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1. 发明申请

US20050079501A1 Method and apparatus for detecting nucleic acid data 审中-公开
标题翻译：检测核酸数据的方法和装置
公开(公告)号：US20050079501A1
公开(公告)日：2005-04-14
申请号：US10502513
申请日：2003-01-24
申请人： Hisashi Koike , Tomonori Nagaoka , Takatomo Satoh , Yoshioki Kaneko , Midori Hatanaka , Morinao Fukuoka , Hiroko Sakamoto , Hiroyuki Yonekawa
发明人： Hisashi Koike , Tomonori Nagaoka , Takatomo Satoh , Yoshioki Kaneko , Midori Hatanaka , Morinao Fukuoka , Hiroko Sakamoto , Hiroyuki Yonekawa
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/58
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q2565/501 , C12Q2561/12 , C12Q2527/107
摘要： That invention provides a nucleic acid information detection method which, in a method wherein a target nucleic acid, and probes having a complementary sequence with at least a portion of the target nucleic acid sequence, are contacted with each other in order to form hybrids between the target nucleic acid and the probes, and the amount of signal generated depending on the amount of hybrids is measured in order to detect the information on the target nucleic acid, includes kinetically obtaining data of the signal. Furthermore the invention provides a nucleic acid information detection method which, in a method wherein a perfect matched probe having a perfect complementary sequence with respect to at least part of a target nucleic acid sequence, and one or more types of imperfectly matched probes having at least one part of the perfect matched probe mutated, are contacted with the target nucleic acid in order to hybridize between the target nucleic acid and the perfect matched probe, or the imperfect matched probes, so that the information on the target nucleic acid can be detected based on the difference in binding strength of the hybrids, includes kinetically obtaining data of the signal while changing continuously or stepwise the condition for measuring or detecting the signal from the hybrids.
摘要翻译：本发明提供了一种核酸信息检测方法，其方法是使靶核酸和与靶核酸序列的至少一部分具有互补序列的探针彼此接触，以形成混合物靶核酸和探针，并且测量根据杂交体量产生的信号量，以便检测关于靶核酸的信息，包括动态获得信号的数据。此外，本发明提供了一种核酸信息检测方法，其方法中，其中完全匹配的探针具有相对于目标核酸序列的至少一部分具有完全互补序列，以及一种或多种不完全匹配的探针，其至少具有至少突变的完美匹配探针的一部分与目标核酸接触以便在靶核酸和完全匹配的探针之间进行杂交，或者不完全匹配的探针，使得可以基于目标核酸的信息被检测关于混合物的结合强度的差异，包括动态获得信号的数据，同时连续或逐步地改变用于测量或检测来自杂交体的信号的条件。

2. 发明申请

US20070015223A1 Method of detecting substance to be analyzed 审中-公开
标题翻译：检测待分析物质的方法
公开(公告)号：US20070015223A1
公开(公告)日：2007-01-18
申请号：US11440675
申请日：2006-05-25
申请人： Hiromi Sanuki , Hiroko Sakamoto , Morinao Fukuoka
发明人： Hiromi Sanuki , Hiroko Sakamoto , Morinao Fukuoka
IPC分类号： G01N33/542 , G01N33/558
CPC分类号： G01N33/557 , G01N33/54306 , G01N33/581
摘要： An object of the invention is to provide a quick, easy, and highly-sensitive method of detecting a substance to be analyzed, and to provide a method of supporting the analysis results by quantitativeness even if the amount of samples to be handled is a very small amount. The invention is a method of detecting a substance to be analyzed, including: measuring a intensity of a signal derived from a labeled substance to be analyzed, in a time series during an increase in the signal intensity; and representing the signal intensity by a function of time, and using the quantitative value of the signal intensity for when the slope of an approximated line of the measured signal intensity is within a range between 0.5 and 1.5 times the slope of the approximated line of the previously measured signal intensity.
摘要翻译：本发明的目的是提供一种检测待分析物质的快速，容易和高灵敏度的方法，并且提供一种通过定量分析支持分析结果的方法，即使要处理的样品量非常多小数量。本发明是检测待分析物质的方法，包括：在信号强度增加期间以时间序列测量从待分析标记物质得到的信号的强度; 并且通过时间函数表示信号强度，并且当所测量的信号强度的近似行的斜率在所述信号强度的近似行的斜率的0.5和1.5倍之间的范围内时，使用信号强度的定量值先前测量的信号强度。

