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1. 发明申请

US20060280998A1 Electrode and catalytic materials 有权
标题翻译：电极和催化材料
公开(公告)号：US20060280998A1
公开(公告)日：2006-12-14
申请号：US11438079
申请日：2006-05-19
申请人： Jackie Ying , Steven Weiss
发明人： Jackie Ying , Steven Weiss
IPC分类号： H01M4/90 , H01M8/12 , H01M8/06
CPC分类号： H01M4/9066 , B01J23/002 , B01J23/10 , B01J23/26 , B01J23/835 , B01J2523/00 , C01B3/38 , C01B2203/0238 , C01B2203/0283 , C01B2203/067 , C01B2203/1041 , C01B2203/1058 , C01B2203/1082 , C01B2203/1241 , C01B2203/82 , C22C1/0491 , C22C19/03 , C22C29/12 , C22C30/00 , C22C30/04 , H01M4/90 , H01M4/905 , H01M8/0612 , H01M8/1231 , H01M8/1253 , H01M2008/1293 , Y02E60/525 , Y02E60/566 , Y02P20/52 , Y02P70/56 , B01J2523/32 , B01J2523/36 , B01J2523/48 , B01J2523/847 , B01J2523/54 , B01J2523/33 , B01J2523/43 , B01J2523/42 , B01J2523/52 , B01J2523/34 , B01J2523/3706 , B01J2523/3712 , B01J2523/67 , B01J2523/23 , B01J2523/3737 , B01J2523/47 , B01J2523/53 , B01J2523/44
摘要： The invention relates to materials used as electrodes and/or catalysts, as well as methods associated with the same. The materials may comprise an alloy or intermetallic compound of a transition metal (e.g., Ni) and a metal additive (e.g., Sn). The transition metal and additive are selected to provide improved electrode and/or catalytic performance. For example, the materials of the invention may have a high catalytic activity, while being less susceptible to coking than certain conventional electrode/catalytic materials. These performance advantages can simplify the equipment used in certain applications, as well as reducing energy and capital requirements. Furthermore, the materials may be manufactured using traditional ceramic processing methods, without the need for complex, unconventional fabrication techniques. The materials are particularly suitable for use in fuel cells (e.g., SOFCs electrodes) and in reactions that use or produce synthesis gas.
摘要翻译：本发明涉及用作电极和/或催化剂的材料，以及与其相关的方法。这些材料可以包括过渡金属（例如Ni）和金属添加剂（例如Sn）的合金或金属间化合物。选择过渡金属和添加剂以提供改善的电极和/或催化性能。例如，本发明的材料可能具有高催化活性，同时比某些常规电极/催化材料不易于焦化。这些性能优势可以简化某些应用中使用的设备，以及降低能源和资本要求。此外，材料可以使用传统的陶瓷加工方法制造，而不需要复杂的非常规制造技术。这些材料特别适用于燃料电池（例如，SOFC电极）和使用或生产合成气的反应中。

2. 发明申请

US20070141726A1 Detection via switchable emission of nanocrystals 审中-公开
标题翻译：通过纳米晶体的可切换发射进行检测
公开(公告)号：US20070141726A1
公开(公告)日：2007-06-21
申请号：US11313218
申请日：2005-12-19
申请人： Jackie Ying , Hsiao-Hua Yu , Emril Ali , Nikhil Jana
发明人： Jackie Ying , Hsiao-Hua Yu , Emril Ali , Nikhil Jana
IPC分类号： G01N33/553
CPC分类号： G01N21/6489 , B82Y15/00 , B82Y20/00 , B82Y30/00 , G01N21/6408 , G01N21/77 , G01N2021/7786
摘要： The present invention relates to methods for determination of an analyte. The invention provides various methods involving exposure of a luminescent material to an analyte wherein, upon interaction with the analyte, a change in luminescence may be observed as a function of the duration of exposure to electromagnetic radiation, thereby determining the analyte. Some embodiments of the invention include the use of highly emissive semiconductor nanocrystals.
摘要翻译：本发明涉及测定分析物的方法。本发明提供了将发光材料暴露于分析物的各种方法，其中在与分析物相互作用时，可以观察到发光变化作为暴露于电磁辐射的持续时间的函数，从而确定分析物。本发明的一些实施方案包括使用高发射半导体纳米晶体。

