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1. 发明申请

US20080214447A1 Cyclic Peptide Compound 失效
标题翻译：环状肽化合物
公开(公告)号：US20080214447A1
公开(公告)日：2008-09-04
申请号：US11719921
申请日：2005-11-21
申请人： Motoo Kobayashi , Satoshi Sasamura , Hideyuki Muramatsu , Yasuhisa Tsurumi , Shigehiro Takase , Kazuki Okada
发明人： Motoo Kobayashi , Satoshi Sasamura , Hideyuki Muramatsu , Yasuhisa Tsurumi , Shigehiro Takase , Kazuki Okada
IPC分类号： A61K38/12 , C07K7/64 , A61P31/12 , C12P21/04
CPC分类号： C07K7/645
摘要： A cyclic peptide compound of the following general formula (I): Wherein R1, R2 and R3 are defined in the description, or a salt thereof. The compound (I) is useful for the prophylactic and/or therapeutic treatment of hepatitis C.
摘要翻译：下列通式（I）的环肽化合物：其中R 1，R 2和R 3 3定义在说明书中，或其盐。化合物（I）可用于预防和/或治疗丙型肝炎。

2. 发明授权

US07696167B2 Cyclic peptide compound 失效
标题翻译：环肽化合物
公开(公告)号：US07696167B2
公开(公告)日：2010-04-13
申请号：US11719921
申请日：2005-11-21
申请人： Motoo Kobayashi , Satoshi Sasamura , Hideyuki Muramatsu , Yasuhisa Tsurumi , Shigehiro Takase , Kazuki Okada
发明人： Motoo Kobayashi , Satoshi Sasamura , Hideyuki Muramatsu , Yasuhisa Tsurumi , Shigehiro Takase , Kazuki Okada
IPC分类号： A61K38/00 , C12P21/06 , A61K38/12
CPC分类号： C07K7/645
摘要： A cyclic peptide compound of the following general formula (I): Wherein R1, R2 and R3 are defined in the description, or a salt thereof. The compound (I) is useful for the prophylactic and/or therapeutic treatment of hepatitis C.
摘要翻译：下述通式（I）的环状肽化合物或其盐，其中R1，R2和R3定义在说明书中。化合物（I）可用于预防和/或治疗丙型肝炎。

3. 发明授权

US06521600B1 Compound, WF002, production thereof and use thereof 失效
标题翻译：化合物，WF002，其制备及其用途
公开(公告)号：US06521600B1
公开(公告)日：2003-02-18
申请号：US09720331
申请日：2001-01-18
申请人： Yasuhiro Hori , Masami Ezaki , Yasuhisa Tsurumi , Shigehiro Takase , Motohiro Hino
发明人： Yasuhiro Hori , Masami Ezaki , Yasuhisa Tsurumi , Shigehiro Takase , Motohiro Hino
IPC分类号： A61K317028
CPC分类号： C12R1/645 , C07J63/008 , C12P19/60 , Y10S435/911
摘要： The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprising the compound and pharmaceutically acceptable carrier, a use of the WF002 as a medicament and use of the compound for manufacture of the medicament for treatment of infectious disease.
摘要翻译：本发明提供了具有抗病原微生物的抗微生物活性的新的式（I）生物活性化合物及其生产方法。还提供了包含该化合物和药学上可接受的载体的药物组合物，该WF002作为药物的用途以及该化合物用于制备用于治疗感染性疾病的药物的用途。

