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1. 发明申请

US20180354889A1 NEW PROCESS AND INTERMEDIATES 审中-公开
公开(公告)号：US20180354889A1
公开(公告)日：2018-12-13
申请号：US15780957
申请日：2016-12-08
申请人： Novartis AG
发明人： Florian Karl KLEINBECK-RINIKER , Benjamin MARTIN , Gerhard PENN , Francesco VENTURONI , Thierry SCHLAMA , Thomas RUCH , Thomas ALLMENDINGER , Bernhard WIETFELD , Paolo FILIPPONI
IPC分类号： C07C69/738 , C07C67/035 , C07C59/84 , C07C51/373 , C07C229/34 , C07C251/40 , C07C251/66 , C07C313/06
CPC分类号： C07C69/738 , C07B2200/07 , C07C51/373 , C07C59/84 , C07C67/035 , C07C229/34 , C07C251/40 , C07C251/66 , C07C313/06 , C07D207/36 , C07D265/02
摘要： The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

2. 发明授权

US09663542B2 O-phenyl chalcone compounds and preparation method and use thereof 有权
公开(公告)号：US09663542B2
公开(公告)日：2017-05-30
申请号：US15218738
申请日：2016-07-25
申请人： Sun Yat-Sen University
发明人： Xianzhang Bu , Cuige Zhu , Xin Yue , Yinglin Zuo , Yu Chen , Gesi Wen
IPC分类号： C07C255/56 , C07C51/373 , C07C45/63 , C07C253/30 , C07C303/22 , C07C309/44 , C07C225/22 , C07C65/38 , C07C49/84 , C07D295/12 , C07D207/08 , C07F9/12 , C07C49/835 , C07F5/02 , C07C45/45 , C07C51/347 , C07C221/00
CPC分类号： C07F9/12 , C07C45/45 , C07C45/63 , C07C49/248 , C07C49/255 , C07C49/835 , C07C49/84 , C07C51/347 , C07C51/373 , C07C65/38 , C07C221/00 , C07C225/22 , C07C253/30 , C07C255/56 , C07C303/22 , C07C309/44 , C07D207/08 , C07D295/112 , C07D295/12 , C07F5/025 , C07C49/813
摘要： Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and have a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.

3. 发明授权

US09604903B2 Metathesis process 有权
公开(公告)号：US09604903B2
公开(公告)日：2017-03-28
申请号：US14383348
申请日：2013-03-18
申请人： CRODA INTERNATIONAL PLC
发明人： Bastiaan Wels , Hans Ridderikhoff , Tanja Van Bergen-Brenkman , Dessy Liminto
IPC分类号： C07C67/475 , C07C6/04 , C07C6/02 , B01J31/12 , B01J31/14 , B01J31/22 , C07C1/213 , C07C51/373 , C07C67/27 , C11C3/00
CPC分类号： C11C3/00 , B01J31/128 , B01J31/146 , B01J31/2273 , B01J31/2278 , B01J2231/54 , B01J2531/821 , C07C1/213 , C07C6/02 , C07C6/04 , C07C51/373 , C07C67/27 , C07C67/475 , C07C2527/135 , C07C2531/12 , C07C2531/22 , C07C2531/30 , C10G2300/1014 , C07C11/02 , C07C69/593
摘要： A process of metathesizing a feedstock in the presence of a metathesis catalyst and at least one catalyst enhancer. The catalyst enhancer can be selected from a sacrificial catalyst or a non-catalyst enhancer. The process exhibits improved reaction times and/or the metathesis catalyst can be used at very low concentrations.

4. 发明授权

US09586883B2 Aldehyde-selective wacker-type oxidation of unbiased alkenes 有权
标题翻译：醛类选择性瓦克型氧化无偏烯烃
公开(公告)号：US09586883B2
公开(公告)日：2017-03-07
申请号：US14255049
申请日：2014-04-17
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Zachary K. Wickens , Bill Morandi , Robert H. Grubbs , Kacper Skakuj , Sarah M. Bronner
IPC分类号： C07C45/34 , C07C249/04 , C07C253/00 , C07C201/12 , C07C205/44 , C07C209/60 , C07C213/00 , C07C227/08 , C07C51/373 , C07C59/235 , C07C211/48 , C07C217/48 , C07D301/22
CPC分类号： C07C45/34 , C07C51/373 , C07C201/12 , C07C205/44 , C07C209/60 , C07C213/00 , C07C227/08 , C07C249/04 , C07C253/00 , C07D301/22 , C07C59/235 , C07C211/48 , C07C217/48 , C07C229/18 , C07C47/02 , C07C47/11 , C07C47/14 , C07C47/19 , C07C47/198 , C07C47/277
摘要： This disclosure is directed to methods of preparing organic aldehydes, each method comprising contacting a terminal olefin with an oxidizing mixture comprising: (a) a dichloro-palladium complex; (b) a copper complex; (c) a source of nitrite; under aerobic reaction conditions sufficient to convert at least a portion of the terminal olefin to an aldehyde.
摘要翻译：本公开涉及制备有机醛的方法，每种方法包括使末端烯烃与氧化混合物接触，所述氧化混合物包含：（a）二氯 - 钯络合物; （b）铜络合物; （c）亚硝酸盐源; 在需氧反应条件下，足以将至少一部分末端烯烃转化为醛。

