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1. 发明授权

US10724012B2 Glycosyltransferase glycosylating flavokermesic acid and/or kermesic acid 有权
公开(公告)号：US10724012B2
公开(公告)日：2020-07-28
申请号：US16160396
申请日：2018-10-15
申请人： Københavns Universitet , Danmarks Tekniske Universitet
发明人： Rubini Maya Kannangara , Mads Bennedsen , Bjørn Madsen , Kim Binderup , Ulf Thrane , Rasmus John Normand Frandsen , Uffe Hasbro Mortensen , Birger Lindberg Møller , Finn Thyge Okkels
IPC分类号： C12P7/66 , C12N9/10 , C12N15/81 , C12N15/63 , C12N1/14 , C12N15/80 , C12N1/20
摘要： An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic acid (KA) and use of this GT to e.g. make Carminic acid.

2. 发明申请

US20190194704A1 Method for Fermentative Production of Oxidized Coenzyme Q10 and High-Content Oxidized Coenzyme Q10 Prepared Therefrom 审中-公开
公开(公告)号：US20190194704A1
公开(公告)日：2019-06-27
申请号：US16016813
申请日：2018-06-25
申请人： ZHEJIANG NHU COMPANY LTD. , ZHEJIANG UNIVERSITY , HEILONGJIANG NHU BIOTECHNOLOGY COMPANY LTD. , SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD.
发明人： Shenfeng YUAN , Hongwei YU , Zhaofeng CHEN , Yongqiang ZHU , Yi MIN , Yong LI , Baishan HU , Guisheng QIU , Kai YU
IPC分类号： C12P7/66
摘要： The present application relates to a method for fermentative production of oxidized coenzyme Q10 and high-content oxidized coenzyme Q10 prepared therefrom. For the method for fermentative production of oxidized coenzyme Q10, in a fermentation process of a production strain, the oxidation-reduction potential (ORP) of a fermentation broth is controlled to be −50 to 300 Mv, and preferably the oxidation-reduction potential (ORP) of the fermentation broth is controlled to be 50 to 200 mV. By controlling the ORP of the fermentation broth, the method for fermentative production of oxidized coenzyme Q10 enables the oxidized coenzyme Q10 content in the coenzyme Q10 produced by microorganisms to reach 96% or more, and the product is substantially composed of a single component, which makes post-treatment more convenient. Oxidized coenzyme Q10 is more stable than reduced coenzyme Q10, and as compared with the coenzyme Q10 obtained by fermentative production in the prior art, high-content oxidized coenzyme Q10 degrades in a less amount in organisms. In addition, the fermentation method of the present application has a high potency.

3. 发明申请

US20160376569A1 GLYCOSYLTRANSFERASE GLYCOSYLATING FLAVOKERMESIC ACID AND/OR KERMESIC ACID 审中-公开
标题翻译：谷氨酰胆碱酯酶蛋白酶和/或灭活酸
公开(公告)号：US20160376569A1
公开(公告)日：2016-12-29
申请号：US15105673
申请日：2014-12-18
申请人： Kobenhavns Universitet , Marks Tekniske Universitet
发明人： Rubini Maya Kannangara , Mads Bennedsen , Bjon Madsen , Kim Binderup , Ulf Thrane , Rasmus John Normand Frandsen , Uffe Hasbro Mortensen , Birger Lindberg Moller , Finn Thyge Okkels
IPC分类号： C12N9/10 , C12P7/66
CPC分类号： C12N9/1048 , C12N1/14 , C12N1/20 , C12N9/1051 , C12N15/63 , C12N15/80 , C12N15/81 , C12N15/815 , C12P7/66 , C12Y204/00
摘要： An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic acid (KA) and use of this GT to e.g. make Carminic acid.
摘要翻译：一种分离的糖基转移酶（GT）多肽，其能够：（I）：将葡萄糖与黄酮酸（FK）缀合; 和/或（II）：将葡萄糖与凯麦酸（KA）缀合，并使用该GT至例如制成胭脂红酸。

4. 发明申请

US20160304915A1 PROCESS FOR PRODUCING COENZYME Q10 审中-公开
标题翻译：生产聚苯乙烯Q10的方法
公开(公告)号：US20160304915A1
公开(公告)日：2016-10-20
申请号：US15076025
申请日：2016-03-21
申请人： KANEKA CORPORATION
发明人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C12P7/66
CPC分类号： C12P7/66 , C12P7/22
摘要： A process for producing on an industrial scale the oxidized coenzyme Q10, includes culturing a reduced coenzyme Q10-producing microorganism selected from the group consisting of the genus Rhodobacter, the genus Saitoella, the genus Schizosaccharomyces and the genus Trichosporon, to obtain microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10; and one of: (a) oxidizing thus-obtained reduced coenzyme Q10 to oxidized coenzyme Q10 and then extracting the oxidized coenzyme Q10 by an organic solvent; or (b) extracting reduced coenzyme Q10 by an organic solvent and oxidizing the extracted reduced coenzyme Q10 to oxidized coenzyme Q10.
摘要翻译：一种在工业规模上生产氧化型辅酶Q10的方法，包括培养选自Rhodobacter属，Saitoella属，粟酒裂殖酵母属和Trichosporon属的还原型辅酶Q10产生微生物，以获得含有还原型辅酶Q10在整个辅酶Q10中的比例不小于70摩尔％; 和（a）将由此得到的还原型辅酶Q10氧化成氧化型辅酶Q10，然后用有机溶剂萃取氧化型辅酶Q10; 或（b）用有机溶剂萃取还原型辅酶Q10，将提取的还原型辅酶Q10氧化成氧化型辅酶Q10。