3. 发明授权

US5439495A Solution doping of sol gel bodies to make graded index glass articles 失效
标题翻译：溶胶凝胶体的溶液掺杂制成渐变折射率玻璃制品
公开(公告)号：US5439495A
公开(公告)日：1995-08-08
申请号：US119735
申请日：1993-09-10
申请人： Hisashi Koike , Morinao Fukuoka , Yuko Kurasawa , Minoru Inami , Masayuki Yamane
发明人： Hisashi Koike , Morinao Fukuoka , Yuko Kurasawa , Minoru Inami , Masayuki Yamane
IPC分类号： C03B8/00 , C03B19/12 , C03C1/00
CPC分类号： C03C1/006 , C03B19/12 , Y10S501/901
摘要： A method for manufacturing a glass is provided, comprising converting a porous body to a multi-component glass, wherein a porous body containing at least one metal component in the form of a metal salt is immersed in a solution containing at least one compound selected from the group consisting of an acid, an ammonium salt and an alkylammonium salt to precipitate the metal salt as microcrystals in the pore. Also, a method for manufacturing a glass for use as a gradient index optical element is provided, comprising converting a porous body to a multi-component glass, wherein a porous body containing at least one metal component in the form of a metal salt is immersed in a solution containing a salt of a metal component different from the above-mentioned at least one component and at least one compound selected from the group consisting of an acid and a salt to provide the metal components with concentration distributions. In these methods, not only the metal salt present in dissolved form in the pores of the porous body can be fixed to the pores with certainty, but also it is feasible to individually control the behaviors of a plurality of metal salts in the porous body.
摘要翻译：提供了一种制造玻璃的方法，包括将多孔体转化为多组分玻璃，其中将含有金属盐形式的至少一种金属组分的多孔体浸入含有至少一种选自以下的化合物的溶液中：由酸，铵盐和烷基铵盐组成的组，以将金属盐作为细孔中的微晶析出。另外，提供了一种用于制造用作梯度折射率光学元件的玻璃的方法，包括将多孔体转化为多组分玻璃，其中将含有金属盐形式的至少一种金属组分的多孔体浸入在含有不同于上述至少一种组分的金属组分的盐和至少一种选自酸和盐的化合物的溶液中以提供金属组分的浓度分布的溶液中。在这些方法中，不仅可以确定地将多孔体的孔中溶解形式的金属盐固定在孔中，而且可以单独控制多孔体中多种金属盐的行为。

4. 发明申请

US20060275918A1 Immersion objective lens, retention mechanism for immersion medium, and manufacturing method 有权
公开(公告)号：US20060275918A1
公开(公告)日：2006-12-07
申请号：US11505164
申请日：2006-08-16
申请人： Mitsuo Harada , Akihiro Namba , Morinao Fukuoka
发明人： Mitsuo Harada , Akihiro Namba , Morinao Fukuoka
IPC分类号： G01N1/00
CPC分类号： G02B21/33 , Y10T29/49826 , Y10T436/25
摘要： There is provided a retention mechanism for an immersion medium, for use in a device which observes/measures a sample by use of an immersion objective lens, includes a member which retains the immersion medium near a tip portion of the objective lens, wherein the member is configured to include at least first and second materials.

