会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明申请
    • Needle Insertion Sensor
    • 插针式传感器
    • US20070239133A1
    • 2007-10-11
    • US11763024
    • 2007-06-14
    • Lars ChristensenJens PoulsenJan Simonsen
    • Lars ChristensenJens PoulsenJan Simonsen
    • A61M31/00
    • A61B5/0404A61B5/14532
    • This invention relates to a doser comprising a syringe (2) with a needle (3) which extends beyond the doser (1), which comprises an engagement face (4) in the vicinity of the needle so that the engagement face rests against the surface of the tissue into which the needle is inserted. Detector means (5) are provided on said engagement face to sample signals on the skin of the patient. The invention further provides means (13) for receiving external information related to health monitoring of a patient. This provides a doser that may record heart rate, EKG, BGM and hypo-alarm administered medicine. The doser may further be arranged to calculate an appropriate dose of medication on the basis of a number of acquired inputs.
    • 本发明涉及一种配料器,其包括具有延伸超过定料器(1)的针(3)的注射器(2),其包括在针附近的接合面(4),使得接合面靠在表面 的针被插入其中的组织。 检测器装置(5)设置在所述接合面上以对患者的皮肤采样信号。 本发明还提供了用于接收与患者的健康监测相关的外部信息的装置(13)。 这提供了可以记录心率,EKG,BGM和低报警药物的加药器。 可以进一步将加料器设置为基于所获取的输入的数量来计算适当剂量的药物。
    • 10. 发明申请
    • CELLULASE VARIANTS
    • 纤维素酶变体
    • US20090170747A1
    • 2009-07-02
    • US12394202
    • 2009-02-27
    • Kim Vilbour AndersenMartin SchuleinTorben HenriksenLars ChristensenBo DamgaardClaus Von der Osten
    • Kim Vilbour AndersenMartin SchuleinTorben HenriksenLars ChristensenBo DamgaardClaus Von der Osten
    • C11D3/386C12N9/42
    • C11D3/38645C12N9/2437C12Y302/01004
    • The present invention relates to a method for improving the properties of a cellulolytic enzyme by amino acid substitution, deletion or insertion, the method comprising the steps of:a. constructing a multiple alignment of at least two amino acid sequences known to have three-dimensional structures similar to endoglucanase V (EGV) from Humicola insolens known from Protein Data Bank entry 4ENG; b. constructing a homology-built three-dimensional structure of the cellulolytic enzyme based on the structure of the EGV; c. identifying amino acid residue positions present in a distance from the substrate binding cleft of not more than 5 Å; d. identifying surface-exposed amino acid residues of the enzyme; e. identifying all charged or potentially charged amino acid residue positions of the enzyme; f. choosing one or more positions wherein the amino acid residue is to be substituted, deleted or where an insertion is to be provided; and g. carrying out the substitution, deletion or insertion by using conventional protein engineering techniques. Also described are cellulase variants obtained by this method.
    • 本发明涉及通过氨基酸取代,缺失或插入改进纤维素分解酶的性质的方法,该方法包括以下步骤:a。 构建已知具有类似于蛋白质数据库条目4ENG中已知的Humicola insolens的内切葡聚糖酶V(EGV)的三维结构的至少两个氨基酸序列的多重比对; b。 基于EGV的结构构建纤维素分解酶的同源构建的三维结构; C。 鉴定存在于与所述基质结合裂缝一定距离的氨基酸残基位置不大于5埃; d。 鉴定酶的表面暴露的氨基酸残基; e。 鉴定酶的所有带电荷或潜在带电的氨基酸残基位置; F。 选择其中氨基酸残基被取代,缺失或提供插入的一个或多个位置; 和g。 通过使用常规蛋白质工程技术进行取代,缺失或插入。 还描述了通过该方法获得的纤维素酶变体。