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1. 发明授权

US07238324B2 Microfluidic device for the controlled movement of fluid 失效
标题翻译：用于流体控制运动的微流体装置
公开(公告)号：US07238324B2
公开(公告)日：2007-07-03
申请号：US10615441
申请日：2003-07-07
申请人： Jong Soo Ko , Hyun Chul Yoon , Hae Sik Yang , Dae-Sik Lee , Kwang Hyo Chung , Hyeon Bong Pyo , Sung Jin Kim , Yun Tae Kim
发明人： Jong Soo Ko , Hyun Chul Yoon , Hae Sik Yang , Dae-Sik Lee , Kwang Hyo Chung , Hyeon Bong Pyo , Sung Jin Kim , Yun Tae Kim
IPC分类号： B01L3/02
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502746 , B01L2200/16 , B01L2300/0645 , B01L2300/0867 , B01L2400/0406 , B01L2400/0442 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , B01L2400/088 , B33Y70/00 , B33Y80/00 , Y10T436/25
摘要： A microfluidic device for controlling the flow of a micro amount of fluid is provided. The microfluidic device is manufactured by binding a sensing substrate including a sensing electrode, an electrode interconnect, and a electrode pad, with a channel substrate including at least two fluid inlet ports, a chamber, and a channel, wherein a first fluid injected via one of the fluid inlet ports flows by natural capillary force, and a second fluid injected via another fluid inlet port is forced to flow by an external pump. The microfluidic device controls fluid flow and flow stoppage by a combination of natural capillary flow and an externally applied pressure as a result of the action of a pump.
摘要翻译：提供了用于控制微量流体流动的微流体装置。微流体装置通过将包括感测电极，电极互连和电极焊盘的感测衬底与包括至少两个流体入口端口，腔室和通道的通道衬底结合来制造，其中通过一个注入的第一流体的流体入口端口通过天然毛细管力流动，并且通过另一流体入口喷射的第二流体被迫使外部泵流动。由于泵的作用，微流体装置通过天然毛细管流动和外部施加的压力的组合来控制流体流动和流动停止。

2. 发明申请

US20080064086A1 PLASTIC-BASED MICROFABRICATED THERMAL DEVICE, MANUFACTURING METHOD THEREOF, DNA AMPLIFICATION CHIP USING THE PLASTIC-BASED MICROFABRICATED THERMAL DEVICE, AND METHOD FOR MANUFACTURING THE DNA AMPLIFICATION CHIP 审中-公开
标题翻译：基于塑料的微晶热装置，其制造方法，使用基于塑料的微晶热装置的DNA扩增芯片，以及用于制造DNA扩增芯片的方法
公开(公告)号：US20080064086A1
公开(公告)日：2008-03-13
申请号：US11854401
申请日：2007-09-12
申请人： Dae-Sik Lee , Se-Ho Park , Kwang-Hyo Chung , Hyeon-Bong Pyo
发明人： Dae-Sik Lee , Se-Ho Park , Kwang-Hyo Chung , Hyeon-Bong Pyo
IPC分类号： C12M1/02 , B05D3/00 , H05B3/03 , B05D5/00
CPC分类号： H05B3/267 , B01J2219/00317 , B01J2219/00662 , B01J2219/00722 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/12 , B01L2200/147 , B01L2300/0645 , B01L2300/12 , B01L2300/1827 , G01N2035/00158
摘要： Provided are a microfabricated thermal device using a thin plastic substrate, a manufacturing method thereof, a silicon micro-chamber, a double-stranded deoxyribonucleic acid (DNA) amplification chip employing the microfabricated thermal device and the silicon micro-chamber, and a manufacturing method thereof, and a DNA amplification chip array, and a method for manufacturing the DNA amplification chip array. The microfabricated thermal device using a thin plastic substrate can be used for DNA amplification, i.e., a polymerase chain reaction (PCR), which is essential to DNA related diagnosis and analysis. The plastic-based microfabricated thermal device, includes: a plastic substrate; a heating unit disposed on the top surface of the plastic substrate to supply heat to the plastic substrate; a sensing unit disposed on the top surface of the plastic substrate to detect heat; and a diffusing unit disposed on the bottom surface of the plastic substrate to diffuse heat to the plastic substrate.
摘要翻译：提供使用薄塑料基板的微制造热装置，其制造方法，硅微室，采用微制造热装置和硅微室的双链脱氧核糖核酸（DNA）扩增芯片，以及制造方法以及DNA扩增芯片阵列，以及DNA扩增芯片阵列的制造方法。使用薄塑料底物的微制造热装置可以用于DNA扩增，即聚合酶链式反应（PCR），这对DNA相关的诊断和分析至关重要。基于塑料的微制造热装置，包括：塑料基板; 加热单元，设置在所述塑料基板的顶表面上以向所述塑料基板供应热量; 感测单元，设置在所述塑料基板的顶表面上以检测热量; 以及设置在塑料基板的底表面上以将热量扩散到塑料基板的漫射单元。

