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1. 发明申请

US20050256180A1 Substituted pyrazolyl compounds for the treatment of inflammation 失效
标题翻译：用于治疗炎症的取代的吡唑基化合物
公开(公告)号：US20050256180A1
公开(公告)日：2005-11-17
申请号：US11113926
申请日：2005-04-25
申请人： Arija Bergmanis , Michael Clare , Joyce Crich , Lifeng Geng , Timothy Hagen , Gunnar Hanson , Stephen Houdek , He Huang , Donna Iula , Francis Koszyk , Shuyuan Liao , Scott Mohler , Maria Nguyen , Richard Partis , Michael Stealey , Michael Tollefson , Richard Weier , Xiangdong Xu , Dominique Bonafoux , Theresa Fletcher , Bruce Hamper , Patrick Lennon , Subo Liao , Suzanne Metz , David Oburn , Thomas Owen , Angela Scates , Michael Vazquez , Serge Wolfson
发明人： Arija Bergmanis , Michael Clare , Joyce Crich , Lifeng Geng , Timothy Hagen , Gunnar Hanson , Stephen Houdek , He Huang , Donna Iula , Francis Koszyk , Shuyuan Liao , Scott Mohler , Maria Nguyen , Richard Partis , Michael Stealey , Michael Tollefson , Richard Weier , Xiangdong Xu , Dominique Bonafoux , Theresa Fletcher , Bruce Hamper , Patrick Lennon , Subo Liao , Suzanne Metz , David Oburn , Thomas Owen , Angela Scates , Michael Vazquez , Serge Wolfson
IPC分类号： A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P19/02 , A61P25/04 , A61P29/00 , A61P35/00 , C07D231/54 , C07D333/62 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/4162
CPC分类号： C07D403/12 , C07D231/54 , C07D333/62 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
摘要翻译：本发明涉及取代的吡唑基衍生物，包含这些的组合物，中间体，制备取代的吡唑基衍生物的方法，以及用于治疗癌症，炎症和炎症相关疾病如关节炎的方法。

2. 发明授权

US07186743B2 Substituted pyrazolyl compounds for the treatment of inflammation 失效
标题翻译：用于治疗炎症的取代的吡唑基化合物
公开(公告)号：US07186743B2
公开(公告)日：2007-03-06
申请号：US11113926
申请日：2005-04-25
申请人： Arija A. Bergmanis , Michael Clare , Joyce Z. Crich , Lifeng Geng , Timothy J. Hagen , Gunnar J. Hanson , Stephen C. Houdek , He Huang , Donna M. Iula , Francis J. Koszyk , Shuyuan Liao , Scott B. Mohler , Maria Nguyen , Richard A. Partis , Michael A. Stealey , Michael B. Tollefson , Richard M. Weier , Xiangdong Xu , Dominique Bonafoux , Theresa R. Fletcher , Bruce C Hamper , Patrick J. Lennon , Subo Liao , Suzanne Metz , David S. Oburn , Thomas J. Owen , Angela M. Scates , Michael L. Vazquez , Serge G. Wolfson
发明人： Arija A. Bergmanis , Michael Clare , Joyce Z. Crich , Lifeng Geng , Timothy J. Hagen , Gunnar J. Hanson , Stephen C. Houdek , He Huang , Donna M. Iula , Francis J. Koszyk , Shuyuan Liao , Scott B. Mohler , Maria Nguyen , Richard A. Partis , Michael A. Stealey , Michael B. Tollefson , Richard M. Weier , Xiangdong Xu , Dominique Bonafoux , Theresa R. Fletcher , Bruce C Hamper , Patrick J. Lennon , Subo Liao , Suzanne Metz , David S. Oburn , Thomas J. Owen , Angela M. Scates , Michael L. Vazquez , Serge G. Wolfson
IPC分类号： A61K31/416 , A61K31/454 , A61K31/5395 , A61K31/429 , A61K31/433 , A61K31/506 , A61K31/496
CPC分类号： C07D403/12 , C07D231/54 , C07D333/62 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
摘要翻译：本发明涉及取代的吡唑基衍生物，包含这些的组合物，中间体，制备取代的吡唑基衍生物的方法，以及用于治疗癌症，炎症和炎症相关疾病如关节炎的方法。

