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1. 发明授权

US07302348B2 Method and system for quantifying and removing spatial-intensity trends in microarray data 有权
标题翻译：用于量化和消除微阵列数据中的空间强度趋势的方法和系统
公开(公告)号：US07302348B2
公开(公告)日：2007-11-27
申请号：US10859868
申请日：2004-06-02
申请人： Jayati Ghosh , Bill J. Peck , Eric M. Leproust , Charles David Troup , Glenda Choate Delenstarr , Patrick J. Collins , John F. Corson , Paul K. Wolber , Xiangyang Zhou
发明人： Jayati Ghosh , Bill J. Peck , Eric M. Leproust , Charles David Troup , Glenda Choate Delenstarr , Patrick J. Collins , John F. Corson , Paul K. Wolber , Xiangyang Zhou
IPC分类号： G06F19/00 , G06F15/00 , G11C17/00
CPC分类号： G06F19/24 , G06F19/20
摘要： A method and system for quantifying and correcting spatial-intensity trends for each channel of a microarray data set having one or more channels. The method and system of one embodiment of the present invention selects a set of features from each channel of the microarray data set. Based on the selected set of features, a surface is used to determine the intensities for all features in each channel of the microarray data set. Spatial-intensity trends within the microarray data set are quantified, based on the surface to the intensities for each channel of the microarray data set. After the surface has been determined, the spatial-intensity trend can be removed from the microarray data set.
摘要翻译：一种用于量化和校正具有一个或多个通道的微阵列数据集的每个通道的空间强度趋势的方法和系统。本发明的一个实施例的方法和系统从微阵列数据集的每个通道中选择一组特征。基于所选择的特征集合，使用表面来确定微阵列数据集的每个通道中的所有特征的强度。基于微阵列数据集的每个通道的表面到强度，量化微阵列数据集内的空间强度趋势。在确定表面后，可以从微阵列数据集中去除空间强度趋势。

2. 发明授权

US07078505B2 Manufacture of arrays with varying deposition parameters 失效
标题翻译：制造具有不同沉积参数的阵列
公开(公告)号：US07078505B2
公开(公告)日：2006-07-18
申请号：US10165783
申请日：2002-06-06
申请人： Jay K. Bass , Maryam Mobed-Miremadi , Michelle M. Maranowski , Roy H. Kanemoto , Bill J. Peck , Eric M. Leproust , Michael P. Caren
发明人： Jay K. Bass , Maryam Mobed-Miremadi , Michelle M. Maranowski , Roy H. Kanemoto , Bill J. Peck , Eric M. Leproust , Michael P. Caren
IPC分类号： C07H21/04 , C12Q1/68 , C12M1/36
CPC分类号： C03C17/32 , B01J2219/00286 , B01J2219/00378 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00722 , B01L3/0241 , C03C17/002 , C40B40/06 , C40B60/14
摘要： Methods are disclosed for synthesizing a plurality of compounds on the surface of supports. The synthesis comprises a series of cycles of steps in which reagents for conducting the synthesis are deposited on the surface of the support to form the chemical compounds. At least one physical parameter of the deposition varies between cycles The method comprises conducting the synthesis in at least two sets of cycles, arbitrarily designated as a first set and a second set. Each cycle comprises at least one step of depositing reagents on a surface by means of droplet dispensing elements that traverse the surface of the support. At least one, and desirably all, of the following deposition parameters are employed as indicated: The number of times of repetition for a step of depositing reagents in at least one cycle of the second set is less than the number of times of repetition for a corresponding step in at least one cycle of the first set. The rate of deposition in at least one cycle of the second set is slower than or equal to the rate of deposition in at least one cycle of the first set. The rate of traversal of the dispensing elements over the surface of the support in at least one cycle of the second set is greater than such rate of traversal in at least one cycle of the first set.
摘要翻译：公开了在载体表面上合成多种化合物的方法。该合成包括一系列循环的步骤，其中用于进行合成的试剂沉积在载体的表面上以形成化合物。沉积物的至少一个物理参数在循环之间变化。该方法包括以任意指定为第一组和第二组的至少两组循环进行合成。每个循环包括至少一个步骤，其通过穿过载体表面的液滴分配元件在表面上沉积试剂。如下所示使用以下沉积参数中的至少一个，期望地全部以下沉积参数：在第二组的至少一个循环中沉积试剂的步骤的重复次数小于第二组的重复次数在第一组的至少一个循环中的对应步骤。在第二组的至少一个循环中的沉积速率慢于或等于第一组的至少一个循环中的沉积速率。在第二组的至少一个循环中，分配元件在支撑体表面上的遍历速率大于在第一组的至少一个循环中的穿过速率。

