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    • 8. 发明授权
    • Process for production of biphenyltetracarboxylic acid tetraesters
    • 联苯四羧酸四酯的制备方法
    • US06914154B2
    • 2005-07-05
    • US10639324
    • 2003-08-12
    • Yasushi YamamotoTetsuro TsujiJun HarutaKikuo AtakaNoboru Kakeya
    • Yasushi YamamotoTetsuro TsujiJun HarutaKikuo AtakaNoboru Kakeya
    • C07C67/343C07C6/12C07C69/00C07C69/76C07F9/94
    • C07C67/343C07C69/76
    • A production process, especially a continuous production process, for a biphenyltetracarboxylic acid tetraester characterized by carrying out, in parallel, a step of preliminarily mixing a phthalic acid diester and a palladium compound-containing catalyst to prepare a starting mixture, a step of continuously or intermittently supplying the starting mixture to a reactor, a step of conducting oxidative dimerization reaction of the phthalic acid diester in a temperature range of from 140° C. and lower than 250° C. while supplying molecular oxygen to the reactor to form a reaction mixture in the reactor, and a step of continuously or intermittently removing a portion of the reaction mixture from the reactor. Preferably, the palladium compound-containing catalyst in the starting mixture is dissolved in the phthalic acid diester, the palladium compound-containing catalyst comprises a palladium compound, a bidentate ligand and a copper compound, the reactor consists of a plurality of serially connected reactors and a carboxylic acid is also continuously or intermittently supplied to the reactor.
    • 一种联苯四甲酸四酯的生产方法,特别是连续制备方法,其特征在于并行地进行预先混合邻苯二甲酸二酯和含钯化合物的催化剂以制备起始混合物的步骤,连续或 将起始混合物间歇地供应到反应器中,在140℃和低于250℃的温度范围内进行邻苯二甲酸二酯的氧化二聚反应的步骤,同时向反应器中供应分子氧以形成反应混合物 在反应器中,以及从反应器连续或间歇地除去反应混合物的一部分的步骤。 优选地,起始混合物中含钯化合物的催化剂溶解在邻苯二甲酸二酯中,含钯化合物的催化剂包括钯化合物,二齿配位体和铜化合物,反应器由多个串联的反应器和 羧酸也连续地或间歇地供应到反应器中。
    • 10. 发明授权
    • 2-silyloxy-tetrahydrothienopyridine, salt thereof and process for
preparing the same
    • 2-甲基氧基 - 四氢噻吩并吡啶及其盐及其制备方法
    • US5874581A
    • 1999-02-23
    • US817001
    • 1997-03-31
    • Kikuo AtakaHiroyuki MiyataMasahiko KohnoNaoyuki YokotaYasuhito Yamamoto
    • Kikuo AtakaHiroyuki MiyataMasahiko KohnoNaoyuki YokotaYasuhito Yamamoto
    • C07F7/18C07D471/04
    • C07F7/1856
    • A 2-silyloxy-4,5,6,7-tetrahydrothieno�3,2-c!pyridine represented by the formula (I): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each independently represent an alkyl group having 1 to 10 carbon atoms or an aryl group,and a salt thereof and a process for preparing the same, and a 5-alkyl-2-silyloxy-4,5,6,7-tetrahydrothieno�3,2-c!-pyridine represented by the formula (IV): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 represent the same meanings as described above; R.sup.4 represents a hydrogen atom, an alkoxycarbonyl group having 2 to 10 carbon atoms, an acyl group having 2 to 10 carbon atoms or a cyclo-alkylcarbonyl group having 4 to 10 carbon atoms; andR.sup.5 represents a halogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms,which is useful as a synthetic intermediate of an antiplatelet medicine and an elastase inhibitor, etc., and a process for preparing the same.
    • PCT No.PCT / JP95 / 02023 Sec。 371日期1997年3月31日 102(e)1997年3月31日PCT PCT 1995年10月4日PCT公布。 公开号WO96 / 11203 日期:1996年4月18日由式(I)表示的2-甲硅烷氧基-4,5,6,7-四氢噻吩并[3,2-c]吡啶:其中R 1,R 2和R 3各自独立地表示 具有1-10个碳原子的烷基或芳基,及其盐及其制备方法,和5-烷基-2-甲硅烷氧基-4,5,6,7-四氢噻吩并[3,2- (IV)表示的c]吡啶:其中R 1,R 2和R 3表示与上述相同的含义; R 4表示氢原子,碳原子数2〜10的烷氧基羰基,碳原子数2〜10的酰基或碳原子数4〜10的环烷基羰基。 R5表示卤素原子,碳原子数1〜4的烷基或碳原子数1〜4的烷氧基,可用作抗血小板药和弹性蛋白酶抑制剂的合成中间体等, 准备一样