4. 发明授权

US06730776B1 WF14573 or its salt, production thereof and use thereof 失效
标题翻译： WF14573或其盐，其制备及其用途
公开(公告)号：US06730776B1
公开(公告)日：2004-05-04
申请号：US09646342
申请日：2000-09-18
申请人： Yasuhiro Hori , Shigehiro Takase , Yasuhisa Tsurumi , Michizane Hashimoto , Motohiro Hino
发明人： Yasuhiro Hori , Shigehiro Takase , Yasuhisa Tsurumi , Michizane Hashimoto , Motohiro Hino
IPC分类号： C07K750
CPC分类号： C07K7/56 , A61K38/00
摘要： The present invention provides a new antimicrobial compound WF14573, and a process for producing WF14573 by (a) culturing a WF14573A and/or B-producing microorganism in a nutrient medium and recovering WF14573A and/or B from the resultant cultured broth or (b) deacylating WF14573A and/or B in the presence of a microbial substance which is capable of deacylating WF14573A and/or B. Also provided are an antimicrobial agent comprising WF14573 and carrier(s), a pharmaceutical composition comprising an effective amount of WF14573 and pharmaceutically acceptable carrier(s), a method for killing microorganisms by applying WF14573 to the microorganisms, and use of WF14573 for the treatment of infectious diseases caused by pathogenic microorganisms.
摘要翻译：本发明提供了一种新的抗微生物化合物WF14573，以及（a）在营养培养基中培养WF14573A和/或产生B生物的微生物并从所得培养液中回收WF14573A和/或B或（b）生产WF14573的方法，在能够脱酰基WF14573A和/或B的微生物物质存在下脱酰基WF14573A和/或B。还提供了包含WF14573和载体的抗微生物剂，包含有效量的WF14573和药学上可接受的药物组合物载体，通过向微生物施用WF14573杀死微生物的方法，以及使用WF14573来治疗由病原微生物引起的感染性疾病。

5. 发明授权

US06331521B1 Echinocandine derivatives with antimicrobial activity 失效
标题翻译：棘皮类衍生物具有抗菌活性
公开(公告)号：US06331521B1
公开(公告)日：2001-12-18
申请号：US09423654
申请日：1999-12-01
申请人： Yasuhiro Hori , Yasuhisa Tsurumi , Shigehiro Takase , Hiroshi Hatanaka , Kazutoshi Sakamoto , Seiji Hashimoto , Hidenori Ohki , Takashi Tojo , Keiji Matsuda , Kohji Kawabata
发明人： Yasuhiro Hori , Yasuhisa Tsurumi , Shigehiro Takase , Hiroshi Hatanaka , Kazutoshi Sakamoto , Seiji Hashimoto , Hidenori Ohki , Takashi Tojo , Keiji Matsuda , Kohji Kawabata
IPC分类号： A61K3800
CPC分类号： C07K7/56 , A61K38/00
摘要： The invention relates to new polypeptide compounds represented by the following formula [I]: wherein R1 is hydrogen, etc, R2 is hydrogen, etc, R3 is hydrogen, etc, and R4 is hydrogen, etc, or a salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
摘要翻译：本发明涉及由下式[I]表示的新的多肽化合物：其中R 1为氢等，R 2为氢等，R 3为氢等，R 4为氢等，或其具有抗微生物活性的盐，抗真菌活性），对β-1,3-葡聚糖合酶的抑制活性，其制备方法，包含其的药物组合物，以及用于预防和/或治疗感染性疾病包括卡氏肺囊虫感染的方法（例如卡氏肺囊虫肺炎）在人或动物中。

