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1. 发明授权

US5538950A Endothelin antagonists and their preparation 失效
标题翻译：内皮素拮抗剂及其制备
公开(公告)号：US5538950A
公开(公告)日：1996-07-23
申请号：US232156
申请日：1994-05-12
申请人： Keiji Hemmi , Masahiro Neya , Naoki Fukami , Masashi Hashimoto , Hirokazu Tanaka , Natsuko Kayakiri
发明人： Keiji Hemmi , Masahiro Neya , Naoki Fukami , Masashi Hashimoto , Hirokazu Tanaka , Natsuko Kayakiri
IPC分类号： A61K38/22 , A61K38/00 , A61P9/12 , C07K1/113 , C07K5/078 , C07K5/083 , C07K5/103 , C07K5/117 , C07K5/08
CPC分类号： C07K5/06156 , C07K5/0808 , C07K5/1005 , C07K5/1024 , A61K38/00
摘要： A compound of the formula: ##STR1## in which R.sup.3 is hydrogen or lower alkyl, R.sup.4 is pyridyl (lower) alkyl; andR.sup.1, R.sup.2, R.sup.5 and A are defined in the description;or a pharmaceutically acceptable salt thereof, which have endothelin antagonistic activity.
摘要翻译： PCT No.PCT / JP92 / 01405 Sec。 371日期：1994年5月12日 102（e）日期1994年5月12日PCT提交1992年10月30日PCT公布。公开号WO93 / 10144 日期：1993年5月27日分子式为下式的化合物：其中R 3为氢或低级烷基，R 4为吡啶基（低级）烷基; 在说明书中定义了R1，R2，R5和A; 或其药学上可接受的盐，其具有内皮素拮抗活性。

2. 发明授权

US5656604A Peptide compound and its preparation 失效
标题翻译：肽化合物及其制备
公开(公告)号：US5656604A
公开(公告)日：1997-08-12
申请号：US422944
申请日：1995-04-17
申请人： Keiji Hemmi , Masahiro Neya , Naoki Fukami , Masashi Hashimoto , Hirokazu Tanaka , Natsuko Kayakiri
发明人： Keiji Hemmi , Masahiro Neya , Naoki Fukami , Masashi Hashimoto , Hirokazu Tanaka , Natsuko Kayakiri
IPC分类号： A61K38/00 , C07K5/02 , C07K5/078 , C07K5/083 , C07K5/103 , A61K38/06 , C07K5/087 , C07K5/097
CPC分类号： C07K5/06156 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/0217 , C07K5/0808 , C07K5/101 , A61K38/00
摘要： Peptide compounds of the formula (I') ##STR1## in which R.sup.1 is acyl,R.sup.2 is lower alkyl, cyclo(lower)alkyl(lower)alkyl or optionally substituted heterocyclic(lower)alkyl,R.sup.3 is optionally substituted heterocyclic(lower)alkyl or optionally substituted ar(lower)alkyl,R.sup.4 is lower alkyl, amino(lower)alkyl, protected amino(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or optionally substituted heterocyclic(lower)alkyl,R.sup.5 is carboxy, protected carboxy, carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.6 is hydrogen, lower alkyl, C.sub.6-10 ar(lower)alkyl amino(lower)alkyl, protected amino(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, or heterocyclic(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is --O--, --NH--, lower alkylimino or lower alkylene, or a pharmaceutically acceptable salt thereof are disclosed. The compounds can be used to treat and prevent endothelin mediated diseases such as hypertension. The preparation of such peptides is also disclosed.
摘要翻译：式（I'）的肽化合物其中R 1是酰基，R 2是低级烷基，环（低级）烷基（低级）烷基或任选取代的杂环（低级）烷基），其中R 1是任选取代的杂环（低级）烷基或任选取代的芳（低级）烷基，R 4是低级烷基，氨基（低级）烷基，保护的氨基（低级）烷基，羧基烷基，R 5为羧基，保护的羧基，羧基（低级）烷基或保护的羧基（低级）烷基，R6为氢，低级烷基，C6-10ar（低级）烷基氨基（低级）烷基，被保护的氨基（低级）烷基，受保护的羧基（低级）烷基或杂环（低级）烷基，R7是氢或低级烷基，A是-O - ， - NH-，低级烷基亚氨基或低级亚烷基或其药学上可接受的盐是披露该化合物可用于治疗和预防内皮素介导的疾病如高血压。还公开了这种肽的制备。