5. 发明授权

US09278899B2 Method for producing 3,5-dimethyldodecanoic acid; and 4-carboxy-3,5-Dimethyl-3,5-dodecadienoic acid 有权
标题翻译： 3,5-二甲基十二烷酸的制备方法和4-羧基-3,5-二甲基-3,5-二十二碳烯酸
公开(公告)号：US09278899B2
公开(公告)日：2016-03-08
申请号：US14713582
申请日：2015-05-15
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Akihiro Baba , Takeshi Kinsho , Naoki Ishibashi
IPC分类号： C07C51/36 , C07C51/373 , C07C51/09 , C07C51/38 , C07C57/13
CPC分类号： C07C51/36 , C07C51/09 , C07C51/373 , C07C51/38 , C07C57/13 , C07C57/03 , C07C53/126
摘要： Provided is a process for producing 3,5-dimethyldodecanoic acid, which is an active ingredient of the pheromone of California prionus, and 4-carboxy-3,5-dimethyl-3,5-dodecadienoic acid which is an intermediate useful for producing 3,5-dimethyldodecanoic acid. More specifically, provided is a method for producing 3,5-dimethyldodecanoic acid, comprising the steps of subjecting 3-methyl-2-pentene-1,5-diacid diester (1) and 2-nonanone (2) to a condensation reaction and subsequent hydrolysis into 4-carboxy-3,5-dimethyl-3,5-dodecadienoic acid (3); decarboxylating or decarboxylating and hydrolyzing the 4-carboxy-3,5-dimethyl-3,5-dodecadienoic acid (3) into 3,5-dimethyl-2,4-dodecadienoic acid (4); and hydrogenating the 3,5-dimethyl-2,4-dodecadienoic acid (4) into 3,5-dimethyldodecanoic acid (5), as shown in the following scheme:
摘要翻译：提供了作为加利福尼亚朊病毒的信息素的活性成分的3,5-二甲基十二烷酸的制造方法和作为生产3的中间体的4-羧基-3,5-二甲基-3,5-癸二烯酸，5-二甲基十二烷酸。更具体地说，提供了一种3,5-二甲基十二烷酸的制造方法，其特征在于，包括使3-甲基-2-戊烯-1,5-二酸二酯（1）和2-壬酮（2）进行缩合反应的工序，随后水解成4-羧基-3,5-二甲基-3,5-二十二碳烯酸（3）; 脱羧或脱羧并将4-羧基-3,5-二甲基-3,5-二十二碳烯酸（3）水解成3,5-二甲基-2,4-十二碳二烯酸（4）; 并将3,5-二甲基-2,4-十二碳二烯酸（4）氢化成3,5-二甲基十二烷酸（5），如下列方案所示：

6. 发明申请

US20150259713A1 PROCESS FOR PREPARING SEBACIC ACID 有权
标题翻译：制备硫酸的方法
公开(公告)号：US20150259713A1
公开(公告)日：2015-09-17
申请号：US14423448
申请日：2013-09-03
申请人： BASF SE
发明人： Andrea Piatesi , Kai-Uwe Baldenius , Klaus Ditrich , Alois Kindler , Marta Zajaczkowski-Fischer , Ralf Boehling , Alwin Rehfinger
IPC分类号： C12P7/64 , C07C51/235 , C07C51/373
CPC分类号： C12P7/6427 , C07C51/235 , C07C51/373 , C12P7/6409 , C12Y402/01053 , C07C59/147 , C07C55/20
摘要： A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.
摘要翻译：在第二步（ii）中热解10-羟基-12-十八碳烯酸，通过在第一步骤（i）中将亚油酸与由油酸水合酶催化形成10-羟基-12-十八碳烯酸的水反应制备癸二酸的方法，十八碳烯酸至1-辛烯和10-氧代癸酸，并且在第三步骤（iii）中将10-氧代癸酸氧化成癸二酸。

7. 发明授权

US09073838B2 Method of making indeno-fused naphthol materials 有权
标题翻译：茚并稠合萘酚材料的制备方法
公开(公告)号：US09073838B2
公开(公告)日：2015-07-07
申请号：US14276337
申请日：2014-05-13
申请人： Transitions Optical, Inc.
发明人： Anu Chopra , Barry Van Gemert , Wenjing Xiao , Huayun Yu
IPC分类号： C07D311/78 , C07C41/30 , C07C51/09 , C07C51/353 , C07C51/373 , C07C51/377 , C07C51/56 , C07C57/34 , C07D263/14 , C07D307/93 , C07D311/94 , C07C37/00 , C07C51/285 , C07D263/10 , C07D307/60
CPC分类号： C07C41/30 , C07C37/001 , C07C51/09 , C07C51/285 , C07C51/353 , C07C51/373 , C07C51/377 , C07C51/56 , C07C57/34 , C07C2603/40 , C07D263/10 , C07D263/14 , C07D307/60 , C07D307/93 , C07D311/94 , C07C57/62 , C07C59/86 , C07C59/72
摘要： The present invention relates to a method of making indeno-fused naphthol materials, that involves, with some embodiments, forming an indanone acid intermediate, represented by the following general Formula V, With Formula V, m is from 0 to 4, and R1 for each m, Rg and Rh can each be independently selected from, for example, hydrogen and hydrocarbyl.
摘要翻译：本发明涉及一种制备茚并稠合的萘酚材料的方法，在一些实施方案中涉及形成由以下通式V表示的茚满酮酸中间体：式V中，m为0-4，R1为每个m，R g和Rh可各自独立地选自例如氢和烃基。

