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1. 发明申请

US20050148672A1 Quaternary ammonium compounds 失效
标题翻译：季铵化合物
公开(公告)号：US20050148672A1
公开(公告)日：2005-07-07
申请号：US11074914
申请日：2005-03-08
申请人： Ivan Richards , Sue Cammarata , Craig Wegner , Michael Hawley , Mark Warchol , Mark Kontny , Walter Morozowich , Karen Kolbasa , Malcolm Moon , Dominique Bonafoux , Sergey Wolfson , Patrick Lennon
发明人： Ivan Richards , Sue Cammarata , Craig Wegner , Michael Hawley , Mark Warchol , Mark Kontny , Walter Morozowich , Karen Kolbasa , Malcolm Moon , Dominique Bonafoux , Sergey Wolfson , Patrick Lennon
IPC分类号： C07D295/08 , A61K31/14 , A61K31/166 , A61K31/222 , A61K31/40 , A61K31/4453 , A61K31/55 , A61P11/00 , A61P11/06 , A61P27/16 , A61P37/08 , A61P43/00 , C07B53/00 , C07C211/63 , C07C215/54 , C07C215/66 , C07C217/62 , C07C219/28 , C07C237/30 , C07C237/50 , C07D223/04 , C07D295/096 , A61K31/205
CPC分类号： C07D295/096 , C07C215/54 , C07C215/66 , C07C217/62 , C07C219/28 , C07C237/30
摘要： The compound 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-(trifluoromethyl) phenol may be used to prepare the compound (3R)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-N,N-diisopropyl-N-methyl-3-phenylpropan-1-aminium bromide by reaction with methyl bromide.
摘要翻译：化合物2 - [（1R）-3-（二异丙基氨基）-1-苯基丙基] -4-（三氟甲基）苯酚可用于制备化合物（3R）-3- [2-羟基-5-（三氟甲基）苯基 ] -N，N-二异丙基-N-甲基-3-苯基丙-1-胺与溴甲烷反应。

2. 发明申请

US20050256180A1 Substituted pyrazolyl compounds for the treatment of inflammation 失效
标题翻译：用于治疗炎症的取代的吡唑基化合物
公开(公告)号：US20050256180A1
公开(公告)日：2005-11-17
申请号：US11113926
申请日：2005-04-25
申请人： Arija Bergmanis , Michael Clare , Joyce Crich , Lifeng Geng , Timothy Hagen , Gunnar Hanson , Stephen Houdek , He Huang , Donna Iula , Francis Koszyk , Shuyuan Liao , Scott Mohler , Maria Nguyen , Richard Partis , Michael Stealey , Michael Tollefson , Richard Weier , Xiangdong Xu , Dominique Bonafoux , Theresa Fletcher , Bruce Hamper , Patrick Lennon , Subo Liao , Suzanne Metz , David Oburn , Thomas Owen , Angela Scates , Michael Vazquez , Serge Wolfson
发明人： Arija Bergmanis , Michael Clare , Joyce Crich , Lifeng Geng , Timothy Hagen , Gunnar Hanson , Stephen Houdek , He Huang , Donna Iula , Francis Koszyk , Shuyuan Liao , Scott Mohler , Maria Nguyen , Richard Partis , Michael Stealey , Michael Tollefson , Richard Weier , Xiangdong Xu , Dominique Bonafoux , Theresa Fletcher , Bruce Hamper , Patrick Lennon , Subo Liao , Suzanne Metz , David Oburn , Thomas Owen , Angela Scates , Michael Vazquez , Serge Wolfson
IPC分类号： A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P19/02 , A61P25/04 , A61P29/00 , A61P35/00 , C07D231/54 , C07D333/62 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/4162
CPC分类号： C07D403/12 , C07D231/54 , C07D333/62 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
摘要翻译：本发明涉及取代的吡唑基衍生物，包含这些的组合物，中间体，制备取代的吡唑基衍生物的方法，以及用于治疗癌症，炎症和炎症相关疾病如关节炎的方法。

