专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20210123108A1 KLEBSIELLA PNEUMONIAE STRAIN INDUCING INFLAMMATION IN LIVER 有权
公开(公告)号：US20210123108A1
公开(公告)日：2021-04-29
申请号：US17130557
申请日：2020-12-22
申请人： KEIO UNIVERSITY
发明人： Nobuhiro Nakamoto , Nobuo Sasaki , Ryo Aoki , Kentaro Miyamoto , Toshiro Sato , Takanori Kanai
IPC分类号： C12R1/22 , C12R1/37 , A01K67/027 , C12R1/46
摘要： To identify a microorganism causing the development of primary sclerosing cholangitis associated with ulcerative colitis. A Klebsiella pneumoniae strain inducing inflammation in the liver.

2. 发明授权

US5300430A Biocatalytic process for the production of L-(-)-carnitine from crotonobetaine and strains of proteus for use in said process 失效
标题翻译：用于生产来自巴豆甜菜碱的L-（ - ） - 肉碱的生物催化方法和用于所述方法的蛋白酶菌株
公开(公告)号：US5300430A
公开(公告)日：1994-04-05
申请号：US1403
申请日：1993-01-07
申请人： Stuart Shapiro , Manrico Bernardini , Charles J. Sih
发明人： Stuart Shapiro , Manrico Bernardini , Charles J. Sih
IPC分类号： C12N1/20 , C12N9/88 , C12P13/00 , C12R1/37
CPC分类号： C12P13/007 , C12N9/88 , Y10S435/873
摘要： A process is described for stereospecifically hydrating crotonobetaine to L-(-)-carnitine via the action of an enzyme produced by four new strains of Proteus mirabilis (NRRL B-18480, NRRL B-18481, NRRL B-18482, and NRRL B-18483) in biotransformation media containing from 10 to 12% (w/v) crotonobetaine inner salt.
摘要翻译：描述了通过四种新的变形杆菌（NRRL B-18480，NRRL B-18481，NRRL B-18482和NRRL B-18482）产生的酶的作用，将巴豆甜菜碱立体特异性水解成L-（ - ） - 肉碱的方法， 18483）在含有10至12％（w / v）巴豆甜菜碱内盐的生物转化培养基中。

3. 发明授权

US5028538A Process for the production of L-carnitine and its deivatives 失效
标题翻译：生产左旋肉碱及其衍生物的方法
公开(公告)号：US5028538A
公开(公告)日：1991-07-02
申请号：US349929
申请日：1989-05-09
申请人： Hermann Seim , Heniz Loester , Rainer Claus , Hans-Peter Kleber , Erich Strack
发明人： Hermann Seim , Heniz Loester , Rainer Claus , Hans-Peter Kleber , Erich Strack
IPC分类号： C12P13/02 , C12P13/00 , C12R1/01 , C12R1/145 , C12R1/185 , C12R1/37 , C12R1/42
CPC分类号： C12P13/007
摘要： The invention relates to a process for the L(-)-carnitine biochemical production, in an economically favorable way.This new process is technically achievable with easily available raw, materials in simple reaction conditions and with not complicated substance separation techniques.This process is carried out with bacteria that stereo-specifically hydrates crotonobetaine to L(-)-carnitine.
摘要翻译：本发明涉及一种以经济上有利的方式生产L（ - ） - 肉碱的方法。这种新工艺在技术上可以通过简单的原料，简单的反应条件和不复杂的物质分离技术实现。这个过程是用立体特异性将巴豆甜菜碱水解成L（ - ） - 肉碱的细菌进行的。

4. 发明授权

US4863862A Microbial method of producing C.sub.3 and/or C.sub.4 hydrocarbons 失效
标题翻译：生产C3和/或C4烃的微生物方法
公开(公告)号：US4863862A
公开(公告)日：1989-09-05
申请号：US225589
申请日：1988-07-26
申请人： Hideo Fukuda , Takahira Ogawa , Takao Fujii
发明人： Hideo Fukuda , Takahira Ogawa , Takao Fujii
IPC分类号： C12P5/00 , C12P5/02 , C12R1/01 , C12R1/02 , C12R1/04 , C12R1/07 , C12R1/13 , C12R1/15 , C12R1/265 , C12R1/37 , C12R1/38 , C12R1/42 , C12R1/425 , C12R1/465 , C12R1/54 , C12R1/645 , C12R1/65 , C12R1/66 , C12R1/725 , C12R1/78 , C12R1/785 , C12R1/84 , C12R1/845 , C12R1/85 , C12R1/885
CPC分类号： C12P5/02 , Y02E50/343 , Y10S435/822 , Y10S435/911
摘要： C.sub.3 and/or C.sub.4 hydrocarbons(s) is produced by the aerobic cultivation of a microorganism belonging to a wide variety of genera of Fungi, Yeasts, Bacteria and Actinomycetes. Industrial wastes and various biomass can be employed as nutrient source in the cultivation.
摘要翻译： C3和/或C4烃是通过有益培养属于各种各样的真菌，酵母菌，细菌和放线菌属的微生物产生的。工业废物和各种生物质可以作为养分的养分来源。