3. 发明授权

US5057513A Spiro-thiazepine derivatives useful as PAF antagonists 失效
标题翻译：螺旋噻吩衍生物作为PAF拮抗剂有用
公开(公告)号：US5057513A
公开(公告)日：1991-10-15
申请号：US518951
申请日：1990-05-04
申请人： Keiji Hemmi , Ichiro Shima , Naoki Fukami , Masashi Hashimoto
发明人： Keiji Hemmi , Ichiro Shima , Naoki Fukami , Masashi Hashimoto
IPC分类号： A61K31/00 , A61K31/55 , A61K31/554 , A61P7/00 , A61P7/02 , A61P11/08 , A61P37/08 , C07D281/10 , C07D281/12 , C07D417/06
CPC分类号： C07D417/06 , C07D281/10 , C07D281/12
摘要： The invention relates to thiazepine derivatives, which are antagonists of platelet activating factor, of the formula: ##STR1## wherein R.sup.1 is ar(lower)alkyl which may have suitable substituent(s),R.sup.2 is hydrogen, lower alkyl which may have suitable substituent(s), or a group of the formula: ##STR2## in which A is lower alkylene and X is halogen, n is 0, 1 or 2 and Y is --CH.sub.2 --CH.sub.2 -- or ##STR3## or a pharmaceutically acceptable salt thereof.

4. 发明授权

US08349656B2 Manufacturing method of leadframe and semiconductor device 有权
标题翻译：引线框和半导体器件的制造方法
公开(公告)号：US08349656B2
公开(公告)日：2013-01-08
申请号：US12877457
申请日：2010-09-08
申请人： Yusuke Etou , Naoki Fukami , Kiyoshi Matsunaga
发明人： Yusuke Etou , Naoki Fukami , Kiyoshi Matsunaga
IPC分类号： H01L21/00
CPC分类号： H01L21/4832 , H01L23/49582 , H01L24/48 , H01L2224/32245 , H01L2224/32257 , H01L2224/48247 , H01L2224/73265 , H01L2924/00014 , H01L2924/01046 , H01L2924/01078 , H01L2924/01079 , H01L2924/181 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： In order to remove plating burrs generated in etching step, there is provided a manufacturing method of semiconductor devices on each of unit leadframes in a leadframe material in which a plurality of the unit leadframes are arranged in plural rows or a single row, wherein at least two types of plating burr removals are conducted after a half-etching is performed onto a front surface side of the leadframe material, using a first plating layer as resist film.
摘要翻译：为了消除在蚀刻步骤中产生的电镀毛刺，提供了一种在引线框架材料中的每个单元引线框架上的半导体器件的制造方法，其中多个单元引线框架排列成多行或单行，其中至少使用第一镀层作为抗蚀剂膜，在对引线框架材料的正面进行半蚀刻之后进行两种电镀毛刺去除。

5. 发明申请

US20110059577A1 MANUFACTURING METHOD OF LEADFRAME AND SEMICONDUCTOR DEVICE 有权
标题翻译：铅和半导体器件的制造方法
公开(公告)号：US20110059577A1
公开(公告)日：2011-03-10
申请号：US12877457
申请日：2010-09-08
申请人： Yusuke ETOU , Naoki FUKAMI , Kiyoshi MATSUNAGA
发明人： Yusuke ETOU , Naoki FUKAMI , Kiyoshi MATSUNAGA
IPC分类号： H01L21/98
CPC分类号： H01L21/4832 , H01L23/49582 , H01L24/48 , H01L2224/32245 , H01L2224/32257 , H01L2224/48247 , H01L2224/73265 , H01L2924/00014 , H01L2924/01046 , H01L2924/01078 , H01L2924/01079 , H01L2924/181 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： In order to remove plating burrs generated in etching step, there is provided a manufacturing method of semiconductor devices on each of unit leadframes in a leadframe material in which a plurality of the unit leadframes are arranged in plural rows or a single row, wherein at least two types of plating burr removals are conducted after a half-etching is performed onto a front surface side of the leadframe material, using a first plating layer as resist film.
摘要翻译：为了消除在蚀刻步骤中产生的电镀毛刺，提供了一种在引线框架材料中的每个单元引线框架上的半导体器件的制造方法，其中多个单元引线框架排列成多行或单行，其中至少使用第一镀层作为抗蚀剂膜，在对引线框架材料的正面进行半蚀刻之后进行两种电镀毛刺去除。