5. 发明授权

US09284537B2 Cytochrome P450 enzymes from Sorghum bicolor 有权
标题翻译：高粱双色细胞色素P450酶
公开(公告)号：US09284537B2
公开(公告)日：2016-03-15
申请号：US13862883
申请日：2013-04-15
申请人： The United States of America, as Represented by the Secretary of Agriculture
发明人： Zhiqiang Pan , Scott R. Baerson
IPC分类号： C12N9/02 , C12P7/22 , C12P7/66
CPC分类号： C12N9/0073 , C12N9/0071 , C12N15/82 , C12N2820/002 , C12N2820/007 , C12P7/22 , C12P7/66 , C12Y114/13
摘要： Two novel cytochrome P450 genes are isolated from sorghum, each gene encoding a protein having pentadecatrienyl resorcinol hydroxylase activity. Expression vectors containing these sequences are made and used to elevate levels of pentadecatrienyl resorcinol hydroxylase in transgenic cells and organisms.
摘要翻译：从高粱中分离出两种新的细胞色素P450基因，每种基因编码具有十五碳烯基间苯二酚羟化酶活性的蛋白质。制备含有这些序列的表达载体并用于提高转基因细胞和生物体中十五碳三烯基间苯二酚羟化酶的水平。

6. 发明申请

US20150240218A1 Polypeptides Having Peroxygenase Activity 有权
标题翻译：具有过氧化酶活性的多肽
公开(公告)号：US20150240218A1
公开(公告)日：2015-08-27
申请号：US14431925
申请日：2013-10-08
申请人： NOVOZYMES A/S
发明人： Sara Landvik , Lars Henrik Oestergaard , Lisbeth Kalum
IPC分类号： C12N9/08 , C12P17/00 , C12P7/22 , C12P7/66 , C11D3/386 , C12P7/40 , C12P7/42 , C12P7/04 , C12P7/26 , C12P13/00 , C12P7/24
CPC分类号： C12N9/0065 , C11D3/38654 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12P7/04 , C12P7/22 , C12P7/24 , C12P7/26 , C12P7/40 , C12P7/42 , C12P7/66 , C12P13/008 , C12P17/00 , C12Y111/02001 , C12Y111/02004
摘要： The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. A polynucleotide encoding a peroxygenase was isolated from Myceliophthora fergusii.
摘要翻译：本发明涉及具有过氧化酶活性的分离的多肽和编码多肽的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。编码过氧化酶的多核苷酸从丝状球菌中分离出来。

7. 发明授权

US08961963B2 Pharmacological composition whereby statin and COQ10 compounds are enhanced 有权
标题翻译：使他汀和COQ10化合物增强的药理学组成
公开(公告)号：US08961963B2
公开(公告)日：2015-02-24
申请号：US13501841
申请日：2009-12-28
申请人： Young-Hee Pyo
发明人： Young-Hee Pyo
IPC分类号： A61K35/00 , C12P1/00 , C12P7/66 , A61K31/122 , A61K36/062 , A61K45/06 , C12P17/06
CPC分类号： C12P7/66 , A61K31/122 , A61K36/062 , A61K45/06 , C12P17/06 , A61K2300/00
摘要： Disclosed is a pharmaceutical natural composition containing both statin compounds (mevinolin and mevinolinic acid) serving as cholesterol biosynthesis inhibitors and coenzyme Q (ubiquinone-10: CoQ10 and ubiquinone-9: CoQ9) compounds which are substances that inhibit factors causing complications such as myalgia involved in long-term use of the statin, prepared using Monascus sp. and natural medicinal substances such as ginseng, mushrooms and cereals.
摘要翻译：公开了含有作为胆固醇生物合成抑制剂的他汀类化合物（美维林和甲维林酸）和辅酶Q（泛醌-10：CoQ10和泛醌-9：CoQ9）化合物的药物天然组合物，其是抑制引起并发症的因素，例如涉及肌痛在长期使用他汀类药物，使用红曲霉制备。和天然药用物质如人参，蘑菇和谷物。