3. 发明申请

US20050261130A1 Novel surfactants and formulations 审中-公开
标题翻译：新型表面活性剂和配方
公开(公告)号：US20050261130A1
公开(公告)日：2005-11-24
申请号：US11122454
申请日：2005-05-05
申请人： Patrick Lennon , Xiangyang Chen , Graciela Arhancet , Jeanette Glaenzer , Jane Gillespie , Jeffrey Graham , David Becher , Daniel Wright , Henry Agbaje , Xiaodong Xu , William Abraham , Ronald Brinker , Norman Pallas , Al Wideman , Martin Mahoney , Susan Henke
发明人： Patrick Lennon , Xiangyang Chen , Graciela Arhancet , Jeanette Glaenzer , Jane Gillespie , Jeffrey Graham , David Becher , Daniel Wright , Henry Agbaje , Xiaodong Xu , William Abraham , Ronald Brinker , Norman Pallas , Al Wideman , Martin Mahoney , Susan Henke
IPC分类号： A01N25/02 , A01N25/04 , A01N25/16 , A01N25/30 , A01N37/04 , A01N57/18 , A01N57/20 , A01N61/00 , C11D1/40 , C11D1/42 , C11D1/44 , C11D1/62 , C11D1/72 , C11D1/75
CPC分类号： A01N61/00 , A01N25/30 , A01N37/04 , A01N57/20 , A01N2300/00
摘要： A herbicidal composition is provided comprising an aqueous solution of N-phosphonomethylglycine, predominantly in the form of the potassium salt thereof, at a concentration of at least 300 g a.e./l of the composition; and a surfactant component in solution or stable suspension, emulsion, or dispersion in the water, comprising one or more surfactants in a total amount of about 20 to about 300 g/l of the composition, wherein the composition has a viscosity of less than about 250 centipoise at 0° C. or a Gardner color value less than 10.
摘要翻译：提供除草组合物，其包含主要以其钾盐形式的N-膦酰基甲基甘氨酸的水溶液，其浓度为组合物的至少300g a.e./l; 和在水中的溶液或稳定悬浮液，乳液或分散体中的表面活性剂组分，其包含总量为组合物总量约20至约300g / l的一种或多种表面活性剂，其中所述组合物的粘度小于约在0°C时250厘泊或加德纳颜色值小于10。

4. 发明申请

US20050197338A1 Substituted pyrazole urea compounds for the treatment of inflammation 审中-公开
标题翻译：用于治疗炎症的取代的吡唑脲化合物
公开(公告)号：US20050197338A1
公开(公告)日：2005-09-08
申请号：US10970769
申请日：2004-10-21
申请人： He Huang , Michael Stealey , Gunnar Hanson , Patrick Lennon , Bruce Hamper , Jin Xie , David Oburn , Serge Wolfson , Theresa Fletcher , Richard Heier , Matthew Reding , Michael Clare
发明人： He Huang , Michael Stealey , Gunnar Hanson , Patrick Lennon , Bruce Hamper , Jin Xie , David Oburn , Serge Wolfson , Theresa Fletcher , Richard Heier , Matthew Reding , Michael Clare
IPC分类号： A61K31/415 , A61K31/416 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/53 , C07D231/38 , C07D231/40 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
CPC分类号： C07D403/10 , C04B35/632 , C07D231/38 , C07D401/12 , C07D403/04 , C07D405/10 , C07D409/10 , C07D413/10
摘要： Compounds of Formula I: wherein X1, X2, L1, A, R, L2, R1, R12, R12a, R13, R14 and R14a are as defined herein, are disclosed.
摘要翻译：式I的化合物：其中X 1，X 2，L 1，A，R，L 2， R 1，R 12，R 12，R 13，R 14和R 14，和 R 14a如本文所定义。