3. 发明申请

US20060068203A1 Coated composites of magnetic material and quantum dots 失效
公开(公告)号：US20060068203A1
公开(公告)日：2006-03-30
申请号：US10950194
申请日：2004-09-24
申请人： Jackie Ying , Subramanian Selvan , Dong Yi , Su Lee
发明人： Jackie Ying , Subramanian Selvan , Dong Yi , Su Lee
IPC分类号： H01F1/00 , C09K11/08 , B32B5/16
CPC分类号： H01F1/0063 , B82Y10/00 , B82Y15/00 , B82Y25/00 , B82Y30/00 , C30B7/00 , G01N33/54326 , G01N33/588 , H01F1/0054 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996
摘要： Composites and methods associated with the same are provided. The composite structures are formed of quantum dots and magnetic nanoparticles. The structures may be coated, for example, with a non-organic shell such as silica. In some cases, the shell may be functionalized or derivatized to include compounds, atoms, or materials that can alter or improve properties such as water solubility, water stability, photo-stability and biocompatibility. A reverse microemulsion process can be used to form the coated composites. The composition and other characteristics of the composites may be controlled to provide desired magnetic and optical properties. The structures may be used in a variety of applications including biological labeling, magnetic resonance imagine (MRI) and drug targeting, amongst others.

4. 发明申请

US20070218544A1 Three-dimensional fabrication of biocompatible structures in anatomical shapes and dimensions for tissue engineering and organ replacement 失效
标题翻译：用于组织工程和器官置换的解剖学形状和尺寸的生物相容性结构的三维制造
公开(公告)号：US20070218544A1
公开(公告)日：2007-09-20
申请号：US11375375
申请日：2006-03-14
申请人： Jackie Ying , Shyi-Herng Kan , Jeremy Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
发明人： Jackie Ying , Shyi-Herng Kan , Jeremy Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
IPC分类号： C12M1/34 , H01L21/00 , C12M3/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： The present invention relates to methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, to methods and apparatuses involving biocompatible structures formed by three-dimensional fabrication for tissue engineering and organ replacement. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three-dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. In some cases, a structure formed by three-dimensional fabrication comprises a wall defining a cavity and a plurality of pores in at least a portion of the wall. The pores may permeate the wall and enable exchange of a component (e.g., a molecule and/or a cell) between a portion interior to the cavity and a portion exterior to the cavity. For instance, pores may allow delivery of molecules, cell migration, and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal, or alternatively and/or additionally, can be used ex vivo as bioartificial assist devices.
摘要翻译：本发明涉及包括用于组织工程和器官置换的生物相容结构的方法和装置，更具体地涉及涉及通过用于组织工程和器官置换的三维制造形成的生物相容性结构的方法和装置。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。在一些情况下，通过三维制造形成的结构包括在壁的至少一部分中限定空腔和多个孔的壁。孔可以渗透到壁上并且使得能够在空腔内部的部分和腔外部的部分（例如，分子和/或细胞）之间进行交换。例如，孔可以允许在结构和其宿主环境之间传递分子，细胞迁移和/或结缔组织的产生。本发明的结构可以植入哺乳动物，或者另外地和/或另外可以作为生物人造辅助装置离体使用。

5. 发明申请

US20050239634A1 Mesostructured zeolitic materials, and methods of making and using the same 有权
标题翻译：介孔结构的沸石材料及其制造和使用方法
公开(公告)号：US20050239634A1
公开(公告)日：2005-10-27
申请号：US10830714
申请日：2004-04-23
申请人： Jackie Ying , Javier Martinez
发明人： Jackie Ying , Javier Martinez
IPC分类号： B01J20/18 , B01J29/00 , B01J29/04 , B01J29/08 , B01J29/18 , B01J29/40 , B01J29/80 , C01B39/02 , C01B39/04 , C10G1/08 , C10G11/02 , C10G11/05 , C10G11/18
CPC分类号： B01J29/40 , B01J20/18 , B01J20/186 , B01J29/005 , B01J29/0308 , B01J29/041 , B01J29/084 , B01J29/106 , B01J29/18 , B01J29/80 , B01J2229/62 , B82Y30/00 , C01B39/02 , C01B39/023 , C01B39/026 , C01B39/04 , C10G1/086 , C10G11/02 , C10G11/05 , C10G11/18 , C10G45/04 , C10G47/02 , C10G2300/1033 , C10G2300/1074 , C10G2300/1096 , C10G2400/02 , C10G2400/20 , Y10T428/26
摘要： One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for organic compounds and degradation catalysts for polymers.
摘要翻译：本发明的一个方面涉及介孔结构的沸石。本发明还涉及一种制备介孔结构的沸石的方法，以及它们用作有机化合物的裂化催化剂和聚合物的降解催化剂。

