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1. 发明申请

US20050287191A1 Hydrogel composites 审中-公开
标题翻译：水凝胶复合材料
公开(公告)号：US20050287191A1
公开(公告)日：2005-12-29
申请号：US11146276
申请日：2005-06-07
申请人： Hugh Munro , Philip Andrews , Gareth Jeffrey , Susana Sainz Garcia
发明人： Hugh Munro , Philip Andrews , Gareth Jeffrey , Susana Sainz Garcia
IPC分类号： C08F2/44 , A61K9/70
CPC分类号： C08F2/44 , Y10T442/2566
摘要： A method for producing a hydrogel/fibre composite comprises: impregnating fibres of a fibrous material with a precursor solution comprising at least one polymerisable, and optionally also crosslinkable, monomer such that at least partial swelling of the fibres takes place; and polymerising, and optionally also crosslinking, the at least one monomer after impregnation and at least partial swelling of the fibres such that the integrity of the fibrous material is at least partially preserved in the resulting hydrogel/fibre composite, provided that the crosslinking is not initiated solely by cation release from the fibres of the fibrous material. The invention provides a hydrogel/fibre composite prepared or preparable by the said method. The hydrogel/fibre composite may be adhesive to human skin with good properties of performance and subsequent painless removal. The composite is found to maintain acceptable strength and structural integrity on hydration or across one or more hydration/dehydration cycle, and thus finds use in, for example, biomedical products where this property is required.
摘要翻译：制备水凝胶/纤维复合材料的方法包括：用包含至少一种可聚合和任选地可交联的单体的前体溶液浸渍纤维材料的纤维，使得发生纤维的至少部分溶胀; 并且在浸渍之后聚合和任选地还交联至少一种单体，并且纤维的至少部分溶胀，使得纤维材料的完整性至少部分地保留在所得水凝胶/纤维复合材料中，条件是交联不是仅由纤维材料纤维的阳离子释放引发。本发明提供了通过所述方法制备或制备的水凝胶/纤维复合材料。水凝胶/纤维复合材料可以具有良好的性能性能和随后的无痛去除对人体皮肤的粘合性。发现复合材料在水合或一个或多个水化/脱水循环中保持可接受的强度和结构完整性，因此可用于例如需要该性质的生物医学产品。

2. 发明申请

US20060251880A1 Absorbent hydrogel composites 审中-公开
标题翻译：吸水性水凝胶复合材料
公开(公告)号：US20060251880A1
公开(公告)日：2006-11-09
申请号：US11287174
申请日：2005-11-23
申请人： Hugh Munro , Philip Andrews , Susana Sainz Garcia
发明人： Hugh Munro , Philip Andrews , Susana Sainz Garcia
IPC分类号： B32B3/26
CPC分类号： A61L15/425 , A61L15/60 , Y10T428/249953 , Y10T442/3935
摘要： The invention provides an absorbent material or article comprising an absorbent hydrogel composite sheet. The sheet includes an absorbent layer part having two major faces which comprises a flexible plasticised hydrophilic polymer matrix having an internal cellular structure, and a second part which comprises a flexible plasticised hydrophilic polymer matrix having a relatively continuous internal structure. The second part may be associated with the layer part such that the second part infiltrates some but not all of the cellular voids of the absorbent layer part over a major face of the absorbent layer part. Alternatively, the second part may be associated with the layer part such that the second part overlies a major face of the absorbent layer part. By this arrangement, some but not all of the absorbent layer part is effectively exposed for absorption of external water or other fluid through the side of the sheet corresponding to that said major face of the absorbent layer.
摘要翻译：本发明提供了一种包含吸收性水凝胶复合片材的吸收材料或制品。片材包括具有两个主表面的吸收层部分，其包含具有内部细胞结构的柔性增塑的亲水性聚合物基质，和包含具有相对连续的内部结构的柔性增塑的亲水性聚合物基质的第二部分。第二部分可以与层部分相关联，使得第二部分在吸收层部分的主表面上渗透吸收层部分的一些但不是全部的细胞空隙。或者，第二部分可以与层部分相关联，使得第二部分覆盖在吸收层部分的主表面上。通过这种布置，一些但不是全部的吸收层部分被有效地暴露以吸收外部水或其它流体通过与吸收层的所述主面对应的片材的侧面。