5. 发明申请

US20050054871A1 Process for the preparation of N-phosphonomethylglycine and derivatives thereof 有权
标题翻译： N-膦酰基甲基甘氨酸及其衍生物的制备方法
公开(公告)号：US20050054871A1
公开(公告)日：2005-03-10
申请号：US10924265
申请日：2004-08-23
申请人： James Coleman , Jerry Ebner , Eric Haupfear , Patrick Lennon , Joseph Schaper , Samuel Tremont , Serge Wolfson , Philip Brodsky
发明人： James Coleman , Jerry Ebner , Eric Haupfear , Patrick Lennon , Joseph Schaper , Samuel Tremont , Serge Wolfson , Philip Brodsky
IPC分类号： C07F9/28 , C07F9/38
CPC分类号： C07F9/3813 , Y02P20/582
摘要： N-phosphonomethylamines are produced by reaction of an amine substrate with a halomethylphosphonic acid or salt thereof, a hydroxymethylphosphonic acid or salt thereof, or a dehydrated self-ester dimer, trimer or oligomer of hydroxymethylphosphonic acid. Among the products that may be prepared according to the process are N-phosphonomethylaminocarboxylic acids such as (e.g.) glyphosate, N-phosphonomethylaminoalkanols such as (e.g.) hydroxyethlaminomethylphosphonic acid, and N-acylaminomethylphosphonic acids such as (e.g.) N-carbamylaminomethylphosphonic acid. Certain reactions are conducted with a substantial excess of amine reactant in order to drive the conversion while avoiding excessive formation of bis(N-phosphonomethyl)amine by-products. Other reactions use a secondary amine substrate (such as iminodiacetic acid) and can be conducted at substantial equimolar ratios of halomethylaminomethylphosphonic acid or hydroxyaminomethylphosphonic acid to secondary amine reactant without significant formation of bis(phosphonomethyl)amine by-products. Further disclosed is a process for the preparation of hydroxymethylphosphonic acid self-ester dimers, trimers and oligomers by azeotropic dehydration.
摘要翻译： N-膦酰基甲胺通过胺底物与卤甲基膦酸或其盐，羟甲基膦酸或其盐或羟甲基膦酸的脱水的自酯二聚物，三聚体或低聚物的反应来制备。可根据该方法制备的产物是N-膦酰基乙基氨基羧酸，例如（例如）草甘膦，N-膦酰基甲基氨基链烷醇如（例如）羟基乙基氨基甲基膦酸和N-酰基氨基甲基膦酸如（例如）N-氨基甲酰基氨基甲基膦酸。某些反应用大量过量的胺反应物进行，以驱动转化，同时避免过度形成双（N-膦酰基甲基）胺副产物。其他反应使用仲胺底物（例如亚氨基二乙酸），并且可以以基本上等摩尔比率的卤代甲基氨基甲基膦酸或羟基氨基甲基膦酸与仲胺反应物进行反应，而不显着形成双（膦酰基甲基）胺副产物。进一步公开了通过共沸脱水制备羟甲基膦酸自酯二聚体，三聚体和低聚物的方法。

6. 发明授权

US06214817B1 Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity 有权
标题翻译：具有超氧化物歧化酶活性的取代的吡啶并五氮杂胞苷复合物
公开(公告)号：US06214817B1
公开(公告)日：2001-04-10
申请号：US09398120
申请日：1999-09-16
申请人： Dennis P. Riley , William L. Neumann , Susan L. Henke , Patrick Lennon , Karl W. Aston , Daniela Salvemini , James A. Sikorski , Yvette M. Fobian , Margaret Lanahan Grapperhaus , Carrie L. Kusturin
发明人： Dennis P. Riley , William L. Neumann , Susan L. Henke , Patrick Lennon , Karl W. Aston , Daniela Salvemini , James A. Sikorski , Yvette M. Fobian , Margaret Lanahan Grapperhaus , Carrie L. Kusturin
IPC分类号： C07D48722
CPC分类号： C07D471/06 , A61K31/555 , C07D471/08 , C07F13/005 , Y02A50/473
摘要： The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic pentaazacyclopentadecane ligands which catalytically dismutate superoxide.
摘要翻译：本发明涉及有效作为用于分解超氧化物的催化剂的化合物，更具体地说，涉及催化分解超氧化物的取代的，不饱和杂环五氮杂环十五烷配体的锰或铁络合物。

7. 发明申请

US20050129819A1 Process and apparatus for preparing frozen confection 审中-公开
标题翻译：制备冷冻甜食的方法和设备
公开(公告)号：US20050129819A1
公开(公告)日：2005-06-16
申请号：US10732629
申请日：2003-12-10
申请人： Patrick Lennon
发明人： Patrick Lennon
IPC分类号： A01J1/00
CPC分类号： A23G9/285 , A23G9/22 , A23G9/44 , A23G9/48
摘要： A method of making a combined frozen confection, equipment for forming same. The equipment especially comprises a filling nozzle. The invention is particularly directed to combined frozen confections formed in pop ups or the like. The combined frozen confection is especially a pop up having a shape extruded down the center, preferably an intricate shape such as a star or a pineapple, which remains recognizable over the length of the pop up cylinder. A second confection, preferably one having a different color or other appearance, flows into the pop-up cylinder around the periphery of the centrally extruded frozen confection to form a frozen confection combining the extruded frozen confection design and the peripheral frozen confection identifiable by consumers as different.
摘要翻译：一种冷冻甜食联合方法，其形成设备。该设备特别包括一个填充喷嘴。本发明特别涉及在弹出窗等中形成的组合冷冻甜点。组合的冷冻甜食特别是具有从中心向下挤出的形状的弹出物，优选地是复杂的形状，例如星形或菠萝，其在弹出筒的长度上保持可识别。第二个糖果，优选具有不同颜色或其他外观的糖果，流入围绕中央挤出的冷冻甜食周边的弹出圆筒，以形成冷冻甜食，将挤出的冷冻甜食设计和消费者可识别的外围冷冻甜点组合不同。

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