6. 发明授权

US5888972A Peptide compounds, their preparation and uses 失效
标题翻译：肽化合物，其制备和用途
公开(公告)号：US5888972A
公开(公告)日：1999-03-30
申请号：US564271
申请日：1997-06-24
申请人： Keiji Hemmi, deceased , Masahiro Neya , Naoki Fukami , Natsuko Kayakiri , Hirokazu Tanaka
发明人： Keiji Hemmi, deceased , Masahiro Neya , Naoki Fukami , Natsuko Kayakiri , Hirokazu Tanaka
IPC分类号： A61K38/00 , A61P9/12 , C07K5/02 , C07K5/03 , C07K5/062 , C07K5/08 , C07K5/083 , A61K38/06 , A61K38/07
CPC分类号： C07K5/0808 , C07K5/0207 , C07K5/0827 , A61K38/00 , Y02P20/55
摘要： A compound of the formula: ##STR1## in which R.sup.4 is acyl,R.sup.5 is lower alkyl,R.sup.6 is optionally substituted ar(lower)alkyl or optionally substituted heterocyclic-(lower)alkyl,R.sup.7 is lower alkyl or lower alkylthio(lower)alkyl,R.sup.8 is carboxy or protected carboxy,A is lower alkylene,Z is a group of the formula: ##STR2## wherein R.sup.1 is hydrogen, lower alkyl, common amino-protective group or optionally substituted ar(lower)alkyl,R.sup.2 is hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, optionally substituted heterocyclic-(lower)alkyl, optionally substituted cyclo(lower)alkyl(lower)alkyl, common amino-protective group, amino(or protected amino)(lower)alkyl, optionally substituted heterocyclic-carbonyl or cyclo(lower)alkyl, andR.sup.3 is optionally substituted heterocyclic(lower)alkyl, andm is an integer of 0 to 2,or pharmaceutically acceptable salts thereof, useful as endothelin antagonist.
摘要翻译： PCT No.PCT / JP94 / 01042 Sec。 371日期1996年6月24日 102（e）1996年6月24日PCT 1994年6月28日PCT公布。公开号WO95 / 00537 日期1995年1月5日具有下式的化合物：其中R 4为酰基，R 5为低级烷基，R 6为任选取代的芳（低级）烷基或任选取代的杂环 - （低级）烷基，R 7为低级烷基或低级烷硫基（低级）烷基，R 8为羧基或被保护的羧基，A为低级亚烷基，Z为下式基团：其中R 1为氢，低级烷基，普通氨基保护基或任选取代的芳（低级）烷基（低级）烷基，任选取代的杂环 - （低级）烷基，任选取代的环（低级）烷基（低级）烷基，常用氨基保护基，氨基（或被保护的氨基）（低级烷基，任选取代的杂环羰基或环（低级）烷基，R 3为任选取代的杂环（低级）烷基，m为0-2的整数，或其药学上可接受的盐，可用作内皮素拮抗剂。

