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    • 6. 发明申请
    • Preparation of biopolymer arrays
    • 生物聚合物阵列的制备
    • US20080085511A1
    • 2008-04-10
    • US11543369
    • 2006-10-05
    • Bill J. PeckEric M. Leproust
    • Bill J. PeckEric M. Leproust
    • C12Q1/68B41J2/01G06F19/00C12M3/00
    • C07K1/047B01J19/0046B01J2219/0036B01J2219/00378B01J2219/00529B01J2219/00585B01J2219/00596B01J2219/00659B01J2219/00675B01J2219/00695B01J2219/00722B01J2219/00725B01J2219/00729B01J2219/00731B82Y30/00
    • Methods and apparatus are disclosed for preparing an array of biopolymer features on a substrate by initiating multiple cycles of drop deposition of biopolymer forming reagents to feature locations on the surface of the substrate. Each cycle comprises at least one step of deposition of biopolymer monomers or biopolymer subunits. For at least one of the biopolymer forming reagents and for at least a portion of the method, a dispensing protocol is employed wherein the biopolymer forming reagent is dispensed from a separate drop dispenser of a drop dispensing device and each drop dispenser comprises multiple nozzles. Multiple passes of the drop dispensing devices are employed for each cycle. In each cycle of the dispensing protocol drops of reagents are dispensed to feature locations from at least two different nozzles for each reagent in at least two different passes of a drop dispensing device. The cycles are repeated a sufficient number of times to prepare the array of biopolymer features.
    • 公开了用于通过引发多个循环的生物聚合物形成试剂的滴加沉积在基底表面上的特征位置来制备基底上生物聚合物特征阵列的方法和装置。 每个循环包括沉积生物聚合物单体或生物聚合物亚单元的至少一个步骤。 对于生物聚合物形成试剂和至少一部分方法中的至少一种,使用分配方案,其中生物聚合物形成试剂从滴剂分配装置的单独的液滴分配器分配,并且每个滴液分配器包括多个喷嘴。 每个循环采用多次滴液分配装置。 在分配方案的每个循环中,在液滴分配装置的至少两个不同通道中,每个试剂滴从多个不同喷嘴的至少两个不同喷嘴分配到特征位置。 循环重复足够次数以制备生物聚合物特征阵列。
    • 10. 发明授权
    • Flow cell humidity sensor system
    • 流量计湿度传感器系统
    • US07051574B2
    • 2006-05-30
    • US10990941
    • 2004-11-16
    • Bill J. Peck
    • Bill J. Peck
    • G01N19/10G01N27/22G01R27/26
    • G01N27/225
    • A system for monitoring water concentration in gaseous sample is disclosed. It is readily applicable in the synthesis of biopolymer arrays/microarrays involving the use of water-sensitive reagents. A flow cell is provided in which a capacitance sensor is placed separate from a production or synthesis environment. Sample and dry gas may be provided to the flow cell via conduits and valves or a manifold system. Dry gas, such as N2, is used to dry the sensor or simply to maintain it in a dried condition. The same gas may be used to drive an optional venturi pump to draw sample for measurement into the cell from the synthesis environment.
    • 公开了一种监测气态样品中水浓度的系统。 它很容易适用于涉及使用水敏试剂的生物聚合物阵列/微阵列的合成。 提供了一种流动池,其中电容传感器与生产或合成环境分离放置。 可以通过导管和阀或歧管系统向流动池提供样品和干燥气体。 干燥的气体,例如N 2 N,用于干燥传感器或简单地将其保持在干燥状态。 可以使用相同的气体来驱动可选的文丘里泵从合成环境中抽出样品用于测量。