3. 发明申请

US20080085511A1 Preparation of biopolymer arrays 审中-公开
标题翻译：生物聚合物阵列的制备
公开(公告)号：US20080085511A1
公开(公告)日：2008-04-10
申请号：US11543369
申请日：2006-10-05
申请人： Bill J. Peck , Eric M. Leproust
发明人： Bill J. Peck , Eric M. Leproust
IPC分类号： C12Q1/68 , B41J2/01 , G06F19/00 , C12M3/00
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00659 , B01J2219/00675 , B01J2219/00695 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B82Y30/00
摘要： Methods and apparatus are disclosed for preparing an array of biopolymer features on a substrate by initiating multiple cycles of drop deposition of biopolymer forming reagents to feature locations on the surface of the substrate. Each cycle comprises at least one step of deposition of biopolymer monomers or biopolymer subunits. For at least one of the biopolymer forming reagents and for at least a portion of the method, a dispensing protocol is employed wherein the biopolymer forming reagent is dispensed from a separate drop dispenser of a drop dispensing device and each drop dispenser comprises multiple nozzles. Multiple passes of the drop dispensing devices are employed for each cycle. In each cycle of the dispensing protocol drops of reagents are dispensed to feature locations from at least two different nozzles for each reagent in at least two different passes of a drop dispensing device. The cycles are repeated a sufficient number of times to prepare the array of biopolymer features.
摘要翻译：公开了用于通过引发多个循环的生物聚合物形成试剂的滴加沉积在基底表面上的特征位置来制备基底上生物聚合物特征阵列的方法和装置。每个循环包括沉积生物聚合物单体或生物聚合物亚单元的至少一个步骤。对于生物聚合物形成试剂和至少一部分方法中的至少一种，使用分配方案，其中生物聚合物形成试剂从滴剂分配装置的单独的液滴分配器分配，并且每个滴液分配器包括多个喷嘴。每个循环采用多次滴液分配装置。在分配方案的每个循环中，在液滴分配装置的至少两个不同通道中，每个试剂滴从多个不同喷嘴的至少两个不同喷嘴分配到特征位置。循环重复足够次数以制备生物聚合物特征阵列。