6. 发明申请

US20070134788A1 Manipulation of chemical and/or biological species using magnetic field modulators 审中-公开
标题翻译：使用磁场调制器操纵化学和/或生物物种
公开(公告)号：US20070134788A1
公开(公告)日：2007-06-14
申请号：US11297797
申请日：2005-12-08
申请人： Karl Schumacher , Jackie Ying , Jeremy Loh , Shyi Kan
发明人： Karl Schumacher , Jackie Ying , Jeremy Loh , Shyi Kan
IPC分类号： C12N5/06 , C12M3/00
CPC分类号： C12N5/0062 , C12N2535/10
摘要： The present invention relates to methods and apparatus for manipulating chemical and/or biological species (e.g., cells) and, more specifically, to methods and apparatus for manipulating chemical and/or biological species using magnetic fields. In one embodiment, a method of manipulating cells involves the patterning of cells using a magnetic field modulator, which can modulate the magnetic field created by a magnetic field source. The cells may be magnetically susceptible in some cases; for instance, they may be tagged with magnetic particles. When a fluid containing cells is brought in contact with a surface, and the magnetic field modulator is positioned proximate the surface, the cells may form a pattern proximate the surface by aligning with portions of the modulated magnetic field. The position of the pattern of cells may be at least partially determined by the position of the magnetic field modulator in relation to the surface. Advantageously, in certain embodiments, the magnetic field modulator is not integrally connected to the surface. Thus, patterns of cells can be formed on various types of surfaces and the magnetic field modulator may be repositioned without altering the surface. In one particular embodiment, moving the magnetic field modulator from a first to a second position enables the formation of a second pattern of cells on the surface. This method can allow the formation of patterns comprising multiple cell types on a single surface. The methods and apparatuses of the present invention can be used in a variety of settings. One such setting involves the patterning of multiple cell types proximate a surface, i.e., for studying cell-cell interactions. Another setting involves the formation of three-dimensional cellular structures (e.g., tissues).
摘要翻译：本发明涉及用于操纵化学和/或生物物种（例如细胞）的方法和装置，更具体地涉及使用磁场操纵化学和/或生物物种的方法和装置。在一个实施例中，一种操纵单元的方法涉及使用磁场调制器对单元进行图案化，该磁场调制器可以调制由磁场源产生的磁场。在某些情况下细胞可能是磁性敏感的; 例如，它们可以被磁性颗粒标记。当含有细胞的流体与表面接触并且磁场调制器位于表面附近时，细胞可以通过与调制磁场的部分对准而形成靠近表面的图案。电池图案的位置可以至少部分地由磁场调制器相对于表面的位置决定。有利地，在某些实施例中，磁场调制器不一体地连接到表面。因此，可以在各种类型的表面上形成单元的图案，并且可以在不改变表面的情况下重新定位磁场调制器。在一个特定实施例中，将磁场调制器从第一位置移动到第二位置使得能够在表面上形成第二图案的单元。该方法可以允许在单个表面上形成包括多个单元格类型的图案。本发明的方法和装置可以用于多种设置。一种这样的设置涉及在表面附近形成多种细胞类型，即用于研究细胞 - 细胞相互作用。另一种设置涉及三维细胞结构（例如，组织）的形成。

7. 发明申请

US20060099146A1 NIR-sensitive nanoparticle 失效
标题翻译： NIR敏感纳米粒子
公开(公告)号：US20060099146A1
公开(公告)日：2006-05-11
申请号：US10985018
申请日：2004-11-10
申请人： Gan Chow , Mei Tan , Lei Ren , Jackie Ying
发明人： Gan Chow , Mei Tan , Lei Ren , Jackie Ying
IPC分类号： A61K49/00 , A61K9/14
CPC分类号： A61K9/5115 , A61K41/0028 , A61K47/6923 , A61K47/6929 , B82Y5/00
摘要： It is provided a Near Infrared Sensitive (NIR-sensitive) nanoparticle complex comprising a NIR-sensitive nanoparticle and surfactant(s) adsorbed on the nanoparticle, wherein the surfactant is at least one surfactant selected from: wherein X=1-9; Y=0-9; n=0-9; Z=1-9; W=0-9; m=0-9; each of R1, R2, R3 and R4, if present, is H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 aryl, HS, COOH, NH2 or OH; R5 is COOH, NH2 or OH; with the proviso that n+m is
摘要翻译：提供了一种近红外敏感（NIR敏感）纳米颗粒复合物，其包含吸收在纳米颗粒上的NIR敏感纳米颗粒和表面活性剂，其中表面活性剂是选自以下的至少一种表面活性剂：其中X = 1-9; Y = 0-9; n = 0-9; Z = 1-9; W = 0-9; m = 0-9; R 1，R 2，R 3和R 4中的每一个如果存在，是H，取代或未取代的C 1 -C 6烷基，取代或未取代的C 1 -C 6芳基，HS，COOH， NH 2或OH; R 5是COOH，NH 2或OH; 条件是n + m <10; （b）具有（a）结构的氨基酸，其中X = 1; Y = 2; Z = 1; W = 1; R 1，R 2，R 4和R 4不存在; R 3是NH 2; R 5是COOH; 或（c）肽，其中所述肽包含至少一个氨基酸（b）。此外，提供了具有负载在表面活性剂上的生物分子例如药物的NIR敏感纳米颗粒复合物。

