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1. 发明申请

US20120191157A1 TARGET THERAPY DELIVERY SITE SELECTION 有权
标题翻译：目标治疗交付网站选择
公开(公告)号：US20120191157A1
公开(公告)日：2012-07-26
申请号：US13358179
申请日：2012-01-25
申请人： Paul H. Stypulkowski , Jonathon E. Giftakis
发明人： Paul H. Stypulkowski , Jonathon E. Giftakis
IPC分类号： A61N1/36
CPC分类号： A61N1/36064 , A61N1/0534 , A61N1/36135 , A61N1/36171 , A61N1/36185
摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
摘要翻译：在选择用于治疗患者状况的靶治疗递送部位的一些实例中，相对高频率的电刺激信号被递送到患者脑部的第一区域（例如，丘脑的前核）内的至少两个区域并且确定响应于递送的刺激的患者脑的第二区域（例如，海马）中的脑活动（例如，由生物电脑信号所示）的变化。可以基于脑活动的变化来选择靶治疗递送部位，电极组合或两者。

2. 发明授权

US08116876B2 Multiplexed electrode array extension 有权
标题翻译：复用电极阵列扩展
公开(公告)号：US08116876B2
公开(公告)日：2012-02-14
申请号：US11865093
申请日：2007-10-01
申请人： Paul H. Stypulkowski
发明人： Paul H. Stypulkowski
IPC分类号： A61N1/05
CPC分类号： A61N1/32 , A61B5/04288 , A61N1/36071
摘要： A method for selectively interacting with electrically excitable tissue of a patient is provided. In one configuration, an implantable pulse generator with a number of outputs and an array of electrodes with a number of electrodes being greater than the number of outputs may be implanted in a patient. An extension unit may be implanted between the implantable pulse generator and array. The extension unit acts to electrically couple the inputs of implantable pulse generator with the greater number of electrodes in the array so that the output sources are coupled to a portion of the electrodes.
摘要翻译：提供了一种用于选择性地与患者的可电激发组织相互作用的方法。在一种配置中，可以将具有多个输出的可植入脉冲发生器和具有大于输出数量的多个电极的电极阵列植入患者体内。可以在可植入脉冲发生器和阵列之间植入延伸单元。扩展单元用于将可植入脉冲发生器的输入与阵列中较大数量的电极电耦合，使得输出源耦合到电极的一部分。

3. 发明授权

US07873418B2 Variation of neural stimulation parameters 有权
标题翻译：神经刺激参数的变化
公开(公告)号：US07873418B2
公开(公告)日：2011-01-18
申请号：US11380857
申请日：2006-04-28
申请人： Paul H. Stypulkowski
发明人： Paul H. Stypulkowski
IPC分类号： A61N1/36
CPC分类号： A61N1/36071
摘要： Techniques for varying stimulus parameters used in neural stimulation to improve therapy efficacy, minimize energy consumption, minimize undesired side effects, and minimize loss of therapeutic effectiveness due to physiologic tolerance to stimulation. Neural stimulation is provided having a stimulation amplitude, a stimulation frequency, a stimulation pulse duration, an electrode-firing pattern, and a set of electrode-firing-polarity conditions. At least one of the stimulation parameters is pseudo-randomly varied. A second stimulation parameter is changed based upon having pseudo-randomly varied the first stimulation parameter and based upon a predetermined relationship specifying how changes in the first parameter affect desirable values for the second parameter.
摘要翻译：用于改变神经刺激中使用的刺激参数以改善治疗功效，最小化能量消耗，最小化不期望的副作用并且最小化由于对刺激的生理耐受性引起的治疗有效性的损失的技术。提供具有刺激振幅，刺激频率，刺激脉冲持续时间，电极点火图案和一组电极点火极性条件的神经刺激。刺激参数中的至少一个是伪随机变化的。基于具有伪随机变化的第一刺激参数并且基于规定第一参数中的变化如何影响第二参数的期望值的预定关系来改变第二刺激参数。

4. 发明授权

US5024612A External ear canal pressure regulating device and tinnitus suppression device 失效
标题翻译：外耳道压力调节装置和耳鸣抑制装置
公开(公告)号：US5024612A
公开(公告)日：1991-06-18
申请号：US359025
申请日：1989-05-30
申请人： Christopher van den Honert , Paul H. Stypulkowski
发明人： Christopher van den Honert , Paul H. Stypulkowski
IPC分类号： A61F11/00 , A61F11/06 , A61F11/08 , A61F11/10
CPC分类号： A61F11/08 , A61F11/00 , A61F11/10 , H04R25/75 , A61F2011/085
摘要： A tinnitus suppression device using an in-the-canal external ear canal pressure regulating device to alter the pressure of the fluid of the external ear canal interior of the pressure regulating device. The device has a body which can be inserted into the external ear canal and which seals the canal from ambient pressure. An adjustably sized body such as a collapsible bulbous portion or a bellows type wall provides a mechanism for altering the pressure in the canal. Either a valve or a mechanical displacement device maintains the pressure differential created.
摘要翻译：一种使用管内外耳道压力调节装置改变压力调节装置的外耳道内部的流体压力的耳鸣抑制装置。该装置具有可以插入外耳道并且将运河与环境压力密封的主体。诸如可折叠的球状部分或波纹管型壁的可调节尺寸的体部提供了改变管道中的压力的机构。阀或机械位移装置都保持所产生的压力差。