6. 发明授权

US06656905B1 Cyclic tetrapeptide compound and use thereof 失效
标题翻译：环状四肽化合物及其用途
公开(公告)号：US06656905B1
公开(公告)日：2003-12-02
申请号：US09806500
申请日：2001-05-04
申请人： Hiroaki Mori , Kazutoshi Sakamoto , Yasuhisa Tsurumi , Shigehiro Takase , Motohiro Hino
发明人： Hiroaki Mori , Kazutoshi Sakamoto , Yasuhisa Tsurumi , Shigehiro Takase , Motohiro Hino
IPC分类号： A61K3807
CPC分类号： A61K38/12 , C07K5/126
摘要： A cyclic tetrapeptide compound and use thereof. Especially, a compound WF27082, a process for production of the compound by culturing, in a nutrient medium, a WF27082-producing strain belonging to Acremonium and recovering the compound from a culture broth, a pharmaceutical composition containing the compound as an active ingredient, in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound for use as a medicament, a use of the compound for manufacture of a medicament for inhibiting histone deacetylase, a use of the compound for manufacture of a medicament for treating or preventing inflammatory disorders, diabetes, diabetic complications, homozygous thalassemia, fibrosis, cirrhosis, acute promyelocytic leukaemia (APL), protozoal infections, organ transplant rejections, autoimmune diseases, or tumors, a use of histone deacetylase inhibitors as an immunosuppressant or an antitumor agent, and a use of histone deacetylase inhibitors for manufacture of a medicament for treating or preventing organ transplant rejections, autoimmune diseases or tumors are described.
摘要翻译：一种环状四肽化合物及其用途。特别地，化合物WF27082是通过在营养培养基中培养属于顶孢菌属的WF27082产生菌株并从培养液中回收化合物，将含有该化合物作为活性成分的药物组合物生产化合物的方法，与药学上可接受的，基本上无毒的载体或赋形剂的相关联，用作药物的化合物，该化合物用于制备用于抑制组蛋白脱乙酰酶的药物的用途，该化合物用于制备用于治疗或预防炎性疾病，糖尿病，糖尿病并发症，纯合地中海贫血，纤维化，肝硬化，急性早幼粒细胞白血病（APL），原生动物感染，器官移植排斥，自身免疫疾病或肿瘤，组蛋白脱乙酰酶抑制剂作为免疫抑制剂或抗肿瘤剂的用途，以及使用组蛋白脱乙酰酶抑制剂来制造用于治疗或预防的药物描述器官移植排斥，自身免疫性疾病或肿瘤。

7. 发明授权

US6110933A Amino acid derivatives and their use as phospholipase A.sub.2 inhibitor 失效
标题翻译：氨基酸衍生物及其作为磷脂酶A2抑制剂的用途
公开(公告)号：US6110933A
公开(公告)日：2000-08-29
申请号：US669395
申请日：1996-11-12
申请人： Shigehiro Takase , Nobuharu Shigematsu , Seiji Yoshimura , Satoshi Okada , Keiji Hemmi, deceased , Hirokazu Tanaka , Takanao Otsuka , Yasuhisa Tsurumi , Masanori Okamoto , Masakuni Okuhara , Naoki Fukami
发明人： Shigehiro Takase , Nobuharu Shigematsu , Seiji Yoshimura , Satoshi Okada , Keiji Hemmi, deceased , Hirokazu Tanaka , Takanao Otsuka , Yasuhisa Tsurumi , Masanori Okamoto , Masakuni Okuhara , Naoki Fukami
IPC分类号： C07D295/20 , A61K31/165 , A61K31/18 , A61K31/215 , A61K31/27 , A61K31/415 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/47 , A61K31/472 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P1/16 , A61P3/06 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P27/02 , A61P27/14 , A61P27/16 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07C227/02 , C07C227/08 , C07C229/22 , C07C235/08 , C07C235/12 , C07C237/04 , C07C237/22 , C07C271/22 , C07C271/54 , C07C275/14 , C07C275/16 , C07C311/19 , C07C311/42 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/75 , C07D213/78 , C07D213/81 , C07D213/82 , C07D215/36 , C07D215/38 , C07D215/44 , C07D215/48 , C07D217/06 , C07D217/26 , C07D233/54 , C07D233/64 , C07D241/14 , C07D241/24 , C07D241/44 , C07D263/58 , C07D277/82 , C07D295/215 , C07D295/22 , C07D295/28 , C07D317/58 , C07D471/04 , A61K31/325 , A61K31/16 , C07D215/02 , C07D217/00
CPC分类号： C07D213/40 , C07C235/08 , C07C235/12 , C07C271/22 , C07C271/54 , C07C275/16 , C07C311/42 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/36 , C07D215/38 , C07D215/44 , C07D215/48 , C07D217/06 , C07D217/26 , C07D233/64 , C07D241/24 , C07D241/44 , C07D263/58 , C07D277/82 , C07D295/215 , C07D295/32 , C07D317/58 , C07D471/04
摘要： The present invention relates to a novel fatty acid derivative of the following formula: ##STR1## wherein R.sup.1 is acyl group, etc.;R.sup.2 is acyl(lower)alkyl;R.sup.3 is lower alkyl, etc.;R.sup.4 is hydrogen, etc.; andX is --O--, etc;and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.
摘要翻译： PCT No.PCT / JP95 / 00068 Sec。 371日期：1996年11月12日 102（e）日期1996年11月12日PCT 1995年1月23日PCT PCT。第WO95 / 19959号公报日期：1995年7月27日本发明涉及下式的新型脂肪酸衍生物：其中R1为酰基等; R2是酰基（低级）烷基; R3是低级烷基等; R4是氢等; X为-O-等; 和其药学上可接受的盐，其可用作药物; 所述脂肪酸衍生物或其盐的制备方法; 包含所述脂肪酸衍生物或其药学上可接受的盐的药物组合物; 等等

