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1. 发明授权

US4627445A Glucose medical monitoring system 失效
标题翻译：葡萄糖医疗监护系统
公开(公告)号：US4627445A
公开(公告)日：1986-12-09
申请号：US720906
申请日：1985-04-08
申请人： Fernando S. Garcia , Hartmut Ginnow-Merkert , Paul J. Anderson , David E. Linde , Bertram J. Hudson
发明人： Fernando S. Garcia , Hartmut Ginnow-Merkert , Paul J. Anderson , David E. Linde , Bertram J. Hudson
IPC分类号： A61B20060101 , A61B5/00 , A61B5/15 , G01N33/48 , G01N33/487 , A61B5/14
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150099 , A61B5/150404 , A61B5/150435 , A61B5/150511 , A61B5/150519 , A61B5/150786 , A61B5/15107 , A61B5/15111 , A61B5/15117 , A61B5/1519 , A61B5/15194 , C12Q1/006 , A61B2562/0295
摘要： Hand-held shirt-pocket portable medical diagnostic system for checking measurement of blood glucose, urea nitrogen, hemoglobin, blood components or other body qualities. The system includes the engagement of a disposable needle or lance probe package which carries a chemical reagent strip such as blood reacting chemistry. The system includes a pen structure having a visual readout, a microcomputer, and photosensing circuitry which measures the change of color of the blood reacting chemistry of the disposable probe package. The pen also includes a spring arrangement for actuating a needle or lance into the skin for transferring blood from a finger or other area to the chemical reagent strip. A disposable probe structure package includes configurations for transferring of the blood to the reagent strip of the reagent strip to the blood. The pen can also create a vacuum about a time period that the needle is penetrating the skin. The system includes a verification sequence of the electronics, the chemistry of an unused disposable probe package, the presence of blood sample and multiple readings to average results. The system can also be provided with provisions for storing a plurality of readings, communicating with a personal computer, and can act as an alarm and chime to indicate time periods for blood sensing.
摘要翻译：手提式袖珍便携式医疗诊断系统，用于检查血糖，尿素氮，血红蛋白，血液成分或其他身体素质的测量。该系统包括携带化学试剂条（例如血液反应化学物质）的一次性针头或喷枪探针包的接合。该系统包括具有视觉读出器的笔式结构，微型计算机和光敏电路，其测量一次性探头封装的血液反应化学品的颜色变化。该笔还包括用于致动针头或喷枪进入皮肤以将血液从手指或其他区域传送到化学试剂条的弹簧装置。一次性探针结构包装包括用于将血液转移到试剂条的试剂条到血液的构造。笔也可以在针穿透皮肤的时间段内产生真空。该系统包括电子设备的验证序列，未使用的一次性探头包装的化学性质，血液样品的存在和多个读数以获得平均结果。该系统还可以提供用于存储与个人计算机通信的多个读数的设置，并且可以用作警报和钟声以指示血液感测的时间段。

2. 发明申请

US20130053722A1 Method and Apparatus for Detecting a Biomarker in the Presence of Electrical Stimulation 有权
标题翻译：在电刺激下检测生物标志物的方法和装置
公开(公告)号：US20130053722A1
公开(公告)日：2013-02-28
申请号：US13589270
申请日：2012-08-20
申请人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
发明人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
IPC分类号： A61B5/05 , A61N1/36
CPC分类号： A61B5/04012 , A61B5/04001 , A61B5/04014 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/4082 , A61B5/4094 , A61B5/7264 , A61B5/7282
摘要： Various embodiments concern identifying a biomarker in the presence of electrical stimulation. Various embodiments concern delivering electrical stimulation to a patient and sensing one or more signals while the electrical stimulation is being delivered, the one or more signals including data indicative of physiological activity. Various embodiments further include determining an intensity of the electrical stimulation and determining whether the data indicates the presence of a biomarker based on a variable threshold, the variable threshold being variable based on the intensity of the electrical stimulation. Various embodiments concern determining a relationship between stimulation intensity and a biomarker parameter to determine the variability of the variable threshold.
摘要翻译：各种实施方案涉及在存在电刺激的情况下鉴定生物标志物。各种实施例涉及向患者提供电刺激并且在电刺激被传送的同时感测一个或多个信号，所述一个或多个信号包括指示生理活动的数据。各种实施例还包括确定电刺激的强度并且基于可变阈值来确定数据是否指示生物标志物的存在，所述可变阈值基于电刺激的强度而变化。各种实施方案涉及确定刺激强度和生物标记参数之间的关系以确定可变阈值的可变性。

