专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08187181B2 Scoring of sensed neurological signals for use with a medical device system 有权
标题翻译：感觉神经信号的评分与医疗器械系统一起使用
公开(公告)号：US08187181B2
公开(公告)日：2012-05-29
申请号：US10687389
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Nina M. Graves , Jonathon E. Giftakis
发明人： Ivan Osorio , Mark G. Frei , Nina M. Graves , Jonathon E. Giftakis
IPC分类号： A61B5/00
CPC分类号： A61N1/3702 , A61B5/048 , A61B5/4064 , A61B5/4094 , A61N1/36017 , A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/37252 , Y10S128/92
摘要： A medical device system capable of scoring a severity of sensed neurological signals relating to a nervous system disorder. The system comprises a monitoring element that receives a neurological signal having at least one event to be scored. The medical device system identifies one or more features of the neurological signal to use in scoring and computes a score of relative severity of the event using the identified feature. Once two or more events have been scored, the events may be ranked by severity relative to each other.
摘要翻译：一种能够评估与神经系统疾病相关的感觉神经信号的严重性的医疗装置系统。该系统包括监测元件，其接收具有至少一个待评分事件的神经信号。医疗设备系统识别用于评分的神经信号的一个或多个特征，并且使用所识别的特征来计算事件的相对严重程度的得分。一旦两次或更多次的事件得分，事件可能会相对于彼此的严重程度进行排名。

2. 发明授权

US07933646B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US07933646B2
公开(公告)日：2011-04-26
申请号：US11837987
申请日：2007-08-13
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61M5/1723 , A61B5/04001 , A61B5/0476 , A61B5/4094 , A61B5/6843 , A61B5/721 , A61N1/36025 , A61N1/36064 , A61N1/36082 , A61N1/361
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

3. 发明授权

US07280867B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US07280867B2
公开(公告)日：2007-10-09
申请号：US10687571
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法的每个连续的应用组或每个第n个检测簇进行更新。

4. 发明授权

US07242983B2 Channel-selective blanking for a medical device system 有权
标题翻译：用于医疗设备系统的通道选择性消隐
公开(公告)号：US07242983B2
公开(公告)日：2007-07-10
申请号：US10687133
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Mark T. Rise , Jonathon E. Giftakis , Nina M. Graves , David L. Carlson , Randy M. Jensen
发明人： Mark G. Frei , Ivan Osorio , Mark T. Rise , Jonathon E. Giftakis , Nina M. Graves , David L. Carlson , Randy M. Jensen
IPC分类号： A61N1/00
CPC分类号： A61N1/37264 , A61N1/36146 , A61N2/00
摘要： Apparatuses and methods selectively blank a neurological channel of a medical device system in the treatment of a nervous system disorder. A selected signal of a selected channel may be blanked if it is determined that the selected signal may be affected by an artifact when the medical device system delivers a treatment therapy. The selected signal may be blanked by hardware, in which the selected electrode is disconnected from the selected channel (which may include an selected amplifier) and is connected to a fixed voltage in order to avoid saturation of the selected amplifier. The selected channel may be blanked by software, in which a signal processor is instructed not to process neurological data on the selected channel for a determined time duration. Embodiments may combine hardware and software blanking for the selected signal.
摘要翻译：装置和方法选择性地将医疗装置系统的神经通道置于神经系统疾病的治疗中。如果在医疗设备系统递送治疗疗法时确定所选择的信号可能受到伪像的影响，则选定信道的所选信号可能被消隐。所选择的信号可能被硬件消隐，其中所选择的电极与所选择的通道（其可以包括所选择的放大器）断开连接，并且连接到固定电压，以避免所选放大器的饱和。所选择的通道可以被软件置空，其中指示信号处理器不在所选择的通道上处理确定的持续时间的神经学数据。实施例可以组合所选信号的硬件和软件消隐。

5. 发明授权

US08738136B2 Clustering of recorded patient neurological activity to determine length of a neurological event 有权
标题翻译：记录患者神经活动的聚类，以确定神经系统事件的长度
公开(公告)号：US08738136B2
公开(公告)日：2014-05-27
申请号：US11837994
申请日：2007-08-13
申请人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
发明人： Mark G. Frei , Ivan Osorio , Nina M. Graves , Scott F. Schaffner , Mark T. Rise , Jonathon E. Giftakis , David L. Carlson
IPC分类号： A61N1/36
CPC分类号： A61M5/1723 , A61B5/04001 , A61B5/0476 , A61B5/4094 , A61B5/6843 , A61B5/721 , A61N1/36025 , A61N1/36064 , A61N1/36082 , A61N1/361
摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.
摘要翻译：装置和方法检测与神经系统疾病的神经系统事件如癫痫发作相关联的检测簇，以及与治疗疗法相关联的更新治疗参数。当最大比例超过强度阈值时，检测到簇的出现。如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联。因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。可以通过提供电刺激，药物输注或组合来提供治疗治疗。治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