8. 发明授权

US5447854A Production of cyclosporin A and/or C with a strain of NECTRIA 失效
标题翻译：用NECTRIA菌株生产环孢菌素A和/或C
公开(公告)号：US5447854A
公开(公告)日：1995-09-05
申请号：US90138
申请日：1993-11-10
申请人： Toshio Goto , Toru Kino , Masakuni Okuhara , Hirokazu Tanaka , Yasuhisa Tsurumi , Shigehiro Takase
发明人： Toshio Goto , Toru Kino , Masakuni Okuhara , Hirokazu Tanaka , Yasuhisa Tsurumi , Shigehiro Takase
IPC分类号： C07K7/64 , C12P21/04 , C12N1/14
CPC分类号： C12R1/645 , C07K7/645
摘要： The invention relates to a method of producing cyclosporin A and/or C which is characterized by culturing a cyclosporin A and/or C-producing strain of microorganism belonging to the genus Nectria (e.g. Nectria sp. F-4908) and recovering cyclosporin A and/or C from the resulting cultured broth.
摘要翻译： PCT No.PCT / JP92 / 00047 Sec。 371日期：1993年11月10日 102（e）日期1993年11月10日PCT 1992年1月22日PCT PCT。公开号WO92 / 13094 本发明涉及一种生产环孢菌素A和/或C的方法，其特征在于培养属于Nectria属的微生物的环孢菌素A和/或C产生菌株（例如Nectria sp.F- 4908），并从得到的培养肉汤中回收环孢菌素A和/或C。

9. 发明授权

US07741085B2 Compound WS727713 失效
标题翻译：化合物WS727713
公开(公告)号：US07741085B2
公开(公告)日：2010-06-22
申请号：US11547729
申请日：2005-03-22
申请人： Takanao Otsuka , Hirotsugu Ueda , Keiko Fujie , Hideyuki Muramatsu , Michizane Hashimoto , Shigehiro Takase
发明人： Takanao Otsuka , Hirotsugu Ueda , Keiko Fujie , Hideyuki Muramatsu , Michizane Hashimoto , Shigehiro Takase
IPC分类号： C12P1/04 , A61K38/12
CPC分类号： C12R1/01 , A61K8/99 , A61K35/74 , A61K2800/85 , A61Q5/065 , A61Q19/00 , C07G17/00 , C12P1/06
摘要： The present invention relates to a compound WS727713, useful as a modulator of melanocortin receptors, and a process for its production by culturing in a culture medium the actinomycetes strain of the genus Pseudonocardia, deposit number FERM BP-7570 and recovering the compound.
摘要翻译：本发明涉及可用作黑皮质素受体的调节剂的化合物WS727713，以及通过在培养基中培养假诺卡氏菌属的放线菌菌株FERM BP-7570并回收该化合物来生产的方法。

