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1. 发明授权

US07727191B2 Compliant balloon catheter 有权
标题翻译：符合气囊导管
公开(公告)号：US07727191B2
公开(公告)日：2010-06-01
申请号：US11129210
申请日：2005-05-13
申请人： Teresa Ann Mihalik , Jean-Luc Pageard , John W. Lehmann
发明人： Teresa Ann Mihalik , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61M29/00 , A61F7/12
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M2025/1013
摘要： A catheter includes a first expandable membrane having a first pressurization limit and a second expandable membrane, having a second pressurization limit, wherein the second pressurization limit is greater than the first pressurization limit, the first expandable membrane defines a cooling chamber, the second expandable membrane being disposed around the first expandable membrane to define an junction therebetween. The catheter includes a coolant injection lumen in fluid communication with the at least one fluid inlet port and the cooling chamber, and a primary coolant return lumen in fluid communication with the at least one fluid outlet port and the cooling chamber. The coolant injection tube, the cooling chamber, and the primary coolant return lumen define a first fluid pathway. The catheter further includes a secondary coolant return lumen in fluid communication with the at least one fluid outlet port and the junction. The junction and the secondary coolant return lumen define a second fluid pathway. The catheter provides a fail-safe feature by selecting the appropriate first and second pressurization limits for the first and second expandable membranes.
摘要翻译：导管包括具有第一加压极限的第一可膨胀膜和具有第二加压极限的第二可膨胀膜，其中所述第二加压极限大于所述第一加压极限，所述第一可膨胀膜限定冷却室，所述第二可膨胀膜被布置在第一可膨胀膜周围以限定它们之间的接合部。所述导管包括与所述至少一个流体入口和所述冷却室流体连通的冷却剂注入腔，以及与所述至少一个流体出口和所述冷却室流体连通的主冷却剂返回内腔。冷却剂注入管，冷却室和主冷却剂回流腔限定第一流体通路。导管还包括与至少一个流体出口和接合部流体连通的二次冷却剂返回内腔。连接点和二次冷却剂回流腔限定第二流体通路。该导管通过为第一和第二可膨胀膜选择适当的第一和第二加压限制来提供故障安全特征。

2. 发明授权

US09027389B2 Fluid control system for a medical device 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US09027389B2
公开(公告)日：2015-05-12
申请号：US13526620
申请日：2012-06-19
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61B18/02 , G01M3/28 , A61B17/00 , A61B18/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. A check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. Additionally, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。包括止回阀，其与第一柔韧元件和第二柔韧元件之间的接合部流体连通，所述阀还与排气腔流体连通。此外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监测装置。

3. 发明授权

US08206345B2 Fluid control system for a medical device 有权
公开(公告)号：US08206345B2
公开(公告)日：2012-06-26
申请号：US11074293
申请日：2005-03-07
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61M29/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.

4. 发明申请

US20080221508A1 FLUID CONTROL SYSTEM FOR A MEDICAL DEVICE 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US20080221508A1
公开(公告)日：2008-09-11
申请号：US12125533
申请日：2008-05-22
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61M1/00
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔性元件之间的接合部。此外，包括与第一柔韧元件和第二柔韧元件之间的接合部流体连通的止回阀，阀还与排气腔流体连通。另外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监控装置。

5. 发明授权

US08425456B2 Compliant balloon catheter 有权
标题翻译：符合气囊导管
公开(公告)号：US08425456B2
公开(公告)日：2013-04-23
申请号：US12768218
申请日：2010-04-27
申请人： Teresa Ann Mihalik , Jean-Luc Pageard , John W. Lehmann
发明人： Teresa Ann Mihalik , Jean-Luc Pageard , John W. Lehmann
IPC分类号： A61M29/00 , A61F7/12
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M2025/1013
摘要： A catheter includes a first expandable membrane having a first pressurization limit and a second expandable membrane, having a second pressurization limit, wherein the second pressurization limit is greater than the first pressurization limit, the first expandable membrane defines a cooling chamber, the second expandable membrane being disposed around the first expandable membrane to define an junction therebetween. The catheter includes a coolant injection lumen in fluid communication with the at least one fluid inlet port and the cooling chamber, and a primary coolant return lumen in fluid communication with the at least one fluid outlet port and the cooling chamber. The coolant injection tube, the cooling chamber, and the primary coolant return lumen define a first fluid pathway. The catheter further includes a secondary coolant return lumen in fluid communication with the at least one fluid outlet port and the junction. The junction and the secondary coolant return lumen define a second fluid pathway. The catheter provides a fail-safe feature by selecting the appropriate first and second pressurization limits for the first and second expandable membranes.
摘要翻译：导管包括具有第一加压极限的第一可膨胀膜和具有第二加压极限的第二可膨胀膜，其中所述第二加压极限大于所述第一加压极限，所述第一可膨胀膜限定冷却室，所述第二可膨胀膜被布置在第一可膨胀膜周围以限定它们之间的接合部。所述导管包括与所述至少一个流体入口和所述冷却室流体连通的冷却剂注入腔，以及与所述至少一个流体出口和所述冷却室流体连通的主冷却剂返回内腔。冷却剂注入管，冷却室和主冷却剂回流腔限定第一流体通路。导管还包括与至少一个流体出口和接合部流体连通的二次冷却剂返回内腔。连接点和二次冷却剂回流腔限定第二流体通路。该导管通过为第一和第二可膨胀膜选择适当的第一和第二加压限制来提供故障安全特征。