5. 发明授权

US4604234A Protein having cell growth stimulating action, composition thereof and method for producing the same 失效
标题翻译：具有细胞生长刺激作用的蛋白质，其组合物及其制备方法
公开(公告)号：US4604234A
公开(公告)日：1986-08-05
申请号：US584335
申请日：1984-02-28
申请人： Setsuro Fujii , Nobumoto Chikazawa , Teruo Arima , Masakazu Fukushima
发明人： Setsuro Fujii , Nobumoto Chikazawa , Teruo Arima , Masakazu Fukushima
IPC分类号： C12P21/00 , A61K31/714 , A61K33/30 , A61K35/74 , A61K38/00 , A61P1/04 , A61P1/16 , A61P17/00 , A61P43/00 , C07K1/22 , C07K14/005 , C07K14/195 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/28 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/41 , C12R1/01 , C12R1/07 , C12R1/125 , C12R1/145 , C12R1/15 , C12R1/185 , C12R1/19 , C12R1/20 , C12R1/37 , C12R1/38 , C12R1/42 , C12R1/425 , C12R1/43 , C12R1/44 , C12R1/445 , C12R1/45 , C12R1/46 , C07K15/04 , A61K37/00
CPC分类号： C07K14/34 , A61K33/30 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/28 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , A61K38/00 , Y10S435/823 , Y10S435/839 , Y10S435/842 , Y10S435/843 , Y10S435/849 , Y10S435/879 , Y10S435/88 , Y10S435/884 , Y10S435/885
摘要： A protein effective in stimulating cell growth activity. The protein has a molecular weight of from 5,000 to about 160,000, is composed predominantly of neutral and acidic amino acids, contains a significant amount of glutamic acid and aspartic acid, and is substantially free of nucleoside phosphotransferase. The protein is useful as wound treatment agent and as promoting agent in the synthesis of DNA. A method of producing the protein and compositions containing the same are also disclosed.
摘要翻译：有效刺激细胞生长活性的蛋白质。该蛋白质具有5,000至约160,000的分子量，主要由中性和酸性氨基酸组成，含有显着量的谷氨酸和天冬氨酸，并且基本上不含核苷磷酸转移酶。该蛋白质可用作伤口治疗剂，并用作DNA合成中的促进剂。还公开了生产蛋白质的方法和含有该蛋白质的组合物。

6. 发明授权

US4278593A Glucocorticoid sparing factor and process for the production of the same 失效
标题翻译：糖皮质激素保留因子及其制备方法相同
公开(公告)号：US4278593A
公开(公告)日：1981-07-14
申请号：US109095
申请日：1980-01-02
申请人： Nobuhiko Katsunuma
发明人： Nobuhiko Katsunuma
IPC分类号： C07G99/00 , A61K35/74 , C07H19/10 , C12P1/04 , C12R1/225 , C12R1/37 , C12R1/46 , C12P21/00 , C07G7/00
CPC分类号： A61K31/70 , C07H19/10 , C12P1/04 , Y10S435/822 , Y10S435/847 , Y10S435/849 , Y10S435/852 , Y10S435/873 , Y10S435/879 , Y10S435/881 , Y10S530/824 , Y10S530/825
摘要： A glucocorticoid sparing factor (GSF) which amplifies liver enzyme induction which is caused in glucocorticoid and a process for the production of GSF are disclosed. GSF can be isolated from the culture broth of a microorganism of the Family Enterobacteriaceae.
摘要翻译：公开了一种糖皮质激素保护因子（GSF），其扩增了在糖皮质激素中引起的肝酶诱导和GSF的生产过程。 GSF可以从肠杆菌科的微生物的培养液中分离出来。

