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    • 1. 发明授权
    • Cyclic tetrapeptide compound and use thereof
    • 环状四肽化合物及其用途
    • US06656905B1
    • 2003-12-02
    • US09806500
    • 2001-05-04
    • Hiroaki MoriKazutoshi SakamotoYasuhisa TsurumiShigehiro TakaseMotohiro Hino
    • Hiroaki MoriKazutoshi SakamotoYasuhisa TsurumiShigehiro TakaseMotohiro Hino
    • A61K3807
    • A61K38/12C07K5/126
    • A cyclic tetrapeptide compound and use thereof. Especially, a compound WF27082, a process for production of the compound by culturing, in a nutrient medium, a WF27082-producing strain belonging to Acremonium and recovering the compound from a culture broth, a pharmaceutical composition containing the compound as an active ingredient, in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound for use as a medicament, a use of the compound for manufacture of a medicament for inhibiting histone deacetylase, a use of the compound for manufacture of a medicament for treating or preventing inflammatory disorders, diabetes, diabetic complications, homozygous thalassemia, fibrosis, cirrhosis, acute promyelocytic leukaemia (APL), protozoal infections, organ transplant rejections, autoimmune diseases, or tumors, a use of histone deacetylase inhibitors as an immunosuppressant or an antitumor agent, and a use of histone deacetylase inhibitors for manufacture of a medicament for treating or preventing organ transplant rejections, autoimmune diseases or tumors are described.
    • 一种环状四肽化合物及其用途。 特别地,化合物WF27082是通过在营养培养基中培养属于顶孢菌属的WF27082产生菌株并从培养液中回收化合物,将含有该化合物作为活性成分的药物组合物生产化合物的方法, 与药学上可接受的,基本上无毒的载体或赋形剂的相关联,用作药物的化合物,该化合物用于制备用于抑制组蛋白脱乙酰酶的药物的用途,该化合物用于制备用于治疗或 预防炎性疾病,糖尿病,糖尿病并发症,纯合地中海贫血,纤维化,肝硬化,急性早幼粒细胞白血病(APL),原生动物感染,器官移植排斥,自身免疫疾病或肿瘤,组蛋白脱乙酰酶抑制剂作为免疫抑制剂或抗肿瘤剂的用途, 以及使用组蛋白脱乙酰酶抑制剂来制造用于治疗或预防的药物 描述器官移植排斥,自身免疫性疾病或肿瘤。