6. 发明授权

US08225643B2 Fluid control system for a medical device 有权
标题翻译：用于医疗设备的流体控制系统
公开(公告)号：US08225643B2
公开(公告)日：2012-07-24
申请号：US12125533
申请日：2008-05-22
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Jean-Luc Pageard , John W. Lehmann
IPC分类号： G01M3/26
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2018/0022 , A61B2018/00577 , A61B2018/00744 , A61B2018/00863 , A61B2018/00898 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , G01M3/02 , G01M3/2846
摘要： The present invention provides a medical device having an elongate body with both a proximal end and a distal end, wherein the elongate body defines an intake lumen and an exhaust lumen. The medical device also has a first pliable element defining a cooling chamber disposed at a point along the elongate body, with the cooling chamber being in fluid communication with the intake lumen and the exhaust lumen. A second pliable element is provided which at least partially encloses the first pliable element, thereby defining a junction between the first and second pliable element. Moreover, a check valve is included which is in fluid communication with the junction between the first pliable element and second pliable element, the valve further being in fluid communication with the exhaust lumen. In addition, the medical device may include sensors or other monitoring means in fluid communication with the junction and the cooling chamber.
摘要翻译：本发明提供一种医疗装置，其具有具有近端和远端两者的细长主体，其中细长主体限定进气腔和排气腔。医疗装置还具有限定设置在沿着细长体的点处的冷却室的第一柔性元件，其中冷却室与进气腔和排气腔流体连通。提供了第二柔韧元件，其至少部分地包围第一柔韧元件，从而限定第一和第二柔韧元件之间的接合部。此外，包括与第一柔韧元件和第二柔韧元件之间的接合部流体连通的止回阀，阀还与排气腔流体连通。另外，医疗装置可以包括与接头和冷却室流体连通的传感器或其它监控装置。

7. 发明申请

US20120283713A1 COMPLIANT SLEEVES COUPLED WITH WIRE STRUCTURES FOR CRYOABLATION 审中-公开
标题翻译：合适的纱线与结扎线结合使用
公开(公告)号：US20120283713A1
公开(公告)日：2012-11-08
申请号：US13098551
申请日：2011-05-02
申请人： Teresa Ann Mihalik , David J. Zarbatany , Kaushik A. Patel , Alexander J. Asconeguy , Sitha Lay
发明人： Teresa Ann Mihalik , David J. Zarbatany , Kaushik A. Patel , Alexander J. Asconeguy , Sitha Lay
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B5/068 , A61B18/1492 , A61B18/16 , A61B2018/00023 , A61B2018/00267 , A61B2018/00577 , A61B2018/00613 , A61B2018/00815 , A61B2018/00875 , A61B2018/00892 , A61B2018/0212 , A61B2018/0262 , A61B2090/065
摘要： A medical system, including a catheter body, a mesh coupled to the catheter body; an expandable element enclosing the mesh, the expandable element made from a compliant natural rubber emulsion, such as Yulex® HA; and a cryogenic coolant source in fluid communication with the expandable element.
摘要翻译：医疗系统，包括导管主体，联接到导管主体的网; 包围网的可膨胀元件，由柔顺天然橡胶乳液（例如Yulex HA）制成的可膨胀元件; 以及与可膨胀元件流体连通的低温冷却剂源。

