专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06468229B1 Apparatus and method for the collection of interstitial fluids 有权
标题翻译：用于收集间质液的装置和方法
公开(公告)号：US06468229B1
公开(公告)日：2002-10-22
申请号：US09529148
申请日：2001-01-26
申请人： John P. Grace , Neil W. Loomis , Thomas G. Schapira , Sie Ting Wong , Kristin M. Noonan , Michael G. Lowery , Pete M. Bojan , Daniel P. Schmidt , Tung-Ming Huang , Robert G. Hiltibran , Mark R. Pope , John J. Kotlarik , Brian Joseph Tarkowski , David Dean Cunningham
发明人： John P. Grace , Neil W. Loomis , Thomas G. Schapira , Sie Ting Wong , Kristin M. Noonan , Michael G. Lowery , Pete M. Bojan , Daniel P. Schmidt , Tung-Ming Huang , Robert G. Hiltibran , Mark R. Pope , John J. Kotlarik , Brian Joseph Tarkowski , David Dean Cunningham
IPC分类号： A61B500
CPC分类号： A61B10/0045 , A61B2010/008 , A61B2017/00765
摘要： The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.
摘要翻译：本发明涉及用于从动物的表皮层收集诸如间质液体的体液的装置和方法。优选的装置包括压头和可选的用于向头部供应正压力的保持器。所述方法包括对已被破坏角质层的表皮部位周围的区域施加正压，例如通过激光消融，使体液如间质液从所述部位渗出并收集流出的液体由此。

2. 发明授权

US6077660A Diagnostic assay requiring a small sample of biological fluid 失效
标题翻译：诊断测定需要一小部分生物液样品
公开(公告)号：US6077660A
公开(公告)日：2000-06-20
申请号：US095683
申请日：1998-06-10
申请人： Sie Ting Wong , Robert G. Hiltibran , Tung-Ming Huang
发明人： Sie Ting Wong , Robert G. Hiltibran , Tung-Ming Huang
IPC分类号： G01N33/52 , C12Q1/32 , C12Q1/54 , G01N33/53 , G01N33/543 , G01N33/66 , G01N37/00 , C12Q1/00 , A01N1/02
CPC分类号： G01N33/54373 , G01N33/5304
摘要： An article and a method for monitoring the concentration of glucose in blood. In one aspect, the invention involves an article comprising a multiple-layer element utilizing reagents capable of reacting with an analyte of interest. In a preferred embodiment, the element comprises:(a) a core layer having two major surfaces, an optical reading chamber extending from a first opening in one of the two major surfaces to a second opening in the other of the two major surfaces, the core layer further having a third opening therein and a flow channel, one end of which flow channel communicates with the third opening and the other end of which flow channel communicates with the optical reading chamber;(b) a base layer in face-to-face contact with one major surface of the core layer; and(c) a cover layer in face-to-face contact with the other major surface of the core layer, the cover layer having an opening therein to vent the element.In another aspect, the invention involves a method comprising the steps of:(a) obtaining a sample of biological fluid, e.g., interstitial fluid, from the body of a patient;(b) introducing the sample to an article comprising a multiple-layer element having an optical reading chamber;(c) allowing reagents to react with an analyte of interest in the sample; and(d) measuring the concentration of analyte in the sample by means of an optical instrument.
摘要翻译：一种用于监测血液中葡萄糖浓度的文章和方法。一方面，本发明涉及一种包含多层元件的制品，该多层元件利用能够与感兴趣的分析物反应的试剂。在优选实施例中，元件包括：（a）具有两个主表面的芯层，从两个主表面中的一个主表面中的一个中的第一开口延伸到两个主表面中另一个中的第二开口的光学读取室，芯层还具有第三开口和流动通道，其一端的流动通道与第三开口连通，另一端与光学读取室连通。（b）与芯层的一个主表面面对面接触的基层; 和（c）与所述芯层的另一个主表面面对面接触的覆盖层，所述覆盖层在其中具有用于排出所述元件的开口。在另一方面，本发明涉及一种方法，包括以下步骤：（a）从患者的身体获得生物流体样品，例如间质液; （b）将样品引入包含具有光学读取室的多层元件的制品; （c）允许试剂与样品中感兴趣的分析物反应; 和（d）通过光学仪器测量样品中分析物的浓度。

3. 发明授权

US06455261B1 Diagnostic assay using microperoxidase 失效
标题翻译：使用微过氧化物酶进行诊断测定
公开(公告)号：US06455261B1
公开(公告)日：2002-09-24
申请号：US07511878
申请日：1990-04-20
申请人： Sie-Ting Wong , Sung-Chul Lee
发明人： Sie-Ting Wong , Sung-Chul Lee
IPC分类号： G01N3353
CPC分类号： C12Q1/28 , G01N33/535
摘要： A method for determining the presence and/or the amount of an analyte in a sample which method comprises contacting the sample containing the analyte with a peroxidatively-active material to produce a peroxide, a substance capable of producing a detectable response in the presence of the peroxide as a measure of the analyte present in the sample, and a microperoxidase catalyst.
摘要翻译：用于确定样品中分析物的存在和/或量的方法，该方法包括使含有分析物的样品与过氧化活性物质接触以产生过氧化物，能够在存在下产生可检测反应的物质过氧化物作为样品中存在的分析物的量度，以及微过氧化物酶催化剂。

