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    • 9. 发明授权
    • Diagnosis of central nervous system white matter pathology using diffusion MRI
    • 诊断中枢神经系统白质病变使用扩散MRI
    • US09494669B2
    • 2016-11-15
    • US13109986
    • 2011-05-17
    • Sheng-Kwei SongQing WangYong Wang
    • Sheng-Kwei SongQing WangYong Wang
    • A61B5/055G01R33/563
    • G01R33/56341A61B5/055
    • Determining diffusivity of multiple diffusion components within a tissue using diffusion magnetic resonance data representing a volume of the tissue. A plurality of candidate fibers having a direction is defined within the volume. A possibility coefficient is calculated by a processor for each candidate fiber of the plurality of candidate fibers based on the magnetic resonance data and the direction of the candidate fiber. The possibility coefficient represents a likelihood that the candidate fiber exists in the volume. Candidate fibers associated with a possibility coefficient greater than a threshold value are selected by the processor to create one or more probable fibers. For each probable fiber of the one or more probable fibers, an axial diffusivity indicating a diffusion of water in the direction of the probable fiber and a radial diffusivity indicating a diffusion of water perpendicular to the direction of the probable fiber are calculated by the processor. The diffusivity of isotropic diffusion component and the volume ratios of each fiber component and isotropic components are calculated.
    • 使用表示组织体积的扩散磁共振数据确定组织内多个扩散组分的扩散系数。 具有方向的多个候选光纤被定义在体积内。 基于磁共振数据和候选光纤的方向,由处理器对多个候选光纤中的每个候选光纤计算可能性系数。 可能性系数表示候选光纤存在于卷中的可能性。 与大于阈值的可能性系数相关联的候选光纤由处理器选择以产生一个或多个可能的光纤。 对于一个或多个可能纤维的每个可能的纤维,通过处理器计算指示水在可能纤维的方向上的扩散的轴向扩散率和指示垂直于可能纤维的方向的水的扩散的径向扩散率。 计算各向同性扩散成分的扩散系数和各纤维成分与各向同性成分的体积比。