4. 发明授权

US06858186B2 Chambers for storing arrays 失效
标题翻译：存储阵列的房间
公开(公告)号：US06858186B2
公开(公告)日：2005-02-22
申请号：US10035907
申请日：2001-12-24
申请人： Richard O. Hilson , Bill J. Peck , Eric M. Leproust
发明人： Richard O. Hilson , Bill J. Peck , Eric M. Leproust
IPC分类号： A61B17/06 , A61B19/02 , B01J19/00 , B01L9/00 , B05D3/00 , C12M1/34 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00286 , B01J2219/00328 , B01J2219/00353 , B01J2219/00369 , B01J2219/00378 , B01J2219/00387 , B01J2219/00432 , B01J2219/00497 , B01J2219/00518 , B01J2219/00527 , B01J2219/00536 , B01J2219/00538 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00657 , B01J2219/00659 , B01J2219/00664 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14
摘要： Apparatus and methods are disclosed for storing a plurality of supports having a plurality of chemical compounds bound to the surfaces of the supports. In the apparatus, a mechanism for diffusively introducing pressurized gas into the apparatus is in fluid communication with an outlet element comprising a plurality of openings. A holding chamber for the supports is in fluid communication with the outlet element. The outlet element and the holding chamber are disposed such that gas flow through the chamber is substantially uniform and unidirectional. The holding chamber comprises an opening sufficient to permit movement of the supports to and from the holding chamber and comprises a plurality of holding elements for holding the supports.
摘要翻译：公开了用于存储多个支撑体的装置和方法，所述多个支撑件具有结合到支撑体表面的多个化学化合物。在该装置中，用于将加压气体扩散地引入到装置中的机构与包括多个开口的出口元件流体连通。用于支撑件的保持室与出口元件流体连通。出口元件和保持室被布置成使得通过腔室的气体流体基本上均匀且单向。保持室包括足以允许支撑件移动到保持室和从保持室移动的开口，并且包括用于保持支撑件的多个保持元件。

5. 发明授权

US07875463B2 Generalized pulse jet ejection head control model 有权
标题翻译：广义脉冲喷射头控制模型
公开(公告)号：US07875463B2
公开(公告)日：2011-01-25
申请号：US10809981
申请日：2004-03-26
申请人： David R. Adaskin , Bill J. Peck , Stanley P. Woods , William G. Chesk
发明人： David R. Adaskin , Bill J. Peck , Stanley P. Woods , William G. Chesk
IPC分类号： B01L3/02 , G01N1/10 , G05B15/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00695 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , Y10T436/11 , Y10T436/114998 , Y10T436/2575
摘要： A generalized printhead control model is provided herein as a basis for configuring printhead control software that will operate any selected printhead or group of printheads. The subject model covers a hierarchy of classes for the attributes of software that controls the printheads in a system, such as for producing a biopolymer array.
摘要翻译：本文提供了广义的打印头控制模型，作为配置打印头控制软件的基础，打印头控制软件将操作任何所选的打印头或打印头组。主题模型涵盖了控制系统中的打印头的软件的属性的类的层次结构，例如用于生产生物聚合物阵列。

6. 发明申请

US20080085514A1 Methods and devices for array synthesis 审中-公开
标题翻译：阵列合成的方法和装置
公开(公告)号：US20080085514A1
公开(公告)日：2008-04-10
申请号：US11546177
申请日：2006-10-10
申请人： Bill J. Peck , Eric Leproust , Lawrence J. DaQuino , Heather Brummel McCuen
发明人： Bill J. Peck , Eric Leproust , Lawrence J. DaQuino , Heather Brummel McCuen
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00659 , B01J2219/00722 , B01L2300/105 , B01L2400/0439 , B01L2400/0442 , B01L2400/0487 , B01L2400/0633
摘要： Aspects of the invention include methods of fabricating an array. In an embodiment of the invention, a dry gas is vertically directed onto a solid support surface prior to deposition of a fluid reagent on a surface of the support. Also provided are devices and systems for practicing the methods.
摘要翻译：本发明的方面包括制造阵列的方法。在本发明的一个实施方案中，在将流体试剂沉积在载体的表面上之前，将干燥气体垂直地引导到固体支撑体表面上。还提供了用于实施该方法的装置和系统。

