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1. 发明申请

US20100121215A1 SEIZURE DETECTION ALGORITHM ADJUSTMENT 审中-公开
标题翻译：检测检测算法调整
公开(公告)号：US20100121215A1
公开(公告)日：2010-05-13
申请号：US12432268
申请日：2009-04-29
申请人： Jonathon E. Giftakis , Nathan A. Torgerson
发明人： Jonathon E. Giftakis , Nathan A. Torgerson
IPC分类号： A61B5/0476 , A61B5/11
摘要： A medical system implements a seizure detection algorithm to detect a seizure based on a first patient parameter. The medical system monitors a second patient parameter to adjust the seizure detection algorithm. In some examples, the medical system determines whether a seizure for which therapy delivery is desirable occurred based on a second patient parameter. If a target seizure occurred, and the seizure detection algorithm did not detect the target seizure, the medical system adjusts the seizure detection algorithm to detect the target seizure. For example, the medical system may determine a first patient parameter characteristic indicative of the target seizure detected based on the second patient parameter and store the first patient parameter characteristic as part of the seizure detection algorithm. In some examples, the first patient parameter is an electrical brain signal and the second patient parameter is patient activity (e.g., patient motion or posture).
摘要翻译：医疗系统实施缉获检测算法以基于第一患者参数检测癫痫发作。医疗系统监测第二个患者参数以调整发作检测算法。在一些示例中，医疗系统基于第二患者参数确定是否期望发生治疗递送的癫痫发作。如果发生目标发作，并且癫痫发作检测算法未检测到目标癫痫发作，则医疗系统调整癫痫发作检测算法以检测目标癫痫发作。例如，医疗系统可以基于第二患者参数确定指示检测到的目标发作的第一患者参数特征，并将第一患者参数特征存储为发作检测算法的一部分。在一些示例中，第一患者参数是电脑信号，第二患者参数是患者活动（例如患者运动或姿势）。

2. 发明授权

US09333350B2 Psychiatric disorder therapy control 有权
标题翻译：精神障碍治疗控制
公开(公告)号：US09333350B2
公开(公告)日：2016-05-10
申请号：US12425903
申请日：2009-04-17
申请人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
发明人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
IPC分类号： A61N1/00 , A61N1/36 , A61B5/16 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/00
CPC分类号： A61N1/36082 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/0816 , A61B5/165 , A61B5/441 , A61B5/4836 , A61B5/7275 , G06F19/00 , G16H20/70 , G16H40/63
摘要： A therapy system for managing a psychiatric disorder of the patient may be controlled based on a patient mood state. Therapy may be delivered to a patient according to a therapy program, and a physiological parameter of the patient may be monitored during or after therapy delivery. The patient mood state may be determined based on the monitored physiological parameter, and the therapy delivery may be controlled based on the determined mood state. In some embodiments, the therapy delivery is stopped prior to determining the patient mood state and the therapy delivery is restarted upon detecting a negative mood state. In other embodiments, therapy delivery is delivered until a positive mood state is detected, at which point the therapy delivery may be stopped.
摘要翻译：可以基于患者情绪状态来控制用于管理患者精神障碍的治疗系统。治疗可以根据治疗程序递送到患者，并且可以在治疗递送期间或之后监测患者的生理参数。可以基于所监测的生理参数来确定患者情绪状态，并且可以基于所确定的情绪状态来控制治疗递送。在一些实施例中，在确定患者情绪状态之前停止治疗递送，并且在检测到负情绪状态时重新开始治疗递送。在其它实施方案中，递送治疗递送直到检测到正状态，此时可以停止治疗递送。

