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1. 发明申请

US20050079501A1 Method and apparatus for detecting nucleic acid data 审中-公开
标题翻译：检测核酸数据的方法和装置
公开(公告)号：US20050079501A1
公开(公告)日：2005-04-14
申请号：US10502513
申请日：2003-01-24
申请人： Hisashi Koike , Tomonori Nagaoka , Takatomo Satoh , Yoshioki Kaneko , Midori Hatanaka , Morinao Fukuoka , Hiroko Sakamoto , Hiroyuki Yonekawa
发明人： Hisashi Koike , Tomonori Nagaoka , Takatomo Satoh , Yoshioki Kaneko , Midori Hatanaka , Morinao Fukuoka , Hiroko Sakamoto , Hiroyuki Yonekawa
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/58
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q2565/501 , C12Q2561/12 , C12Q2527/107
摘要： That invention provides a nucleic acid information detection method which, in a method wherein a target nucleic acid, and probes having a complementary sequence with at least a portion of the target nucleic acid sequence, are contacted with each other in order to form hybrids between the target nucleic acid and the probes, and the amount of signal generated depending on the amount of hybrids is measured in order to detect the information on the target nucleic acid, includes kinetically obtaining data of the signal. Furthermore the invention provides a nucleic acid information detection method which, in a method wherein a perfect matched probe having a perfect complementary sequence with respect to at least part of a target nucleic acid sequence, and one or more types of imperfectly matched probes having at least one part of the perfect matched probe mutated, are contacted with the target nucleic acid in order to hybridize between the target nucleic acid and the perfect matched probe, or the imperfect matched probes, so that the information on the target nucleic acid can be detected based on the difference in binding strength of the hybrids, includes kinetically obtaining data of the signal while changing continuously or stepwise the condition for measuring or detecting the signal from the hybrids.
摘要翻译：本发明提供了一种核酸信息检测方法，其方法是使靶核酸和与靶核酸序列的至少一部分具有互补序列的探针彼此接触，以形成混合物靶核酸和探针，并且测量根据杂交体量产生的信号量，以便检测关于靶核酸的信息，包括动态获得信号的数据。此外，本发明提供了一种核酸信息检测方法，其方法中，其中完全匹配的探针具有相对于目标核酸序列的至少一部分具有完全互补序列，以及一种或多种不完全匹配的探针，其至少具有至少突变的完美匹配探针的一部分与目标核酸接触以便在靶核酸和完全匹配的探针之间进行杂交，或者不完全匹配的探针，使得可以基于目标核酸的信息被检测关于混合物的结合强度的差异，包括动态获得信号的数据，同时连续或逐步地改变用于测量或检测来自杂交体的信号的条件。

2. 发明申请

US20080079747A1 DISPLAY METHOD OF MEASUREMENT INFORMATION OF BIOLOGICALLY RELEVANT MATERIAL 审中-公开
标题翻译：生物相关材料测量信息的显示方法
公开(公告)号：US20080079747A1
公开(公告)日：2008-04-03
申请号：US11864188
申请日：2007-09-28
申请人： Yuko SAIDA , Hiroko SAKAMOTO , Takatomo SATOH , Tomoko OKAZAKI , Hiromi SANUKI
发明人： Yuko SAIDA , Hiroko SAKAMOTO , Takatomo SATOH , Tomoko OKAZAKI , Hiromi SANUKI
IPC分类号： G09G5/02 , G06T11/00 , G06T11/20
CPC分类号： C12Q1/6837 , G16B25/00 , G16B45/00
摘要： A display method of measurement information of a biologically relevant material according to the invention displays measurement information on a computer screen when measuring the amount of a biologically relevant material of a test sample or the amount ratio of a biologically relevant material among a plurality of test samples with a microarray.
摘要翻译：根据本发明的生物相关材料的测量信息的显示方法当测量测试样品的生物相关材料的量或多个测试样品中生物相关材料的量比时，在计算机屏幕上显示测量信息用微阵列

3. 发明申请

US20070134712A1 Gene examining apparatus and method of detecting target nucleic acid using the same 审中-公开
标题翻译：检测靶核酸的基因检测装置及方法
公开(公告)号：US20070134712A1
公开(公告)日：2007-06-14
申请号：US11655316
申请日：2007-01-19
申请人： Hiroyuki Yonekawa , Takami Shibazaki , Takatomo Satoh , Hiroko Sakamoto
发明人： Hiroyuki Yonekawa , Takami Shibazaki , Takatomo Satoh , Hiroko Sakamoto
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： B01L3/50255 , B01J2219/00608 , B01J2219/00612 , B01J2219/00641 , B01J2219/00722 , B01L2300/0819 , B01L2400/0487 , C40B40/06
摘要： The present invention relates to a gene examining apparatus utilizing a computer, the apparatus comprising (1) DNA microarrays in each of which a large number of fine liquid accommodating sections are two-dimensionally arranged so that openings of the fine liquid accommodating sections are located on the same plane, in which each of the liquid accommodating sections can three-dimensionally accommodate a liquid, and in which hybridization reaction occurs in the liquid accommodating section between a target nucleic acid already labeled with an optical marker substance and the nucleic acid probe, and (2) a microscope comprising a stage supporting the DNA microarrays set forth in (1), a temperature regulating section that regulates the temperature of each DNA microarray, and imaging means for picking up an image of an optical signal from the DNA microarray.
摘要翻译：本发明涉及一种利用计算机的基因检查装置，该装置包括：（1）DNA微阵列，其中大量微细液体容纳部分被二维地布置成使得细液体容纳部分的开口位于其中每个液体容纳部分可以三维地容纳液体，并且在已经用光学标记物质标记的靶核酸和核酸探针之间的液体容纳部分中发生杂交反应的同一平面，以及（2）显微镜，其包括支持（1）中所述的DNA微阵列的阶段，调节每个DNA微阵列的温度的温度调节部和用于从DNA微阵列拾取光信号的图像的成像装置。

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