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1. 发明授权

US09149320B2 Isolation of pulmonary vein 有权
标题翻译：肺静脉隔离
公开(公告)号：US09149320B2
公开(公告)日：2015-10-06
申请号：US12363832
申请日：2009-02-02
申请人： Karl Heinz Kuck , Julian Chun , Feifan Ouyang , Nicolas Coulombe , Jean-Luc Pageard , Randy Jordan
发明人： Karl Heinz Kuck , Julian Chun , Feifan Ouyang , Nicolas Coulombe , Jean-Luc Pageard , Randy Jordan
IPC分类号： A61B18/02 , A61B18/00 , A61M25/10
CPC分类号： A61B18/02 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M2025/1097
摘要： The present invention advantageously provides a method and system for the improved isolation and corresponding treatment of tissue targeted for cryogenic or other thermal therapy to increase the thermal efficacy and thermal efficiency of the treatment. In particular, the present invention provides methods and systems for improved thermal treatment of target tissue, such as a pulmonary vein and/or regions of the left atrium by reducing the resistive forces and/or increased thermal energy experienced from blood flow exiting the pulmonary vein into the left atrium during treatment.
摘要翻译：本发明有利地提供了一种方法和系统，用于改进针对低温或其他热疗法的组织的分离和相应治疗，以增加治疗的热功效和热效率。特别地，本发明提供了用于通过减少从肺静脉血流出现的阻力和/或增加的热能来改善目标组织例如肺静脉和/或左心房区域的热处理的方法和系统在治疗期间进入左心房。

2. 发明授权

US09027389B2 Fluid control system for a medical device 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US09027389B2
公开(公告)日：2015-05-12
申请号：US13526620
申请日：2012-06-19
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61B18/02 , G01M3/28 , A61B17/00 , A61B18/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. A check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. Additionally, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。包括止回阀，其与第一柔韧元件和第二柔韧元件之间的接合部流体连通，所述阀还与排气腔流体连通。此外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监测装置。

3. 发明授权

US08206345B2 Fluid control system for a medical device 有权
公开(公告)号：US08206345B2
公开(公告)日：2012-06-26
申请号：US11074293
申请日：2005-03-07
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61M29/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.

4. 发明申请

US20110144637A1 Vein Occlusion Devices and Methods for Catheter-Based Ablation 审中-公开
标题翻译：静脉闭塞装置及基于导管消融的方法
公开(公告)号：US20110144637A1
公开(公告)日：2011-06-16
申请号：US12635821
申请日：2009-12-11
申请人： Jean-Luc Pageard , Teresa A. Mihalik
发明人： Jean-Luc Pageard , Teresa A. Mihalik
IPC分类号： A61B18/14
CPC分类号： A61B5/02158 , A61B5/026 , A61B5/04085 , A61B5/6853 , A61B5/6869 , A61B5/6885 , A61B18/14 , A61B2017/00039 , A61B2017/00084 , A61B2017/00243 , A61B2017/22067 , A61B2018/00011 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M2025/1052 , A61M2025/1086
摘要： Medical devices and methods for deriving an indication of occlusion of a blood vessel from one or more physiologic sensor are disclosed. The physiological parameters contemplated for implementation in accordance with embodiments of the disclosure may include pressure, flow, force, temperature, or tension.An exemplary device comprises a catheter having an expandable chamber coupled to a distal end portion of the catheter shaft. In various embodiments, one or more physiologic sensors may be disposed on the catheter shaft and electrically coupled to control electronics that may be provided in a console for measurement of a physiologic signal. Alternatively, an external sensor may be disposed in fluid communication with a lumen of the catheter to derive a physiological parameter such as pressure via mechanical coupling of pressure distal to the expandable chamber to the fluid in the lumen.The parameters measured by the physiologic sensor(s) provide a measure of the physiological parameters in at least a first region. The physiological parameter measured in the first region is evaluated to obtain an indication of occlusion distal to the expandable chamber. In other embodiments, measurements of the physiological parameters may be performed in the first region and a second region to derive differential measurements that are evaluated to obtain an indication of occlusion.
摘要翻译：公开了用于从一个或多个生理传感器导出血管闭塞指示的医疗装置和方法。根据本公开的实施例预期实施的生理参数可以包括压力，流量，力，温度或张力。示例性装置包括具有联接到导管轴的远端部分的可扩张腔的导管。在各种实施例中，一个或多个生理传感器可以设置在导管轴上并且电耦合到可以设置在控制台中用于测量生理信号的控制电子装置。或者，可以将外部传感器设置成与导管的内腔流体连通，从而通过机械耦合到可扩张腔的压力到腔内的流体而获得生理参数，例如压力。由生理传感器测量的参数提供至少第一区域中的生理参数的度量。评估在第一区域中测量的生理参数以获得在可扩展腔室远端的闭塞指示。在其他实施例中，生理参数的测量可以在第一区域和第二区域中进行，以得到被评估以获得闭塞指示的差异测量值。

