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1. 发明申请

US20070134788A1 Manipulation of chemical and/or biological species using magnetic field modulators 审中-公开
标题翻译：使用磁场调制器操纵化学和/或生物物种
公开(公告)号：US20070134788A1
公开(公告)日：2007-06-14
申请号：US11297797
申请日：2005-12-08
申请人： Karl Schumacher , Jackie Ying , Jeremy Loh , Shyi Kan
发明人： Karl Schumacher , Jackie Ying , Jeremy Loh , Shyi Kan
IPC分类号： C12N5/06 , C12M3/00
CPC分类号： C12N5/0062 , C12N2535/10
摘要： The present invention relates to methods and apparatus for manipulating chemical and/or biological species (e.g., cells) and, more specifically, to methods and apparatus for manipulating chemical and/or biological species using magnetic fields. In one embodiment, a method of manipulating cells involves the patterning of cells using a magnetic field modulator, which can modulate the magnetic field created by a magnetic field source. The cells may be magnetically susceptible in some cases; for instance, they may be tagged with magnetic particles. When a fluid containing cells is brought in contact with a surface, and the magnetic field modulator is positioned proximate the surface, the cells may form a pattern proximate the surface by aligning with portions of the modulated magnetic field. The position of the pattern of cells may be at least partially determined by the position of the magnetic field modulator in relation to the surface. Advantageously, in certain embodiments, the magnetic field modulator is not integrally connected to the surface. Thus, patterns of cells can be formed on various types of surfaces and the magnetic field modulator may be repositioned without altering the surface. In one particular embodiment, moving the magnetic field modulator from a first to a second position enables the formation of a second pattern of cells on the surface. This method can allow the formation of patterns comprising multiple cell types on a single surface. The methods and apparatuses of the present invention can be used in a variety of settings. One such setting involves the patterning of multiple cell types proximate a surface, i.e., for studying cell-cell interactions. Another setting involves the formation of three-dimensional cellular structures (e.g., tissues).
摘要翻译：本发明涉及用于操纵化学和/或生物物种（例如细胞）的方法和装置，更具体地涉及使用磁场操纵化学和/或生物物种的方法和装置。在一个实施例中，一种操纵单元的方法涉及使用磁场调制器对单元进行图案化，该磁场调制器可以调制由磁场源产生的磁场。在某些情况下细胞可能是磁性敏感的; 例如，它们可以被磁性颗粒标记。当含有细胞的流体与表面接触并且磁场调制器位于表面附近时，细胞可以通过与调制磁场的部分对准而形成靠近表面的图案。电池图案的位置可以至少部分地由磁场调制器相对于表面的位置决定。有利地，在某些实施例中，磁场调制器不一体地连接到表面。因此，可以在各种类型的表面上形成单元的图案，并且可以在不改变表面的情况下重新定位磁场调制器。在一个特定实施例中，将磁场调制器从第一位置移动到第二位置使得能够在表面上形成第二图案的单元。该方法可以允许在单个表面上形成包括多个单元格类型的图案。本发明的方法和装置可以用于多种设置。一种这样的设置涉及在表面附近形成多种细胞类型，即用于研究细胞 - 细胞相互作用。另一种设置涉及三维细胞结构（例如，组织）的形成。

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