6. 发明授权

US08579786B2 Screening techniques for management of a nervous system disorder 有权
标题翻译：用于管理神经系统疾病的筛查技术
公开(公告)号：US08579786B2
公开(公告)日：2013-11-12
申请号：US10687344
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Nina M. Graves , Scott F. Schaffner , Jonathon E. Giftakis , Mark T. Rise , Jonathan C. Werder
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Nina M. Graves , Scott F. Schaffner , Jonathon E. Giftakis , Mark T. Rise , Jonathan C. Werder
IPC分类号： A61N2/00
CPC分类号： A61N1/08 , A61B5/0476 , A61B5/4094 , A61B5/7275 , A61N1/36025 , A61N1/36082 , A61N1/361 , A61N1/37217
摘要： Apparatus and method support a neurological event screening for a medical device. The medical device assists a user in determining a configuration of the medical device for delivering an effective treatment for a nervous system disorder. The medical device detects a neurological event, such as a seizure, and reports a neurological event focus location and a neurological event spread to the user. The user may use the information to provide a configuration of a therapeutic delivery unit and associated therapy parameters. Therapeutic treatment is delivered to the patient, and the medical device is provided an indication of the patient's acceptance to the treatment. The user may modify the configuration and therapy parameters in order to achieve efficacy and acceptance. Depending upon the patient's acceptance, therapy is applied in either an open loop mode or a closed loop mode. The medical device determines whether the treatment is successful in accordance with a criterion.
摘要翻译：装置和方法支持用于医疗装置的神经事件筛查。医疗装置帮助用户确定医疗装置的配置以递送用于神经系统障碍的有效治疗。医疗装置检测诸如癫痫发作的神经系统事件，并向用户报告神经系统事件焦点位置和神经系统事件。用户可以使用该信息来提供治疗递送单元的配置和相关联的治疗参数。向患者传送治疗性治疗，并且向患者提供患者接受治疗的指示。用户可以修改配置和治疗参数，以达到功效和验收。根据患者的接受程度，治疗以开环模式或闭环模式应用。医疗设备根据标准确定治疗是否成功。

7. 发明授权

US07282030B2 Timed delay for redelivery of treatment therapy for a medical device system 有权
标题翻译：为医疗器械系统重新交付治疗疗法的定时延迟
公开(公告)号：US07282030B2
公开(公告)日：2007-10-16
申请号：US10687567
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Naresh C. Bhavaraju , David L. Carlson , Jonathon E. Giftakis , Nina M. Graves
发明人： Mark G. Frei , Ivan Osorio , Naresh C. Bhavaraju , David L. Carlson , Jonathon E. Giftakis , Nina M. Graves
IPC分类号： A61B5/00 , A61B5/04
CPC分类号： A61B5/04012 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61N1/36025 , A61N1/36082 , A61N1/361 , Y10S128/92
摘要： Apparatus and method support a repetitive administration of a therapeutic treatment through a delivery unit during a neurological event, such as a seizure, of a nervous system disorder. The medical device system monitors signal data from a sensor and through an amplifier. A neurological event is detected by a medical device system using a detection algorithm. Consequently, a electrical stimulation pulse is applied to an electrode. During the delivery of the electrical stimulation pulse, the medical device system blanks signal data that is associated with the electrode. Subsequently, additional blanking is providing during a time interval in which signal artifacts may occur and the amplifier is stabilizing. The medical device system then collects signal data for the detection algorithm to stabilize. Subsequently, the medical device system collects additional signal data in order to obtain statistically meaningful data. If the medical device system detects a continuation of the seizure, therapeutic treatment continues.
摘要翻译：装置和方法支持在神经系统疾病的神经事件（例如癫痫发作）期间通过递送单元重复施用治疗性治疗。医疗设备系统监控来自传感器和放大器的信号数据。通过使用检测算法的医疗装置系统检测到神经系统事件。因此，电刺激脉冲被施加到电极。在递送电刺激脉冲期间，医疗装置系统消除与电极相关联的信号数据。随后，在可能发生信号伪影的时间间隔内提供额外的消隐，并且放大器正在稳定。然后，医疗装置系统收集用于检测算法的信号数据以稳定。随后，医疗设备系统收集附加信号数据，以获得统计上有意义的数据。如果医疗器械系统检测到持续的癫痫发作，则继续治疗。