3. 发明授权

US08735103B2 Natural convection-driven PCR apparatus and method using disposable polymer chip 有权
标题翻译：自然对流驱动PCR装置及使用一次性聚合物芯片的方法
公开(公告)号：US08735103B2
公开(公告)日：2014-05-27
申请号：US11866979
申请日：2007-10-03
申请人： Kwang-Hyo Chung , Dae-Sik Lee , Hyeon-Bong Pyo , Seon-Hee Park
发明人： Kwang-Hyo Chung , Dae-Sik Lee , Hyeon-Bong Pyo , Seon-Hee Park
IPC分类号： C12P19/62 , C12M1/36 , C12M1/38 , C12Q1/68 , B01L7/00
CPC分类号： C12Q1/686 , B01L3/5027 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2300/088 , B01L2300/1827 , B01L2400/0445 , B01L2400/0472 , B01L2400/0688 , B33Y80/00 , C12Q1/6844
摘要： Provided is a natural convection-driven polymerase chain reaction (PCR) apparatus and method, which can periodically change temperature of a sample to make a natural convection-driven flow in a loop-shaped channel on a disposable polymer chip and contacting heating metal members maintained at different temperatures with channels. The natural convection-driven PCR apparatus includes: a polymer chip having a plurality of channels connected together to form a loop-shaped microchannel, a sample being filled inside the channels; a plurality of heating metal members contacting the loop-shaped microchannel of the polymer chip and transferring heat; a temperature controller connected to the heating metal members to maintain the heating metal members at different temperatures; a plurality of heaters connected to the heating metal members and the temperature controller to supply heat to the heating metal members; and temperature sensors connected to the heating metal members and the temperature controller.
摘要翻译：提供了一种自然对流驱动的聚合酶链反应（PCR）装置和方法，其可以周期性地改变样品的温度以在一次性聚合物芯片上的环形通道中进行自然对流驱动的流动，并且接触保持的加热金属构件在不同的温度与通道。自然对流驱动PCR装置包括：聚合物芯片，具有连接在一起形成环形微通道的多个通道，样品填充在通道内; 与聚合物芯片的环形微通道接触并传递热量的多个加热金属构件; 连接到所述加热金属部件以将所述加热金属部件保持在不同温度的温度控制器; 连接到加热金属部件的多个加热器和温度控制器，以向加热金属部件供热; 温度传感器连接到加热金属部件和温度控制器。

4. 发明申请

US20080286153A1 Affinity Chromatography Microdevice and Method for Manufacturing the Same 审中-公开
标题翻译：亲和层析微装置及其制造方法
公开(公告)号：US20080286153A1
公开(公告)日：2008-11-20
申请号：US12094980
申请日：2006-11-27
申请人： Dae-Sik Lee , Hyun-Cheol Yoon , Kwang-Hyo Chung , Hyeon-Bong Pyo , Chang-Auck Choi
发明人： Dae-Sik Lee , Hyun-Cheol Yoon , Kwang-Hyo Chung , Hyeon-Bong Pyo , Chang-Auck Choi
IPC分类号： G01N30/02 , B05D3/14
CPC分类号： G01N30/6095 , B01L3/5027
摘要： An affinity chromatography microdevice includes a top board and a bottom board. The top board includes an inlet and an outlet through which microfluid flows, and a reaction chamber for limiting the flow of the microfluid for reaction. The bottom board includes a microelectrode for independently controlling a micro-temperature, and a thermosensitive polymer matrix formed on the microelectrode. The thermosensitive polymer matrix is contracted or expanded according to temperature change.
摘要翻译：亲和层析微装置包括顶板和底板。顶板包括微流体流过的入口和出口，以及用于限制用于反应的微流体流动的反应室。底板包括用于独立控制微温度的微电极和形成在微电极上的热敏聚合物基体。热敏聚合物基体根据温度变化而收缩或膨胀。