3. 发明申请

US20100280335A1 PATIENT STATE DETECTION BASED ON SUPERVISED MACHINE LEARNING BASED ALGORITHM 审中-公开
标题翻译：基于监督机器学习算法的患者状态检测
公开(公告)号：US20100280335A1
公开(公告)日：2010-11-04
申请号：US12694044
申请日：2010-01-26
申请人： David L. Carlson , Timothy J. Denison , Ali H. Shoeb , David E. Linde
发明人： David L. Carlson , Timothy J. Denison , Ali H. Shoeb , David E. Linde
IPC分类号： A61B5/00 , A61B5/11
CPC分类号： A61N1/36082 , G06F2221/2101 , G06F2221/2105 , G06K9/6268 , G06N20/00 , G16H50/50
摘要： A patient state is detected with at least one classification boundary generated by a supervised machine learning technique, such as a support vector machine. In some examples, the patient state detection is used to at least one of control the delivery of therapy to a patient, to generate a patient notification, to initiate data recording, or to evaluate a patient condition. In addition, an evaluation metric can be determined based on a feature vector, which is determined based on characteristics of a patient parameter signal, and the classification boundary. Example evaluation metrics can be based on a distance between at least one feature vector and the classification boundary and/or a trajectory of a plurality of feature vectors relative to the classification boundary over time.
摘要翻译：用监督机器学习技术（例如支持向量机）生成的至少一个分类边界来检测病人状态。在一些示例中，患者状态检测用于控制对患者的治疗递送，产生患者通知，开始数据记录或评估患者状况中的至少一个。此外，可以基于基于患者参数信号的特性确定的特征向量和分类边界来确定评估度量。示例评估度量可以基于至少一个特征向量与分类边界之间的距离和/或相对于分类边界随时间的多个特征向量的轨迹。

4. 发明申请

US20100280579A1 POSTURE STATE DETECTION 审中-公开
标题翻译：姿态检测
公开(公告)号：US20100280579A1
公开(公告)日：2010-11-04
申请号：US12694053
申请日：2010-01-26
申请人： Timothy J. Denison , David L. Carlson , Ali H. Shoeb , David E. Linde
发明人： Timothy J. Denison , David L. Carlson , Ali H. Shoeb , David E. Linde
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , G06F2221/2101 , G06F2221/2105 , G06K9/6268 , G06N20/00 , G16H50/50
摘要： A patient state is detected with at least one classification boundary generated by a supervised machine learning technique, such as a support vector machine. The patient state can be, for example, a patient posture state. In some examples, the patient state detection is used to at least one of control the delivery of therapy to a patient, to generate a patient notification, to initiate data recording, or to evaluate a patient condition. In addition, an evaluation metric can be determined based on a feature vector, which is determined based on characteristics of a patient parameter signal, and the classification boundary. Example evaluation metrics can be based on a distance between at least one feature vector and the classification boundary and/or a trajectory of a plurality of feature vectors relative to the classification boundary over time.
摘要翻译：用监督机器学习技术（例如支持向量机）生成的至少一个分类边界来检测病人状态。患者状态可以是例如患者姿势状态。在一些示例中，患者状态检测用于控制对患者的治疗递送，产生患者通知，开始数据记录或评估患者状况中的至少一个。此外，可以基于基于患者参数信号的特性确定的特征向量和分类边界来确定评估度量。示例评估度量可以基于至少一个特征向量与分类边界之间的距离和/或相对于分类边界随时间的多个特征向量的轨迹。

