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1. 发明授权

US06214817B1 Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity 有权
标题翻译：具有超氧化物歧化酶活性的取代的吡啶并五氮杂胞苷复合物
公开(公告)号：US06214817B1
公开(公告)日：2001-04-10
申请号：US09398120
申请日：1999-09-16
申请人： Dennis P. Riley , William L. Neumann , Susan L. Henke , Patrick Lennon , Karl W. Aston , Daniela Salvemini , James A. Sikorski , Yvette M. Fobian , Margaret Lanahan Grapperhaus , Carrie L. Kusturin
发明人： Dennis P. Riley , William L. Neumann , Susan L. Henke , Patrick Lennon , Karl W. Aston , Daniela Salvemini , James A. Sikorski , Yvette M. Fobian , Margaret Lanahan Grapperhaus , Carrie L. Kusturin
IPC分类号： C07D48722
CPC分类号： C07D471/06 , A61K31/555 , C07D471/08 , C07F13/005 , Y02A50/473
摘要： The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic pentaazacyclopentadecane ligands which catalytically dismutate superoxide.
摘要翻译：本发明涉及有效作为用于分解超氧化物的催化剂的化合物，更具体地说，涉及催化分解超氧化物的取代的，不饱和杂环五氮杂环十五烷配体的锰或铁络合物。

2. 发明申请

US20080318917A1 POLYETHYLENE GLYCOLATED SUPEROXIDE DISMUTASE MIMETICS 有权
标题翻译：聚乙烯甘油超氧化物歧化酶
公开(公告)号：US20080318917A1
公开(公告)日：2008-12-25
申请号：US11766221
申请日：2007-06-21
申请人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
发明人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
IPC分类号： A61K31/555 , A61P25/00 , A61P37/00 , C07D259/00
CPC分类号： A61K47/60
摘要： Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide, dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds ere also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
摘要翻译：用于利用包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物的化合物和方法。还提供了用于制备与聚乙二醇共价连接的超氧化物歧化酶模拟物的方法，所述方法包括使活化的聚乙二醇与超氧化物反应，模拟物歧化酶，或者将超氧化物歧化酶模拟物与活化的聚乙二醇反应。还提供了一种用于预防或治疗涉及超氧化物阴离子的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物。还提供了确定化合物的安全性和功效的方法。确定安全性和功效的方法可以包括实验动物和人类的方法。

3. 发明申请

US20120301403A1 POLYETHYLENE GLYCOLATED SUPEROXIDE DISMUTASE MIMETICS 审中-公开
标题翻译：聚乙烯甘油超氧化物歧化酶
公开(公告)号：US20120301403A1
公开(公告)日：2012-11-29
申请号：US13526111
申请日：2012-06-18
申请人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
发明人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
IPC分类号： A61K31/28 , A61P29/00 , A61P1/00 , A61P19/02 , A61P9/12 , A61P17/06 , A61P37/06 , A61P7/02 , A61P37/00 , A61P11/00 , A61P25/00 , A61P25/04 , A61P31/00 , A61K49/00 , C12Q1/18 , A61P9/10
CPC分类号： C12N9/0089 , A61K47/60 , C12Q1/26 , C12Q1/28 , G01N33/5014
摘要： Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds are also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
摘要翻译：用于利用包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物的化合物和方法。还提供了制备与聚乙二醇共价连接的超氧化物歧化酶模拟物的方法，所述方法包括使活化的聚乙二醇与超氧化物歧化酶模拟物反应，或者使超氧化物歧化酶模拟物与活化的聚乙二醇反应。还提供了一种用于预防或治疗涉及超氧化物阴离子的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物。还提供了确定化合物的安全性和功效的方法。确定安全性和功效的方法可以包括实验动物和人类的方法。

4. 发明授权

US08217166B2 Polyethylene glycolated superoxide dismutase mimetics 有权
标题翻译：聚乙烯甘氨酸超氧化物歧化酶模拟物
公开(公告)号：US08217166B2
公开(公告)日：2012-07-10
申请号：US11766221
申请日：2007-06-21
申请人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
发明人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
IPC分类号： C07B47/00 , C07D487/22
CPC分类号： A61K47/60
摘要： Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds ere also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
摘要翻译：用于利用包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物的化合物和方法。还提供了制备与聚乙二醇共价连接的超氧化物歧化酶模拟物的方法，所述方法包括使活化的聚乙二醇与超氧化物歧化酶模拟物反应，或者使超氧化物歧化酶模拟物与活化的聚乙二醇反应。还提供了一种用于预防或治疗涉及超氧化物阴离子的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物。还提供了确定化合物的安全性和功效的方法。确定安全性和功效的方法可以包括实验动物和人类的方法。