7. 发明授权

US5284828A Peptide compound and its preparation 失效
标题翻译：肽化合物及其制备
公开(公告)号：US5284828A
公开(公告)日：1994-02-08
申请号：US696701
申请日：1991-05-07
申请人： Keiji Hemmi , Masahiro Neya , Naoki Fukami , Masashi Hashimoto , Hirokazu Tanaka , Hatsuko Kayakiri
发明人： Keiji Hemmi , Masahiro Neya , Naoki Fukami , Masashi Hashimoto , Hirokazu Tanaka , Hatsuko Kayakiri
IPC分类号： A61K38/55 , A61K38/00 , A61K38/06 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/103 , A61K37/02
CPC分类号： C07K5/06156 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/0217 , C07K5/0808 , C07K5/101 , A61K38/00 , Y02P20/55
摘要： Novel peptides of the formula (I") ##STR1## in which R.sup.1 is hydrogen or acyl,R.sup.2.sub.c is lower alkyl,R.sup.3.sub.c is optionally N-substituted indolylmethyl,R.sup.4 is hydrogen, lower alkyl, C.sub.6-10 ar(lower)alkyl, amino(lower)alkyl, protected amino (lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or optionally substituted heterocyclic (lower)alkyl,R.sup.5 is carboxy, protected carboxy, carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is --O--, --NH--, lower alkylamino or lower alkylene,or a pharmaceutically acceptable salt thereof are disclosed.Additionally, the preparation of such peptides is described. The peptides are used to treat endothelin mediated diseases such as hypertension.
摘要翻译：式（I“）（*化学结构*）（I”）的新肽，其中R 1为氢或酰基，R 2c为低级烷基，R 3c为任选N-取代的吲哚基甲基，R 4为氢，低级烷基，C 6-10 芳基（低级）烷基，氨基（低级）烷基，被保护的氨基（低级）烷基，羧基（低级）烷基，被保护的羧基（低级）烷基或任选取代的杂环（低级）烷基，R5是羧基，被保护的羧基，羧基）烷基或受保护的羧基（低级）烷基，R7是氢或低级烷基，A是-O - ， - NH-，低级烷基氨基或低级亚烷基或其药学上可接受的盐。另外，描述了这种肽的制备。肽用于治疗内皮素介导的疾病，如高血压。

8. 发明授权

US6110933A Amino acid derivatives and their use as phospholipase A.sub.2 inhibitor 失效
标题翻译：氨基酸衍生物及其作为磷脂酶A2抑制剂的用途
公开(公告)号：US6110933A
公开(公告)日：2000-08-29
申请号：US669395
申请日：1996-11-12
申请人： Shigehiro Takase , Nobuharu Shigematsu , Seiji Yoshimura , Satoshi Okada , Keiji Hemmi, deceased , Hirokazu Tanaka , Takanao Otsuka , Yasuhisa Tsurumi , Masanori Okamoto , Masakuni Okuhara , Naoki Fukami
发明人： Shigehiro Takase , Nobuharu Shigematsu , Seiji Yoshimura , Satoshi Okada , Keiji Hemmi, deceased , Hirokazu Tanaka , Takanao Otsuka , Yasuhisa Tsurumi , Masanori Okamoto , Masakuni Okuhara , Naoki Fukami
IPC分类号： C07D295/20 , A61K31/165 , A61K31/18 , A61K31/215 , A61K31/27 , A61K31/415 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/47 , A61K31/472 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P1/16 , A61P3/06 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P27/02 , A61P27/14 , A61P27/16 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07C227/02 , C07C227/08 , C07C229/22 , C07C235/08 , C07C235/12 , C07C237/04 , C07C237/22 , C07C271/22 , C07C271/54 , C07C275/14 , C07C275/16 , C07C311/19 , C07C311/42 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/75 , C07D213/78 , C07D213/81 , C07D213/82 , C07D215/36 , C07D215/38 , C07D215/44 , C07D215/48 , C07D217/06 , C07D217/26 , C07D233/54 , C07D233/64 , C07D241/14 , C07D241/24 , C07D241/44 , C07D263/58 , C07D277/82 , C07D295/215 , C07D295/22 , C07D295/28 , C07D317/58 , C07D471/04 , A61K31/325 , A61K31/16 , C07D215/02 , C07D217/00
CPC分类号： C07D213/40 , C07C235/08 , C07C235/12 , C07C271/22 , C07C271/54 , C07C275/16 , C07C311/42 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/36 , C07D215/38 , C07D215/44 , C07D215/48 , C07D217/06 , C07D217/26 , C07D233/64 , C07D241/24 , C07D241/44 , C07D263/58 , C07D277/82 , C07D295/215 , C07D295/32 , C07D317/58 , C07D471/04
摘要： The present invention relates to a novel fatty acid derivative of the following formula: ##STR1## wherein R.sup.1 is acyl group, etc.;R.sup.2 is acyl(lower)alkyl;R.sup.3 is lower alkyl, etc.;R.sup.4 is hydrogen, etc.; andX is --O--, etc;and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.
摘要翻译： PCT No.PCT / JP95 / 00068 Sec。 371日期：1996年11月12日 102（e）日期1996年11月12日PCT 1995年1月23日PCT PCT。第WO95 / 19959号公报日期：1995年7月27日本发明涉及下式的新型脂肪酸衍生物：其中R1为酰基等; R2是酰基（低级）烷基; R3是低级烷基等; R4是氢等; X为-O-等; 和其药学上可接受的盐，其可用作药物; 所述脂肪酸衍生物或其盐的制备方法; 包含所述脂肪酸衍生物或其药学上可接受的盐的药物组合物; 等等