8. 发明授权

US08460904B2 Method of producing reduced coenzyme Q10 有权
标题翻译：生产还原型辅酶Q10的方法
公开(公告)号：US08460904B2
公开(公告)日：2013-06-11
申请号：US13054560
申请日：2009-04-15
申请人： Lei Ren , Qiao Ren
发明人： Lei Ren , Qiao Ren
IPC分类号： C12P7/66
CPC分类号： C12P7/66 , C12P7/22
摘要： The present invention relates to a method of producing high-quality reduced coenzyme Q10 converted from oxidized coenzyme Q10 by natural reductase. It is stable, completely natural and can be used on injection. This method is suitable for large-scale industrial production without special protective environment/atmosphere. The method of producing reduced coenzyme Q10 includes three stages: {circle around (1)} phosphorylation of oxidized coenzyme Q10 {circle around (2)} reduction of phosphorylated oxidized coenzyme Q Q10 by biological reductase {circle around (3)} extracting reduced coenzyme Q10 from reductases.
摘要翻译：本发明涉及通过天然还原酶从氧化型辅酶Q10生成高品质还原型辅酶Q10的方法。它是稳定的，完全天然的，可以用于注射。该方法适用于没有特殊保护环境/大气的大规模工业化生产。生产还原型辅酶Q10的方法包括三个阶段：生物还原酶（（3）周围）环氧化辅酶Q10（环绕（2）周围的磷酸化氧化辅酶Q Q10的周期循环（3）}提取还原型辅酶 Q10来自还原酶。

9. 发明授权

US08318463B2 Δ8 desaturases and their use in making polyunsaturated fatty acids 有权
标题翻译：＆Dgr; 8去饱和酶及其在制备多不饱和脂肪酸中的用途
公开(公告)号：US08318463B2
公开(公告)日：2012-11-27
申请号：US12825537
申请日：2010-06-29
申请人： Howard Glenn Damude , Quinn Qun Zhu
发明人： Howard Glenn Damude , Quinn Qun Zhu
IPC分类号： C12P7/66 , C12N15/74 , A01N63/00 , C07H21/04 , A61K48/00
CPC分类号： C12P7/6427 , C12N9/0083 , C12N15/8247
摘要： The present invention relates to Δ8 desaturase genes, which have the ability to convert eicosadienoic acid (EDA; 20:2 ω-6) to dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) and/or eicosatrienoic acid (ETrA; 20:3 ω-3) to eicosatetraenoic acid (ETA; (20:3 ω-3). Isolated nucleic acid fragments and recombinant DNA constructs comprising such fragments encoding Δ8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ8 desaturases in oleaginous yeast are disclosed.
摘要翻译：本发明涉及具有将二十碳二烯酸（EDA; 20：2ω-6）转化为二高-γ-亚麻酸（DGLA; 20：3ω-6）和/或二十碳三烯酸的能力的Dgr .8去饱和酶基因分离的核酸片段和重组DNA构建体，其包含编码“Dgr。8”去饱和酶的片段，以及一种制备长链多糖的方法，公开了在含油酵母中使用这些＆Dgr。8去饱和酶的链多不饱和脂肪酸（PUFA）。

10. 发明授权

US08114642B2 Method for producing vitamin K2 from culture of Bacillus natto 有权
标题翻译：从纳豆芽孢杆菌培养物生产维生素K2的方法
公开(公告)号：US08114642B2
公开(公告)日：2012-02-14
申请号：US11823769
申请日：2007-06-28
申请人： Shinsaku Takaoka , Masaharu Yoshida
发明人： Shinsaku Takaoka , Masaharu Yoshida
IPC分类号： C12P7/66
CPC分类号： A23L33/15
摘要： A method for producing vitamin K2 comprising: culturing Bacillus natto in a liquid medium to obtain a Bacillus natto culture or culture supernatant thereof, wherein the culture or culture supernatant contains vitamin K2; treating the culture or culture supernatant with at least one coagulant selected from the group consisting of an inorganic coagulant and a cationic polymer coagulant, with the proviso that the coagulant excludes chitosan, so as to obtain a treated coagulant to which vitamin K2 is absorbed or aggregated; separating the treated coagulant from the treated culture or culture supernatant, and obtaining an oily product that contains vitamin K2 from the separated coagulant.
摘要翻译：一种生产维生素K2的方法，包括：在液体培养基中培养纳豆芽孢杆菌以获得纳豆芽孢杆菌培养物或其培养物上清液，其中培养物或培养物上清液含有维生素K2; 用选自无机凝结剂和阳离子聚合物凝结剂的至少一种凝结剂处理培养物或培养物上清液，条件是凝结剂不含壳聚糖，以获得维生素K2被吸收或聚集的处理过的凝结剂 ; 从经处理的培养物或培养上清液中分离经处理的凝结剂，从分离的凝结剂中获得含有维生素K2的油状产物。

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