3. 发明申请

US20090264956A1 PSYCHIATRIC DISORDER THERAPY CONTROL 有权
标题翻译：心理障碍治疗控制
公开(公告)号：US20090264956A1
公开(公告)日：2009-10-22
申请号：US12425903
申请日：2009-04-17
申请人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
发明人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/0816 , A61B5/165 , A61B5/441 , A61B5/4836 , A61B5/7275 , G06F19/00 , G16H20/70 , G16H40/63
摘要： A therapy system for managing a psychiatric disorder of the patient may be controlled based on a patient mood state. Therapy may be delivered to a patient according to a therapy program, and a physiological parameter of the patient may be monitored during or after therapy delivery. The patient mood state may be determined based on the monitored physiological parameter, and the therapy delivery may be controlled based on the determined mood state. In some embodiments, the therapy delivery is stopped prior to determining the patient mood state and the therapy delivery is restarted upon detecting a negative mood state. In other embodiments, therapy delivery is delivered until a positive mood state is detected, at which point the therapy delivery may be stopped.
摘要翻译：可以基于患者情绪状态来控制用于管理患者精神障碍的治疗系统。治疗可以根据治疗程序递送到患者，并且可以在治疗递送期间或之后监测患者的生理参数。可以基于所监测的生理参数来确定患者情绪状态，并且可以基于所确定的情绪状态来控制治疗递送。在一些实施例中，在确定患者情绪状态之前停止治疗递送，并且在检测到负情绪状态时重新开始治疗递送。在其它实施方案中，递送治疗递送直到检测到正状态，此时可以停止治疗递送。

4. 发明授权

US10543359B2 Seizure detection algorithm adjustment 有权
公开(公告)号：US10543359B2
公开(公告)日：2020-01-28
申请号：US12432268
申请日：2009-04-29
申请人： Jonathon E. Giftakis , Nathan A. Torgerson
发明人： Jonathon E. Giftakis , Nathan A. Torgerson
IPC分类号： A61B5/0476 , A61N1/05 , A61B5/03 , A61B5/00 , A61N1/36
摘要： A medical system implements a seizure detection algorithm to detect a seizure based on a first patient parameter. The medical system monitors a second patient parameter to adjust the seizure detection algorithm. In some examples, the medical system determines whether a seizure for which therapy delivery is desirable occurred based on a second patient parameter. If a target seizure occurred, and the seizure detection algorithm did not detect the target seizure, the medical system adjusts the seizure detection algorithm to detect the target seizure. For example, the medical system may determine a first patient parameter characteristic indicative of the target seizure detected based on the second patient parameter and store the first patient parameter characteristic as part of the seizure detection algorithm. In some examples, the first patient parameter is an electrical brain signal and the second patient parameter is patient activity (e.g., patient motion or posture).

5. 发明授权

US10369353B2 Seizure disorder evaluation based on intracranial pressure and patient motion 有权
公开(公告)号：US10369353B2
公开(公告)日：2019-08-06
申请号：US12359037
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
IPC分类号： A61B5/03 , A61N1/05 , A61B5/00 , A61N1/36
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.

6. 发明授权

US10111613B2 Methods for data retention in an implantable medical device 有权
公开(公告)号：US10111613B2
公开(公告)日：2018-10-30
申请号：US11264846
申请日：2005-11-02
申请人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , David L. Carlson
发明人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , David L. Carlson
IPC分类号： A61B5/00 , A61B5/04 , A61N1/372 , G06F19/00 , G06F17/30 , A61B5/0205 , A61B5/0402 , A61B5/0476 , A61B5/11 , A61B5/16 , G16H10/60 , A61N1/36 , A61N1/365 , A61N1/37 , A61B5/021 , A61B5/024 , A61B5/03 , A61B5/08 , G16H40/63
摘要： Methods for storing data records associated with a medical monitoring event in a data structure. An implanted device obtains data and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.

7. 发明授权

US09888861B2 Method and apparatus for detecting a biomarker in the presence of electrical stimulation 有权
公开(公告)号：US09888861B2
公开(公告)日：2018-02-13
申请号：US13589270
申请日：2012-08-20
申请人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
发明人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0476 , A61B5/0488 , A61B5/0496
CPC分类号： A61B5/04012 , A61B5/04001 , A61B5/04014 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/4082 , A61B5/4094 , A61B5/7264 , A61B5/7282
摘要： Various embodiments concern identifying a biomarker in the presence of electrical stimulation. Various embodiments concern delivering electrical stimulation to a patient and sensing one or more signals while the electrical stimulation is being delivered, the one or more signals including data indicative of physiological activity. Various embodiments further include determining an intensity of the electrical stimulation and determining whether the data indicates the presence of a biomarker based on a variable threshold, the variable threshold being variable based on the intensity of the electrical stimulation. Various embodiments concern determining a relationship between stimulation intensity and a biomarker parameter to determine the variability of the variable threshold.