5. 发明申请

US20050130164A1 Test piece for analyzing substance with biological origin, process for producing the same and method of examining test piece for substance with biological origin 审中-公开
标题翻译：用于分析具有生物来源的物质的试片，其制造方法和用于检测具有生物来源的物质的试片的方法
公开(公告)号：US20050130164A1
公开(公告)日：2005-06-16
申请号：US10508815
申请日：2003-03-27
申请人： Yoshinobu Akimoto , Morinao Fukuoka
发明人： Yoshinobu Akimoto , Morinao Fukuoka
IPC分类号： B01J19/00 , C12M1/00 , C12N15/00 , C40B40/06 , G01N33/543 , C12Q1/68 , A61L2/00 , C12M1/34
CPC分类号： B82Y10/00 , B01J19/0046 , B01J2219/00529 , B01J2219/00545 , B01J2219/00576 , B01J2219/00596 , B01J2219/00641 , B01J2219/00659 , B01J2219/00693 , B01J2219/00702 , B01J2219/00722 , B82Y5/00 , B82Y30/00 , C40B40/06 , G01N33/543
摘要： A process for producing a test piece for analyzing a labeled substance with a biological origin which comprises the step of supplying a solution containing a substance capable of specifically binding to the substance with the biological origin onto a support and fixing the specifically binding substance at a definite position on the support, characterized in that the solution contains a substance to be detected, which is either the same as the label or different therefrom, uniformly dissolved or dispersed therein independently from the specifically binding substance. A method of examining a test piece having a substance specifically binding to a substance with a biological origin fixed at a definite position on a support, characterized by comprising the step of supplying a labeled test substance onto a support and fixing it at a position different from the position of the specifically binding substance, and the step of eliminating the unfixed test substance.
摘要翻译：一种制备用于分析具有生物来源的标记物质的试片的方法，该方法包括以下步骤：将含有能够与所述物质特异性结合的物质的生物来源的溶液供应到载体上并将所述特异性结合物质固定在一定的位置其特征在于，所述溶液含有与所述特异性结合物质独立地均匀溶解或分散的待检测物质，其与标记物或与其不同的物质均匀溶解或分散。一种检查具有特异性结合到具有固定在载体上的确定位置的具有生物来源的物质的物质的试样的方法，其特征在于包括将标记的测试物质供应到载体上并将其固定在不同于特异性结合物质的位置，以及消除未固定试验物质的步骤。

6. 发明申请

US20060275892A1 Reaction vessel, reaction apparatus and detection apparatus using the same, and method of manufacturing reaction vessel 审中-公开
标题翻译：反应容器，反应装置及使用其的检测装置以及反应容器的制造方法
公开(公告)号：US20060275892A1
公开(公告)日：2006-12-07
申请号：US11445999
申请日：2006-06-02
申请人： Takami Shibazaki , Morinao Fukuoka , Yoshinobu Akimoto
发明人： Takami Shibazaki , Morinao Fukuoka , Yoshinobu Akimoto
IPC分类号： C12M1/34
CPC分类号： G01N35/10 , B01J2219/00378 , B01J2219/00641 , B01J2219/00664 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/0275 , B01L3/508 , B01L2300/0609 , B01L2300/0636 , G01N2035/1025 , G01N2035/1062
摘要： A reaction vessel includes a three-dimensional substrate on which a probe applied to detection of a biorelated substance is immobilized, a coupling portion allowed to be coupled to a liquid driver in an airtight fashion, and a solution sucking portion allowed to suck a solution. The coupling portion and the solution sucking portion are arranged with a three-dimensional substrate held between them.
摘要翻译：反应容器包括其上固定有用于检测生物矫正物质的探针的三维基板，允许以气密方式与液体驱动器结合的联接部分和允许吸取溶液的溶液吸入部分。联接部和溶液吸引部配置有保持在它们之间的三维基板。

7. 发明授权

US08465709B2 Immersion objective lens, retention mechanism for immersion medium, and manufacturing method thereof 有权
标题翻译：浸没物镜，浸渍介质的保持机构及其制造方法
公开(公告)号：US08465709B2
公开(公告)日：2013-06-18
申请号：US12851096
申请日：2010-08-05
申请人： Mitsuo Harada , Akihiro Namba , Morinao Fukuoka
发明人： Mitsuo Harada , Akihiro Namba , Morinao Fukuoka
IPC分类号： B01L3/00
CPC分类号： G02B21/33 , Y10T29/49826 , Y10T436/25
摘要： There is provided a retention mechanism for an immersion medium, for use in a device which observes/measures a sample by use of an immersion objective lens, includes a member which retains the immersion medium near a tip portion of the objective lens, wherein the member is configured to include at least first and second materials.
摘要翻译：提供了一种用于浸没介质的保持机构，用于通过使用浸入式物镜观察/测量样品的装置，包括将浸没介质保持在物镜的末端部分附近的构件，其中构件被配置为至少包括第一和第二材料。