5. 发明申请

US20100159576A1 BIOCHIP AND BIOMATERIAL DETECTION APPARATUS 审中-公开
标题翻译：生物和生物材料检测装置
公开(公告)号：US20100159576A1
公开(公告)日：2010-06-24
申请号：US12643969
申请日：2009-12-21
申请人： Hyun Woo SONG , Dae-Sik Lee , Hyeon-Bong Pyo , Kwang Hyo Chung , Moon Youn Jung
发明人： Hyun Woo SONG , Dae-Sik Lee , Hyeon-Bong Pyo , Kwang Hyo Chung , Moon Youn Jung
IPC分类号： C12M1/34 , G01N21/64
CPC分类号： G01N21/648 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00702 , B01L3/502715
摘要： Provided are a biochip and a biomaterial detection apparatus. The biochip includes a substrate, a metal layer, and a dielectric layer. The substrate includes a surface having a plurality of acute parts which are formed by first and second inclined planes. The metal layer is formed on at least one of the first and second inclined planes. The dielectric layer is formed on the metal layer, and capture molecules specifically binding to target molecules which are marked with a fluorescent substance are immobilized to a surface of the dielectric layer.
摘要翻译：提供了生物芯片和生物材料检测装置。生物芯片包括衬底，金属层和电介质层。基板包括具有由第一和第二倾斜平面形成的多个锐角部分的表面。金属层形成在第一和第二倾斜平面中的至少一个上。电介质层形成在金属层上，捕获与荧光物质标记的靶分子特异结合的捕获分子被固定在电介质层的表面。

6. 发明申请

US20080131956A1 NATURAL CONVECTION-DRIVEN PCR APPARATUS AND METHOD USING DISPOSABLE POLYMER CHIP 有权
标题翻译：自然对流驱动PCR装置和使用可分散聚合物芯片的方法
公开(公告)号：US20080131956A1
公开(公告)日：2008-06-05
申请号：US11866979
申请日：2007-10-03
申请人： Kwang-Hyo CHUNG , Dae-Sik Lee , Hyeon-Bong Pyo , Seon-Hee Park
发明人： Kwang-Hyo CHUNG , Dae-Sik Lee , Hyeon-Bong Pyo , Seon-Hee Park
IPC分类号： C12M1/36
CPC分类号： C12Q1/686 , B01L3/5027 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2300/088 , B01L2300/1827 , B01L2400/0445 , B01L2400/0472 , B01L2400/0688 , B33Y80/00 , C12Q1/6844
摘要： Provided is a natural convection-driven polymerase chain reaction (PCR) apparatus and method, which can periodically change temperature of a sample to make a natural convection-driven flow in a loop-shaped channel on a disposable polymer chip and contacting heating metal members maintained at different temperatures with channels. The natural convection-driven PCR apparatus includes: a polymer chip having a plurality of channels connected together to form a loop-shaped microchannel, a sample being filled inside the channels; a plurality of heating metal members contacting the loop-shaped microchannel of the polymer chip and transferring heat; a temperature controller connected to the heating metal members to maintain the heating metal members at different temperatures; a plurality of heaters connected to the heating metal members and the temperature controller to supply heat to the heating metal members; and temperature sensors connected to the heating metal members and the temperature controller.
摘要翻译：提供了一种自然对流驱动的聚合酶链反应（PCR）装置和方法，其可以周期性地改变样品的温度以在一次性聚合物芯片上的环形通道中进行自然对流驱动的流动，并且接触保持的加热金属构件在不同的温度与通道。自然对流驱动PCR装置包括：聚合物芯片，具有连接在一起形成环形微通道的多个通道，样品填充在通道内; 与聚合物芯片的环形微通道接触并传递热量的多个加热金属构件; 连接到所述加热金属部件以将所述加热金属部件保持在不同温度的温度控制器; 连接到加热金属部件的多个加热器和温度控制器，以向加热金属部件供热; 温度传感器连接到加热金属部件和温度控制器。

7. 发明申请

US20100158761A1 MICROFLUIDIC CONTROL APPARATUS AND METHOD OF ASSEMBLING THE SAME 有权
标题翻译：微流控制装置及其装配方法
公开(公告)号：US20100158761A1
公开(公告)日：2010-06-24
申请号：US12542627
申请日：2009-08-17
申请人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
发明人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
IPC分类号： B01J19/00 , B23P11/00 , B81C1/00
CPC分类号： B01J19/0093 , B01J2219/00373 , B01J2219/00376 , B01J2219/00891 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2300/044 , B01L2300/0816 , B01L2300/0867 , B01L2400/0457 , B01L2400/0487 , B01L2400/06 , Y10T29/494 , Y10T29/49826
摘要： Provided is a microfluidic control apparatus that includes at least one control means and a microfluidic control chip. When the microfluidic control chip is loaded to the control means, a needle provided to the control means is inserted into a reaction solution storage chamber of the microfluidic control chip, in which the reaction solution storage chamber is sealed with a sealing tape. Thus, fluid connection is easily formed between the microfluidic control chip and the control means without leakage.
摘要翻译：提供了一种微流控制装置，其包括至少一个控制装置和微流控制芯片。当将微流控制芯片装载到控制装置时，将提供给控制装置的针插入到微流控制芯片的反应溶液储存室中，其中反应溶液储存室用密封胶带密封。因此，在微流控制芯片和控制装置之间容易形成流体连接而没有泄漏。

