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    • 2. 发明授权
    • Diacetylenics containing adjacent triple bonds
    • 含有相邻三键的二乙酰基
    • US06440056B1
    • 2002-08-27
    • US09845106
    • 2001-04-27
    • Alok SinghPaul SchoenDan ZabetakisJoel M. Schnur
    • Alok SinghPaul SchoenDan ZabetakisJoel M. Schnur
    • C11B300
    • C07C51/373C07C51/353C07C57/24C07C59/76C07C59/84
    • This invention pertains to a process for preparing diacetylenics, to diacetylenic compounds and to reduced diacetylenic compounds. The process includes the steps of reacting coupling an acetylenic acid in presence of cupric chloride in Ethylamine and hydroxylamine hydrochloride to form a diacetylenic diacid; reacting the diacetylenic diacid with a lithium compound, trimethylsilyl chloride and hydrochloric acid to form a diacetylenic compound; and reducing the diacetylenic compound to a reduced diacetylenic compound. The diacetylenic compounds have the formula COOH—(CH2)m—C≡C—C≡C—(CH2)m—C(═O)—R or R—C(═O)—(CH2)m—C≡C—C≡C—(CH2)m—C(═O)—R and the reduced cyclic diacetylenic compounds have the formula COOH—(CH2)m—C≡C—C≡C—(CH2)m—CH2—R or R—CH2—(CH2)m—C≡C—C≡C—(CH2)m—CH2—R, where m is 1-18 and R is selected from alkyl groups of 1-10 and cyclic groups containing 6-35 carbon atoms and aryl moieties
    • 本发明涉及制备二乙炔基化合物,二乙炔化合物和还原二炔化合物的方法。 该方法包括使乙酸氯化物在乙胺和盐酸羟胺存在下偶联乙酸以形成二乙炔二酸的步骤; 使二乙炔二酸与锂化合物,三甲基甲硅烷基氯和盐酸反应,形成二乙炔化合物; 并将二乙炔化合物还原成还原的二乙炔化合物。 二乙炔化合物具有式COOH-(CH2)mC = CC = C-(CH2)mC(= O)-R或RC(= O) - (CH2)mC = CC = C-(CH2)mC(= O )-R并且还原的环状二炔化合物具有式COOH-(CH 2)m C = CC = C-(CH 2)m -CH 2 -R或R-CH 2 - (CH 2)m C = CC = C-(CH 2)m - CH2-R,其中m为1-18,R选自1-10的烷基和含有6-35个碳原子的环状基团和芳基部分