8. 发明授权

US08594798B2 Multi-modal operation of a medical device system 有权
标题翻译：医疗器械系统的多模式操作
公开(公告)号：US08594798B2
公开(公告)日：2013-11-26
申请号：US10687289
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Mark T. Rise , Scott F. Schaffner , Nina M. Graves
发明人： Ivan Osorio , Mark G. Frei , Mark T. Rise , Scott F. Schaffner , Nina M. Graves
IPC分类号： A61N1/08
CPC分类号： A61N1/36025 , A61N1/08 , A61N1/36082
摘要： Apparatuses and methods support multi-modal operation of a medical device system for a nervous system disorder. The medical device system comprises an implanted component and an external component and supports a first feature and a second feature that are associated with the treatment therapy. The medical device system supports both features when the implanted component and the external component are coupled. If the external component is decoupled, the implanted component continues to support the first feature. Moreover, the embodiment may support a plurality of features during a treatment interval. Another aspect of the invention allows for modularly expanding a medical device system in order to add a feature that enhances existing functionality or that provides additional functionality. In an embodiment, a module that is associated with an external component of the medical device system supports the added feature.
摘要翻译：装置和方法支持用于神经系统障碍的医疗装置系统的多模式操作。医疗装置系统包括植入部件和外部部件，并且支撑与治疗疗法相关联的第一特征和第二特征。当植入部件和外部部件联接时，医疗装置系统支持两个特征。如果外部组件解耦，则植入组件继续支持第一个特征。此外，该实施例可以在治疗间隔期间支持多个特征。本发明的另一方面允许模块化地扩展医疗设备系统，以便添加增强现有功能或提供附加功能的特征。在一个实施例中，与医疗设备系统的外部部件相关联的模块支持附加的特征。

9. 发明授权

US08417344B2 Dynamic cranial nerve stimulation based on brain state determination from cardiac data 有权
标题翻译：基于心脏数据的脑状态测定的动态颅神经刺激
公开(公告)号：US08417344B2
公开(公告)日：2013-04-09
申请号：US12258019
申请日：2008-10-24
申请人： John C. Colborn , Mark G. Frei , Ivan Osorio
发明人： John C. Colborn , Mark G. Frei , Ivan Osorio
IPC分类号： A61N1/00
CPC分类号： A61B5/0205 , A61B5/04012 , A61N1/36082 , A61N1/36114
摘要： A method of treating a medical condition in a patient using an implantable medical device, comprising providing an electrical signal generator; providing at least a first electrode operatively coupled to the electrical signal generator and to a vagus nerve of the patient; sensing cardiac data of the patient; determining at least a first cardiac parameter based upon said cardiac data; setting at least a first value; declaring an unstable brain state of a patient from said at least a first cardiac parameter and said at least a first value; and adjusting the at least a first value. Also, a computer readable program storage device encoded with instructions that, when executed by a computer, performs the method. In addition, the implantable medical device used in the method.
摘要翻译：一种使用可植入医疗装置治疗患者的医疗状况的方法，包括提供电信号发生器; 提供至少可操作地耦合到所述电信号发生器和所述患者的迷走神经的第一电极; 感测患者的心脏数据; 基于所述心脏数据确定至少第一心脏参数; 设置至少第一个值; 从所述至少第一心脏参数和所述至少第一值宣告患者的不稳定脑状态; 以及调整所述至少第一值。另外，一种计算机可读程序存储装置，其编码有由计算机执行时执行该方法的指令。此外，该方法中使用的可植入医疗装置。

10. 发明授权

US08348842B1 Method and system for implantable glucose monitoring and control of a glycemic state of a subject 失效
标题翻译：监测和控制受试者血糖状态的方法和系统
公开(公告)号：US08348842B1
公开(公告)日：2013-01-08
申请号：US13135375
申请日：2011-07-01
申请人： Ivan Osorio , Mark G. Frei
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/4839 , A61B5/14528 , A61B5/14532 , A61B5/686 , A61M5/14244 , A61M5/16877 , A61M5/1723 , A61M2205/50 , A61M2230/201
摘要： A method and system for monitoring and/or controlling a glycemic state of a subject, comprising a housing device having one or more chambers, extendable and retractable sensors, extendable and retractable catheters, insulin reservoir, neuroprotective agent reservoir, release mechanism for releasing insulin and neuroprotective agent into the subject, and a control mechanism with a processor for receiving and analyzing outputs from the sensors and for controlling the release mechanism, a clock mechanism for providing logging and/or circadian information to the processor.
摘要翻译：一种用于监测和/或控制受试者血糖状态的方法和系统，包括具有一个或多个腔室，可伸缩和可伸缩传感器，可伸缩导管，胰岛素储存器，神经保护剂储存器，用于释放胰岛素的释放机构的壳体装置和神经保护剂，以及具有处理器的控制机构，用于接收和分析来自传感器的输出和用于控制释放机构的时钟机构，用于向处理器提供记录和/或昼夜节律信息。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式