4. 发明申请

US20050043344A1 Heteroarylalkanoic acids as integrin receptor antagonists derivatives 审中-公开
标题翻译：杂芳基链烷酸作为整联蛋白受体拮抗剂衍生物
公开(公告)号：US20050043344A1
公开(公告)日：2005-02-24
申请号：US10743354
申请日：2003-12-22
申请人： Mark Boys , Lori Schretzman , Michael Tollefson , Nizal Chandrakumar , Ish Khanna , Maria Nguyen , Victoria Downs , Scott Mohler , Glen Gesicki , Thomas Penning , Barbara Chen , Yaping Wang , Albert Khilevich , Bipinchandra Desai , Yi Yu , John Wendt , Heather Stenmark , Hongwei Wu , Renee Huff , Srinivasan Nagarajan , Balekudru Devadas , Hwang-Fun Lu , Mark Russell , Dale Spangler , Mihir Parikh
发明人： Mark Boys , Lori Schretzman , Michael Tollefson , Nizal Chandrakumar , Ish Khanna , Maria Nguyen , Victoria Downs , Scott Mohler , Glen Gesicki , Thomas Penning , Barbara Chen , Yaping Wang , Albert Khilevich , Bipinchandra Desai , Yi Yu , John Wendt , Heather Stenmark , Hongwei Wu , Renee Huff , Srinivasan Nagarajan , Balekudru Devadas , Hwang-Fun Lu , Mark Russell , Dale Spangler , Mihir Parikh
IPC分类号： A61K31/4245 , A61K31/4745 , A61P19/02 , A61P19/10 , A61P27/00 , A61P35/00 , A61P35/04 , A61P43/00
CPC分类号： A61K31/4245 , A61K31/4745
摘要： The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the αVβ3 and/or the αVβ5 integrin without significantly inhibiting the αVβ6 integrin.
摘要翻译：本发明涉及包含式I化合物或其药学上可接受的盐的药物组合物，以及选择性抑制或拮抗αVβ3和/或αVβ5整联蛋白而不显着抑制αVβ6整联蛋白的方法。

5. 发明申请

US20070240071A1 System management user interface providing user access to status information for process control system equipment including a search function 有权
标题翻译：系统管理用户界面提供用户访问包括搜索功能的过程控制系统设备的状态信息
公开(公告)号：US20070240071A1
公开(公告)日：2007-10-11
申请号：US11403223
申请日：2006-04-11
申请人： Thomas Sherrill , Maria Nguyen , Donald Wayland , Kristen Garrison , Brian Barry , Naredla Murty
发明人： Thomas Sherrill , Maria Nguyen , Donald Wayland , Kristen Garrison , Brian Barry , Naredla Murty
IPC分类号： G06F9/00
CPC分类号： G05B23/0267
摘要： A system management human-machine interface application for use in a process control system is described herein that enables users to view/monitor information regarding system status and performance and to initiate changes to the operation of system equipment, checkpoint control stations and execute diagnostics. A system management graphical user interface (GUI) includes a number of interface features that enhance the accessibility of system status information to users. Such enhancements include rendering selectable diagnostic information (e.g., online/offline status) on a system component navigation view. The GUI also provides access to a variety of system information including: alarms, messages, watched system management parameters, and a legend for symbols displayed in a system management navigation tree. Other enhancements include: a search function for quickly locating a device in the system to render detailed information, a navigation tree that displays equipment status via icons, and propagating fault statuses up to a highest level of the navigation tree.
摘要翻译：本文描述了一种用于过程控制系统的系统管理人机界面应用程序，使用户能够查看/监视有关系统状态和性能的信息，并启动对系统设备，检查点控制站的操作以及执行诊断的更改。系统管理图形用户界面（GUI）包括许多接口特征，其增强系统状态信息对用户的可访问性。这样的增强包括在系统组件导航视图上呈现可选择的诊断信息（例如，在线/离线状态）。 GUI还提供对各种系统信息的访问，包括：系统管理导航树中显示的符号的警报，消息，监视系统管理参数和图例。其他增强功能包括：快速定位系统中的设备以呈现详细信息的搜索功能，通过图标显示设备状态的导航树，以及将故障状态传播到导航树的最高级别。

6. 发明申请

US20070240051A1 System management user interface providing user access to status information for process control system equipment 有权
标题翻译：系统管理用户界面提供用户访问过程控制系统设备的状态信息
公开(公告)号：US20070240051A1
公开(公告)日：2007-10-11
申请号：US11402645
申请日：2006-04-11
申请人： Thomas Sherrill , Maria Nguyen , Donald Wayland , Kristen Garrison , Brian Barry , Naredla Murty
发明人： Thomas Sherrill , Maria Nguyen , Donald Wayland , Kristen Garrison , Brian Barry , Naredla Murty
IPC分类号： G06F3/00
CPC分类号： G06F3/048 , G05B23/0267 , G06F2203/04803
摘要： A system management human-machine interface application for use in a process control system is described herein that enables users to view/monitor information regarding system status and performance and to initiate changes to the operation of system equipment, checkpoint control stations and execute diagnostics. A system management graphical user interface (GUI) includes a number of interface features that enhance the accessibility of system status information to users. Such enhancements include rendering selectable diagnostic information (e.g., online/offline status) on a system component navigation view. The GUI also provides access to a variety of system information including: alarms, messages, watched system management parameters, and a legend for symbols displayed in a system management navigation tree. Other enhancements include: a search function for quickly locating a device in the system to render detailed information, a navigation tree that displays equipment status via icons, and propagating fault statuses up to a highest level of the navigation tree.
摘要翻译：本文描述了一种用于过程控制系统的系统管理人机界面应用程序，使用户能够查看/监视有关系统状态和性能的信息，并启动对系统设备，检查点控制站的操作以及执行诊断的更改。系统管理图形用户界面（GUI）包括许多接口特征，其增强系统状态信息对用户的可访问性。这样的增强包括在系统组件导航视图上呈现可选择的诊断信息（例如，在线/离线状态）。 GUI还提供对各种系统信息的访问，包括：系统管理导航树中显示的符号的警报，消息，监视系统管理参数和图例。其他增强功能包括：快速定位系统中的设备以呈现详细信息的搜索功能，通过图标显示设备状态的导航树，以及将故障状态传播到导航树的最高级别。