8. 发明授权

US08744562B2 Method for monitoring or treating nervous system disorders 有权
标题翻译：监测或治疗神经系统疾病的方法
公开(公告)号：US08744562B2
公开(公告)日：2014-06-03
申请号：US12965608
申请日：2010-12-10
申请人： Jonathon E. Giftakis , Nina M. Graves
发明人： Jonathon E. Giftakis , Nina M. Graves
IPC分类号： A61B5/04
CPC分类号： A61B5/0476 , A61B5/0031 , A61B5/02 , A61B5/0245 , A61B5/0402 , A61B5/0452 , A61B5/0478 , A61B5/053 , A61B5/08 , A61B5/0816 , A61B5/1135 , A61B5/4094 , A61N1/05 , A61N1/3601 , A61N1/36082 , A61N1/36135 , A61N1/362 , A61N1/36521 , A61N1/36585 , A61N1/37 , A61N1/37247 , A61N1/37282 , A61N1/37288 , A61N1/3962
摘要： A medical device system that includes a brain monitoring element, cardiac monitoring element and a processor. The processor is configured to receive a brain signal from the brain monitoring element and a cardiac signal from the cardiac monitoring element. The processor is further configured to compare the brain signal to the cardiac signal. A method of comparing a brain signal to a cardiac signal is also provided.
摘要翻译：一种包括脑部监测元件，心脏监测元件和处理器的医疗装置系统。处理器被配置为从脑监测元件接收脑信号和来自心脏监测元件的心脏信号。处理器还被配置为将脑信号与心脏信号进行比较。还提供了将脑信号与心脏信号进行比较的方法。

9. 发明申请

US20120191157A1 TARGET THERAPY DELIVERY SITE SELECTION 有权
标题翻译：目标治疗交付网站选择
公开(公告)号：US20120191157A1
公开(公告)日：2012-07-26
申请号：US13358179
申请日：2012-01-25
申请人： Paul H. Stypulkowski , Jonathon E. Giftakis
发明人： Paul H. Stypulkowski , Jonathon E. Giftakis
IPC分类号： A61N1/36
CPC分类号： A61N1/36064 , A61N1/0534 , A61N1/36135 , A61N1/36171 , A61N1/36185
摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
摘要翻译：在选择用于治疗患者状况的靶治疗递送部位的一些实例中，相对高频率的电刺激信号被递送到患者脑部的第一区域（例如，丘脑的前核）内的至少两个区域并且确定响应于递送的刺激的患者脑的第二区域（例如，海马）中的脑活动（例如，由生物电脑信号所示）的变化。可以基于脑活动的变化来选择靶治疗递送部位，电极组合或两者。

10. 发明授权

US08187181B2 Scoring of sensed neurological signals for use with a medical device system 有权
标题翻译：感觉神经信号的评分与医疗器械系统一起使用
公开(公告)号：US08187181B2
公开(公告)日：2012-05-29
申请号：US10687389
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Nina M. Graves , Jonathon E. Giftakis
发明人： Ivan Osorio , Mark G. Frei , Nina M. Graves , Jonathon E. Giftakis
IPC分类号： A61B5/00
CPC分类号： A61N1/3702 , A61B5/048 , A61B5/4064 , A61B5/4094 , A61N1/36017 , A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/37252 , Y10S128/92
摘要： A medical device system capable of scoring a severity of sensed neurological signals relating to a nervous system disorder. The system comprises a monitoring element that receives a neurological signal having at least one event to be scored. The medical device system identifies one or more features of the neurological signal to use in scoring and computes a score of relative severity of the event using the identified feature. Once two or more events have been scored, the events may be ranked by severity relative to each other.
摘要翻译：一种能够评估与神经系统疾病相关的感觉神经信号的严重性的医疗装置系统。该系统包括监测元件，其接收具有至少一个待评分事件的神经信号。医疗设备系统识别用于评分的神经信号的一个或多个特征，并且使用所识别的特征来计算事件的相对严重程度的得分。一旦两次或更多次的事件得分，事件可能会相对于彼此的严重程度进行排名。

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