5. 发明授权

US4706682A External ear canal electrode to be placed proximate the tympanic membrane 失效
标题翻译：外耳道电极放置在鼓膜附近
公开(公告)号：US4706682A
公开(公告)日：1987-11-17
申请号：US36209
申请日：1987-04-09
申请人： Paul H. Stypulkowski , Christopher van den Honert
发明人： Paul H. Stypulkowski , Christopher van den Honert
IPC分类号： A61B5/042 , A61F11/04 , A61N1/05 , A61B5/04
CPC分类号： A61N1/0541 , A61B5/042 , A61B5/6817 , A61B5/6852 , A61B5/6853 , A61F11/04 , A61N1/0551 , A61N1/0558
摘要： An electrode adapted to be utilized within the external ear canal for applying/recording electrical signals to/from the neural/neuromuscular system of a person having an external ear canal and adjacent tympanic membrane. The electrode utilizes an elongated flexible body having a proximate end and a distal end. The elongated flexible body is stiff enough to be inserted into the external ear canal but is flexible enough to bend if the electrode is inserted against the tympanic membrane without rupturing the tympanic membrane. A compressible material is mounted at the distal end of the body and an electrically conductive gel is carried by the compressible material. An electrical conductor communicates with the body and electrically couples the conductive gel to the proximate end of the electrode.
摘要翻译：适于在外耳道内使用的电极，用于向具有外耳道和相邻鼓膜的人的神经/神经肌肉系统施加/记录电信号。电极使用具有近端和远端的细长柔性体。细长的柔性体足够坚固以插入外耳道，但是如果电极相对于鼓膜插入而不破坏鼓膜，则其足够弯曲。可压缩材料安装在主体的远端，并且导电凝胶由可压缩材料承载。电导体与主体连通并将导电凝胶电耦合到电极的近端。

6. 发明授权

US09724514B2 Variation of neural stimulation parameters 有权
公开(公告)号：US09724514B2
公开(公告)日：2017-08-08
申请号：US12970237
申请日：2010-12-16
申请人： Paul H. Stypulkowski
发明人： Paul H. Stypulkowski
IPC分类号： A61N1/36
CPC分类号： A61N1/36071
摘要： Techniques for varying stimulus parameters used in neural stimulation to improve therapy efficacy, minimize energy consumption, minimize undesired side effects, and minimize loss of therapeutic effectiveness due to physiologic tolerance to stimulation. Neural stimulation is provided having a stimulation amplitude, a stimulation frequency, a stimulation pulse duration, an electrode-firing pattern, and a set of electrode-firing-polarity conditions. At least one of the stimulation parameters is pseudo-randomly varied. A second stimulation parameter is changed based upon having pseudo-randomly varied the first stimulation parameter and based upon a predetermined relationship specifying how changes in the first parameter affect desirable values for the second parameter.

7. 发明授权

US08706181B2 Target therapy delivery site selection 有权
标题翻译：目标治疗递送现场选择
公开(公告)号：US08706181B2
公开(公告)日：2014-04-22
申请号：US13358179
申请日：2012-01-25
申请人： Paul H. Stypulkowski , Jonathon E. Giftakis
发明人： Paul H. Stypulkowski , Jonathon E. Giftakis
IPC分类号： A61B5/04 , A61N1/00
CPC分类号： A61N1/36064 , A61N1/0534 , A61N1/36135 , A61N1/36171 , A61N1/36185
摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
摘要翻译：在选择用于治疗患者状况的靶治疗递送部位的一些实例中，相对高频率的电刺激信号被递送到患者脑部的第一区域（例如，丘脑的前核）内的至少两个区域并且确定响应于递送的刺激的患者脑的第二区域（例如，海马）中的脑活动（例如，由生物电脑信号所示）的变化。可以基于脑活动的变化来选择靶治疗递送部位，电极组合或两者。