3. 发明申请

US20070282237A1 ABSORBENT MATERIALS AND ARTICLES 审中-公开
标题翻译：吸收材料和文章
公开(公告)号：US20070282237A1
公开(公告)日：2007-12-06
申请号：US11840536
申请日：2007-08-17
申请人： Hugh Munro , Philip Andrews , Susana Garcia
发明人： Hugh Munro , Philip Andrews , Susana Garcia
IPC分类号： A61F13/00
CPC分类号： A61L15/60 , Y10T442/15 , Y10T442/159 , Y10T442/164 , Y10T442/183 , Y10T442/2484 , Y10T442/2508 , Y10T442/2525
摘要： An absorbent material comprises a flexible, skin-conformable, moisture-absorbent sheet member, optionally a net member in sheet form overlying and associated with the absorbent sheet member on at least one face thereof, and a hydrogel disposed on at least one of the net member, when present, and the absorbent sheet member in an amount of less than about 500 g of hydrogel per square metre per face, wherein the aqueous saline absorbency rate of the absorbent material through the face on which the hydrogel is disposed is less than about 300 seconds. Absorbent articles comprising the absorbent material and methods of manufacturing the material or articles are also described.
摘要翻译：一种吸收性材料包括柔性的，适合皮肤的吸湿性片材构件，任选的在片材形式的网状构件，其在至少一个表面上覆盖并与吸收性片材构件相关联，以及水凝胶，其设置在至少一个网并且吸收性片材的用量小于约500g每平方米每面的水凝胶，其中通过其上设置水凝胶的面的吸收材料的盐水吸收率低于约 300秒还描述了包含吸收材料的吸收制品和制造材料或制品的方法。

4. 发明申请

US20060148352A1 Absorbent materials and articles 审中-公开
标题翻译：吸收材料和制品
公开(公告)号：US20060148352A1
公开(公告)日：2006-07-06
申请号：US11256183
申请日：2005-10-24
申请人： Hugh Munro , Philip Andrews , Susana Garcia
发明人： Hugh Munro , Philip Andrews , Susana Garcia
IPC分类号： B32B5/24 , B32B27/12 , D03D9/00 , B32B5/26
CPC分类号： A61L15/60 , Y10T442/15 , Y10T442/159 , Y10T442/164 , Y10T442/183 , Y10T442/2484 , Y10T442/2508 , Y10T442/2525
摘要： An absorbent material comprises a flexible, skin-conformable, moisture-absorbent sheet member, optionally a net member in sheet form overlying and associated with the absorbent sheet member on at least one face thereof, and a hydrogel disposed on at least one of the net member, when present, and the absorbent sheet member in an amount of less than about 500 g of hydrogel per square metre per face, wherein the aqueous saline absorbency rate of the absorbent material through the face on which the hydrogel is disposed is less than about 300 seconds. Absorbent articles comprising the absorbent material and methods of manufacturing the material or articles are also described.
摘要翻译：一种吸收性材料包括柔性的，适合皮肤的吸湿性片材构件，任选的在片材形式的网状构件，其在至少一个表面上覆盖并与吸收性片材构件相关联，以及水凝胶，其设置在至少一个网并且吸收性片材的用量小于约500g每平方米每面的水凝胶，其中通过其上设置水凝胶的面的吸收材料的盐水吸收率低于约 300秒还描述了包含吸收材料的吸收制品和制造材料或制品的方法。

5. 发明申请

US20060200063A1 Absorbent multilayer hydrogel wound dressings 有权
标题翻译：吸收性多层水凝胶伤口敷料
公开(公告)号：US20060200063A1
公开(公告)日：2006-09-07
申请号：US10538427
申请日：2003-12-12
申请人： Hugh Munro , Derek Silcock , Simon Bayliff , Richard Hoskins , Susana Garcia , Helen Burgess , Justin Barnes
发明人： Hugh Munro , Derek Silcock , Simon Bayliff , Richard Hoskins , Susana Garcia , Helen Burgess , Justin Barnes
IPC分类号： A61F13/00 , A61F15/00
CPC分类号： A61L15/60 , A61L15/425 , A61L15/58
摘要： The invention provides wound dressings comprising an absorbent (porous) hydrogel composition comprising a foam portion which comprises a flexible plasticised hydrophilic polymer matrix having an internal cellular structure, and a continuous portion which comprises a flexible plasticised hydrophilic polymer matrix having relatively continuous internal structure. The continuous portion of the hydrogel composition includes apertures providing fluid flow communication through the continuous portion between an external surface of the continuous portion and the foam portion whereby the foam portion can take up external water or other fluid into the cellular structure through the apertures of the continuous portion. The continuous portion of the hydrogel composition may be tacky to the skin, allowing its use as a bioadhesive.
摘要翻译：本发明提供了包含吸收剂（多孔）水凝胶组合物的伤口敷料，其包含泡沫部分，该泡沫部分包含具有内部细胞结构的柔性增塑的亲水性聚合物基质，以及包含具有相对连续的内部结构的柔性增塑的亲水性聚合物基质的连续部分。水凝胶组合物的连续部分包括通过连续部分的外表面和泡沫部分之间的连续部分提供流体流动连通的孔，由此泡沫部分可以通过孔的部分将外部水或其它流体吸收到多孔结构中连续部分。水凝胶组合物的连续部分可能对皮肤发粘，允许其用作生物粘合剂。