7. 发明申请

US20190338374A1 KLEBSIELLA PNEUMONIAE STRAIN THAT INDUCES INFLAMMATION IN THE LIVER 审中-公开
公开(公告)号：US20190338374A1
公开(公告)日：2019-11-07
申请号：US16389454
申请日：2019-04-19
申请人： KEIO UNIVERSITY
发明人： Nobuhiro Nakamoto , Nobuo Sasaki , Ryo Aoki , Kentaro Miyamoto , Toshiro Sato , Takanori Kanai
IPC分类号： C12R1/22 , C12R1/37 , C12R1/46 , A01K67/027
摘要： To identify a microorganism causing the development of primary sclerosing cholangitis associated with ulcerative colitis. A Klebsiella pneumoniae strain inducing inflammation in the liver.

8. 发明申请

US20090142446A1 METHOD OF PRODUCING FOAMING ALCOHOLIC DRINK AND FOAMING ALCOHOLIC DRINK PRODUCED BY USING THE METHOD 审中-公开
标题翻译：生产泡沫酒精饮料的方法和使用该方法生产的泡沫酒精饮料
公开(公告)号：US20090142446A1
公开(公告)日：2009-06-04
申请号：US11814440
申请日：2006-01-20
申请人： Tatsuji Kimura , Shigehisa Yokoi , Syunsuke Fukuhara , Takeshi Nakamura , Atsuki Kawamura
发明人： Tatsuji Kimura , Shigehisa Yokoi , Syunsuke Fukuhara , Takeshi Nakamura , Atsuki Kawamura
IPC分类号： C12H1/15 , C12R1/37
CPC分类号： C12C7/053 , C12C5/00 , C12C12/00 , C12G3/02
摘要： A production method of a beer-taste alcoholic beverage with foaming properties which does not use barley wheat and malt, in which a proteolytic enzyme improving generating foam and foam stability is used as a part of a substance of raw materials, and the alcoholic beverage with foaming properties produced by the production method are disclosedThe production method of an alcoholic beverage with foaming properties, in which a pre-fermentation liquid is processed using a syrup containing sources of carbon, sources of nitrogen, hops, coloring matter, an improving substance for generating foam and for foam stability, and water as raw materials without using barley, wheat and malt, and the pre-fermentation liquid is fermented using a brewers' yeast. A proteolytic enzyme which has high enzymatic activity of the end-type protease activity and partially decomposes macro molecular protein is added into a mashing process as one part of a substance of raw materials together with pea protein, and a enzymatic reaction is performed. Thereby the production method of the alcoholic beverage with foaming properties having improved foaming properties and the alcoholic beverage with foaming properties produced by the production method can be provided. Also, the suitable ratio for the using amount of the added proteolytic enzyme having high enzymatic activity of the e protease is preferably 0.5-2% of the enzymatic amount per pea protein as a substrate which is condensed 10 fold, the reaction temperature of the enzyme is preferably 80-85° C., and the reaction time is preferably 30 minutes.
摘要翻译：具有发泡性的啤酒味酒精饮料的生产方法，其不使用大麦小麦和麦芽，其中使用提高发泡泡沫和泡沫稳定性的蛋白水解酶作为原料物质的一部分，并且含酒精饮料公开了通过制造方法制造的发泡性能具有发泡性的酒精饮料的制造方法，其中使用含碳源，氮源，啤酒花，着色剂，改良物质，产生泡沫和泡沫稳定性，以水为原料，不使用大麦，小麦和麦芽，并且使用酿造酵母发酵预发酵液体。作为原料物质的一部分与豌豆蛋白一起添加作为末端型蛋白酶活性的高酶活性并部分分解大分子蛋白质的蛋白水解酶作为糖化过程，并进行酶反应。因此，可以提供具有发泡性能发泡性的醇类饮料的制造方法和通过制造方法制造的具有起泡性的醇饮料。此外，e蛋白酶具有高酶活性的添加的蛋白水解酶的使用量的合适比例优选为每豌豆蛋白作为底物的酶量的0.5-2％，其浓缩10倍，酶的反应温度优选为80〜85℃，反应时间优选为30分钟。