7. 发明申请

US20070240052A1 System management user interface providing user access to status information for process control system equipment including a status monitor 有权
标题翻译：系统管理用户界面提供用户访问过程控制系统设备的状态信息，包括状态监视器
公开(公告)号：US20070240052A1
公开(公告)日：2007-10-11
申请号：US11403220
申请日：2006-04-11
申请人： Thomas Sherrill , Maria Nguyen , Donald Wayland , Kristen Garrison , Brian Barry , Naredla Murty
发明人： Thomas Sherrill , Maria Nguyen , Donald Wayland , Kristen Garrison , Brian Barry , Naredla Murty
IPC分类号： G06F3/00
CPC分类号： G06F3/048 , G06F2203/04803
摘要： A system management human-machine interface application for use in a process control system is described herein that enables users to view/monitor information regarding system status and performance and to initiate changes to the operation of system equipment, checkpoint control stations and execute diagnostics. A system management graphical user interface (GUI) includes a number of interface features that enhance the accessibility of system status information to users. Such enhancements include rendering selectable diagnostic information (e.g., online/offline status) on a system component navigation view. The GUI also provides access to a variety of system information including: alarms, messages, watched system management parameters, and a legend for symbols displayed in a system management navigation tree. Other enhancements include: a search function for quickly locating a device in the system to render detailed information, a navigation tree that displays equipment status via icons, and propagating fault statuses up to a highest level of the navigation tree.
摘要翻译：本文描述了一种用于过程控制系统的系统管理人机界面应用程序，使用户能够查看/监视有关系统状态和性能的信息，并启动对系统设备，检查点控制站的操作以及执行诊断的更改。系统管理图形用户界面（GUI）包括许多接口特征，其增强系统状态信息对用户的可访问性。这样的增强包括在系统组件导航视图上呈现可选择的诊断信息（例如，在线/离线状态）。 GUI还提供对各种系统信息的访问，包括：系统管理导航树中显示的符号的警报，消息，监视系统管理参数和图例。其他增强功能包括：快速定位系统中的设备以呈现详细信息的搜索功能，通过图标显示设备状态的导航树，以及将故障状态传播到导航树的最高级别。

8. 发明申请

US20070239351A1 System management user interface providing user access to status information for process control system equipment including displayed propagated status in a navigation pane 有权
标题翻译：系统管理用户界面提供用户访问过程控制系统设备的状态信息，包括在导航窗格中显示的传播状态
公开(公告)号：US20070239351A1
公开(公告)日：2007-10-11
申请号：US11402633
申请日：2006-04-11
申请人： Thomas Sherrill , Maria Nguyen , Donald Wayland , Kristen Garrison , Brian Barry , Naredla Murty
发明人： Thomas Sherrill , Maria Nguyen , Donald Wayland , Kristen Garrison , Brian Barry , Naredla Murty
IPC分类号： G01C21/00
CPC分类号： G05B23/0216 , G05B23/0267 , G05B2219/31471 , G05B2219/36121 , G06Q10/06
摘要： A system management human-machine interface application for use in a process control system is described herein that enables users to view/monitor information regarding system status and performance and to initiate changes to the operation of system equipment, checkpoint control stations and execute diagnostics. A system management graphical user interface (GUI) includes a number of interface features that enhance the accessibility of system status information to users. Such enhancements include rendering selectable diagnostic information (e.g., online/offline status) on a system component navigation view. The GUI also provides access to a variety of system information including: alarms, messages, watched system management parameters, and a legend for symbols displayed in a system management navigation tree. Other enhancements include: a search function for quickly locating a device in the system to render detailed information, a navigation tree that displays equipment status via icons, and propagating fault statuses up to a highest level of the navigation tree.
摘要翻译：本文描述了一种用于过程控制系统的系统管理人机界面应用程序，使用户能够查看/监视有关系统状态和性能的信息，并启动对系统设备，检查点控制站的操作以及执行诊断的更改。系统管理图形用户界面（GUI）包括许多接口特征，其增强系统状态信息对用户的可访问性。这样的增强包括在系统组件导航视图上呈现可选择的诊断信息（例如，在线/离线状态）。 GUI还提供对各种系统信息的访问，包括：系统管理导航树中显示的符号的警报，消息，监视系统管理参数和图例。其他增强功能包括：快速定位系统中的设备以呈现详细信息的搜索功能，通过图标显示设备状态的导航树，以及将故障状态传播到导航树的最高级别。

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