5. 发明授权

US07648497B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US07648497B2
公开(公告)日：2010-01-19
申请号：US11244710
申请日：2005-10-06
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

6. 发明申请

US20080221508A1 FLUID CONTROL SYSTEM FOR A MEDICAL DEVICE 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US20080221508A1
公开(公告)日：2008-09-11
申请号：US12125533
申请日：2008-05-22
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61M1/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔性元件之间的接合部。此外，包括与第一柔韧元件和第二柔韧元件之间的接合部流体连通的止回阀，阀还与排气腔流体连通。另外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监控装置。

7. 发明授权

US08926602B2 Triple balloon catheter 有权
标题翻译：三重气囊导管
公开(公告)号：US08926602B2
公开(公告)日：2015-01-06
申请号：US12695423
申请日：2010-01-28
申请人： Jean-Luc Pageard
发明人： Jean-Luc Pageard
IPC分类号： A61B18/02 , A61B18/00
CPC分类号： A61B18/02 , A61B2018/0022 , A61B2018/00255 , A61B2018/00261 , A61B2018/00375 , A61B2018/00577 , A61B2018/0212
摘要： The present invention advantageously provides a method and system for cryogenically ablating large areas of tissue within the left atrium. In an exemplary embodiment a cryotherapy device includes a catheter body, a proximal end and a distal end; a first lumen; a second lumen; and an ablation element expandable from a first diameter to a second diameter, the ablation element having a surface portion that conforms to the uneven surface topography of the cardiac tissue. The ablation element can include one or more deformable balloon and/or flexible elements. The surface of the balloon can further be shaped by regulation of pressure within the one or more balloons. In an exemplary method, a tissue ablation device is provided and tissue in the left atrium is ablated with the device, whereby the ablation is created by freezing tissue.
摘要翻译：本发明有利地提供了用于低温切除左心房内的大面积组织的方法和系统。在示例性实施例中，冷冻治疗装置包括导管主体，近端和远端; 第一个管腔第二个管腔以及可从第一直径扩展到第二直径的消融元件，所述消融元件具有与心脏组织的不平坦表面形貌一致的表面部分。消融元件可以包括一个或多个可变形的球囊和/或柔性元件。球囊的表面可以通过调节一个或多个气囊内的压力而进一步成形。在一种示例性方法中，提供组织消融装置，并且使用该装置消除左心房中的组织，由此通过冷冻组织产生消融。