6. 发明申请

US20060068014A1 Ionic hydrogels with controlled aqueous fluid absorption 审中-公开
标题翻译：离子水凝胶具有受控的水溶液吸收
公开(公告)号：US20060068014A1
公开(公告)日：2006-03-30
申请号：US10515028
申请日：2003-05-20
申请人： Hugh Munro , Richard Hoskins
发明人： Hugh Munro , Richard Hoskins
IPC分类号： C07C69/52 , A61K9/14
CPC分类号： A61L24/0036 , A61L15/425 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L26/008 , A61L26/0085
摘要： A cross-linked plasticised polymeric hydrogel suitable for use in mammalian body tissue (e.g. skin) contacting applications, which comprises a cross-linked copolymer formed from a first monomer comprising one or more pendant anionic group and a second monomer comprising one or more pendant cationic group, the relative amounts of the said monomers in the copolymer being such that the anionic groups and cationic groups are present in essentially equimolar quantities.
摘要翻译：一种适用于哺乳动物身体组织（例如皮肤）接触应用的交联的增塑聚合物水凝胶，其包含由包含一个或多个侧阴离子基团的第一单体形成的交联共聚物和包含一个或多个阳离子阳离子所述单体在共聚物中的相对量使得阴离子基团和阳离子基团以基本上等摩尔量存在。

7. 发明申请

US20060029652A1 Absorbent hydrogel compositions 审中-公开
标题翻译：吸收性水凝胶组合物
公开(公告)号：US20060029652A1
公开(公告)日：2006-02-09
申请号：US11150757
申请日：2005-06-10
申请人： Hugh Munro , Richard Hoskins , Susana Garcia , Helen Burgess , Justin Barnes
发明人： Hugh Munro , Richard Hoskins , Susana Garcia , Helen Burgess , Justin Barnes
IPC分类号： A61L15/16
CPC分类号： A61L15/60 , A61B5/04087 , A61L15/425 , A61L15/58 , A61N1/0428 , A61N1/0456 , A61N1/046 , A61N1/0468 , A61N1/0496 , C08L33/08
摘要： The invention provides an absorbent (porous) hydrogel composition comprising a foam portion which comprises a flexible plasticised hydrophilic polymer matrix having an internal cellular structure, and a continuous portion which comprises a flexible plasticised hydrophilic polymer matrix having a relatively continuous internal structure. The continuous portion of the hydrogel composition includes apertures providing fluid flow communication through the continuous portion between an external surface of the continuous portion and the foam portion whereby the foam portion can take up external water or other fluid into the cellular structure through the apertures of the continuous portion. The continuous portion of the hydrogel composition may be tacky to the skin, allowing its use as a bioadhesive. The porous hydrogel has wide applicability, e.g. in wound or burn dressings, biomedical electrodes, etc., as an absorbent and/or adhesive component.
摘要翻译：本发明提供一种吸收剂（多孔）水凝胶组合物，其包含泡沫部分，其包含具有内部细胞结构的柔性增塑的亲水性聚合物基质，以及包含具有相对连续的内部结构的柔性增塑的亲水性聚合物基质的连续部分。水凝胶组合物的连续部分包括通过连续部分的外表面和泡沫部分之间的连续部分提供流体流动连通的孔，由此泡沫部分可以通过孔的部分将外部水或其它流体吸收到多孔结构中连续部分。水凝胶组合物的连续部分可能对皮肤发粘，允许其用作生物粘合剂。多孔水凝胶具有广泛的适用性，例如作为吸收剂和/或粘合剂组分的伤口或烧伤敷料，生物医学电极等。