7. 发明申请

US20090325821A1 In Situ Nucleic Acid Array Synthesis Compositions 审中-公开
标题翻译：原位核酸阵列合成组合物
公开(公告)号：US20090325821A1
公开(公告)日：2009-12-31
申请号：US12340796
申请日：2008-12-22
申请人： Eric Leproust , Bill J. Peck , Xiaohua C. Huang
发明人： Eric Leproust , Bill J. Peck , Xiaohua C. Huang
IPC分类号： C40B50/18 , C40B60/14
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00527
摘要： In situ nucleic acid synthesis compositions are provided. The compositions include a solvent; and at least one of: a viscosity modifier; and a surface tension modifier. During use, the compositions further include one of a phosphoramidite and an activator. Also provide are methods of using the compositions, e.g., in the synthesis of nucleic acid arrays, and systems kits for practicing the methods.
摘要翻译：提供原位核酸合成组合物。组合物包括溶剂; 和至少一种：粘度调节剂; 和表面张力调节剂。在使用期间，组合物还包括亚磷酰胺和活化剂之一。还提供使用组合物的方法，例如在核酸阵列的合成中以及用于实施该方法的系统试剂盒。

8. 发明申请

US20080085513A1 In situ nucleic acid array synthesis compositions 审中-公开
标题翻译：原位核酸阵列合成组合物
公开(公告)号：US20080085513A1
公开(公告)日：2008-04-10
申请号：US11545931
申请日：2006-10-10
申请人： Eric Leproust , Bill J. Peck , Xiaohua C. Huang
发明人： Eric Leproust , Bill J. Peck , Xiaohua C. Huang
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00527
摘要： In situ nucleic acid synthesis compositions are provided. The compositions include a solvent; and at least one of: a viscosity modifier; and a surface tension modifier. During use, the compositions further include one of a phosphoramidite and an activator. Also provide are methods of using the compositions, e.g., in the synthesis of nucleic acid arrays, and systems kits for practicing the methods.
摘要翻译：提供原位核酸合成组合物。组合物包括溶剂; 和至少一种：粘度调节剂; 和表面张力调节剂。在使用期间，组合物还包括亚磷酰胺和活化剂之一。还提供使用组合物的方法，例如在核酸阵列的合成中以及用于实施该方法的系统试剂盒。

9. 发明授权

US06838888B2 Flow cell humidity sensor system 失效
标题翻译：流量计湿度传感器系统
公开(公告)号：US06838888B2
公开(公告)日：2005-01-04
申请号：US10017336
申请日：2001-12-13
申请人： Bill J. Peck
发明人： Bill J. Peck
IPC分类号： G01N27/22 , G01R27/26 , G01N33/543
CPC分类号： G01N27/225
摘要： A system for monitoring water concentration in gaseous sample is disclosed. It is readily applicable in the synthesis of biopolymer arrays/microarrays involving the use of water-sensitive reagents. A flow cell is provided in which a capacitance sensor is placed separate from a production or synthesis environment. Sample and dry gas may be provided to the flow cell via conduits and valves or a manifold system. Dry gas, such as N2, is used to dry the sensor or simply to maintain it in a dried condition. The same gas may be used to drive an optional venturi pump to draw sample for measurement into the cell from the synthesis environment.

10. 发明授权

US06846454B2 Fluid exit in reaction chambers 失效
公开(公告)号：US06846454B2
公开(公告)日：2005-01-25
申请号：US10035789
申请日：2001-12-24
申请人： Bill J. Peck
发明人： Bill J. Peck
IPC分类号： B01J19/00 , B01L3/00 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , B01L1/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00337 , B01J2219/0036 , B01J2219/00378 , B01J2219/00389 , B01J2219/00477 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： Apparatus and methods are disclosed for controlling flow of fluid inside a chamber. A device comprises a chamber comprising at least one wall, a first opening for introducing a fluid into the interior of the chamber, and a second opening opposite the first opening. The at least one wall of the chamber is designed to provide a contracting section, a section having substantially constant cross-sectional area and a diffusing section through the chamber from the first opening to the second opening. The device may be employed as a gas outlet in a reaction chamber for conducting reactions where it is desired to control the internal atmosphere of the reaction chamber. The apparatus may be employed in the manufacture of biopolymers on the surface of a support such as an array of biopolymer features on the support. Also disclosed is a holding element for a support wherein the holding element is a low drag body.

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