8. 发明授权

US07727191B2 Compliant balloon catheter 有权
标题翻译：符合气囊导管
公开(公告)号：US07727191B2
公开(公告)日：2010-06-01
申请号：US11129210
申请日：2005-05-13
申请人： Teresa Ann Mihalik , Jean-Luc Pageard , John W. Lehmann
发明人： Teresa Ann Mihalik , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61M29/00 , A61F7/12
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M2025/1013
摘要： A catheter includes a first expandable membrane having a first pressurization limit and a second expandable membrane, having a second pressurization limit, wherein the second pressurization limit is greater than the first pressurization limit, the first expandable membrane defines a cooling chamber, the second expandable membrane being disposed around the first expandable membrane to define an junction therebetween. The catheter includes a coolant injection lumen in fluid communication with the at least one fluid inlet port and the cooling chamber, and a primary coolant return lumen in fluid communication with the at least one fluid outlet port and the cooling chamber. The coolant injection tube, the cooling chamber, and the primary coolant return lumen define a first fluid pathway. The catheter further includes a secondary coolant return lumen in fluid communication with the at least one fluid outlet port and the junction. The junction and the secondary coolant return lumen define a second fluid pathway. The catheter provides a fail-safe feature by selecting the appropriate first and second pressurization limits for the first and second expandable membranes.
摘要翻译：导管包括具有第一加压极限的第一可膨胀膜和具有第二加压极限的第二可膨胀膜，其中所述第二加压极限大于所述第一加压极限，所述第一可膨胀膜限定冷却室，所述第二可膨胀膜被布置在第一可膨胀膜周围以限定它们之间的接合部。所述导管包括与所述至少一个流体入口和所述冷却室流体连通的冷却剂注入腔，以及与所述至少一个流体出口和所述冷却室流体连通的主冷却剂返回内腔。冷却剂注入管，冷却室和主冷却剂回流腔限定第一流体通路。导管还包括与至少一个流体出口和接合部流体连通的二次冷却剂返回内腔。连接点和二次冷却剂回流腔限定第二流体通路。该导管通过为第一和第二可膨胀膜选择适当的第一和第二加压限制来提供故障安全特征。

9. 发明授权

US07300433B2 Endovascular cryotreatment catheter 有权
标题翻译：血管内冷冻治疗导管
公开(公告)号：US07300433B2
公开(公告)日：2007-11-27
申请号：US10397619
申请日：2003-03-26
申请人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
发明人： Miriam Lane , Leonilda Capuano , David Holtan , Jean-Pierre Lalonde , Claudia Lückge , Jean-Luc Pageard , Marwan Abboud , Johnny Al Asmar , Abderrahim Benrabah , Ken Chen , John W. Lehmann , Philippe Marchand , Robert Martin , Fredric L. Milder , Daniel Nahon
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/22001 , A61B2017/22051 , A61B2017/22054 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268
摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.
摘要翻译：具有远端球囊组件的细长导管装置适于血管内插入。在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置，冷却室周围的绝热体。可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

10. 发明申请

US20060270982A1 Compliant balloon catheter 有权
公开(公告)号：US20060270982A1
公开(公告)日：2006-11-30
申请号：US11129210
申请日：2005-05-13
申请人： Teresa Mihalik , Jean-Luc Pageard , John Lehmann
发明人： Teresa Mihalik , Jean-Luc Pageard , John Lehmann
IPC分类号： A61F7/12 , A61M29/00
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M2025/1013
摘要： A catheter includes a first expandable membrane having a first pressurization limit and a second expandable membrane, having a second pressurization limit, wherein the second pressurization limit is greater than the first pressurization limit, the first expandable membrane defines a cooling chamber, the second expandable membrane being disposed around the first expandable membrane to define an junction therebetween. The catheter includes a coolant injection lumen in fluid communication with the at least one fluid inlet port and the cooling chamber, and a primary coolant return lumen in fluid communication with the at least one fluid outlet port and the cooling chamber. The coolant injection tube, the cooling chamber, and the primary coolant return lumen define a first fluid pathway. The catheter further includes a secondary coolant return lumen in fluid communication with the at least one fluid outlet port and the junction. The junction and the secondary coolant return lumen define a second fluid pathway. The catheter provides a fail-safe feature by selecting the appropriate first and second pressurization limits for the first and second expandable membranes.

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