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1. 发明授权

US06604054B2 Method of detecting fluid flow through a conduit 有权
标题翻译：检测流经管道的流体的方法
公开(公告)号：US06604054B2
公开(公告)日：2003-08-05
申请号：US09794255
申请日：2001-02-28
申请人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
发明人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
IPC分类号： G01F15075
CPC分类号： G01N35/1009 , G01N35/1016 , G01N2035/1025 , Y10T137/8326
摘要： A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.
摘要翻译：用于检测流体传送探针与流体表面的接触并用于检测通过探针的流体流动的传感器包括沿着探针的远侧末端上游的探针的流体流动路径设置的第一电极和纵向间隔开的第二电极，与第一电极电隔离并设置在探针的远端。振荡信号通过第一电极传输，信号的至少一部分通过第二电极被接收。通过由于探针的远端与流体表面接触或由于流体流过第一和第二电极之间的导管而导致的接收信号的变化，可以检测流体表面接触和流体流动。可以使用压力传感器来监测流体输送探针的流体导管内的内部流体压力，作为用于检测通过导管的流体流动的次要冗余机构。

2. 发明授权

US06663353B2 Fluid transfer system 有权
标题翻译：流体传输系统
公开(公告)号：US06663353B2
公开(公告)日：2003-12-16
申请号：US10214158
申请日：2002-08-08
申请人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
发明人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
IPC分类号： G01F2202
CPC分类号： G01N35/1009 , G01N35/1016 , G01N2035/1025 , Y10T137/8326
摘要： A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant mechanism for detecting fluid flow through the conduit.
摘要翻译：用于检测流体传送探针与流体表面的接触并用于检测通过探针的流体流动的传感器包括沿着探针的远侧末端上游的探针的流体流动路径设置的第一电极和纵向间隔开的第二电极，与第一电极电隔离并设置在探针的远端。振荡信号通过第一电极传输，信号的至少一部分通过第二电极被接收。通过由于探针的远端与流体表面接触或由于流体流过第一和第二电极之间的导管而导致的接收信号的变化，可以检测流体表面接触和流体流动。可以使用压力传感器来监测流体输送探针的流体导管内的内部流体压力，作为用于检测通过导管的流体流动的次要冗余机构。

3. 发明授权

US06658946B2 Method of detecting fluid flow through a conduit 有权
标题翻译：检测流经管道的流体的方法
公开(公告)号：US06658946B2
公开(公告)日：2003-12-09
申请号：US10214161
申请日：2002-08-08
申请人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
发明人： James H. Lipscomb , Larry Jurik , Bernard Katz , Michael J. Keating , Stone Klengler , John J. Kotlarik , Mieczyslaw Wroblewski
IPC分类号： G01F2202
CPC分类号： G01N35/1009 , G01N35/1016 , G01N2035/1025 , Y10T137/8326
摘要： A sensor for detecting contact of a fluid delivery probe with a fluid surface and for detecting fluid flow through the probe includes a first electrode disposed along a fluid flow path of the probe upstream from a distal tip of the probe and a second electrode longitudinally spaced and electrically isolated from the first electrode and disposed at the distal tip of the probe. An oscillating signal is transmitted through the first electrode, and at least a portion of the signal is received through the second electrode. Through changes in the received signal due to the distal tip of the probe coming into contact with a fluid surface or due to fluid flow through the conduit between the first and second electrodes, fluid surface contact and fluid flow can be detected. A pressure sensor can be employed to monitor internal fluid pressure within the fluid conduit of the fluid delivery probe as a secondary, redundant device for detecting fluid flow through the conduit.
摘要翻译：用于检测流体传送探针与流体表面的接触并用于检测通过探针的流体流动的传感器包括沿着探针的远侧末端上游的探针的流体流动路径设置的第一电极和纵向间隔开的第二电极，与第一电极电隔离并设置在探针的远端。振荡信号通过第一电极传输，信号的至少一部分通过第二电极被接收。通过由于探针的远端与流体表面接触或由于流体流过第一和第二电极之间的导管而导致的接收信号的变化，可以检测流体表面接触和流体流动。可以使用压力传感器来监测流体输送探针的流体导管内的内部流体压力，作为用于检测通过导管的流体流动的辅助冗余装置。