8. 发明授权

US5810899A Glass production 失效
标题翻译：玻璃生产
公开(公告)号：US5810899A
公开(公告)日：1998-09-22
申请号：US825921
申请日：1997-04-02
申请人： Morinao Fukuoka
发明人： Morinao Fukuoka
IPC分类号： C01B33/152 , C03B8/02 , C03B19/12 , C03C1/00 , C03B37/016 , C03B8/00
CPC分类号： C03B19/12 , C03C1/006 , Y02P40/57
摘要： A glass with no stria form of defects induced therein is produced by a sol-gel technique. At a sol gelation step, the gelation temperature is maintained constant within the range of .+-.7.degree. C. with respect to the temperature of a sol as charged in a gelation vessel, and the sol is gelated at a constant colloidal particle diameter with no vibrations applied thereto.
摘要翻译：通过溶胶 - 凝胶技术产生在其中不产生缺陷形成缺陷的玻璃。在溶胶凝胶化步骤中，相对于在凝胶化容器中加入的溶胶的温度，凝胶化温度保持恒定在+/- 7℃的范围内，并且将溶胶以恒定的胶体粒径凝胶化，不施加振动。

9. 发明申请

US20070213632A1 Endoscope system, biopsy-sample container, method of obtaining biopsy samples, and method of processing biopsy samples 审中-公开
标题翻译：内窥镜系统，活检样本容器，获取活检样本的方法和加工活检样本的方法
公开(公告)号：US20070213632A1
公开(公告)日：2007-09-13
申请号：US11732753
申请日：2007-04-04
申请人： Tomoko Okazaki , Morinao Fukuoka , Tsuyoshi Kawai
发明人： Tomoko Okazaki , Morinao Fukuoka , Tsuyoshi Kawai
IPC分类号： A61B10/00 , A61B1/06
CPC分类号： A61B10/04 , A61B1/012 , A61B1/018 , A61B10/0096 , A61B2010/0225 , A61B2010/045
摘要： A sample container containing a biopsy sample obtained by an instrument is arranged in the operation section of an endoscope. The sampling means of an instrument inserted into the subject through the instrument channel of the endoscope is used, obtaining a biopsy sample. The biopsy sample is introduced from the instrument into the sample container arranged in the operation section, without pulling the instrument outside. The sample obtained can therefore be stabilized fast and be preserved fresh. The biopsy sample is prevented from being contaminated and from contaminating the environment. The sample can therefore undergo accurate examinations and diagnoses.
摘要翻译：在内窥镜的操作部中配置容纳通过仪器获得的活检样本的样本容器。使用通过内窥镜的仪器通道插入到被检体内的器械的取样装置，得到活检样本。将活检样品从仪器引入到布置在操作部分中的样品容器中，而不将仪器拉出外部。因此获得的样品可以快速稳定并保鲜。防止活检样品被污染并污染环境。因此，样品可以进行准确的检查和诊断。

10. 发明授权

US07160511B2 Liquid pipetting apparatus and micro array manufacturing apparatus 失效
标题翻译：液体移液装置和微阵列制造装置
公开(公告)号：US07160511B2
公开(公告)日：2007-01-09
申请号：US09784977
申请日：2001-02-16
申请人： Seiya Takahashi , Morinao Fukuoka
发明人： Seiya Takahashi , Morinao Fukuoka
IPC分类号： B01L3/02 , G01N1/10
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00641 , B01J2219/00659 , B01J2219/00677 , B01J2219/00691 , B01J2219/00722 , B01L3/0248 , B01L2400/021 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N2035/1037 , Y10T436/2575
摘要： A liquid pipetting apparatus for dispensing liquid of minute volume for use in a survey instruments of a hemanalysis machine, a genetic screening, and a pharmaceutical screening, etc., is disclosed. The liquid pipetting apparatus comprises a liquid holding member for holding the liquid, and capable of dispensing the liquid from one end, and a driving member for moving the liquid holding member forward and backward along the dispensing direction, the liquid holding member being moved by the driving means, thereby dispensing the liquid held on the liquid holding member.
摘要翻译：公开了一种用于分配微量体积用于血液分析仪，遗传筛选和药物筛选等的测量仪器的液体移液装置。液体移液装置包括用于保持液体并能够从一端分配液体的液体保持构件和用于沿着分配方向向前和向后移动液体保持构件的驱动构件，液体保持构件被移动驱动装置，从而分配保持在液体保持构件上的液体。

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