8. 发明申请

US20150045568A1 METATHESIS PROCESS 有权
标题翻译： METATHESIS过程
公开(公告)号：US20150045568A1
公开(公告)日：2015-02-12
申请号：US14383348
申请日：2013-03-18
申请人： CRODA INTERNATIONAL PLC
发明人： Bastiaan Wels , Hans Ridderikhoff , Tanja Van Bergen-Brenkman , Dessy Liminto
IPC分类号： C11C3/00
CPC分类号： C11C3/00 , B01J31/128 , B01J31/146 , B01J31/2273 , B01J31/2278 , B01J2231/54 , B01J2531/821 , C07C1/213 , C07C6/02 , C07C6/04 , C07C51/373 , C07C67/27 , C07C67/475 , C07C2527/135 , C07C2531/12 , C07C2531/22 , C07C2531/30 , C10G2300/1014 , C07C11/02 , C07C69/593
摘要： A process of metathesising a feedstock in the presence of a metathesis catalyst and at least one catalyst enhancer. The catalyst enhancer can be selected from a sacrificial catalyst or a non-catalyst enhancer. The process exhibits improved reaction times and/or the metathesis catalyst can be used at very low concentrations.
摘要翻译：在复分解催化剂和至少一种催化剂增强剂的存在下使原料分离的方法。催化剂增强剂可以选自牺牲催化剂或非催化剂增强剂。该方法表现出改善的反应时间和/或复分解催化剂可以以非常低的浓度使用。

9. 发明申请

US20140316149A1 ALDEHYDE-SELECTIVE WACKER-TYPE OXIDATION OF UNBIASED ALKENES 有权
标题翻译： ALDEHYDE-选择性瓦斯型氧化不饱和烷烃
公开(公告)号：US20140316149A1
公开(公告)日：2014-10-23
申请号：US14255049
申请日：2014-04-17
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： ZACHARY K. WICKENS , BILL MORANDI , ROBERT H. GRUBBS , KACPER SKAKUJ , SARAH BRONNER
IPC分类号： C07C45/34 , C07C29/132 , C07C45/37 , C07C249/04 , C07C253/00 , C07D301/22 , C07C45/00
CPC分类号： C07C45/34 , C07C51/373 , C07C201/12 , C07C205/44 , C07C209/60 , C07C213/00 , C07C227/08 , C07C249/04 , C07C253/00 , C07D301/22 , C07C59/235 , C07C211/48 , C07C217/48 , C07C229/18 , C07C47/02 , C07C47/11 , C07C47/14 , C07C47/19 , C07C47/198 , C07C47/277
摘要： This disclosure is directed to methods of preparing organic aldehydes, each method comprising contacting a terminal olefin with an oxidizing mixture comprising: (a) a dichloro-palladium complex; (b) a copper complex; (c) a source of nitrite; under aerobic reaction conditions sufficient to convert at least a portion of the terminal olefin to an aldehyde.
摘要翻译：本公开涉及制备有机醛的方法，每种方法包括使末端烯烃与氧化混合物接触，所述氧化混合物包含：（a）二氯 - 钯络合物; （b）铜络合物; （c）亚硝酸盐源; 在需氧反应条件下，足以将至少一部分末端烯烃转化为醛。

10. 发明申请

US20140031584A1 Ozonolysis Operations for Generation of Reduced and/or Oxidized Product Streams 有权
标题翻译：用于生成还原和/或氧化产物流的臭氧分解操作
公开(公告)号：US20140031584A1
公开(公告)日：2014-01-30
申请号：US13946767
申请日：2013-07-19
申请人： P2 Science, Inc.
发明人： Patrick Foley , Yonghua Yang
IPC分类号： C07C51/34 , C07C45/40
CPC分类号： C07C51/373 , C07C45/40 , C07C51/34 , C07C47/02 , C07C55/18
摘要： The present invention relates to methods for safe and efficient use of hydrogen and oxygen in ozonolysis operations. The invention also relates to an ozonolysis process involving elements of both reductive and oxidative ozonolysis which are integrated in a continuous process. In one embodiment, the ozonolysis process of the present invention uses hydrogen and/or oxygen generated from water and electricity, which may be recycled to generate water and/or electricity.
摘要翻译：本发明涉及在臭氧分解操作中安全有效地使用氢和氧的方法。本发明还涉及包含还原性和氧化臭氧分解的元素的臭氧分解方法，其被整合在连续方法中。在一个实施方案中，本发明的臭氧分解方法使用由水和电产生的氢和/或氧，其可被再循环以产生水和/或电。

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