4. 发明授权

US06786874B2 Apparatus and method for the collection of interstitial fluids 有权
标题翻译：用于收集间质液的装置和方法
公开(公告)号：US06786874B2
公开(公告)日：2004-09-07
申请号：US10243584
申请日：2002-09-13
申请人： John P. Grace , Neil W. Loomis , Thomas G. Schapira , Sie Ting Wong , Kristin M. Noonan , Michael G. Lowery , Pete M. Bojan , Daniel P. Schmidt , Tung-Ming Huang , Robert G. Hiltibran , Mark R. Pope , John J. Kotlarik , Brian Joseph Tarkowski , David Dean Cunningham
发明人： John P. Grace , Neil W. Loomis , Thomas G. Schapira , Sie Ting Wong , Kristin M. Noonan , Michael G. Lowery , Pete M. Bojan , Daniel P. Schmidt , Tung-Ming Huang , Robert G. Hiltibran , Mark R. Pope , John J. Kotlarik , Brian Joseph Tarkowski , David Dean Cunningham
IPC分类号： A61B1000
CPC分类号： A61B10/0045 , A61B2010/008 , A61B2017/00765
摘要： The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.
摘要翻译：本发明涉及用于从动物的表皮层收集诸如间质液体的体液的装置和方法。优选的装置包括压头和可选的用于向头部供应正压力的保持器。所述方法包括对已被破坏角质层的表皮部位周围的区域施加正压，例如通过激光消融，使体液如间质液从所述部位渗出并收集流出的液体由此。

5. 发明授权

US06312888B1 Diagnostic assay for a sample of biological fluid 失效
标题翻译：生物流体样本的诊断测定
公开(公告)号：US06312888B1
公开(公告)日：2001-11-06
申请号：US09688636
申请日：2000-10-16
申请人： Sie Ting Wong , Robert G. Hiltibran , Tung-Ming Huang , Brenda B. Calfin , Mark R. Pope , Thomas G. Schapira , Eric B. Shain , Douglas F. Young
发明人： Sie Ting Wong , Robert G. Hiltibran , Tung-Ming Huang , Brenda B. Calfin , Mark R. Pope , Thomas G. Schapira , Eric B. Shain , Douglas F. Young
IPC分类号： C12Q100
CPC分类号： G01N33/558 , G01N33/525
摘要： An article and a method for monitoring the concentration of an analyte, e. g., glucose, in blood. In one aspect, the invention involves an article comprising a multiple-layer element. In one embodiment, the article comprises: a multiple-layer element comprising: (a) a base layer (b) a cover layer, the cover layer having a first opening for venting the multiple-layer element and a second opening for receiving a biological sample; and (c) a core layer having a first major surface and a second major surface, the core layer disposed between the base layer and the cover layer, the core layer comprising a sample introduction chamber and a optical reading chamber, the first major surface of the core layer in face-to-face contact with the base layer, the second major surface of the core layer in face-to-face contact with the cover layer. The multiple-layer element of this invention allows the use of samples of blood or other biological fluids, such as interstitial fluid, to provide extremely sensitive assay results. The device has been shown to provide accurate and reproducible results with samples having volumes ranging from about 5 &mgr;L to about 20 &mgr;L. In another aspect, the invention involves a method for using the aforementioned article.
摘要翻译：用于监测分析物浓度的文章和方法，例如血糖中的葡萄糖。一方面，本发明涉及包含多层元件的制品。在一个实施例中，所述制品包括：多层元件，包括：（a）基层（b）覆盖层，所述覆盖层具有用于排出所述多层元件的第一开口和用于接收生物样品; 和（c）具有第一主表面和第二主表面的芯层，所述芯层设置在所述基底层和所述覆盖层之间，所述芯层包括样品引入室和光学读取室，所述芯层的第一主表面芯层与基层面对面接触，芯层的第二主表面与覆盖层面对面接触。本发明的多层元件允许使用血液样品或其他生物流体，例如间质液，以提供极敏感的测定结果。该装置已被证明可以提供具有约5至20微米的体积的样品的准确和可重复的结果。另一方面，本发明涉及使用上述制品的方法。

6. 发明授权

US4639424A Determination of alkali metals 失效
标题翻译：碱金属的测定
公开(公告)号：US4639424A
公开(公告)日：1987-01-27
申请号：US634946
申请日：1984-07-27
申请人： Sie-Ting Wong
发明人： Sie-Ting Wong
IPC分类号： G01N31/22 , G01N33/84 , G01N1/18 , G01N21/75 , G01N33/20 , G01N33/50
CPC分类号： G01N33/84 , G01N31/22 , Y10T436/255
摘要： A method for determining the alkali metal content of a liquid such as protein-containing liquids wherein a liquid containing alkali metal cation is contacted with a monocyclic crown ether capable of forming a complex with the alkali metal cation in a substantially inert solvent and an anionic dye, is disclosed. The alkali metal forms a complex with the ether and the dye in the solvent, the presence of which is a measure of the alkali metal content of the liquid.
摘要翻译：一种确定液体如含蛋白质液体的碱金属含量的方法，其中含有碱金属阳离子的液体与能够在碱性金属阳离子中形成络合物的单环冠醚在基本惰性的溶剂和阴离子染料中接触，被披露。碱金属与溶剂中的醚和染料形成络合物，其存在是液体的碱金属含量的量度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式