8. 发明申请

US20080045736A1 Water-Soluble, Surface-Functionalized Nanoparticle for Bioconjugation Via Universal Silane Coupling 失效
标题翻译：水溶性表面官能化纳米粒子通过通用硅烷偶联生物共轭
公开(公告)号：US20080045736A1
公开(公告)日：2008-02-21
申请号：US11795639
申请日：2005-01-20
申请人： Jackie Ying , Nikhil Jana , Yuangang Zheng
发明人： Jackie Ying , Nikhil Jana , Yuangang Zheng
IPC分类号： C07F1/10 , C07F1/12 , C07F15/02 , C07F3/06 , C07F7/08 , C07F7/10 , C07F9/28 , C07K17/14
CPC分类号： C07K17/14 , A61K47/6923 , A61K47/6929 , B82Y5/00 , C07B2200/11 , C07F7/1804 , C07F9/4012
摘要： The invention provides a process for the preparation of a surface-functionalized nanoparticle comprising: (a) reacting a nanoparticle with a functionalized silane and a base in a substantially non-aqueous solvent to obtain a partially conjugated silanated nanoparticle, wherein the functionalized silane and the base are present in relative amounts such that said functionalized silane undergoes substantially only a single hydrolysis reaction; (b) reacting the partially conjugated silanated nanoparticle formed in step (a) with a base in a solvent in which the partially conjugated silanated nanoparticle is substantially insoluble and in which the base is substantially soluble. The invention also provides a surface-functionalized nanoparticle prepared therefrom and a bioconjugate comprising said a surface-functionalized nanoparticle.
摘要翻译：本发明提供了制备表面官能化纳米颗粒的方法，其包括：（a）使纳米颗粒与官能化的硅烷和碱在基本上非水溶剂中反应，得到部分共轭的硅烷化纳米颗粒，其中官能化的硅烷和碱以相对量存在，使得所述官能化硅烷基本上仅经历单一水解反应; （b）使步骤（a）中形成的部分共轭的硅烷化纳米颗粒与碱在溶剂中反应，其中部分共轭的硅烷化纳米颗粒基本上不溶，其中碱基本上是可溶的。本发明还提供由其制备的表面官能化纳米颗粒和包含所述表面官能化纳米颗粒的生物共轭物。

9. 发明申请

US20060029802A1 Coated water soluble nanoparticles 失效
标题翻译：涂层水溶性纳米粒子
公开(公告)号：US20060029802A1
公开(公告)日：2006-02-09
申请号：US10911402
申请日：2004-08-04
申请人： Jackie Ying , Subramanian Selvan , Timothy Tan
发明人： Jackie Ying , Subramanian Selvan , Timothy Tan
IPC分类号： B05D7/00 , B32B5/16
CPC分类号： C30B29/60 , Y10S977/773 , Y10S977/777 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998
摘要： Nanoparticles and methods of making nanoparticles are provided. The nanoparticles may include semiconductor nanocrystals. A shell may encapsulate a nanoparticle core, and the shell may include non-organic material and may be silica. The shell may also include additional species such as PEG. In some embodiments, a passivation layer is in contact with the core.
摘要翻译：提供纳米颗粒和制备纳米颗粒的方法。纳米颗粒可以包括半导体纳米晶体。壳可以包封纳米颗粒芯，并且壳可以包括非有机材料，并且可以是二氧化硅。壳也可以包括另外的物质如PEG。在一些实施例中，钝化层与芯接触。

10. 发明申请

US20050260276A1 Methods and articles for the delivery of therapeutic agents 有权
标题翻译：用于递送治疗剂的方法和物品
公开(公告)号：US20050260276A1
公开(公告)日：2005-11-24
申请号：US10849498
申请日：2004-05-19
申请人： Yi-Yan Yang , Yong Wang , Cherng-wen Darren Tan , Jackie Ying
发明人： Yi-Yan Yang , Yong Wang , Cherng-wen Darren Tan , Jackie Ying
IPC分类号： A61K9/00 , A61K9/107 , A61K9/16 , A61K9/50 , A61K9/51 , A61K47/48 , A61K48/00 , C08G63/685 , C08G63/91 , C12N15/87
CPC分类号： A61K9/5153 , A61K9/1075 , A61K47/6935 , A61K48/0025 , A61K48/0041 , B82Y5/00 , C08G63/6856 , C08G63/916 , C08L2207/53
摘要： Articles and methods for the delivery of drugs and/or nucleic acids. Articles including a nanoparticle are provided that may be used for the delivery of a drug, a nucleic acid, or both, to a subject. The articles may be of polymeric material and may self-assemble.
摘要翻译：用于递送药物和/或核酸的制品和方法。提供了包括纳米颗粒的制品，其可用于向受试者递送药物，核酸或两者。制品可以是聚合材料并且可以自组装。

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