5. 发明申请

US20120135973A1 METHOD FOR TREATING CHRONIC PAIN 审中-公开
标题翻译：治疗慢性疼痛的方法
公开(公告)号：US20120135973A1
公开(公告)日：2012-05-31
申请号：US13227842
申请日：2011-09-08
申请人： Daniela Salvemini , William L. Neumann , Smita Rausaria
发明人： Daniela Salvemini , William L. Neumann , Smita Rausaria
IPC分类号： A61K31/555 , A61P25/00 , A61P25/04 , C07F13/00
CPC分类号： A61K9/0053 , A61K31/40 , A61K31/555 , A61K45/06 , C07D219/08 , C07D471/22 , C07D487/22 , C07D491/22 , C07D513/22 , C07D517/22
摘要： The present invention provides analgesic compounds comprising at least one modified metalloporphyrin compound. Also provided are methods of treating pain by orally administering an analgesic compounds comprising at least one modified metalloporphyrin compound.
摘要翻译：本发明提供包含至少一种改性金属卟啉化合物的止痛化合物。还提供了通过口服施用包含至少一种改性金属卟啉化合物的止痛化合物来治疗疼痛的方法。

6. 发明授权

US09132131B2 Use of adenosine A3 receptor agonists for treatment of neuropathic pain 有权
标题翻译：使用腺苷A3受体激动剂治疗神经性疼痛
公开(公告)号：US09132131B2
公开(公告)日：2015-09-15
申请号：US13420111
申请日：2012-03-14
申请人： Daniela Salvemini
发明人： Daniela Salvemini
IPC分类号： A01N43/04 , A01N43/42 , A01N37/12 , A01N37/44 , A01N33/02 , A61K31/70 , A61K31/44 , A61K31/195 , A61K31/135 , A61K31/52 , A61K31/7076 , A61K45/06
CPC分类号： A61K31/52 , A61K31/7076 , A61K45/06 , A61K2300/00
摘要： A method of treating neuropathic pain in a subject is provided. The method comprises administering to a subject a pharmaceutical composition comprising a therapeutically effective amount of an A3AR agonist, optionally further including administering an analgesic.
摘要翻译：提供了治疗受试者神经性疼痛的方法。该方法包括向受试者施用包含治疗有效量的A3AR激动剂的药物组合物，任选地还包括施用止痛剂。

7. 发明申请

US20060270639A1 Combinations of superoxide dismutase mimetics and nonsteroidal analgesic/anti-inflammatory drugs 审中-公开
标题翻译：超氧化物歧化酶模拟物和非甾体镇痛/抗炎药物的组合
公开(公告)号：US20060270639A1
公开(公告)日：2006-11-30
申请号：US11329636
申请日：2006-01-10
申请人： Daniela Salvemini
发明人： Daniela Salvemini
IPC分类号： A61K31/60 , A61K31/555 , A61K31/415 , A61K31/192
CPC分类号： A61K31/192 , A61K31/415 , A61K31/555 , A61K31/60 , A61K45/06 , C07F13/005 , A61K2300/00
摘要： Combinations of synthetic low molecular weight catalysts for the dismutation of superoxide and Nonsteroidal Analgesic/Anti-Inflammatory Drugs (NSAIDs) are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions.
摘要翻译：用于分解超氧化物和非甾体镇痛/抗炎药物（NSAIDs）的合成低分子量催化剂的组合是有效的提高痛觉过敏症状的疼痛阈值的强效镇痛药。

