01-30
申请号：US10112706
申请日：2002-04-02
申请人： Yukio Yamada , Akira Iwasaki , Noriyuki Kizaki , Keiji Matsumoto , Yasuhiro Ikenaka , Masahiro Ogura , Junzo Hasegawa
发明人： Yukio Yamada , Akira Iwasaki , Noriyuki Kizaki , Keiji Matsumoto , Yasuhiro Ikenaka , Masahiro Ogura , Junzo Hasegawa
IPC分类号： C12N9/10 , C12N1/21 , C12N15/54 , C12N15/63 , C12N15/82 , C12N15/85 , C07H21/04
CPC分类号： C12P13/001 , C12N9/1096
摘要： To provide a method for preparing optically active compounds, which mainly contain (R)-amino compounds, by microbial enzymes efficiently and inexpensively; a polypeptide having stereoselective transaminase activity which can be suitably used for the above preparation method; and a DNA encoding the polypeptide. A method for preparing an optically active amino compound, characterized in stereoselectively transaminating by acting a transaminase on an amino group acceptor, a ketone compound in the presence of an amino group donor, a primary amine; a DNA comprising a nucleotide sequence encoding a polypeptide having stereoselective transaminase activity; and a polypeptide having stereoselective transaminase activity obtainable from a culture of a microorganism belonging to the genus Arthrobacter.
摘要翻译：提供通过微生物酶有效且廉价地制备主要含有（R） - 氨基化合物的光学活性化合物的方法; 具有立体选择性转氨酶活性的多肽，可适用于上述制备方法; 和编码该多肽的DNA。一种制备光学活性氨基化合物的方法，其特征在于通过在氨基受体上起转氨酶的作用，在氨基供体存在下的酮化合物，伯胺，立体选择性转氨酶; 包含编码具有立体选择性转氨酶活性的多肽的核苷酸序列的DNA; 和具有立体选择性转氨酶活性的多肽，其可从属于节杆菌属的微生物的培养物获得。

8. 发明授权

US06344351B2 (R)-transaminase from arthrobacter 失效
标题翻译：（R） - 转氨酶
公开(公告)号：US06344351B2
公开(公告)日：2002-02-05
申请号：US09794359
申请日：2001-02-28
申请人： Yukio Yamada , Akira Iwasaki , Noriyuki Kizaki , Yasuhiro Ikenaka , Masahiro Ogura , Junzo Hasegawa
发明人： Yukio Yamada , Akira Iwasaki , Noriyuki Kizaki , Yasuhiro Ikenaka , Masahiro Ogura , Junzo Hasegawa
IPC分类号： C12N910
CPC分类号： C12P13/001 , C12N9/1096 , C12P13/005 , C12P13/008 , C12P13/04 , C12P41/006 , Y10S435/83
摘要： The method for preparing an optically active (R)-amino compound characterized by the method comprising stereoselectively carrying out amino group transfer by action of an (R)-form-specific transaminase in the co-presence of a ketone compound (amino acceptor), and an amino compound (amino donor) of a racemic form or an (R)-form, to give an optically active (R)-amino compound. According to the present invention, it is made possible to easily prepare at a high yield the optically active (R)-amino compounds and the like having an aryl group and the like at their 1-position, which have been conventionally difficult to prepare.
摘要翻译：制备光学活性（R） - 氨基化合物的方法，其特征在于在酮化合物（氨基受体）的共存下通过（R） - 形式 - 特异性转氨酶的作用立体选择性地进行氨基转移的方法，和外消旋形式的氨基化合物（氨基供体）或（R） - 形式，得到光学活性（R） - 氨基化合物。根据本发明，可以容易地容易地制备其1-位上具有芳基等的光学活性（R） - 氨基化合物等，其通常难以制备。

9. 发明授权

US4857468A Process for preparing optically active 2-halo-1-phenyl ethanol 失效
标题翻译：制备光学活性2-卤代-1-苯基乙醇的方法
公开(公告)号：US4857468A
公开(公告)日：1989-08-15
申请号：US849985
申请日：1986-04-10
申请人： Hidetoshi Kutsuki , Ikuo Sawa , Natsuki Mori , Junzo Hasegawa , Kiyoshi Watanabe
发明人： Hidetoshi Kutsuki , Ikuo Sawa , Natsuki Mori , Junzo Hasegawa , Kiyoshi Watanabe
IPC分类号： C12P7/22 , C12P41/00
CPC分类号： C12P7/22 , C12P41/00 , Y10S435/911 , Y10S435/921 , Y10S435/933 , Y10S435/94
摘要： A process for preparing optically active 2-halo-1-phenyl ethanol having the general formula [I*]: ##STR1## wherein X is a halogen atom, by asymmetrically reducing 2-halo-acetophenone having the general formula [II]: ##STR2## wherein X is as above, to give optically active 2-halo-1-phenyl ethanol, (R)-form or (S)-form, employing the microorganism. ##STR3## According to the present invention, optically active 2-halo-1-phenyl ethanol can be prepared with a good optical purity and yield in a simple process.
摘要翻译：制备具有通式[I *]的光学活性2-卤代-1-苯基乙醇的方法：其中X为卤素原子，通过不对称地还原具有通式[I *]的2-卤代苯乙酮， II]：其中X如上所述，使用微生物得到光学活性2-卤代-1-苯基乙醇（R） - 型或（S） - 型。根据本发明，可以在简单的工艺中制备具有良好光学纯度和产率的光学活性2-卤代-1-苯基乙醇。

10. 发明授权

US06214610B1 Process for the preparation of optically active N-benzyl-3-pyrrolidinol 有权
标题翻译：制备光学活性N-苄基-3-吡咯烷醇的方法
公开(公告)号：US06214610B1
公开(公告)日：2001-04-10
申请号：US09308754
申请日：1999-06-28
申请人： Yoshihiko Yasohara , Junzo Hasegawa
发明人： Yoshihiko Yasohara , Junzo Hasegawa
IPC分类号： C12D1710
CPC分类号： C12P17/10
摘要： The invention provides an efficient method of producing optically active N-benzyl-3-pyrrolidinol by an enzymatic reaction stereoselectively reducing N-benzyl-3-pyrrolidinone. The invention consists in a method of producing optically active N-benzyl-3-pyrrolidinol which comprises a step of obtaining a reaction mixture by treating N-benzyl-3-pyrrolidinone with cells or a culture of a microorganism, or a material derived therefrom, and a step of recovering optically active N-benzyl-3-pyrrolidinol from said reaction mixture, in which method said microorganism mentioned above is a microorganism belonging to the genus Dipodascus, Debaryomyces, Cryptococcus, Pichia, Rhodosporidium, Trichosporon, Micrococcus, Komagataella, Ogataea or Zygosaccharomyces.
摘要翻译：本发明提供了一种通过立体选择性还原N-苄基-3-吡咯烷酮的酶反应产生光学活性N-苄基-3-吡咯烷醇的有效方法。本发明涉及一种光学活性N-苄基-3-吡咯烷醇的制备方法，其包括通过用细胞或微生物培养物或其衍生物处理N-苄基-3-吡咯烷酮得到反应混合物的步骤和从所述反应混合物中回收旋光性N-苄基-3-吡咯烷醇的步骤，上述微生物是这样的微生物，属于Dipodascus，Debaryomyces，Cryptococcus，Pichia，Rhodosporidium，Trichosporon，Micrococcus，Komagataella，Ogataea或Zygosaccharomyromyces属的微生物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式