8. 发明申请

US20110137371A1 SELECTING THERAPY CYCLE PARAMETERS BASED ON MONITORED BRAIN SIGNAL 有权
标题翻译：基于监测的脑信号选择治疗周期参数
公开(公告)号：US20110137371A1
公开(公告)日：2011-06-09
申请号：US12843665
申请日：2010-07-26
申请人： Jonathon E. Giftakis , Paul H. Stypulkowski
发明人： Jonathon E. Giftakis , Paul H. Stypulkowski
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/0478 , A61B5/4094 , A61N1/37247 , G16H40/63
摘要： Bioelectrical brain signals may be monitored at one more regions of the brain of a patient by a medical device. The monitored bioelectrical signals may be used to select one or more therapy cycle parameters, e.g., on cycle duration and/or off cycle duration, for therapy delivered to treat a patient disorder. In one example, the off cycle duration of a therapy may be selected based on the washout period determined from sensed brain signals of the patient following delivery of therapy during an on cycle. In another example, the on cycle duration and/or off cycle duration of a therapy may be selected to maintain the value of one or more characteristics of a brain signal (e.g., cortical activity) of patient within a threshold range of a target value defined for the characteristic that is associated with effective treatment of the patient disorder.
摘要翻译：可以通过医疗装置在患者的脑的另外一个区域监测生物电脑信号。监测的生物电信号可用于选择一种或多种治疗周期参数，例如循环持续时间和/或关闭循环持续时间，用于治疗递送用于治疗患者病症的治疗。在一个实例中，治疗的关闭周期持续时间可以基于在开启周期期间递送治疗后患者的感测的脑信号所确定的清除时间来选择。在另一个实例中，可以选择治疗的开启周期持续时间和/或关闭周期持续时间以将患者的脑信号的一个或多个特征值（例如，皮层活动）的值保持在定义的目标值的阈值范围内与有效治疗患者障碍有关的特征。

9. 发明申请

US20100114237A1 MOOD CIRCUIT MONITORING TO CONTROL THERAPY DELIVERY 审中-公开
标题翻译： MOOD电路监控以控制治疗
公开(公告)号：US20100114237A1
公开(公告)日：2010-05-06
申请号：US12608815
申请日：2009-10-29
申请人： Jonathon E. Giftakis , Mark T. Rise , David L. Carlson , Paul H. Stypulkowski , Scott R. Stanslaski , Randy M. Jensen , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , David L. Carlson , Paul H. Stypulkowski , Scott R. Stanslaski , Randy M. Jensen , Timothy J. Denison
IPC分类号： A61N1/00
CPC分类号： A61B5/0476 , A61B5/0205 , A61B5/024 , A61B5/0488 , A61B5/16 , A61B5/165 , A61B5/4076 , A61B5/4839 , A61B5/486 , A61M21/00 , A61M2021/0072 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36082
摘要： Brain signals may be monitored at different locations of a mood circuit in order to determine a mood state of the patient. A relationship (e.g., a ratio) between frequency band characteristics of the monitored brain signals may be indicative of a particular mood state. In some examples, therapy parameter values that define the therapy delivered to the patient may be selected to maintain a target relationship (e.g., a target ratio) between the frequency band characteristics of the brain signals monitored within the mood circuit. In addition, in some examples, therapy delivery to the patient may be controlled based on the frequency band characteristics of brain signals sensed at different portions of the mood circuit.
摘要翻译：可以在心情电路的不同位置监测脑信号，以便确定患者的情绪状态。所监视的脑信号的频带特性之间的关系（例如，比率）可以指示特定的情绪状态。在一些示例中，可以选择限定递送给患者的治疗的治疗参数值，以在心情电路内监测的脑信号的频带特性之间维持目标关系（例如，目标比率）。此外，在一些示例中，可以基于在心情电路的不同部分感测到的脑信号的频带特性来控制对患者的治疗递送。

10. 发明授权

US4535785A Method and apparatus for determining the viability and survival of sensori-neutral elements within the inner ear 失效
标题翻译：用于确定内耳内的传感器中性元件的存活力和存活率的方法和装置
公开(公告)号：US4535785A
公开(公告)日：1985-08-20
申请号：US421992
申请日：1982-09-23
申请人： Christopher van den Honert , Paul H. Stypulkowski
发明人： Christopher van den Honert , Paul H. Stypulkowski
IPC分类号： A61B5/12 , A61F11/04 , A61N1/32 , A61N1/36 , A61B5/05
CPC分类号： A61B5/12 , A61F11/04 , A61N1/32 , A61N1/36032
摘要： A method and apparatus for diagnosing the extent of survival of the peripheral sensori-neural elements within the inner ear of a patient by stimulating the patient with one or more pair of electrical stimulus signals having a known amplitude and inter-signal delay, and by measuring the electrical activity within the nervous system of the patient which results from these stimulus signals and comparing the activity which results from the second stimulus signal with the activity which results from the first stimulus signal.
摘要翻译：一种用于通过用具有已知幅度和信号间延迟的一对或多对电刺激信号刺激患者来诊断患者内耳内的外周传感神经元的存活程度的方法和装置，以及通过测量由这些刺激信号产生的患者神经系统内的电活动，并将从第二刺激信号产生的活动与由第一刺激信号产生的活动进行比较。

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