8. 发明申请

US20050175580A1 Compositions and methods for enhancing cytokine activity and treating hypotension associated with the administration of cytokines 审中-公开
标题翻译：用于增强细胞因子活性和治疗与细胞因子施用相关的低血压的组合物和方法
公开(公告)号：US20050175580A1
公开(公告)日：2005-08-11
申请号：US10433290
申请日：2002-01-03
申请人： Daniela Salvemini
发明人： Daniela Salvemini
IPC分类号： A61K45/00 , A61K31/137 , A61K31/555 , A61K38/00 , A61K38/19 , A61K38/20 , A61K38/21 , A61P9/02 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/04 , A61P43/00
CPC分类号： A61K38/191 , A61K31/555 , A61K33/26 , A61K33/32 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/212 , A61K38/217 , A61K2300/00
摘要： This invention relates to compositions which enhance a mammal's immune response to a cytokine by administering therapeutic amounts of catalysts for the dismutation of superoxide which include superoxide dismutase enzyme (SOD) and small molecular weight organic ligand mimics of that enzyme (SOD mimetics or SODms), alone or in combination with a cytokine. These compositions may be used in methods for enhancing a mammal's immune response to a virus such as the hepatitis C virus or the human immunodeficiency virus (HIV) or to a tumor thereby inhibiting the proliferation of the tumor. Relatedly, these compositions may be used in methods of treating mammals infected with HIV or mammals suffering from Hepatitis C or AIDS. This invention also relates to methods of enhancing cancer therapy and methods of preventing and treating hypotension in a mammal resulting from the administration of cytokines by the administration of therapeutic amounts of catalysts for the dismutation of superoxide in combination with a cytokine and catecholamine pressor agents. Also provided are pharmaceutical compositions comprising catalysts for the dismutation of superoxide alone or in combination with cytokines and catecholamine pressor agents for use in the above methods.
摘要翻译：本发明涉及增加哺乳动物对细胞因子免疫应答的组合物，其通过施用治疗量的用于歧化超氧化物的催化剂，其包括超氧化物歧化酶（SOD）和该酶的小分子量有机配体模拟物（SOD模拟物或SODms），单独或与细胞因子组合。这些组合物可用于增强哺乳动物对诸如丙型肝炎病毒或人类免疫缺陷病毒（HIV）的病毒或肿瘤的免疫应答的方法，从而抑制肿瘤的增殖。相关地，这些组合物可以用于治疗感染HIV的哺乳动物或患有丙型肝炎或AIDS的哺乳动物的方法。本发明还涉及增强癌症治疗的方法，以及通过给予治疗量的用于与细胞因子和儿茶酚胺加压剂组合的超氧化物歧化的催化剂来施用哺乳动物所产生的哺乳动物的低血压的方法。还提供了药物组合物，其包含用于单独或与用于上述方法的细胞因子和儿茶酚胺加压剂组合的超氧化物的催化剂。

9. 发明申请

US20120039866A1 METHODS OF TREATING PAIN 有权
标题翻译：治疗疼痛的方法
公开(公告)号：US20120039866A1
公开(公告)日：2012-02-16
申请号：US13189954
申请日：2011-07-25
申请人： Daniela Salvemini
发明人： Daniela Salvemini
IPC分类号： A61K39/395 , A61P29/00 , A61P19/02 , A61K31/135
CPC分类号： A61K31/662 , A61K31/133 , A61K31/137 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/426 , A61K31/475 , A61K31/555 , A61K2039/505 , C07K16/18 , C07K2317/76 , A61K2300/00
摘要： The invention relates to methods for treating pain disorders including neuropathic and inflammatory pain and to methods to reduce or eliminate nociceptive tolerance induced by opiate analgesic use by administering an agent that suppresses or blocks S1P biological activity.
摘要翻译：本发明涉及用于治疗包括神经性和炎性疼痛的疼痛障碍的方法，以及通过施用抑制或阻断S1P生物活性的药物来减少或消除由阿片镇痛药使用引起的伤害感受耐受性的方法。

10. 发明申请

US20090099150A1 Methotrexate Combinations For Treating Inflammatory Diseases 审中-公开
标题翻译：氨甲蝶呤组合治疗炎症性疾病
公开(公告)号：US20090099150A1
公开(公告)日：2009-04-16
申请号：US11814347
申请日：2006-01-19
申请人： Daniela Salvemini
发明人： Daniela Salvemini
IPC分类号： A61K31/4353 , C07F15/00
CPC分类号： A61K31/525 , A61K31/519 , A61K31/555 , A61K2300/00
摘要： Compounds, methods and kits for treating inflammatory diseases are disclosed. The treatment comprises administering to a patient in need thereof, methotrexate and a Reactive Oxygen Species scavenger in a pharmaceutically acceptable formulation.
摘要翻译：公开了用于治疗炎性疾病的化合物，方法和试剂盒。该治疗包括向有需要的患者施用药学上可接受的制剂中的甲氨蝶呤和活性氧清除剂。

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