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    • 5. 发明授权
    • Imino sugar derivatives demonstrate potent antiviral activity and reduced toxicity
    • 亚氨基糖衍生物表现出强大的抗病毒活性和降低的毒性
    • US09040488B2
    • 2015-05-26
    • US13061734
    • 2009-09-02
    • Timothy M. BlockJinhong ChangXiaodong Xu
    • Timothy M. BlockJinhong ChangXiaodong Xu
    • C07D211/46A61K31/445A61K31/47A61K31/7056
    • A61K31/47A61K31/7056C07D211/46Y02A50/393A61K2300/00
    • Imino sugars, such as deoxynojirimycin (DNJ), are glucose analogues that selectively inhibit cellular α-glucosidase I and II (enzymes that process N-linked glycans in glycoprotein) and exhibit broad spectrum antiviral activities against many enveloped viruses. Previously we have reported a novel DNJ derivative, OSL-95II, with antiviral activity and reduced cytotoxicity. In order to develop imino sugars with more potent antiviral activity as well as improved toxicity profile, OSL-95II was modified by diversifying the nitrogen linked alkylated side chain. The antiviral activities were initially tested in bovine viral diarrhea virus (BVDV) infected MDBK cells, yielding several imino sugar derivatives with novel structure and superior antiviral activity and toxicity profile. Furthermore, these new compounds were shown to be active against Dengue virus (DV) and West Nile virus (WNV) infection in BHK cells where potent anti-DV activity having submicromolar EC50 values and SI of greater than 900. These compounds represent a new generation of iminio sugars and their analogues, having application in the clinical treatment of infection of DV and other members of flaviviridae.
    • 诸如脱氧野尻霉素(DNJ)的亚氨基糖是选择性抑制细胞α-葡萄糖苷酶I和II(在糖蛋白中加工N-连接聚糖的酶)并且对许多包膜病毒展现广谱抗病毒活性的葡萄糖类似物。 以前我们已经报道了具有抗病毒活性和降低的细胞毒性的新型DNJ衍生物OSL-95II。 为了开发具有更强的抗病毒活性和改善的毒性特征的亚氨基糖,OSL-95II通过使氮连接的烷基化侧链多样化而被修饰。 首先在牛病毒性腹泻病毒(BVDV)感染的MDBK细胞中测试抗病毒活性,产生几种具有新结构和优良抗病毒活性和毒性特征的亚氨基糖衍生物。 此外,这些新化合物被证明对BHK细胞中登革热病毒(DV)和西尼罗病毒(WNV)感染具有活性,其中具有亚微摩尔EC 50值和SI大于900的有效抗DV活性。这些化合物代表新一代 的亚氨基糖及其类似物,可用于临床治疗DV和其他黄病毒成分的感染。
    • 7. 发明申请
    • METHOD FOR FREQUENCY REUSE IN CELLULAR NETWORK
    • 蜂窝网络频率重用方法
    • US20130308571A1
    • 2013-11-21
    • US13896454
    • 2013-05-17
    • Xiaofeng TaoPing ZhangXiaona LiQimei CuiXiaodong XuYingyue XuWaheed ur Rehman
    • Xiaofeng TaoPing ZhangXiaona LiQimei CuiXiaodong XuYingyue XuWaheed ur Rehman
    • H04W16/02
    • H04W16/02H04W16/12H04W16/30
    • The present invention relates to the technical field of wireless communication, and discloses a method for frequency reuse based on cellular network. The method comprises the following steps: dividing the whole cellular network into a plurality of different cell clusters, wherein each cell cluster comprises three cells, every two of them being adjacent to each other; for each cell in a cell cluster, dividing the cell into a central area and an edge area according to the coverage of the cell; dividing the whole available frequency band of the network according to the user distribution and service distribution in the cell cluster; allocating divided frequency bands to the central area and the edge area in the cell cluster respectively according to preset rule; and applying the method for frequency reuse to other cell clusters, thus achieving the frequency reuse of the whole network. With the method, the average spectrum frequency efficiency of the cellular network can be improved, and interference among cells can be effectively suppressed.
    • 本发明涉及无线通信的技术领域,并且公开了一种基于蜂窝网络的频率复用方法。 该方法包括以下步骤:将整个蜂窝网络划分成多个不同的小区簇,其中每个小区簇包括三个小区,每个小区彼此相邻; 对于小区簇中的每个小区,根据小区的覆盖范围将小区划分成中心区域和边缘区域; 根据用户分布和服务分布对网络的整个可用频带进行划分; 根据预设规则分别将细分簇的频带分配给小区簇中的中心区域和边缘区域; 并将频率重用方法应用于其他小区集群,从而实现整个网络的频率重用。 利用该方法,可以提高蜂窝网络的平均频谱频率效率,并且可以有效地抑制小区之间的干扰。
    • 10. 发明授权
    • Community antenna system in the closed loop mode and the method thereof
    • 社区天线系统在闭环模式及其方法
    • US08134504B2
    • 2012-03-13
    • US12629003
    • 2009-12-01
    • Xiaodong XuGuangyi LiuChunfeng CuiZhigang YanYuhong Huang
    • Xiaodong XuGuangyi LiuChunfeng CuiZhigang YanYuhong Huang
    • H01Q3/01
    • H04B7/10H04B7/0469H04B7/0617H04B7/0626
    • A community antenna system in a closed loop mode and a method thereof are provided, the system includes two groups of pre-weighting processing modules, beamforming modules and antenna arrays connected in turn. The method includes the following processes: performing the pre-weighting processing on a transmission signal respectively according to the channel information corresponding to each of two antenna arrays; determining beamforming weight vectors according to two groups of steering vectors corresponding to the two antenna arrays, and performing weighting processing on the two pre-weighting processed transmission signals respectively to form two directional beams directed to the receiving antenna of a target mobile terminal; and transmitting the two directional beams via two antenna arrays with orthogonal polarization modes respectively.
    • 提供了一种闭环模式的社区天线系统及其方法,该系统包括依次连接的两组预加权处理模块,波束形成模块和天线阵列。 该方法包括以下处理:根据与两个天线阵列中的每一个相对应的信道信息分别对传输信号执行预加权处理; 根据与两个天线阵列相对应的两组导向矢量来确定波束成形权重向量,并且分别对两个预加权处理的传输信号执行加权处理,以形成指向目标移动终端的接收天线的两个定向波束; 并且分别经由具有正交偏振模式的两个天线阵列发送两个定向波束。