4. 发明授权

US5275951A Liquid level sensing method and device 失效
标题翻译：液位感测方法及装置
公开(公告)号：US5275951A
公开(公告)日：1994-01-04
申请号：US939570
申请日：1992-09-03
申请人： Herbert S. Chow , John J. Kotlarik , Mieczyslaw Wroblewski , Thomas J. Wilson , Jimmy D. McCoy
发明人： Herbert S. Chow , John J. Kotlarik , Mieczyslaw Wroblewski , Thomas J. Wilson , Jimmy D. McCoy
IPC分类号： G01N21/17 , B01L3/00 , B01L3/02 , G01N15/14 , G01N21/82 , G01N33/48 , G01N33/483 , G01N33/543 , G01N33/80 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G02B7/28 , G06T1/00 , G01F23/00 , G01F23/28
CPC分类号： G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G02B7/28 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G01N35/1004 , Y10T137/7306 , Y10T436/115831
摘要： An apparatus is provided which includes a reaction cartridge having a plurality of reaction wells having different reagents disposed thereon, at least one well adapted to receive a sample, a well containing particles adapted to bind to the sample and which have the capability of being separated from cells which are not bound to the separation particles and at least one fluorophore adapted to bind to a specific type of cell in the sample, and a wash area adapted for washing a probe. An image forming device is provided to detect images which indicate whether specific reactions have occurred in each of the reaction wells. The apparatus also includes a mechanism for dispensing and aspirating liquids including a mechanism for detecting liquid levels. The device further includes logic for analyzing the information received from the image detection apparatus and processing the information to generate a visual indication of the results of the assays being performed. A microprocessor is provided to assist in the operation of the device as well as in the image processing.
摘要翻译：提供了一种装置，其包括具有多个反应孔的反应筒，反应孔具有设置在其上的不同试剂，至少一个适于接收样品的孔，含有适于结合样品的颗粒的孔，并具有与样品分离的能力不结合分离颗粒的细胞和至少一种适于结合样品中特定类型的细胞的荧光团和适于洗涤探针的洗涤区域。提供图像形成装置以检测指示每个反应孔中是否发生特定反应的图像。该装置还包括用于分配和抽吸液体的机构，包括用于检测液位的机构。该装置还包括用于分析从图像检测装置接收的信息并处理信息以生成正在执行的测定结果的视觉指示的逻辑。提供微处理器以帮助设备的操作以及图像处理。

5. 发明申请

US20100035684A1 SYSTEM AND METHOD FOR CONTROLLING MOVEMENT OF A PLURALITY OF GAME OBJECTS ALONG A PLAYFIELD 审中-公开
标题翻译：用于控制玩家游戏对象运动的系统和方法
公开(公告)号：US20100035684A1
公开(公告)日：2010-02-11
申请号：US12537286
申请日：2009-08-07
申请人： John J. Kotlarik , David A. Myus
发明人： John J. Kotlarik , David A. Myus
IPC分类号： A63F13/00
CPC分类号： A63H17/395 , A63F2300/69 , A63F2300/8017 , A63H30/04
摘要： An amusement game and method that utilize an image sensing device to track and determine the position of a plurality of game objects on a playfield. The amusement game includes an image sensing device, such as a CCD or CMOS camera, that is positioned to view the playfield of the amusement game and track the movement of a plurality of game objects along the playfield. During game play, the control unit may control the movement of one or more of the game objects along the playfield. The control unit receives a series of sequential image scans from the image sensing device and determines the position and movement of the game objects along the playfield. Based upon the detected position of the game objects under computer control, the control unit modifies the control parameters of the game object during game play.
摘要翻译：一种游戏游戏和方法，利用图像感测装置跟踪并确定多个游戏对象在场地上的位置。娱乐游戏包括诸如CCD或CMOS照相机的图像感测装置，其被定位成观看娱乐游戏的游戏场并跟踪多个游戏对象沿游戏场的移动。在游戏过程中，控制单元可以控制一个或多个游戏对象沿游戏场的移动。控制单元从图像感测装置接收一系列连续的图像扫描，并确定游戏对象沿游戏场的位置和移动。基于在计算机控制下的游戏对象的检测位置，控制单元在游戏过程中修改游戏对象的控制参数。