9. 发明授权

US5430022A Peptide compound and its preparation 失效
标题翻译：肽化合物及其制备
公开(公告)号：US5430022A
公开(公告)日：1995-07-04
申请号：US86094
申请日：1993-07-06
申请人： Keiji Hemmi , Masahiro Neya , Naoki Fukami , Masashi Hashimoto , Hirokazu Tanaka , Natsuko Kayakiri
发明人： Keiji Hemmi , Masahiro Neya , Naoki Fukami , Masashi Hashimoto , Hirokazu Tanaka , Natsuko Kayakiri
IPC分类号： A61K38/00 , C07K5/02 , C07K5/078 , C07K5/083 , C07K5/103 , A61K38/06 , C07K1/02 , C07K1/06 , C07K5/08
CPC分类号： C07K5/06156 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/0217 , C07K5/0808 , C07K5/101 , A61K38/00
摘要： Peptide compounds of the formula (I') ##STR1## in which R.sup.1 is acyl,R.sup.2 is lower alkyl, cyclo(lower)alkyl(lower)alkyl or optionally substituted heterocyclic(lower)alkyl,R.sup.3 is optionally substituted heterocyclic(lower)alkyl or optionally substituted ar(lower)alkyl,R.sup.4 is lower alkyl, amino(lower)alkyl, protected amino(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or optionally substituted heterocyclic(lower)alkyl,R.sup.5 is carboxy, protected carboxy, carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.6 is hydrogen, lower alkyl, C.sub.6-10 ar(lower)alkyl amino(lower)alkyl, protected amino(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, or heterocyclic(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is --O--, --NH--, lower alkylimino or lower alkylene, or a pharmaceutically acceptable salt thereof are disclosed. The compounds can be used to treat and prevent endothelin mediated diseases such as hypertension. The preparation of such peptides is also disclosed.
摘要翻译：式（I'）的肽化合物其中R 1是酰基，R 2是低级烷基，环（低级）烷基（低级）烷基或任选取代的杂环（低级）烷基），其中R 1是任选取代的杂环（低级）烷基或任选取代的芳（低级）烷基，R 4是低级烷基，氨基（低级）烷基，保护的氨基（低级）烷基，羧基烷基，R 5为羧基，保护的羧基，羧基（低级）烷基或保护的羧基（低级）烷基，R6为氢，低级烷基，C6-10ar（低级）烷基氨基（低级）烷基，被保护的氨基（低级）烷基，受保护的羧基（低级）烷基或杂环（低级）烷基，R7是氢或低级烷基，A是-O - ， - NH-，低级烷基亚氨基或低级亚烷基或其药学上可接受的盐是披露该化合物可用于治疗和预防内皮素介导的疾病如高血压。还公开了这种肽的制备。

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