9. 发明授权

US5888804A Processes for production of optically active quinuclidinol 失效
标题翻译：光学活性奎宁环醇的制备方法
公开(公告)号：US5888804A
公开(公告)日：1999-03-30
申请号：US034284
申请日：1998-03-04
申请人： Akinobu Matsuyama , Takeshi Hamatani
发明人： Akinobu Matsuyama , Takeshi Hamatani
IPC分类号： C12P17/12 , C12P17/18 , C12R1/06 , C12R1/37 , C12R1/38 , C12R1/645 , C12R1/72 , C12R1/78 , C07C00/00
CPC分类号： C12P17/182 , Y10S435/83 , Y10S435/874
摘要： The present invention provide processes for producing an optically active quinuclidinol from a quinuclidinone using an asymmetric reduction by a microorganism and enzyme with commercial advantages in simple and easy manner. In the present invention, permit a microorganism or preparation thereof to act on a quinuclidinone (3-quinuclidinone), and recover or harvest an optically active quinuclidinol produced (3-quinuclidinol). The microorganisms capable of producing an (R)-3-quinuclidinol from a 3-quinuclidinone include the genus Nakazawaea, the genus Candida and the genus Proteus. The microorganisms capable of producing an (S)-3-quinuclidinol from a 3-quinuclidinone include the genus Arthrobacter, the genus Pseudomonas and the genus Rhodosporidium.
摘要翻译：本发明提供了使用微生物和酶的不对称还原，以简便易行的商业优点从奎宁环酮生产光学活性奎宁环醇的方法。在本发明中，允许微生物或其制备物作用于奎宁环酮（3-奎宁环酮），并回收或收获所产生的光学活性奎宁环醇（3-奎宁环醇）。能够从3-奎宁环酮生成（R）-3-奎宁环醇的微生物包括中爪哇属（Nakazawaea），假丝酵母属（Candida）和变形菌属（Proteus）。能够从3-奎宁环酮生成（S）-3-奎宁环醇的微生物包括节杆菌属，假单胞菌属和红球菌属。

10. 发明授权

US5888798A Chondroitinase I and chondroitinase II producing mutants of P. vulgaris 失效
标题翻译：软骨素酶I和软骨素酶II产生普通寻常型突变体
公开(公告)号：US5888798A
公开(公告)日：1999-03-30
申请号：US476261
申请日：1995-06-07
申请人： Jason Arnold Lotvin , Kiran M. Khandke , Mark E. Ruppen
发明人： Jason Arnold Lotvin , Kiran M. Khandke , Mark E. Ruppen
IPC分类号： C12N15/09 , C12N1/21 , C12N9/88 , C12Q1/527 , C12R1/19 , C12R1/37 , C12N1/20
CPC分类号： C12R1/37 , C12N9/88 , Y10S435/873
摘要： Mutant Proteus vulgaris strains are provided that, when grown in the absence of an exogenous chondroitinase I and II inducer, produce P. vulgans chondroitinase I and chondroitinase II proteins. The mutants typically produce chondroitinase I and II proteins in the absence of exogenous inducers and in amounts in excess of those produced by wild-type P. vulgaris strains induced with such inducers. Two classes of such mutants, Classes 1 and 2, are disclosed. Class 1 and class 2 mutants differ in the relative amounts of chondroitinases I and II produced when cells are grown in casamino acids--supplemented minimal medium. Additional phenotypic variants that release chondroitinase I protein into the culture medium are provided as well. Also contemplated is a method for producing P. vulgaris chondroitinase I and II proteins. The mutant cells described above are cultured in the absence of a conventional exogenous chondroitinase I and II inducer, after which the cells are harvested and chondroitinase I and II are recovered from the harvested cells. A method for in situ detection of chondroitinase I and II production by bacterial colonies is also provided.
摘要翻译：提供突变型普通变形杆菌，当在不存在外源性软骨素酶I和II诱导物的情况下生长时，产生P. vulgans软骨素酶I和软骨素II蛋白。突变体通常在没有外源性诱导物的情况下产生软骨素酶I和II蛋白，并且其量超过由这种诱导物诱导的野生型寻常型菌株产生的那些。披露了两类这类突变体，1类和2类。 1类和2类突变体在细胞生长在补充有酪氨酸氨酸的基本培养基中时产生的软骨素酶I和II的相对量不同。还提供将软骨素酶蛋白质释放到培养基中的其他表型变体。还考虑了用于产生寻常性软骨素酶I和II蛋白质的方法。在不存在常规外源性软骨素酶I和II诱导剂的情况下培养上述突变细胞，之后收获细胞，从收获的细胞中回收软骨素酶I和II。还提供了通过细菌菌落原位检测软骨素酶I和II产生的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式