6. 发明申请

US20090036199A1 GAME OF SKILL AND METHOD OF OPERATING 审中-公开
标题翻译：技能游戏和操作方法
公开(公告)号：US20090036199A1
公开(公告)日：2009-02-05
申请号：US11830073
申请日：2007-07-30
申请人： David A. Myus , John J. Kotlarik
发明人： David A. Myus , John J. Kotlarik
IPC分类号： A63F13/06
CPC分类号： G07F17/34 , G07F17/3295
摘要： A system and method for operating a game of skill to provide awards or prizes to players of the game when the player has been successful in completing the game task. The game of skill is operated at a current skill level and the game monitors a rule parameter, such as a winning percentage or payout percentage, as the game is played. If the rule parameter exceeds a maximum limit, the difficulty level of the game is adjusted. Likewise, if the rule parameter is below a minimum limit, the difficulty level of the game is decreased. At each and every difficulty level, the player is able to succeed in winning the game of skill.
摘要翻译：一种用于操作游戏技能以在玩家已经成功完成游戏任务时为玩家提供奖励或奖品的系统和方法。技能游戏以当前技能水平操作，并且游戏在玩游戏时监视诸如获胜百分比或支付百分比的规则参数。如果规则参数超过最大限制，则调整游戏难度级别。同样，如果规则参数低于最低限度，则游戏的难度级别也会降低。在每个难度级别上，玩家能够成功地赢得技能的游戏。

7. 发明授权

US06468229B1 Apparatus and method for the collection of interstitial fluids 有权
标题翻译：用于收集间质液的装置和方法
公开(公告)号：US06468229B1
公开(公告)日：2002-10-22
申请号：US09529148
申请日：2001-01-26
申请人： John P. Grace , Neil W. Loomis , Thomas G. Schapira , Sie Ting Wong , Kristin M. Noonan , Michael G. Lowery , Pete M. Bojan , Daniel P. Schmidt , Tung-Ming Huang , Robert G. Hiltibran , Mark R. Pope , John J. Kotlarik , Brian Joseph Tarkowski , David Dean Cunningham
发明人： John P. Grace , Neil W. Loomis , Thomas G. Schapira , Sie Ting Wong , Kristin M. Noonan , Michael G. Lowery , Pete M. Bojan , Daniel P. Schmidt , Tung-Ming Huang , Robert G. Hiltibran , Mark R. Pope , John J. Kotlarik , Brian Joseph Tarkowski , David Dean Cunningham
IPC分类号： A61B500
CPC分类号： A61B10/0045 , A61B2010/008 , A61B2017/00765
摘要： The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.
摘要翻译：本发明涉及用于从动物的表皮层收集诸如间质液体的体液的装置和方法。优选的装置包括压头和可选的用于向头部供应正压力的保持器。所述方法包括对已被破坏角质层的表皮部位周围的区域施加正压，例如通过激光消融，使体液如间质液从所述部位渗出并收集流出的液体由此。

8. 发明申请

US20090062002A1 Apparatus And Method of Detecting And Tracking Objects In Amusement Games 审中-公开
标题翻译：在娱乐游戏中检测和跟踪物体的装置和方法
公开(公告)号：US20090062002A1
公开(公告)日：2009-03-05
申请号：US11847746
申请日：2007-08-30
申请人： John J. Kotlarik , David A. Myus , Python Anghelo
发明人： John J. Kotlarik , David A. Myus , Python Anghelo
IPC分类号： A63F9/24
CPC分类号： G07F17/3297 , A63F2300/1093
摘要： An amusement game and method that tracks the movement of a game object utilizing an image sensing device that communicates with a control unit for the amusement game. The amusement game includes an image sensing device, such as a CCD or CMOS camera, that is positioned to view the playfield of the amusement game and track the movement of a game object along the playfield. The control unit receives a series of sequential image scans from the image sensing device and determines the position of the game object along the playfield. Based upon the detected position of the game object, the control unit modifies the operation of the game or awards player points.
摘要翻译：一种娱乐游戏和方法，其利用与娱乐游戏的控制单元进行通信的图像感测装置跟踪游戏对象的移动。娱乐游戏包括诸如CCD或CMOS照相机的图像感测装置，其被定位成观看娱乐游戏的游戏场并跟踪游戏对象沿着游戏场的移动。控制单元从图像感测装置接收一系列连续的图像扫描，并确定游戏对象沿游戏场的位置。基于检测到的游戏对象的位置，控制单元修改游戏或奖励玩家点的操作。

