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1. 发明申请

US20050148672A1 Quaternary ammonium compounds 失效
标题翻译：季铵化合物
公开(公告)号：US20050148672A1
公开(公告)日：2005-07-07
申请号：US11074914
申请日：2005-03-08
申请人： Ivan Richards , Sue Cammarata , Craig Wegner , Michael Hawley , Mark Warchol , Mark Kontny , Walter Morozowich , Karen Kolbasa , Malcolm Moon , Dominique Bonafoux , Sergey Wolfson , Patrick Lennon
发明人： Ivan Richards , Sue Cammarata , Craig Wegner , Michael Hawley , Mark Warchol , Mark Kontny , Walter Morozowich , Karen Kolbasa , Malcolm Moon , Dominique Bonafoux , Sergey Wolfson , Patrick Lennon
IPC分类号： C07D295/08 , A61K31/14 , A61K31/166 , A61K31/222 , A61K31/40 , A61K31/4453 , A61K31/55 , A61P11/00 , A61P11/06 , A61P27/16 , A61P37/08 , A61P43/00 , C07B53/00 , C07C211/63 , C07C215/54 , C07C215/66 , C07C217/62 , C07C219/28 , C07C237/30 , C07C237/50 , C07D223/04 , C07D295/096 , A61K31/205
CPC分类号： C07D295/096 , C07C215/54 , C07C215/66 , C07C217/62 , C07C219/28 , C07C237/30
摘要： The compound 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-(trifluoromethyl) phenol may be used to prepare the compound (3R)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-N,N-diisopropyl-N-methyl-3-phenylpropan-1-aminium bromide by reaction with methyl bromide.
摘要翻译：化合物2 - [（1R）-3-（二异丙基氨基）-1-苯基丙基] -4-（三氟甲基）苯酚可用于制备化合物（3R）-3- [2-羟基-5-（三氟甲基）苯基 ] -N，N-二异丙基-N-甲基-3-苯基丙-1-胺与溴甲烷反应。

2. 发明申请

US20050261641A1 Method for ophthalmic administration of medicament 审中-公开
标题翻译：滴眼剂给药方法
公开(公告)号：US20050261641A1
公开(公告)日：2005-11-24
申请号：US10659813
申请日：2003-09-11
申请人： Mark Warchol , Praveen Tyle
发明人： Mark Warchol , Praveen Tyle
IPC分类号： A61F9/00 , A61M15/02 , B05B17/04 , B05B17/06 , A61M35/00
CPC分类号： A61F9/0008 , A61F9/0026 , A61M15/025 , A61M2205/3306 , A61M2205/8206 , B05B17/04 , B05B17/0607
摘要： A method for treatment or prevention of a disease or disorder of an eye comprises (a) charging a dispenser with a suitable liquid medicament, (b) disposing the dispenser in operative juxtaposition with the eye, and (c) actuating the dispenser to release a therapeutically effective amount of the medicament into the eye. The dispenser comprises an electrically energizable droplet generating device, such as a thermal resistor bubble jet device, together with means for electrically energizing and means for actuating the device. The device, when actuated, is adapted to issue droplets of the liquid medicament at a rate of about 1 to about 300 μl s−1 whereby a therapeutically effective amount of not more than about 50 μl of the medicament is released into the eye in not more than about 1 second. The dispenser further comprises a standoff configured to engage a facial surface proximal to the eye, thereby placing the dispenser in operative juxtaposition with the eye.
摘要翻译：用于治疗或预防眼睛疾病或病症的方法包括（a）用合适的液体药物对分配器充电，（b）将分配器布置成与眼睛并置，以及（c）致动分配器以释放治疗有效量的药物进入眼睛。分配器包括电激励液滴产生装置，例如热电阻气泡喷射装置，以及用于电激励的装置和用于致动装置的装置。该装置在致动时适于以约1至约300μmol-1的速率发出液体药物的液滴，由此治疗有效量的不超过约50μl的药物被释放入眼睛不超过约1秒钟。分配器还包括被配置为接合眼睛近端的面部表面的支架，从而使分配器与眼睛并置。

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