10. 发明申请

US20070254829A1 Compound Ws727713 失效
标题翻译：化合物Ws727713
公开(公告)号：US20070254829A1
公开(公告)日：2007-11-01
申请号：US11547729
申请日：2005-03-22
申请人： Takanao Otsuka , Hirotsugu Ueda , Keiko Fujie , Hideyuki Muramatsu , Michizane Hashimoto , Shigehiro Takase
发明人： Takanao Otsuka , Hirotsugu Ueda , Keiko Fujie , Hideyuki Muramatsu , Michizane Hashimoto , Shigehiro Takase
IPC分类号： A61K38/00 , C07K14/00 , C12N1/21 , C12P1/04
CPC分类号： C12R1/01 , A61K8/99 , A61K35/74 , A61K2800/85 , A61Q5/065 , A61Q19/00 , C07G17/00 , C12P1/06
摘要： The present invention relates to a new compound useful as a modulator of melanxocortin receptors. In particular, the present invention relates to a compound WS727713, a process for production of the compound by culturing, in a culture medium, a WS727713-producing strain belonging to Pseudonocardia and recovering the compound from a culture broth, a pharmaceutical composition containing the compound, a use of the compound for manufacture of a medicament or a cosmetic for melanocortin receptor modulation, a use of the compound for manufacture of a medicament or a cosmetic for treating or preventing ishemia/reperfusion injury, brain and renal inflammatory diseases, hepatitis, sepsis/septic shock, hypoxic shock, acute respiratory distress syndrome (ARDS), rheumatic arthritis (RA), gouty arthritis, aortic regurgitation (AR), juvenile chronic arthritis, osteoarthritis, nephritis, induction of tolerance, contact hypersensitivity, inflammatory bowel disease (IBD), sexual dysfunction, transplantation, pain, disease progression of HIV, postinflammatory hypopigmentation, tinea versicolor, idiopathic guttate hypomelanosis, fever, functional bowel disease, obesity, satiety effect, diabetes mellitus, modulation of dermal exocrine function, canities (canities circumscripta), gray hair, pancreatitis, fibrotic disorders (hypertrophic scars, keloids, localized scleroderma, systematic sclerosis, sclerodermic graft versus host disease of the skin, cirrhosis of the liver, idiopathic and bleomycin induced lung fibrosis, cyclosporin induced nephropathy), uveitis (especially in Behçet's syndrome and sarcoidosis), vasculitis, microbial infections, celiac disease, vulvar vestibulitis syndrome, melonoma invasion, anorexia or the like.
摘要翻译：本发明涉及可用作黑皮皮素受体调节剂的新化合物。特别地，本发明涉及化合物WS727713，该化合物的生产方法是在培养基中培养属于假诺卡氏菌属的WS727713生产菌株并从培养液中回收该化合物，含有该化合物的药物组合物，该化合物用于制造用于黑皮质素受体调节的药物或化妆品的用途，该化合物用于制备用于治疗或预防缺血/再灌注损伤，脑和肾炎性疾病，肝炎，败血症的药物或化妆品的用途 /脓毒性休克，缺氧休克，急性呼吸窘迫综合征（ARDS），风湿性关节炎（RA），痛风性关节炎，主动脉瓣反流（AR），青少年慢性关节炎，骨关节炎，肾炎，耐受诱导，接触性超敏反应，炎性肠病），性功能障碍，移植，疼痛，艾滋病病毒进展，炎性色素沉着，花斑斑，乳糜泻黄斑病，发热，功能性肠病，肥胖症，饱腹感，糖尿病，皮肤外分泌功能的调节，阴毛（canence circumscripta），灰白色头发，胰腺炎，纤维化疾病（肥大性瘢痕，瘢痕疙瘩，局部硬皮病，系统性硬化症，硬皮病皮肤移植物抗宿主病，肝硬化，特发性和博来霉素引起的肺纤维化，环孢菌素诱导的肾病），葡萄膜炎（尤其是Behçet综合征和结节病），血管炎，微生物感染，乳糜泻，外阴前庭炎综合征，美黄酮侵袭，厌食症等。

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