9. 发明授权

US6068978A Apparatus and method for transfer of a fluid sample 失效
标题翻译：用于转移流体样品的装置和方法
公开(公告)号：US6068978A
公开(公告)日：2000-05-30
申请号：US859552
申请日：1997-05-20
申请人： Peter Zaun , Stanley R. Bouma , Julian Gordon , John J. Kotlarik , Natalie A. Solomon
发明人： Peter Zaun , Stanley R. Bouma , Julian Gordon , John J. Kotlarik , Natalie A. Solomon
IPC分类号： B01L3/00 , B01L7/00 , B01L99/00 , C12N15/09 , C12Q1/68 , G01N1/00 , G01N35/00
CPC分类号： B01L7/52 , B01L3/502 , G01N2035/00237 , G01N2035/00366 , G01N2035/00376 , G01N2035/00752 , G01N35/1095 , Y10S435/808
摘要： Methods, devices, apparatus and kits for amplifying and detecting nucleic acid are provided. The apparatus is a one or two-tier thermal cycling device that operates in conjunction with a reaction/detection unit. A sample is loaded into a reaction chamber of the device which is then mated with a detection chamber to form the reaction/detection unit. A first heating element of the thermal cycling apparatus applies a desired temperature to the reaction/detection device to amplify target nucleic acid in the sample. The reaction mixture is then transferred to the detection chamber by the second heating element and amplified target nucleic acid is immobilized on a support in the detection chamber. Microprocessor control controls the heat applied by the second element independently of the heat applied by the first element. A detection system associated with the apparatus detects and analyzes the immobilized amplified nucleic acid target. Images are captured and digitized and subjected to statistical analysis to improve the accuracy of the method.
摘要翻译：提供了扩增和检测核酸的方法，装置，装置和试剂盒。该装置是与反应/检测单元结合操作的一层或两层热循环装置。将样品装载到装置的反应室中，然后将其与检测室配合以形成反应/检测单元。热循环装置的第一加热元件将所需的温度施加到反应/检测装置以扩增样品中的靶核酸。然后将反应混合物通过第二加热元件转移到检测室，并将扩增的靶核酸固定在检测室中的载体上。微处理器控制独立于第一元件施加的热量来控制由第二元件施加的热量。与该装置相关的检测系统检测并分析固定的扩增的核酸靶。图像被捕获并数字化并进行统计分析以提高该方法的准确性。

10. 发明授权

US06786874B2 Apparatus and method for the collection of interstitial fluids 有权
标题翻译：用于收集间质液的装置和方法
公开(公告)号：US06786874B2
公开(公告)日：2004-09-07
申请号：US10243584
申请日：2002-09-13
申请人： John P. Grace , Neil W. Loomis , Thomas G. Schapira , Sie Ting Wong , Kristin M. Noonan , Michael G. Lowery , Pete M. Bojan , Daniel P. Schmidt , Tung-Ming Huang , Robert G. Hiltibran , Mark R. Pope , John J. Kotlarik , Brian Joseph Tarkowski , David Dean Cunningham
发明人： John P. Grace , Neil W. Loomis , Thomas G. Schapira , Sie Ting Wong , Kristin M. Noonan , Michael G. Lowery , Pete M. Bojan , Daniel P. Schmidt , Tung-Ming Huang , Robert G. Hiltibran , Mark R. Pope , John J. Kotlarik , Brian Joseph Tarkowski , David Dean Cunningham
IPC分类号： A61B1000
CPC分类号： A61B10/0045 , A61B2010/008 , A61B2017/00765
摘要： The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.
摘要翻译：本发明涉及用于从动物的表皮层收集诸如间质液体的体液的装置和方法。优选的装置包括压头和可选的用于向头部供应正压力的保持器。所述方法包括对已被破坏角质层的表皮部位周围的区域施加正压，例如通过激光消融，使体液如间质液从所述部位渗出并收集流出的液体由此。

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