5. 发明授权

US4787398A Glucose medical monitoring system 失效
标题翻译：葡萄糖医疗监护系统
公开(公告)号：US4787398A
公开(公告)日：1988-11-29
申请号：US889185
申请日：1986-07-25
申请人： Fernando S. Garcia , Hartmut G. Merkert , Paul J. Anderson , David E. Linde , Bertram J. Hudson
发明人： Fernando S. Garcia , Hartmut G. Merkert , Paul J. Anderson , David E. Linde , Bertram J. Hudson
IPC分类号： A61B5/00 , A61B5/15 , C12Q1/54 , G01N33/487 , G01N33/52 , A61B5/14
CPC分类号： A61B5/15186 , A61B5/14532 , A61B5/150022 , A61B5/150358 , A61B5/150435 , A61B5/150664 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/15194 , A61B5/157 , C12Q1/54 , G01N33/52 , A61B2560/0252 , A61B2562/0295
摘要： Hand-held shirt-pocket portable glucose medical monitoring system for checking measurement of blood glucose or other body qualities. The system includes a disposable diagnostic reagent-lancet unit which carries a chemcial reagent strip of blood reacting chemistry. The system includes a housing structure having a visual LCD readout, a microprocessor, and photosensing circuitry which measures the change of color of the blood reacting chemistry of the disposable unit. The housing also includes a spring arrangement for actuating a lancet into the skin for sampling and transporting blood from a finger to a chemical reagent. The disposable unit includes medical and fluid configurations for transporting of the blood to the reagent strip. The system inlcudes verification and calibration sequences for the electronics, the chemistry of an unused disposable unit, the presence of a blood sample, and multiple readings to an average result. The system also provides for storing a plurality of readings.
摘要翻译：手提式袖珍便携式葡萄糖医疗监测系统，用于检查血糖或其他身体素质的测量。该系统包括携带血液反应化学品的化学试剂条的一次性诊断试剂 - 刺血针单元。该系统包括具有视觉LCD读数的壳体结构，微处理器和光敏电路，其测量一次性单元的血液反应化学品的颜色变化。壳体还包括弹簧装置，用于将刺血针驱动到皮肤中，以将血液从手指取样和输送到化学试剂。一次性单元包括用于将血液输送到试剂条的医疗和流体结构。该系统包括电子设备的验证和校准顺序，未使用的一次性单元的化学性质，血液样品的存在以及平均结果的多次读数。该系统还提供存储多个读数。

6. 发明授权

US09888861B2 Method and apparatus for detecting a biomarker in the presence of electrical stimulation 有权
公开(公告)号：US09888861B2
公开(公告)日：2018-02-13
申请号：US13589270
申请日：2012-08-20
申请人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
发明人： David L. Carlson , Pedram Afshar , Timothy J. Denison , Jonathon E. Giftakis , David E. Linde , Scott R. Stanslaski
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0476 , A61B5/0488 , A61B5/0496
CPC分类号： A61B5/04012 , A61B5/04001 , A61B5/04014 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/4082 , A61B5/4094 , A61B5/7264 , A61B5/7282
摘要： Various embodiments concern identifying a biomarker in the presence of electrical stimulation. Various embodiments concern delivering electrical stimulation to a patient and sensing one or more signals while the electrical stimulation is being delivered, the one or more signals including data indicative of physiological activity. Various embodiments further include determining an intensity of the electrical stimulation and determining whether the data indicates the presence of a biomarker based on a variable threshold, the variable threshold being variable based on the intensity of the electrical stimulation. Various embodiments concern determining a relationship between stimulation intensity and a biomarker parameter to determine the variability of the variable threshold.

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