8. 发明申请

US20080031930A1 Process for coating a perforated substrate 审中-公开
标题翻译：用于涂覆多孔基材的方法
公开(公告)号：US20080031930A1
公开(公告)日：2008-02-07
申请号：US11891944
申请日：2007-08-14
申请人： Hugh Munro , Steven Lawrence
发明人： Hugh Munro , Steven Lawrence
IPC分类号： A61L15/00 , B05D3/06
CPC分类号： A61L15/425 , D06M15/263 , D06M15/285 , D06M15/3566 , D06M23/00 , D06N3/0097 , D06N3/045 , D06N3/047 , D06N3/125 , D06N3/128 , D06N2211/18 , D06N2213/04 , Y10T442/172 , Y10T442/2525
摘要： A process for coating a perforated substrate with a gel (e.g. a polymerised acrylate hydrogel or a xerogel) without substantial occlusion of the perforations comprises (i) forming a layer of a liquid pregel mixture, comprising one or more monomers, on a web coated with a silicone, polyethylene, Teflon® or other coating having a surface energy less than the surface energy of the liquid pregel mixture. Preferably at least part of the curing takes place while the liquid pregel mixture is in contact with both the perforated substrate and the web. The process is especially applicable to the manufacture of attachment tabs for wigs and toupees, wound dressings, patches for transdermal drug delivery, therapeutic patches or biomedical electrodes.
摘要翻译：使用凝胶（例如，聚合的丙烯酸酯水凝胶或干凝胶）涂覆多孔基材的方法而没有实质上阻塞穿孔的步骤包括（i）在涂覆有纤维网的网上形成一层包含一种或多种单体的液体预凝胶混合物层硅氧烷，聚乙烯，特氟隆或具有比液体预凝胶混合物的表面能低的表面能的其它涂层。优选地，当液体预凝胶混合物与多孔基材和网状物接触时，至少部分固化发生。该方法特别适用于制造用于假发和复发的附接片，伤口敷料，用于透皮药物递送的贴片，治疗贴片或生物医学电极。

9. 发明申请

US20060015083A1 Absorbent hydrogels 审中-公开
标题翻译：吸水剂
公开(公告)号：US20060015083A1
公开(公告)日：2006-01-19
申请号：US10507322
申请日：2003-03-11
申请人： Hugh Munro , Richard Hoskins , Susana Garcia
发明人： Hugh Munro , Richard Hoskins , Susana Garcia
IPC分类号： A61F13/15
CPC分类号： A61L15/425 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0036 , A61L26/008 , A61L26/0085
摘要： The invention provides absorbent hydrogel compositions and hydrogel-containing structures. Typically, a first portion of the novel materials comprises a porous flexible plasticised hydrophilic polymer matrix having an internal cellular structure, and a second portion is relatively non-porous, e.g. comprises a flexible plasticised hydrophilic polymer matrix having relatively continuous internal structure. Methods for the manufacture or such hydrogels and structures are provided, as well as uses thereof.
摘要翻译：本发明提供吸收性水凝胶组合物和含水凝胶的结构。典型地，新型材料的第一部分包括具有内部细胞结构的多孔柔性增塑的亲水性聚合物基质，而第二部分是相对无孔的。包括具有相对连续的内部结构的柔性增塑的亲水性聚合物基质。提供了制造方法或这种水凝胶和结构，以及其用途。

10. 发明申请

US20050245801A9 BIOADHESIVE COMPOSITIONS AND BIOMEDICAL ELECTRODES CONTAINING THEM 有权
标题翻译：包含它们的生物组合物和生物医学电极
公开(公告)号：US20050245801A9
公开(公告)日：2005-11-03
申请号：US10282805
申请日：2002-10-29
申请人： Hugh Munro , Mohammed Yasin
发明人： Hugh Munro , Mohammed Yasin
IPC分类号： A61L26/00 , A61B5/0408 , A61F13/00 , A61L15/16 , A61L15/58 , A61L24/00 , A61L24/04 , A61L24/06 , A61N1/04 , C08F220/38 , C08F220/58 , C09J133/00 , C09J133/06 , C09J133/14 , C09J133/26 , C09J141/00 , C09J201/00 , A61B5/04 , H01B1/00 , H01C1/00
CPC分类号： A61L24/06 , A61B5/04087 , A61B2562/0215 , A61B2562/0217 , A61F13/0253 , A61L15/58 , A61L15/585 , A61L24/0021 , A61L24/043 , A61N1/0428 , A61N1/0452 , A61N1/0456 , A61N1/046 , A61N1/0468 , A61N1/0496 , C08L3/02 , C08L33/14 , C08L33/26
摘要： Bioadhesive Compositions which comprise a hydrophobic polymer wherein the concentration of the polymer at the surface of the adhesive is greater than its concentration in the bulk of the adhesive are described; and biomedical electrodes, fixation products and wound dressings containing them.
摘要翻译：描述了包含疏水性聚合物的生物粘合剂组合物，其中粘合剂表面处的聚合物的浓度大于其粘合剂体积中的浓度; 生物医学电极，固定产品和含有它们的伤口敷料。

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