8. 发明授权

US08992515B2 Coolant injection tube 有权
标题翻译：冷却液注射管
公开(公告)号：US08992515B2
公开(公告)日：2015-03-31
申请号：US12269493
申请日：2008-11-12
申请人： Jean-Pierre Lalonde , Marwan Abboud , Teresa Ann Mihalik , Jean-Pierre Desmarais , Dan Wittenberger
发明人： Jean-Pierre Lalonde , Marwan Abboud , Teresa Ann Mihalik , Jean-Pierre Desmarais , Dan Wittenberger
IPC分类号： A61B18/18 , A61B18/02 , A61B17/22 , A61B18/00
CPC分类号： A61B18/02 , A61B2017/00318 , A61B2017/22038 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A medical device includes a steering element defining a passage for a guide wire. A fluid injection tube defining a proximal and a distal end is also included, wherein a portion of the fluid injection tube is contoured about a portion of the steering element. A plurality of injection ports may be disposed in the portion of the fluid injection tube contoured about the steering element.
摘要翻译：医疗装置包括限定用于导丝的通道的操纵元件。还包括限定近端和远端的流体注入管，其中流体注入管的一部分围绕转向元件的一部分成形。多个注射口可以设置在围绕转向元件成形的流体注射管的部分中。

9. 发明授权

US07727228B2 Method and apparatus for inflating and deflating balloon catheters 有权
标题翻译：球囊导管充气和放气的方法和装置
公开(公告)号：US07727228B2
公开(公告)日：2010-06-01
申请号：US10806995
申请日：2004-03-23
申请人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Eric Monger
发明人： Marwan Abboud , Rachid Mahrouche , Teresa Ann Mihalik , Chadi Harmouche , Eric Monger
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/22051 , A61B2018/0022 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262 , A61M25/1011 , A61M25/1018 , A61M25/10185
摘要： A system and method for controlling the inflation, ablation, and deflation of a balloon catheter is provided. The system includes a balloon catheter, a console having a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system comprises a PID (Proportional Integral Derivative) controller or other pressure-sensing device that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.
摘要翻译：提供了一种用于控制气囊导管的充气，消融和放气的系统和方法。该系统包括球囊导管，具有加压气体或液体充气源的控制台，以及将加压的冷却剂输送到球囊导管的脐带系统。该系统包括PID（比例积分微分）控制器或其他压力感测装置，其监测气囊导管内的压力和体积的量。在充气期间，气囊内的流体的压力和/或体积保持在目标量，以便提供相对于期望目标区域的足够的机械化压力。该系统会限制通气压力，以便在发生泄漏时释放出安全数量的气体。如果该量低于某一阈值水平，则假设气体或流体出口，并且暂停充气过程。

10. 发明申请

US20080097373A1 Distal cooling distribution system for a medical device 有权
标题翻译：用于医疗设备的远端冷却分配系统
公开(公告)号：US20080097373A1
公开(公告)日：2008-04-24
申请号：US11476416
申请日：2006-06-28
申请人： Yixin Hu , Vladimir Tzonev , Teresa Ann Mihalik , Benoit Thibault , Dan Wittenberger , Miriam Lane , Cristian Petre
发明人： Yixin Hu , Vladimir Tzonev , Teresa Ann Mihalik , Benoit Thibault , Dan Wittenberger , Miriam Lane , Cristian Petre
IPC分类号： A61M25/10 , A61M29/02 , A61M25/00 , A61M31/00
CPC分类号： A61M25/1025 , A61B18/02 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61M2025/0004 , A61M2025/0175 , A61M2025/1061
摘要： The present invention may include a medical device having a handle, a catheter coupled to the handle, and an expandable element coupled to the catheter. The medical device may also include first and second elongate bodies that traverse a length of the handle and catheter. A housing may be disposed within the handle, with the housing defines a first opening able to receive a portion of the first elongate body, a second opening able to receive a portion of the second elongate body, and a third opening opposite the first and second openings able to receive a portion of both the and second elongate bodies. A separation element may be disposed within the housing, with the separation element defining a path able to receive a portion of the second elongate body, and whereby a portion of the first elongate body forms a loop around the separation element.
摘要翻译：本发明可以包括具有手柄，耦合到手柄的导管和联接到导管的可扩张元件的医疗装置。医疗装置还可以包括穿过手柄和导管的一段长度的第一和第二细长体。壳体可以设置在手柄内，其中壳体限定能够容纳第一细长主体的一部分的第一开口，能够容纳第二细长主体的一部分的第二开口，以及与第一和第二能够容纳第二细长体的一部分的开口。分离元件可以设置在壳体内，其中分离元件限定能够接收第二细长主体的一部分的路径，并且由此第一细长主体的一部分围绕分离元件形成环。

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