8. 发明申请

US20100143194A1 MICROFLUIDIC DEVICE 审中-公开
标题翻译：微流体装置
公开(公告)号：US20100143194A1
公开(公告)日：2010-06-10
申请号：US12493092
申请日：2009-06-26
申请人： Dae-Sik Lee , Yo Han Choi , Kwang Hyo Chung , JuHyun Jeon , Hyun Woo Song , Moon Youn Jung , Seon Hee Park
发明人： Dae-Sik Lee , Yo Han Choi , Kwang Hyo Chung , JuHyun Jeon , Hyun Woo Song , Moon Youn Jung , Seon Hee Park
IPC分类号： B01J19/00
CPC分类号： F04B19/006 , B01L3/50273 , B01L9/52 , B01L13/02 , B01L2300/0681 , B01L2300/0816 , B01L2300/1827 , B01L2400/0406 , B01L2400/046 , B01L2400/0677
摘要： Provided is a microfluidic device. The microfluidic device includes a sample storage chamber storing sample fluid therein, a detection chamber connected to the sample storage chamber and detecting a specific material of the sample fluid, a cleaning liquid storage chamber connected to the detection chamber and storing cleaning liquid therein, a plurality of fluid passages interconnecting the chambers, and a micropump transferring the cleaning liquid. The microfluidic device precisely inspects a sample fluid although a small amount of the sample fluid flows.
摘要翻译：提供了一种微流体装置。微流体装置包括在其中容纳样品流体的样品储存室，连接到样品储存室并检测样品流体的特定材料的检测室，连接到检测室并在其中储存清洗液体的清洗液储存室，多个连接腔室的流体通道和传送清洗液体的微型泵。微流体装置精确检查样品流体，尽管少量样品流体流动。

9. 发明授权

US08309040B2 Microfluidic control apparatus and method of assembling the same 有权
标题翻译：微流控制装置及其组装方法
公开(公告)号：US08309040B2
公开(公告)日：2012-11-13
申请号：US12542627
申请日：2009-08-17
申请人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
发明人： Kwang Hyo Chung , Dae-Sik Lee , Hyun Woo Song , Yo Han Choi
IPC分类号： B01J8/00 , B01L3/00
CPC分类号： B01J19/0093 , B01J2219/00373 , B01J2219/00376 , B01J2219/00891 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2300/044 , B01L2300/0816 , B01L2300/0867 , B01L2400/0457 , B01L2400/0487 , B01L2400/06 , Y10T29/494 , Y10T29/49826
摘要： Provided is a microfluidic control apparatus that includes at least one control means and a microfluidic control chip. When the microfluidic control chip is loaded to the control means, a needle provided to the control means is inserted into a reaction solution storage chamber of the microfluidic control chip, in which the reaction solution storage chamber is sealed with a sealing tape. Thus, fluid connection is easily formed between the microfluidic control chip and the control means without leakage.
摘要翻译：提供了一种微流控制装置，其包括至少一个控制装置和微流控制芯片。当将微流控制芯片装载到控制装置时，将提供给控制装置的针插入到微流控制芯片的反应溶液储存室中，其中反应溶液储存室用密封胶带密封。因此，在微流控制芯片和控制装置之间容易形成流体连接而没有泄漏。

10. 发明申请

US20100159573A1 MICROFLUIDIC DILUTION DEVICE 审中-公开
标题翻译：微流体稀释装置
公开(公告)号：US20100159573A1
公开(公告)日：2010-06-24
申请号：US12534012
申请日：2009-07-31
申请人： Kwang Hyo CHUNG , JuHyun Jeon , Dae-Sik Lee , Moon Youn Jung , Seon Hee Park
发明人： Kwang Hyo CHUNG , JuHyun Jeon , Dae-Sik Lee , Moon Youn Jung , Seon Hee Park
IPC分类号： C12M1/00 , B01L3/00 , G01N33/48
CPC分类号： G01N1/38
摘要： Provided is a microfluidic dilution device that uses capillary force to dilute first and second fluids in a predetermined ratio. The microfluidic dilution device includes a channel plate, a cover plate, fluid chambers, and a confluence chamber. The fluid chambers are filled with first and second fluids in a predetermined ratio. First and second fluids flowing to the confluence chamber are diluted in a predetermined ratio.
摘要翻译：提供了使用毛细管力以预定比例稀释第一和第二流体的微流体稀释装置。微流体稀释装置包括通道板，盖板，流体室和汇合室。流体室以预定比例填充有第一和第二流体。流入合流室的第一和第二流体以预定比例稀释。

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